{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:16:32Z","timestamp":1767906992999,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.bbrc.2018.02.149","type":"journal-article","created":{"date-parts":[[2018,2,17]],"date-time":"2018-02-17T18:12:16Z","timestamp":1518891136000},"page":"769-775","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Additional increased effects of mannitol-temozolomide combined treatment on blood-brain barrier permeability"],"prefix":"10.1016","volume":"497","author":[{"given":"Chunggab","family":"Choi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye Min","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeeheun","family":"Shon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiae","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyeong-Taek","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Hun","family":"Oh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nam Keun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7333-0647","authenticated-orcid":false,"given":"Ok Joon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.02.149_bib1","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1586\/14779072.6.8.1071","article-title":"Pharmacological approaches to improve endothelial repair mechanisms","volume":"6","author":"Besler","year":"2008","journal-title":"Expet Rev. Cardiovasc. Ther."},{"key":"10.1016\/j.bbrc.2018.02.149_bib2","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/978-1-60761-938-3_23","article-title":"Blood-brain barrier disruption in the treatment of brain tumors","volume":"686","author":"Blanchette","year":"2011","journal-title":"Meth. Mol. Biol."},{"key":"10.1016\/j.bbrc.2018.02.149_bib3","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.addr.2012.01.004","article-title":"Challenges in drug delivery to tumors of the central nervous system: an overview of pharmacological and surgical considerations","volume":"64","author":"Serwer","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.bbrc.2018.02.149_bib4","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1038\/sj.jcbfm.9600148","article-title":"VEGF-induced BBB permeability is associated with an MMP-9 activity increase in cerebral ischemia: both effects decreased by Ang-1","volume":"25","author":"Valable","year":"2005","journal-title":"J.\u00a0Cerebr. Blood Flow Metabol. : official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.bbrc.2018.02.149_bib5","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1089\/neu.2005.22.1011","article-title":"Erythropoietin enhances neurogenesis and restores spatial memory in rats after traumatic brain injury","volume":"22","author":"Lu","year":"2005","journal-title":"J.\u00a0Neurotrauma"},{"key":"10.1016\/j.bbrc.2018.02.149_bib6","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/nm.2399","article-title":"The immunology of stroke: from mechanisms to translation","volume":"17","author":"Iadecola","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2018.02.149_bib7","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1189\/jlb.1109766","article-title":"Inflammatory mechanisms in ischemic stroke: role of inflammatory cells","volume":"87","author":"Jin","year":"2010","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.bbrc.2018.02.149_bib8","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.neulet.2013.08.058","article-title":"Mannitol enhances therapeutic effects of intra-arterial transplantation of mesenchymal stem cells into the brain after traumatic brain injury","volume":"554","author":"Okuma","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2018.02.149_bib9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.brainres.2008.05.080","article-title":"Mannitol enhances delivery of marrow stromal cells to the brain after experimental intracerebral hemorrhage","volume":"1224","author":"Seyfried","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2018.02.149_bib10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0361-9230(03)00043-1","article-title":"Facilitation of drug entry into the CNS via transient permeation of blood brain barrier: laboratory and preliminary clinical evidence from bradykinin receptor agonist","volume":"60","author":"Borlongan","year":"2003","journal-title":"Cereport, Brain research bulletin"},{"key":"10.1016\/j.bbrc.2018.02.149_bib11","first-page":"41","article-title":"Ultrasound-mediated drug delivery to the brain: principles, progress and prospects, Drug discovery today","volume":"20","author":"Dasgupta","year":"2016","journal-title":"Technologies"},{"key":"10.1016\/j.bbrc.2018.02.149_bib12","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.3727\/096368916X690971","article-title":"Breaking the blood-brain barrier with mannitol to aid stem cell therapeutics in the chronic stroke brain","volume":"25","author":"Tajiri","year":"2016","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bbrc.2018.02.149_bib13","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s00018-013-1397-y","article-title":"Temozolomide down-regulates P-glycoprotein in human blood-brain barrier cells by disrupting Wnt3 signaling, Cellular and molecular life sciences","volume":"71","author":"Riganti","year":"2014","journal-title":"CMLS"},{"key":"10.1016\/j.bbrc.2018.02.149_bib14","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.3892\/mmr.2015.3754","article-title":"Combination of the multipotent mesenchymal stromal cell transplantation with administration of temozolomide increases survival of rats with experimental glioblastoma","volume":"12","author":"Bryukhovetskiy","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbrc.2018.02.149_bib15","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1161\/01.STR.20.1.84","article-title":"Reversible middle cerebral artery occlusion without craniectomy in rats","volume":"20","author":"Longa","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2018.02.149_bib16","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/0091270009348973","article-title":"Pharmacokinetic characteristics of bolus-administered mannitol in patients undergoing elective craniotomy","volume":"50","author":"Kaneda","year":"2010","journal-title":"J.\u00a0Clin. Pharmacol."},{"key":"10.1016\/j.bbrc.2018.02.149_bib17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1080\/00498250410001685737","article-title":"Disposition and pharmacokinetics of temozolomide in rat","volume":"34","author":"Reyderman","year":"2004","journal-title":"Xenobiotica; the fate of foreign compounds in biological systems"},{"key":"10.1016\/j.bbrc.2018.02.149_bib18","doi-asserted-by":"crossref","first-page":"10523","DOI":"10.1038\/ncomms10523","article-title":"Rapid endothelial cytoskeletal reorganization enables early blood-brain barrier disruption and long-term ischaemic reperfusion brain injury","volume":"7","author":"Shi","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2018.02.149_bib19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0006-8993(95)00511-N","article-title":"Isolation and culture of human brain microvessel endothelial cells for the study of blood-brain barrier properties in\u00a0vitro","volume":"692","author":"Biegel","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2018.02.149_bib20","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.5966\/sctm.2015-0023","article-title":"Intracarotid infusion of mesenchymal stem cells in an animal model of Parkinson's disease, focusing on cell distribution and neuroprotective and behavioral effects","volume":"4","author":"Cerri","year":"2015","journal-title":"Stem cells translational medicine"},{"key":"10.1016\/j.bbrc.2018.02.149_bib21","doi-asserted-by":"crossref","first-page":"531","DOI":"10.3727\/096368914X678337","article-title":"Mannitol-enhanced delivery of stem cells and their growth factors across the blood-brain barrier","volume":"23","author":"Gonzales-Portillo","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bbrc.2018.02.149_bib22","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1161\/01.STR.29.12.2631","article-title":"Mannitol at clinical concentrations activates multiple signaling pathways and induces apoptosis in endothelial cells","volume":"29","author":"Malek","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2018.02.149_bib23","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/WNR.0b013e32835f8acb","article-title":"Intravenous mannitol does not increase blood-brain barrier permeability to inert dyes in the adult rat forebrain","volume":"24","author":"Chen","year":"2013","journal-title":"Neuroreport"},{"key":"10.1016\/j.bbrc.2018.02.149_bib24","doi-asserted-by":"crossref","first-page":"8904","DOI":"10.1038\/ncomms9904","article-title":"Wnt\/beta-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance","volume":"6","author":"Wickstrom","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2018.02.149_bib25","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1385\/MB:30:1:057","article-title":"Molecular biology of the blood-brain barrier","volume":"30","author":"Pardridge","year":"2005","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.bbrc.2018.02.149_bib26","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1038\/jcbfm.2012.126","article-title":"Drug transport across the blood-brain barrier","volume":"32","author":"Pardridge","year":"2012","journal-title":"J.\u00a0Cerebr. Blood Flow Metabol. : official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"Suppl 1","key":"10.1016\/j.bbrc.2018.02.149_bib27","first-page":"S14","article-title":"Guidelines for the management of severe traumatic brain injury. II. Hyperosmolar therapy","volume":"24","author":"Brain Trauma","year":"2007","journal-title":"J.\u00a0Neurotrauma"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18303863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18303863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:32:29Z","timestamp":1762093949000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18303863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S0006291X18303863"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.02.149","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Additional increased effects of mannitol-temozolomide combined treatment on blood-brain barrier permeability","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.02.149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}