{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T17:06:11Z","timestamp":1779815171746,"version":"3.53.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.bbrc.2018.03.023","type":"journal-article","created":{"date-parts":[[2018,3,18]],"date-time":"2018-03-18T20:36:07Z","timestamp":1521405367000},"page":"715-722","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Superoxide dismutase 2 (SOD2) contributes to genetic stability of native and T315I-mutated BCR-ABL expressing leukemic cells"],"prefix":"10.1016","volume":"498","author":[{"given":"Sandrine","family":"Girerd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucie","family":"Tosca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Herault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Vignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Biard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djamel","family":"Aggoune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatima","family":"Dkhissi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Laure","family":"Bonnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Sorel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Desterke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annelise","family":"Bennaceur-Griscelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Tachdjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Guilhot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle","family":"Guilhot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Chomel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali G.","family":"Turhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.03.023_bib1","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1056\/NEJMra020777","article-title":"Chronic myeloid leukemia\u2013advances in biology and new approaches to treatment","volume":"349","author":"Goldman","year":"2003","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2018.03.023_bib2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/PPO.0b013e31823dec8d","article-title":"Evolution of therapies for chronic myelogenous leukemia","volume":"17","author":"Santos","year":"2011","journal-title":"Cancer J. Sudbury Mass"},{"key":"10.1016\/j.bbrc.2018.03.023_bib3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11899-007-0010-6","article-title":"Genomic instability: the cause and effect of BCR\/ABL tyrosine kinase","volume":"2","author":"Skorski","year":"2007","journal-title":"Curr. Hematol. Malig. Rep"},{"key":"10.1016\/j.bbrc.2018.03.023_bib4","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1182\/blood-2007-03-066936","article-title":"Bcr-Abl kinase domain mutations, drug resistance, and the road to a cure for chronic myeloid leukemia","volume":"110","author":"O'Hare","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2018.03.023_bib5","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1038\/sj.onc.1202619","article-title":"Mutator phenotype of BCR\u2013ABL transfected Ba\/F3 cell lines and its association with enhanced expression of DNA polymerase beta","volume":"18","author":"Canitrot","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2018.03.023_bib6","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1182\/blood.V97.7.2084","article-title":"BCR-ABL down-regulates the DNA repair protein DNA-PKcs","volume":"97","author":"Deutsch","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2018.03.023_bib7","doi-asserted-by":"crossref","first-page":"2576","DOI":"10.1158\/0008-5472.CAN-07-6858","article-title":"BCR\/ABL inhibits mismatch repair to protect from apoptosis and induce point mutations","volume":"68","author":"Stoklosa","year":"2008","journal-title":"Canc. Res."},{"key":"10.1016\/j.bbrc.2018.03.023_bib8","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1089\/ars.2009.2692","article-title":"Adaptation to oxidative stress, chemoresistance, and cell survival","volume":"11","author":"Landriscina","year":"2009","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.bbrc.2018.03.023_bib9","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1042\/bj2650659","article-title":"Modulation of fibroblast proliferation by oxygen free radicals","volume":"265","author":"Murrell","year":"1990","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2018.03.023_bib10","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0891-5849(02)00905-X","article-title":"Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression","volume":"33","author":"Zelko","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2018.03.023_bib11","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/jcp.22140","article-title":"Dysregulated calcium homeostasis and oxidative stress in chronic myeloid leukemia (CML) cells","volume":"224","author":"Ciarcia","year":"2010","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.bbrc.2018.03.023_bib12","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1073\/pnas.0510423103","article-title":"Gene expression changes associated with progression and response in chronic myeloid leukemia","volume":"103","author":"Radich","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.bbrc.2018.03.023_bib13","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/sj.leu.2401730","article-title":"Biological effects induced by variable levels of BCR-ABL protein in the pluripotent hematopoietic cell line UT-7","volume":"14","author":"Issaad","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrc.2018.03.023_bib14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.exphem.2012.12.004","article-title":"Biological effects of T315I-mutated BCR-ABL in an embryonic stem cell-derived hematopoiesis model","volume":"41","author":"Melkus","year":"2013","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.bbrc.2018.03.023_bib15","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1093\/nar\/gkm195","article-title":"Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones","volume":"35","author":"Biard","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2018.03.023_bib16","series-title":"DNA Repair - on the Pathways to Fixing DNA Damage and Errors","first-page":"43","article-title":"New insight on entangled DNA repair pathways: stable silenced human cells for unraveling the DDR jigsaw","author":"Biard","year":"2011"},{"key":"10.1016\/j.bbrc.2018.03.023_bib17","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1186\/1471-2105-7-520","article-title":"An accurate and interpretable model for siRNA efficacy prediction","volume":"7","author":"Vert","year":"2006","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.bbrc.2018.03.023_bib18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods San Diego Calif."},{"key":"10.1016\/j.bbrc.2018.03.023_bib19","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1093\/bioinformatics\/bti394","article-title":"MADE4: an R package for multivariate analysis of gene expression data","volume":"21","author":"Culhane","year":"2005","journal-title":"Bioinforma. Oxf. Engl"},{"key":"10.1016\/j.bbrc.2018.03.023_bib20","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.bbrc.2018.03.023_bib21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1046\/j.1474-9728.2003.00062.x","article-title":"Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts","volume":"2","author":"Samper","year":"2003","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbrc.2018.03.023_bib22","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1182\/blood-2011-02-335497","article-title":"Leukemic stem cell persistence in chronic myeloid leukemia patients with sustained undetectable molecular residual disease","volume":"118","author":"Chomel","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2018.03.023_bib23","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1159\/000152594","article-title":"Superoxide dismutase isozymes in different human tissues, their genetic control and intracellular localization","volume":"23","author":"Beckman","year":"1973","journal-title":"Hum. Hered."},{"key":"10.1016\/j.bbrc.2018.03.023_bib24","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ng1295-376","article-title":"Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase","volume":"11","author":"Li","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2018.03.023_bib25","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/ng0298-159","article-title":"A\u00a0novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase","volume":"18","author":"Melov","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2018.03.023_bib26","doi-asserted-by":"crossref","first-page":"H1422","DOI":"10.1152\/ajpheart.2001.281.3.H1422","article-title":"Knockout mice heterozygous for Sod2 show alterations in cardiac mitochondrial function and apoptosis","volume":"281","author":"Van Remmen","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2018.03.023_bib27","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1084\/jem.193.8.925","article-title":"Absence of mitochondrial superoxide dismutase results in a murine hemolytic anemia responsive to therapy with a catalytic antioxidant","volume":"193","author":"Friedman","year":"2001","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2018.03.023_bib28","first-page":"1297","article-title":"The role of manganese superoxide dismutase in the growth of pancreatic adenocarcinoma","volume":"63","author":"Cullen","year":"2003","journal-title":"Canc. Res."},{"key":"10.1016\/j.bbrc.2018.03.023_bib29","doi-asserted-by":"crossref","first-page":"585","DOI":"10.4161\/cbt.4.5.1704","article-title":"Epigenetic silencing of manganese superoxide dismutase (SOD-2) in KAS 6\/1 human multiple myeloma cells increases cell proliferation","volume":"4","author":"Hodge","year":"2005","journal-title":"Canc. Biol. Ther."},{"key":"10.1016\/j.bbrc.2018.03.023_bib30","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/path.946","article-title":"MnSOD expression is less frequent in tumour cells of invasive breast carcinomas than in in situ carcinomas or non-neoplastic breast epithelial cells","volume":"195","author":"Soini","year":"2001","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.bbrc.2018.03.023_bib31","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1038\/sj.onc.1206855","article-title":"Proteomic analysis of hematopoietic stem cell-like fractions in leukemic disorders","volume":"22","author":"Ota","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2018.03.023_bib32","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1182\/blood-2011-06-358705","article-title":"Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene","volume":"119","author":"Agrawal-Singh","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2018.03.023_bib33","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s11030-006-9031-7","article-title":"The changing of the guard: molecular diversity and rapid evolution of beta-defensins","volume":"10","author":"Semple","year":"2006","journal-title":"Mol. Divers."},{"key":"10.1016\/j.bbrc.2018.03.023_bib34","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/01.LAB.0000063929.61760.F6","article-title":"Cancer-specific loss of beta-defensin 1 in renal and prostatic carcinomas","volume":"83","author":"Donald","year":"2003","journal-title":"Lab. Investig. J. Tech. Methods Pathol"},{"key":"10.1016\/j.bbrc.2018.03.023_bib35","doi-asserted-by":"crossref","first-page":"8542","DOI":"10.1158\/0008-5472.CAN-06-0294","article-title":"Human beta-defensin-1, a potential chromosome 8p tumor suppressor: control of transcription and induction of apoptosis in renal cell carcinoma","volume":"66","author":"Sun","year":"2006","journal-title":"Canc. Res."},{"key":"10.1016\/j.bbrc.2018.03.023_bib36","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1155\/2011\/287690","article-title":"\u03b1-defensin 1-3 and \u03b1-defensin 4 as predictive markers of imatinib resistance and relapse in CML patients","volume":"30","author":"Etienne","year":"2011","journal-title":"Dis. Markers"},{"key":"10.1016\/j.bbrc.2018.03.023_bib37","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1172\/JCI4105","article-title":"The cell-surface heparan sulfate proteoglycan glypican-1 regulates growth factor action in pancreatic carcinoma cells and is overexpressed in human pancreatic cancer","volume":"102","author":"Kleeff","year":"1998","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2018.03.023_bib38","first-page":"5562","article-title":"Glypican-1 is overexpressed in human breast cancer and modulates the mitogenic effects of multiple heparin-binding growth factors in breast cancer cells","volume":"61","author":"Matsuda","year":"2001","journal-title":"Canc. Res."},{"key":"10.1016\/j.bbrc.2018.03.023_bib39","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/ijc.10856","article-title":"Glypican-3, overexpressed in hepatocellular carcinoma, modulates FGF2 and BMP-7 signaling","volume":"103","author":"Midorikawa","year":"2003","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.bbrc.2018.03.023_bib40","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.2353\/ajpath.2006.050800","article-title":"Glypican-1 is frequently overexpressed in human gliomas and enhances FGF-2 signaling in glioma cells","volume":"168","author":"Su","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2018.03.023_bib41","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.1182\/blood-2006-09-045104","article-title":"Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells","volume":"109","author":"Venturini","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2018.03.023_bib42","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1182\/blood.V63.4.789.789","article-title":"Prognostic discrimination in \u201cgood-risk\u201d chronic granulocytic leukemia","volume":"63","author":"Sokal","year":"1984","journal-title":"Blood"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18304972?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18304972?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:43:05Z","timestamp":1779813785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18304972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0006291X18304972"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.03.023","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Superoxide dismutase 2 (SOD2) contributes to genetic stability of native and T315I-mutated BCR-ABL expressing leukemic cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.03.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}