{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T11:58:43Z","timestamp":1790855923754,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"am","delay-in-days":354,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD000912-38"],"award-info":[{"award-number":["HD000912-38"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002019","name":"Children's Fund for Glycogen Storage Disease Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002019","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.bbrc.2018.03.083","type":"journal-article","created":{"date-parts":[[2018,3,18]],"date-time":"2018-03-18T11:09:10Z","timestamp":1521371350000},"page":"925-931","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Hepatic glucose-6-phosphatase-\u03b1 deficiency leads to metabolic reprogramming in glycogen storage disease type Ia"],"prefix":"10.1016","volume":"498","author":[{"given":"Jun-Ho","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goo-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian C.","family":"Mansfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4004-6516","authenticated-orcid":false,"given":"Janice Y.","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.03.083_bib1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2174\/1566524024605798","article-title":"Type I glycogen storage diseases: disorders of the glucose-6-phosphatase complex","volume":"2","author":"Chou","year":"2002","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.bbrc.2018.03.083_bib2","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nrendo.2010.189","article-title":"Glycogen storage disease type I and G6Pase-\u03b2 deficiency: etiology and therapy","volume":"6","author":"Chou","year":"2010","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbrc.2018.03.083_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cmet.2007.10.002","article-title":"The biology of cancer: metabolic reprogramming fuels cell growth and proliferation","volume":"7","author":"DeBerardinis","year":"2010","journal-title":"Cell Metabol."},{"key":"10.1016\/j.bbrc.2018.03.083_bib4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.tibs.2014.06.005","article-title":"The pentose phosphate pathway and cancer","volume":"39","author":"Patra","year":"2014","journal-title":"Trends biochem. Sci. Technol. Humanit."},{"key":"10.1016\/j.bbrc.2018.03.083_bib5","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1126\/science.1193494","article-title":"The control of the metabolic switch in cancers by oncogenes and tumor suppressor genes","volume":"330","author":"Levine","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2018.03.083_bib6","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/972913","article-title":"Role of glutathione in cancer progression and chemoresistance","volume":"2013","author":"Traverso","year":"2013","journal-title":"Oxid. Med.cell. longev"},{"key":"10.1016\/j.bbrc.2018.03.083_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006819","article-title":"Downregulation of SIRT1 signaling underlies hepatic autophagy impairment in glycogen storage disease type Ia","volume":"13","author":"Cho","year":"2017","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbrc.2018.03.083_bib8","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1038\/mt.2010.64","article-title":"Complete normalization of hepatic G6PC deficiency in murine glycogen storage disease type Ia using gene therapy","volume":"18","author":"Yiu","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbrc.2018.03.083_bib9","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1002\/hep.25717","article-title":"Prevention of hepatocellular adenoma and correction of metabolic abnormalities in murine glycogen storage disease type Ia by gene therapy","volume":"56","author":"Lee","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2018.03.083_bib10","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/ng0696-203","article-title":"Glucose-6-phosphatase dependent substrate transport in the glycogen storage disease type 1a mouse","volume":"13","author":"Lei","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2018.03.083_bib11","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jhep.2010.08.014","article-title":"Targeted deletion of liver glucose-6 phosphatase mimics glycogen storage disease type 1a including development of multiple adenomas","volume":"54","author":"Mutel","year":"2011","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2018.03.083_bib12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrc2274","article-title":"The interplay between MYC and HIF in cancer","volume":"8","author":"Dang","year":"2008","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bbrc.2018.03.083_bib13","doi-asserted-by":"crossref","first-page":"4777","DOI":"10.1038\/sj.onc.1209603","article-title":"Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria","volume":"25","author":"Mathupala","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2018.03.083_bib14","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.3892\/ol.2016.4168","article-title":"PKM2 and cancer: the function of PKM2 beyond glycolysis","volume":"11","author":"Dong","year":"2016","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.bbrc.2018.03.083_bib15","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature06734","article-title":"The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth","volume":"452","author":"Christofk","year":"2008","journal-title":"Nature"},{"issue":"Suppl 1","key":"10.1016\/j.bbrc.2018.03.083_bib16","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1007\/BF02679990","article-title":"Glycogen storage disease type I: diagnosis, management, clinical course and outcome. Results of the European Study on Glycogen Storage Disease Type I (ESGSD I)","volume":"161","author":"Rake","year":"2002","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.bbrc.2018.03.083_bib17","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10545-005-7500-2","article-title":"Hepatocellular carcinoma in glycogen storage disease type Ia: a case series","volume":"28","author":"Franco","year":"2005","journal-title":"J.\u00a0Inherit. Metab. Dis."},{"key":"10.1016\/j.bbrc.2018.03.083_bib18","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/j.trecan.2017.09.007","article-title":"The glycogen shunt maintains glycolytic homeostasis and the Warburg effect in cancer","volume":"11","author":"Shulman","year":"2017","journal-title":"Trends Cancer"},{"key":"10.1016\/j.bbrc.2018.03.083_bib19","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"Vander Heiden","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2018.03.083_bib20","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.ccr.2008.05.005","article-title":"Tumor cell metabolism: cancer's Achilles' heel","volume":"13","author":"Kroemer","year":"2008","journal-title":"Canc. Cell"},{"key":"10.1016\/j.bbrc.2018.03.083_bib21","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1038\/onc.2016.410","article-title":"Non-metabolic functions of glycolytic enzymes in tumorigenesis","volume":"36","author":"Yu","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2018.03.083_bib22","doi-asserted-by":"crossref","first-page":"4309","DOI":"10.1158\/1078-0432.CCR-12-1424","article-title":"Molecular pathways: reactive oxygen species homeostasis in cancer cells and implications for cancer therapy","volume":"19","author":"Nogueira","year":"2013","journal-title":"Clin. Canc. Res."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18305692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18305692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:42:42Z","timestamp":1779813762000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18305692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S0006291X18305692"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.03.083","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic glucose-6-phosphatase-\u03b1 deficiency leads to metabolic reprogramming in glycogen storage disease type Ia","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.03.083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}