{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:57:11Z","timestamp":1773806231490,"version":"3.50.1"},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"European Union's Seventh Framework Programme","award":["613849"],"award-info":[{"award-number":["613849"]}]},{"name":"European Union's Horizon 2020 Programme","award":["635734"],"award-info":[{"award-number":["635734"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.bbrc.2018.05.014","type":"journal-article","created":{"date-parts":[[2018,5,17]],"date-time":"2018-05-17T22:55:02Z","timestamp":1526597702000},"page":"846-850","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s"],"prefix":"10.1016","volume":"501","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7713-1899","authenticated-orcid":false,"given":"Michele","family":"Tavanti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne L.","family":"Porter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin W.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Rub\u00e9n","family":"G\u00f3mez Castellanos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine L.","family":"Flitsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8708-0781","authenticated-orcid":false,"given":"Nicholas J.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.05.014_bib1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1021\/tx0002583","article-title":"Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity","volume":"14","author":"Guengerich","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bbrc.2018.05.014_bib2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.tibtech.2011.06.012","article-title":"Cytochrome P450 monooxygenases: an update on perspectives for synthetic application","volume":"30","author":"Urlacher","year":"2012","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.bbrc.2018.05.014_bib3","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.tibs.2012.11.006","article-title":"What makes a P450 tick?","volume":"38","author":"Munro","year":"2013","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbrc.2018.05.014_bib4","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bbagen.2006.07.017","article-title":"Cytochrome P450 systems-biological variations of electron transport chains","volume":"1770","author":"Hannemann","year":"2007","journal-title":"Biochim. Biophys. Acta Gen. Subj."},{"key":"10.1016\/j.bbrc.2018.05.014_bib5","series-title":"Cytochrome P450: Structure, Mechanism and Biochemistry","author":"Ortiz de Montellano","year":"2005"},{"key":"10.1016\/j.bbrc.2018.05.014_bib6","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1002\/prot.24840","article-title":"Identification of universal selectivity-determining positions in cytochrome P450 monooxygenases by systematic sequence-based literature mining","volume":"83","author":"Gricman","year":"2015","journal-title":"Proteins"},{"key":"10.1016\/j.bbrc.2018.05.014_bib7","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1089\/ars.2010.3109","article-title":"Conformational plasticity and structure\/function relationships in cytochrome P450","volume":"13","author":"Pochapsky","year":"2010","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.bbrc.2018.05.014_bib8","doi-asserted-by":"crossref","first-page":"3898","DOI":"10.1128\/JB.184.14.3898-3908.2002","article-title":"Identification of a new class of cytochrome P450 from a rhodococcus sp","volume":"184","author":"Roberts","year":"2002","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.bbrc.2018.05.014_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/science.aao1482","article-title":"Anti-Markovnikov alkene oxidation by metal-oxo\u2013mediated enzyme catalysis","volume":"358","author":"Hammer","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2018.05.014_bib10","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s10529-010-0233-9","article-title":"Engineering cytochrome P450 monooxygenase CYP 116B3 for high dealkylation activity","volume":"32","author":"Liu","year":"2010","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.bbrc.2018.05.014_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/cctc.201801078","article-title":"Enhancing the catalytic performance of a CYP116B monooxygenase by transdomain combination mutagenesis","author":"Li","year":"2018","journal-title":"ChemCatChem"},{"key":"10.1016\/j.bbrc.2018.05.014_bib12","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/cctc.201701510","article-title":"Panel of new thermostable CYP116B self-sufficient cytochrome P450 monooxygenases that catalyze C\u2212H activation with a diverse substrate scope","volume":"10","author":"Tavanti","year":"2018","journal-title":"ChemCatChem"},{"key":"10.1016\/j.bbrc.2018.05.014_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.enzmictec.2018.02.005","article-title":"Cloning, expression and characterisation of P450-Hal1 (CYP116B62) from Halomonas sp. NCIMB 172: a self-sufficient P450 with high expression and diverse substrate scope","volume":"113","author":"Porter","year":"2018","journal-title":"Enzym. Microb. Technol."},{"key":"10.1016\/j.bbrc.2018.05.014_bib14","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.febslet.2005.03.016","article-title":"Analysis of the domain properties of the novel cytochrome P450 RhF","volume":"579","author":"Hunter","year":"2005","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2018.05.014_bib15","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1002\/cbic.201402309","article-title":"Unusually Broad substrate profile of self-sufficient cytochrome P450 monooxygenase CYP116B4 from labrenzia aggregata","volume":"15","author":"Yin","year":"2014","journal-title":"Chembiochem"},{"key":"10.1016\/j.bbrc.2018.05.014_bib16","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00253-009-2118-1","article-title":"Sequence analysis and heterologous expression of a new cytochrome P450 monooxygenase from Rhodococcus sp. for asymmetric sulfoxidation","volume":"85","author":"Zhang","year":"2010","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bbrc.2018.05.014_bib17","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1111\/j.1742-4658.2012.08543.x","article-title":"Characterization of Cupriavidus metallidurans CYP116B1-A thiocarbamate herbicide oxygenating P450-phthalate dioxygenase reductase fusion protein","volume":"279","author":"Warman","year":"2012","journal-title":"FEBS J."},{"key":"10.1016\/j.bbrc.2018.05.014_bib18","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/mmi.12883","article-title":"CYP116B5: a new class VII catalytically self-sufficient cytochrome P450 from Acinetobacter radioresistens that enables growth on alkanes","volume":"95","author":"Minerdi","year":"2015","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.bbrc.2018.05.014_bib19","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1007\/s00253-006-0355-0","article-title":"Cloning, expression, and characterization of a self-sufficient cytochrome P450 monooxygenase from Rhodococcus ruber DSM 44319","volume":"72","author":"Liu","year":"2006","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.bbrc.2018.05.014_bib20","doi-asserted-by":"crossref","first-page":"13861","DOI":"10.1021\/jacs.5b07107","article-title":"Structural adaptability facilitates histidine heme ligation in a cytochrome P450","volume":"137","author":"McIntosh","year":"2015","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.bbrc.2018.05.014_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega","volume":"7","author":"Sievers","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.bbrc.2018.05.014_bib22","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/nar\/gku316","article-title":"Deciphering key features in protein structures with the new ENDscript server","volume":"42","author":"Robert","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2018.05.014_bib23","first-page":"2101","article-title":"3DM: systematic analysis of heterogeneous superfamily data to discover protein functionalities","volume":"78","author":"Kuipers","year":"2010","journal-title":"Proteins Struct. Funct. Bioinf."},{"key":"10.1016\/j.bbrc.2018.05.014_bib24","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1093\/bioinformatics\/btm268","article-title":"The cytochrome P450 engineering database: a navigation and prediction tool for the cytochrome P450 protein family","volume":"23","author":"Fischer","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bbrc.2018.05.014_bib25","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: molecular evolutionary genetics analysis version 7.0 for bigger datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.bbrc.2018.05.014_bib26","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/1471-2105-7-316","article-title":"CAVER: a new tool to explore routes from protein clefts, pockets and cavities","volume":"7","author":"Petrek","year":"2006","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.bbrc.2018.05.014_bib27","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1107\/S0907444910007493","article-title":"Features and development of coot","volume":"66","author":"Emsley","year":"2010","journal-title":"Acta Crystallogr. Sect. D Biol. Crystallogr."},{"key":"10.1016\/j.bbrc.2018.05.014_bib28","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1073\/pnas.1702317114","article-title":"Selective oxidation of aliphatic C\u2013H bonds in alkylphenols by a chemomimetic biocatalytic system","volume":"114","author":"Du","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbrc.2018.05.014_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0969-2126(01)00134-4","article-title":"Structure and function of cytochromes P450: a comparative analysis of three crystal structures","volume":"2","author":"Hasemann","year":"1995","journal-title":"Structure"},{"key":"10.1016\/j.bbrc.2018.05.014_bib30","doi-asserted-by":"crossref","first-page":"30344","DOI":"10.1039\/C6CP03692A","article-title":"Lipid molecules can induce an opening of membrane-facing tunnels in cytochrome P450 1A2","volume":"18","author":"\u00c1bek","year":"2016","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.bbrc.2018.05.014_bib31","doi-asserted-by":"crossref","first-page":"14129","DOI":"10.1021\/bi7013695","article-title":"Alteration of P450 distal pocket solvent leads to impaired proton delivery and changes in heme geometry","volume":"46","author":"Makris","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2018.05.014_bib32","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1021\/bi100183g","article-title":"P450cam visits an open conformation in the absence of substrate","volume":"49","author":"Lee","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2018.05.014_bib33","doi-asserted-by":"crossref","first-page":"11530","DOI":"10.1021\/bi00094a009","article-title":"Molecular recognition in cytochrome P-450: mechanism for the control of uncoupling reactions","volume":"32","author":"Loida","year":"1993","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2018.05.014_bib34","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1002\/cctc.201701092","article-title":"Two-enzyme hydrogen-borrowing amination of alcohols enabled by a cofactor switched alcohol dehydrogenase","volume":"9","author":"Thompson","year":"2017","journal-title":"ChemCatChem"},{"key":"10.1016\/j.bbrc.2018.05.014_bib35","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/cbic.201700546","article-title":"Stabilization of the reductase domain in the catalytically self-sufficient cytochrome P450BM3 via consensus-guided mutagenesis","volume":"19","author":"Saab-Rinc\u00f3n","year":"2017","journal-title":"Chembiochem"},{"key":"10.1016\/j.bbrc.2018.05.014_bib36","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/nar\/gkq366","article-title":"Dali server: conservation mapping in 3D","volume":"38","author":"Holm","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2018.05.014_bib37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0021-9258(18)48462-1","article-title":"Substrate recognition sites in cytochrome-P450 family-2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences","volume":"267","author":"Gotoh","year":"1992","journal-title":"J.\u00a0Biol. Chem."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18310593?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18310593?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T21:15:40Z","timestamp":1720300540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18310593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0006291X18310593"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.05.014","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}