{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T14:37:31Z","timestamp":1776004651835,"version":"3.50.1"},"reference-count":47,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006986","name":"Legacy Heritage Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006986","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["321\/11"],"award-info":[{"award-number":["321\/11"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.bbrc.2018.02.116","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T13:04:53Z","timestamp":1518699893000},"page":"605-611","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["NEK3-mediated SNAP29 phosphorylation modulates its membrane association and SNARE fusion dependent processes"],"prefix":"10.1016","volume":"497","author":[{"given":"Debora","family":"Rapaport","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Fichtman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilla","family":"Weidberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eli","family":"Sprecher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Horowitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.02.116_bib1","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0092-8674(03)01079-1","article-title":"The mechanisms of vesicle budding and fusion","volume":"116","author":"Bonifacino","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2018.02.116_bib2","doi-asserted-by":"crossref","first-page":"R187","DOI":"10.1016\/j.cub.2004.02.017","article-title":"Membrane fusion: caught in a trap","volume":"14","author":"Short","year":"2004","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2018.02.116_bib3","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/35052017","article-title":"SNARE-mediated membrane fusion","volume":"2","author":"Chen","year":"2001","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2018.02.116_bib4","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0092-8674(03)00112-0","article-title":"Membrane fusion","volume":"112","author":"Jahn","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2018.02.116_bib5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nrm2002","article-title":"SNAREs\u2013engines for membrane fusion","volume":"7","author":"Jahn","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2018.02.116_bib6","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nrm2417","article-title":"Mechanisms of membrane fusion: disparate players and common principles","volume":"9","author":"Martens","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2018.02.116_bib7","doi-asserted-by":"crossref","first-page":"14861","DOI":"10.1074\/jbc.M700971200","article-title":"Stringent 3Q.1R composition of the SNARE 0-layer can be bypassed for fusion by compensatory SNARE mutation or by lipid bilayer modification","volume":"282","author":"Fratti","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.02.116_bib8","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/j.1471-4159.2009.06205.x","article-title":"Palmitoylation of the synaptic vesicle fusion machinery","volume":"110","author":"Prescott","year":"2009","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.bbrc.2018.02.116_bib9","doi-asserted-by":"crossref","first-page":"34171","DOI":"10.1074\/jbc.273.51.34171","article-title":"Three novel proteins of the syntaxin\/SNAP-25 family","volume":"273","author":"Steegmaier","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.02.116_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0014-5793(96)00362-6","article-title":"Multiple palmitoylation of synaptotagmin and the t-SNARE SNAP-25","volume":"385","author":"Veit","year":"1996","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2018.02.116_bib11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1006\/bbrc.1999.0652","article-title":"SNAP-23 and SNAP-25 are palmitoylated in\u00a0vivo","volume":"258","author":"Vogel","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2018.02.116_bib12","doi-asserted-by":"crossref","first-page":"25769","DOI":"10.1074\/jbc.M502356200","article-title":"SNAP-29-mediated modulation of synaptic transmission in cultured hippocampal neurons","volume":"280","author":"Pan","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.02.116_bib13","doi-asserted-by":"crossref","first-page":"14038","DOI":"10.1073\/pnas.251532398","article-title":"SNAP-29: a general SNARE protein that inhibits SNARE disassembly and is implicated in synaptic transmission","volume":"98","author":"Su","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2018.02.116_bib14","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3109\/09537104.2015.1100282","article-title":"Identification of roles for the SNARE-associated protein, SNAP29, in mouse platelets","volume":"27","author":"Williams","year":"2016","journal-title":"Platelets"},{"key":"10.1016\/j.bbrc.2018.02.116_bib15","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1080\/15548627.2015.1037549","article-title":"ATG14 controls SNARE-mediated autophagosome fusion with a lysosome","volume":"11","author":"Liu","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2018.02.116_bib16","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/ncb3066","article-title":"O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation","volume":"16","author":"Guo","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2018.02.116_bib17","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.4161\/15548627.2014.981913","article-title":"Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila","volume":"10","author":"Morelli","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2018.02.116_bib18","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1086\/432556","article-title":"A\u00a0mutation in SNAP29, coding for a SNARE protein involved in intracellular trafficking, causes a novel neurocutaneous syndrome characterized by cerebral dysgenesis, neuropathy, ichthyosis, and palmoplantar keratoderma","volume":"77","author":"Sprecher","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2018.02.116_bib19","first-page":"610","article-title":"CEDNIK syndrome results from loss-of-function mutations in SNAP29","volume":"164","author":"Fuchs-Telem","year":"2011","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.bbrc.2018.02.116_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009759","article-title":"Loss of SNAP29 impairs endocytic recycling and cell motility","volume":"5","author":"Rapaport","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2018.02.116_bib21","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1091\/mbc.e11-04-0279","article-title":"Caenorhabditis elegans SNAP-29 is required for organellar integrity of the endomembrane system and general exocytosis in intestinal epithelial cells","volume":"22","author":"Sato","year":"2011","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2018.02.116_bib22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1073\/pnas.0706211105","article-title":"Activity-dependent phosphorylation of Ser187 is required for SNAP-25-negative modulation of neuronal voltage-gated calcium channels","volume":"105","author":"Pozzi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2018.02.116_bib23","doi-asserted-by":"crossref","first-page":"14548","DOI":"10.1074\/jbc.271.24.14548","article-title":"Phosphorylation of 25-kDa synaptosome-associated protein. Possible involvement in protein kinase C-mediated regulation of neurotransmitter release","volume":"271","author":"Shimazaki","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.02.116_bib24","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0896-6273(04)00077-7","article-title":"SNAP-25 modulation of calcium dynamics underlies differences in GABAergic and glutamatergic responsiveness to depolarization","volume":"41","author":"Verderio","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2018.02.116_bib25","doi-asserted-by":"crossref","first-page":"17076","DOI":"10.1074\/jbc.M513838200","article-title":"Identification of SNAP-47, a novel Qbc-SNARE with ubiquitous expression","volume":"281","author":"Holt","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.02.116_bib26","doi-asserted-by":"crossref","first-page":"40601","DOI":"10.1074\/jbc.M406896200","article-title":"Inhibition of SNAP-25 phosphorylation at Ser187 is involved in chronic morphine-induced down-regulation of SNARE complex formation","volume":"279","author":"Xu","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.02.116_bib27","doi-asserted-by":"crossref","first-page":"10565","DOI":"10.1074\/jbc.M111.294645","article-title":"Phospholipase C-related but catalytically inactive protein (PRIP) modulates synaptosomal-associated protein 25 (SNAP-25) phosphorylation and exocytosis","volume":"287","author":"Gao","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.02.116_bib28","doi-asserted-by":"crossref","first-page":"44369","DOI":"10.1074\/jbc.M307864200","article-title":"Phosphorylation of SNAP-23 in activated human platelets","volume":"278","author":"Polgar","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.02.116_bib29","doi-asserted-by":"crossref","first-page":"4567","DOI":"10.1182\/blood-2012-11-470468","article-title":"IkappaB kinase phosphorylation of SNAP-23 controls platelet secretion","volume":"121","author":"Karim","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2018.02.116_bib30","doi-asserted-by":"crossref","first-page":"13300","DOI":"10.1074\/jbc.271.23.13300","article-title":"Identification of a novel syntaxin- and synaptobrevin\/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues","volume":"271","author":"Ravichandran","year":"1996","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.02.116_bib31","doi-asserted-by":"crossref","first-page":"11089","DOI":"10.1021\/bi980253t","article-title":"Binary interactions of the SNARE proteins syntaxin-4, SNAP23, and VAMP-2 and their regulation by phosphorylation","volume":"37","author":"Foster","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2018.02.116_bib32","doi-asserted-by":"crossref","first-page":"6610","DOI":"10.1074\/jbc.M412126200","article-title":"Phosphorylation of SNAP-23 regulates exocytosis from mast cells","volume":"280","author":"Hepp","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.02.116_bib33","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cell.2008.05.050","article-title":"Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation","volume":"134","author":"Suzuki","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2018.02.116_bib34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0092-8674(74)90041-5","article-title":"Partial purification and characterization of the SV40 T antigen","volume":"3","author":"Henderson","year":"1974","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2018.02.116_bib35","doi-asserted-by":"crossref","first-page":"33054","DOI":"10.1074\/jbc.M009913200","article-title":"Association of insulin-like growth factor 1 receptor with EHD1 and SNAP29","volume":"276","author":"Rotem-Yehudar","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.02.116_bib36","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1042\/BJ20111010","article-title":"EHD2 mediates trafficking from the plasma membrane by modulating Rac1 activity","volume":"439","author":"Benjamin","year":"2011","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2018.02.116_bib37","doi-asserted-by":"crossref","first-page":"632","DOI":"10.2478\/s11658-008-0027-4","article-title":"EHDS are serine phosphoproteins: EHD1 phosphorylation is enhanced by serum stimulation","volume":"13","author":"Fichtman","year":"2008","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.bbrc.2018.02.116_bib38","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/S0960-9822(99)80332-7","article-title":"The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation","volume":"9","author":"Behn-Krappa","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2018.02.116_bib39","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s000180050328","article-title":"SNAREs and SNARE regulators in membrane fusion and exocytosis","volume":"55","author":"Gerst","year":"1999","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbrc.2018.02.116_bib40","article-title":"Drosophila SNAP-29 is an essential SNARE that binds multiple proteins involved in membrane traffic","volume":"9","author":"Xu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2018.02.116_bib41","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0167-4889(03)00096-X","article-title":"SNARE regulators: matchmakers and matchbreakers","volume":"1641","author":"Gerst","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2018.02.116_bib42","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1046\/j.1471-4159.1999.0720614.x","article-title":"Differential phosphorylation of syntaxin and synaptosome-associated protein of 25 kDa (SNAP-25) isoforms","volume":"72","author":"Risinger","year":"1999","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.bbrc.2018.02.116_bib43","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1523\/JNEUROSCI.5223-09.2010","article-title":"GSK-3 beta inhibits presynaptic vesicle exocytosis by phosphorylating P\/Q-type calcium channel and interrupting SNARE complex formation","volume":"30","author":"Zhu","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2018.02.116_bib44","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/j.bbamcr.2012.09.003","article-title":"Tyrosine phosphorylation of a SNARE protein, syntaxin 17: implications for membrane trafficking in the early secretory pathway","volume":"1823","author":"Muppirala","year":"2012","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2018.02.116_bib45","doi-asserted-by":"crossref","first-page":"11960","DOI":"10.1074\/jbc.M112.415075","article-title":"Increased activity of the vesicular soluble N-ethylmaleimide-sensitive factor attachment protein receptor TI-VAMP\/VAMP7 by tyrosine phosphorylation in the Longin domain","volume":"288","author":"Burgo","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.02.116_bib46","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1523\/JNEUROSCI.20-12-04535.2000","article-title":"Phosphorylated syntaxin 1 is localized to discrete domains along a subset of axons","volume":"20","author":"Foletti","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2018.02.116_bib47","doi-asserted-by":"crossref","first-page":"42893","DOI":"10.1074\/jbc.M103527200","article-title":"IgE receptor type I-dependent regulation of a Rab3D-associated kinase: a possible link in the calcium-dependent assembly of SNARE complexes","volume":"276","author":"Pombo","year":"2001","journal-title":"J.\u00a0Biol. Chem."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18303474?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18303474?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:22:43Z","timestamp":1757762563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18303474"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":47,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S0006291X18303474"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.02.116","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NEK3-mediated SNAP29 phosphorylation modulates its membrane association and SNARE fusion dependent processes","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.02.116","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}