{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T08:38:09Z","timestamp":1767861489136,"version":"3.49.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Foundation of Taizhou Technology Bureau","award":["131ky13"],"award-info":[{"award-number":["131ky13"]}]},{"name":"Province medical science and technology plan","award":["2016KYB325"],"award-info":[{"award-number":["2016KYB325"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.bbrc.2018.05.010","type":"journal-article","created":{"date-parts":[[2018,5,7]],"date-time":"2018-05-07T08:34:58Z","timestamp":1525682098000},"page":"300-306","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Altered expression of PGC-1 \u03b1 and PDX1 and their methylation status are associated with fetal glucose metabolism in gestational diabetes mellitus"],"prefix":"10.1016","volume":"501","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4398-548X","authenticated-orcid":false,"given":"Lizhen","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailing","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ludan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.05.010_bib1","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.physbeh.2010.04.008","article-title":"Perinatal environment and its influences on metabolic programming of offspring","volume":"100","author":"Tamashiro","year":"2010","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbrc.2018.05.010_bib2","first-page":"41","article-title":"The transgenerational mechanisms in developmental programming of metabolic diseases","volume":"61","author":"Zambrano","year":"2009","journal-title":"Rev. Investig. Clin. Organo Hosp. Enfermedades Nutr."},{"key":"10.1016\/j.bbrc.2018.05.010_bib3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cca.2015.01.021","article-title":"Gestational diabetes mellitus: where are we now?","volume":"451","author":"Ashwal","year":"2015","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"key":"10.1016\/j.bbrc.2018.05.010_bib4","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1373\/clinchem.2013.203331","article-title":"Gestational diabetes mellitus","volume":"59","author":"Coustan","year":"2013","journal-title":"Clin. Chem."},{"issue":"Suppl.\u00a02","key":"10.1016\/j.bbrc.2018.05.010_bib5","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000371628","article-title":"Gestational diabetes mellitus and macrosomia: a literature review","volume":"66","author":"Kc","year":"2015","journal-title":"Ann. Nutr. Metabol."},{"key":"10.1016\/j.bbrc.2018.05.010_bib6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13148-016-0247-9","article-title":"Increased global placental DNA methylation levels are associated with gestational diabetes","volume":"8","author":"Reichetzeder","year":"2016","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.bbrc.2018.05.010_bib7","doi-asserted-by":"crossref","first-page":"32268","DOI":"10.1038\/srep32268","article-title":"Up-regulation of miR-98 and unraveling regulatory mechanisms in gestational diabetes mellitus","volume":"6","author":"Cao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2018.05.010_bib8","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ajog.2008.08.022","article-title":"Global placental gene expression in gestational diabetes mellitus","volume":"200","author":"Enquobahrie","year":"2009","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.bbrc.2018.05.010_bib9","doi-asserted-by":"crossref","first-page":"R111","DOI":"10.1530\/REP-14-0334","article-title":"Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment","volume":"148","author":"El Hajj","year":"2014","journal-title":"Reproduction (Cambridge, England)"},{"issue":"Suppl.\u00a01","key":"10.1016\/j.bbrc.2018.05.010_bib10","doi-asserted-by":"crossref","first-page":"S88","DOI":"10.1111\/nure.12057","article-title":"Epigenetic programming of obesity and diabetes by in utero exposure to gestational diabetes mellitus","volume":"71","author":"Ruchat","year":"2013","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.bbrc.2018.05.010_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s00281-013-0406-4","article-title":"Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology","volume":"36","author":"Eisele","year":"2014","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.bbrc.2018.05.010_bib12","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.cmet.2005.05.004","article-title":"Metabolic control through the PGC-1 family of transcription coactivators","volume":"1","author":"Lin","year":"2005","journal-title":"Cell Metabol."},{"key":"10.1016\/j.bbrc.2018.05.010_bib13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/abbs\/gmr007","article-title":"PGC-1 coactivators in the control of energy metabolism","volume":"43","author":"Liu","year":"2011","journal-title":"Acta Biochim. Biophys. Sin."},{"key":"10.1016\/j.bbrc.2018.05.010_bib14","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.molmet.2015.08.001","article-title":"PGC-1 coactivators in beta-cells regulate lipid metabolism and are essential for insulin secretion coupled to fatty acids","volume":"4","author":"Oropeza","year":"2015","journal-title":"Mol. Metabol."},{"key":"10.1016\/j.bbrc.2018.05.010_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11154-013-9273-5","article-title":"Genetic models of PGC-1 and glucose metabolism and homeostasis","volume":"15","author":"Rowe","year":"2014","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.bbrc.2018.05.010_bib16","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.bbamcr.2010.09.019","article-title":"Metabolic control of mitochondrial biogenesis through the PGC-1 family regulatory network","volume":"1813","author":"Scarpulla","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2018.05.010_bib17","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1161\/ATVBAHA.108.181636","article-title":"Regulation of hypoxia-inducible genes by PGC-1 alpha","volume":"30","author":"Shoag","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2018.05.010_bib18","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/febs.13175","article-title":"New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond","volume":"282","author":"Villena","year":"2015","journal-title":"FEBS J."},{"key":"10.1016\/j.bbrc.2018.05.010_bib19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11154-013-9273-5","article-title":"Genetic models of PGC-1 and glucose metabolism and homeostasis","volume":"15","author":"Rowe","year":"2014","journal-title":"Rev. Endocr. Metab. Disord."},{"issue":"2007","key":"10.1016\/j.bbrc.2018.05.010_bib20","first-page":"1302","article-title":"Improved skeletal muscle oxidative enzyme activity and restoration of PGC-1 alpha and PPAR beta\/delta gene expression upon rosiglitazone treatment in obese patients with type 2 diabetes mellitus","volume":"31","author":"Mensink","year":"2005","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.bbrc.2018.05.010_bib21","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00125-007-0916-5","article-title":"Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion","volume":"51","author":"Ling","year":"2008","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2018.05.010_bib22","first-page":"376","article-title":"Association of rs12255372 (TCF7L2) and D76N (PDX-1) polymorphisms with type 2 diabetes in a population living in Northeast Iran","volume":"18","author":"Rafati","year":"2015","journal-title":"Arch. Iran. Med."},{"key":"10.1016\/j.bbrc.2018.05.010_bib23","first-page":"2316","article-title":"Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1","volume":"118","author":"Park","year":"2008","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2018.05.010_bib24","doi-asserted-by":"crossref","first-page":"3475","DOI":"10.2337\/db15-0376","article-title":"Diabetes susceptibility genes Pdx1 and Clec16a function in a pathway regulating mitophagy in beta-cells","volume":"64","author":"Soleimanpour","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2018.05.010_bib25","doi-asserted-by":"crossref","first-page":"14241","DOI":"10.1038\/srep14241","article-title":"Diabetic pdx1-mutant zebrafish show conserved responses to nutrient overload and anti-glycemic treatment","volume":"5","author":"Kimmel","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2018.05.010_bib26","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.2337\/diabetes.50.8.1799","article-title":"IPF1\/PDX1 deficiency and beta-cell dysfunction in Psammomys obesus, an animal with type 2 diabetes","volume":"50","author":"Leibowitz","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2018.05.010_bib27","doi-asserted-by":"crossref","first-page":"4031","DOI":"10.1172\/JCI44011","article-title":"Loss of Nix in Pdx1-deficient mice prevents apoptotic and necrotic beta cell death and diabetes","volume":"120","author":"Fujimoto","year":"2010","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2018.05.010_bib28","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.cmet.2013.12.002","article-title":"Pdx1 maintains beta cell identity and function by repressing an alpha cell program","volume":"19","author":"Gao","year":"2014","journal-title":"Cell Metabol."},{"key":"10.1016\/j.bbrc.2018.05.010_bib29","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1210\/me.2012-1004","article-title":"Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes","volume":"26","author":"Yang","year":"2012","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bbrc.2018.05.010_bib30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1530\/REP-14-0245","article-title":"Regulation of postnatal pancreatic Pdx1 and downstream target genes after gestational exposure to protein restriction in rats","volume":"149","author":"Abuzgaia","year":"2015","journal-title":"Reproduction (Cambridge, England)"},{"key":"10.1016\/j.bbrc.2018.05.010_bib31","first-page":"1224","article-title":"Increased hepatic peroxisome proliferator-activated receptor coactivator-1alpha expression precedes the development of insulin resistance in offspring of rats from severe hyperglycemic mothers","volume":"125","author":"Ma","year":"2012","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.bbrc.2018.05.010_bib32","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1152\/physiolgenomics.00059.2014","article-title":"In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring","volume":"46","author":"Borengasser","year":"2014","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.bbrc.2018.05.010_bib33","doi-asserted-by":"crossref","first-page":"E803","DOI":"10.1210\/jc.2010-2902","article-title":"Higher maternal gestational glucose concentration is associated with lower offspring insulin sensitivity and altered beta-cell function","volume":"96","author":"Bush","year":"2011","journal-title":"J.\u00a0Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.bbrc.2018.05.010_bib34","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.placenta.2014.02.012","article-title":"The human placenta project: placental structure, development, and function in real time","volume":"35","author":"Guttmacher","year":"2014","journal-title":"Placenta"},{"key":"10.1016\/j.bbrc.2018.05.010_bib35","doi-asserted-by":"crossref","first-page":"935","DOI":"10.4161\/epi.25578","article-title":"Gestational diabetes mellitus epigenetically affects genes predominantly involved in metabolic diseases","volume":"8","author":"Ruchat","year":"2013","journal-title":"Epigenetics"},{"key":"10.1016\/j.bbrc.2018.05.010_bib36","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1095\/biolreprod.115.131698","article-title":"DNA methylation and expression patterns of selected genes in first-trimester placental tissue from pregnancies with small-for-gestational-age infants at birth","volume":"94","author":"Leeuwerke","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbrc.2018.05.010_bib37","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13148-016-0239-9","article-title":"PPARGC1\u03b1 gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns","volume":"8","author":"C\u00f4t\u00e9","year":"2016","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.bbrc.2018.05.010_bib38","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.dsx.2012.05.018","article-title":"Mechanisms and techniques of reprogramming: using PDX-1 homeobox protein as a novel treatment of insulin dependent diabetes mellitus","volume":"6","author":"Blyth","year":"2012","journal-title":"Diabetes Metab. Syndrome"},{"key":"10.1016\/j.bbrc.2018.05.010_bib39","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1172\/JCI65390","article-title":"Inactivation of specific beta cell transcription factors in type 2 diabetes","volume":"123","author":"Guo","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2018.05.010_bib40","first-page":"5196","article-title":"High-fat diet induced insulin resistance in pregnant rats through pancreatic pax6 signaling pathway","volume":"8","author":"Wu","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.bbrc.2018.05.010_bib41","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.cbpa.2015.08.004","article-title":"Delayed access of low body weight-selected chicks to food at hatch is associated with up-regulated pancreatic glucagon and glucose transporter gene expression","volume":"189","author":"Parker","year":"2015","journal-title":"Comp. Biochem. Physiol. Mol. Integr. Physiol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18310556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18310556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T19:24:23Z","timestamp":1534879463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18310556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0006291X18310556"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.05.010","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered expression of PGC-1\u03b1 and PDX1 and their methylation status are associated with fetal glucose metabolism in gestational diabetes mellitus","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}