{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:23:49Z","timestamp":1790166229321,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007923","name":"Yangtze University","doi-asserted-by":"publisher","award":["2015610185"],"award-info":[{"award-number":["2015610185"]}],"id":[{"id":"10.13039\/501100007923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.bbrc.2018.02.063","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T13:14:56Z","timestamp":1518095696000},"page":"241-247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":68,"title":["Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress"],"prefix":"10.1016","volume":"497","author":[{"given":"Jiaqiao","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"June","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.02.063_bib1","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1056\/NEJM199904293401706","article-title":"Chronic myeloid leukemia","volume":"340","author":"Sawyers","year":"1999","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2018.02.063_bib2","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1182\/blood.V94.6.2056","article-title":"Isolation of a highly quiescent subpopulation of primitive leukemic cells in chronic myeloid leukemia","volume":"94","author":"Holyoake","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2018.02.063_bib3","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1182\/blood-2012-03-380147","article-title":"How I treat CML blast crisis","volume":"120","author":"Hehlmann","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2018.02.063_bib4","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1056\/NEJMoa040258","article-title":"Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML","volume":"351","author":"Jamieson","year":"2004","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2018.02.063_bib5","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1186\/s13071-015-1159-9","article-title":"Required duration of mass ivermectin treatment for onchocerciasis elimination in Africa: a comparative modelling analysis","volume":"8","author":"Stolk","year":"2015","journal-title":"Parasites Vectors"},{"key":"10.1016\/j.bbrc.2018.02.063_bib6","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1080\/15548627.2016.1231494","article-title":"Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer","volume":"12","author":"Wang","year":"2016","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2018.02.063_bib7","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1158\/0008-5472.CAN-15-2887","article-title":"Ivermectin induces cytostatic autophagy by blocking the PAK1\/Akt Axis in breast cancer","volume":"76","author":"Dou","year":"2016","journal-title":"Canc. Res."},{"key":"10.1016\/j.bbrc.2018.02.063_bib8","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.15252\/emmm.201404084","article-title":"The river blindness drug Ivermectin and related macrocyclic lactones inhibit WNT-TCF pathway responses in human cancer","volume":"6","author":"Melotti","year":"2014","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbrc.2018.02.063_bib9","doi-asserted-by":"crossref","first-page":"3593","DOI":"10.1182\/blood-2010-01-262675","article-title":"The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells","volume":"116","author":"Sharmeen","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2018.02.063_bib10","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.leukres.2016.05.010","article-title":"The sensitivity of chronic myeloid leukemia CD34 cells to Bcr-Abl tyrosine kinase inhibitors is modulated by ceramide levels","volume":"47","author":"Wang","year":"2016","journal-title":"Leuk. Res."},{"key":"10.1016\/j.bbrc.2018.02.063_bib11","doi-asserted-by":"crossref","first-page":"150845","DOI":"10.1155\/2014\/150845","article-title":"Apoptosis and molecular targeting therapy in cancer","volume":"2014","author":"Hassan","year":"2014","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.bbrc.2018.02.063_bib12","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1006\/jmcc.2001.1378","article-title":"Mitochondrial dysfunction in cardiac disease: ischemia\u2013reperfusion, aging, and heart failure","volume":"33","author":"Lesnefsky","year":"2001","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2018.02.063_bib13","doi-asserted-by":"crossref","first-page":"16222","DOI":"10.1038\/srep16222","article-title":"Modulation of P2X4\/P2X7\/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death","volume":"5","author":"Draganov","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2018.02.063_bib14","first-page":"1","article-title":"The direct PAK1 inhibitor, TAT-PAK18, blocks preferentially the growth of human ovarian cancer cell lines in which PAK1 is abnormally activated by autophosphorylation at Thr 423","volume":"4","author":"Hashimoto","year":"2010","journal-title":"Drug Discov. Ther."},{"key":"10.1016\/j.bbrc.2018.02.063_bib15","doi-asserted-by":"crossref","first-page":"E7301","DOI":"10.1073\/pnas.1705441114","article-title":"In\u00a0vivo loss-of-function screens identify KPNB1 as a new druggable oncogene in epithelial ovarian cancer","volume":"114","author":"Kodama","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2018.02.063_bib16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.bbrc.2016.10.064","article-title":"Anthelmintic drug ivermectin inhibits angiogenesis, growth and survival of glioblastoma through inducing mitochondrial dysfunction and oxidative stress","volume":"480","author":"Liu","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2018.02.063_bib17","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.cmet.2013.10.001","article-title":"mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation","volume":"18","author":"Morita","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbrc.2018.02.063_bib18","doi-asserted-by":"crossref","first-page":"22229","DOI":"10.1073\/pnas.0912074106","article-title":"Direct control of mitochondrial function by mTOR","volume":"106","author":"Ramanathan","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2018.02.063_bib19","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","article-title":"Mitochondrial formation of reactive oxygen species","volume":"552","author":"Turrens","year":"2003","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.bbrc.2018.02.063_bib20","first-page":"724360","article-title":"Emerging therapeutic strategies for targeting chronic myeloid leukemia stem cells","volume":"2013","author":"Hamad","year":"2013","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.bbrc.2018.02.063_bib21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.freeradbiomed.2008.10.036","article-title":"Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas","volume":"46","author":"Samper","year":"2009","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2018.02.063_bib22","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.ccr.2011.10.015","article-title":"Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia","volume":"20","author":"Skrtic","year":"2011","journal-title":"Canc. Cell"},{"key":"10.1016\/j.bbrc.2018.02.063_bib23","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.stem.2012.12.013","article-title":"BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells","volume":"12","author":"Lagadinou","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2018.02.063_bib24","article-title":"Drug repositioning for cancer therapy based on large-scale drug-induced transcriptional signatures","volume":"11","author":"Lee","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2018.02.063_bib25","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.bbrc.2015.12.059","article-title":"Pyrvinium selectively induces apoptosis of lymphoma cells through impairing mitochondrial functions and JAK2\/STAT5","volume":"469","author":"Xiao","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2018.02.063_bib26","doi-asserted-by":"crossref","first-page":"33769","DOI":"10.18632\/oncotarget.5615","article-title":"Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration","volume":"6","author":"Xiang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2018.02.063_bib27","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.ccr.2011.10.028","article-title":"Power cut: inhibiting mitochondrial translation to target leukemia","volume":"20","author":"Jaras","year":"2011","journal-title":"Canc. Cell"},{"key":"10.1016\/j.bbrc.2018.02.063_bib28","doi-asserted-by":"crossref","first-page":"102","DOI":"10.2174\/18722148113079990006","article-title":"Mitochondria in cancer stem cells: a target for therapy","volume":"7","author":"Loureiro","year":"2013","journal-title":"Recent Pat. Endocr. Metab. Immune Drug Discov."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18302869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18302869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:33:07Z","timestamp":1762093987000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18302869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["S0006291X18302869"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.02.063","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibiotic ivermectin selectively induces apoptosis in chronic myeloid leukemia through inducing mitochondrial dysfunction and oxidative stress","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.02.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}