{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:54:24Z","timestamp":1777031664551,"version":"3.51.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572291"],"award-info":[{"award-number":["81572291"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY17H160053"],"award-info":[{"award-number":["LY17H160053"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LGF18H160031"],"award-info":[{"award-number":["LGF18H160031"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["GF18H160071"],"award-info":[{"award-number":["GF18H160071"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LGF18H160032"],"award-info":[{"award-number":["LGF18H160032"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical and Health Technology Projects of Zhejiang province","award":["2017187475"],"award-info":[{"award-number":["2017187475"]}]},{"name":"Science and Technology Project of Wenzhou","award":["Y20170030"],"award-info":[{"award-number":["Y20170030"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.bbrc.2018.05.026","type":"journal-article","created":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T04:15:10Z","timestamp":1525925710000},"page":"636-642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Dihydroartemisinin potentiates antitumor activity of 5-fluorouracil against a resistant colorectal cancer cell line"],"prefix":"10.1016","volume":"501","author":[{"given":"Zhihan","family":"Yao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0406-2685","authenticated-orcid":false,"given":"Adheesh","family":"Bhandari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiyuan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongfa","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erjie","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ouchen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"66","key":"10.1016\/j.bbrc.2018.05.026_bib1","first-page":"115","article-title":"Cancer statistics in China","volume":"2016","author":"Chen","year":"2015","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.bbrc.2018.05.026_bib2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3816\/CCC.2006.n.036","article-title":"Liver resection for metastatic colorectal cancer in the age of neoadjuvant chemotherapy and bevacizumab","volume":"6","author":"Yoo","year":"2006","journal-title":"Clin. Colorectal Canc."},{"key":"10.1016\/j.bbrc.2018.05.026_bib3","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nrc864","article-title":"Live or let die: the cell's response to p53","volume":"2","author":"Vousden","year":"2002","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bbrc.2018.05.026_bib4","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ccr.2014.01.021","article-title":"Mutant p53 in cancer: new functions and therapeutic opportunities","volume":"25","author":"Muller","year":"2014","journal-title":"Canc. Cell"},{"key":"10.1016\/j.bbrc.2018.05.026_bib5","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1101\/gad.190678.112","article-title":"Mutant p53: one name, many proteins","volume":"26","author":"Freed-Pastor","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2018.05.026_bib6","first-page":"247","article-title":"TP53 mutation spectra and load: a tool for generating hypotheses on the etiology of cancer","author":"Olivier","year":"2004","journal-title":"IARC Sci. Publ."},{"key":"10.1016\/j.bbrc.2018.05.026_bib7","doi-asserted-by":"crossref","first-page":"5001","DOI":"10.1158\/0008-5472.CAN-15-0563","article-title":"p53: protection against tumor growth beyond effects on cell cycle and apoptosis","volume":"75","author":"Wang","year":"2015","journal-title":"Canc. Res."},{"key":"10.1016\/j.bbrc.2018.05.026_bib8","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nrc2723","article-title":"The first 30 years of p53: growing ever more complex","volume":"9","author":"Levine","year":"2009","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bbrc.2018.05.026_bib9","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1093\/carcin\/bgu073","article-title":"The paradigm of mutant p53-expressing cancer stem cells and drug resistance","volume":"35","author":"Shetzer","year":"2014","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbrc.2018.05.026_bib10","doi-asserted-by":"crossref","first-page":"8921","DOI":"10.18632\/oncotarget.13475","article-title":"The role of p53 in cancer drug resistance and targeted chemotherapy","volume":"8","author":"Hientz","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2018.05.026_bib11","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/sj.cdd.4401194","article-title":"Mutation of p53 and consecutive selective drug resistance in B-CLL occurs as a consequence of prior DNA-damaging chemotherapy","volume":"10","author":"Sturm","year":"2003","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.bbrc.2018.05.026_bib12","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.bcp.2012.02.002","article-title":"Dihydroartemisinin exhibits antitumor activity toward hepatocellular carcinoma in\u00a0vitro and in\u00a0vivo","volume":"83","author":"Zhang","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2018.05.026_bib13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0024-3205(01)01372-8","article-title":"Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells","volume":"70","author":"Singh","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2018.05.026_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082962","article-title":"Anticancer properties of distinct antimalarial drug classes","volume":"8","author":"Hooft van Huijsduijnen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2018.05.026_bib15","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1007\/s00432-014-1771-7","article-title":"Synergic effects of artemisinin and resveratrol in cancer cells","volume":"140","author":"Li","year":"2014","journal-title":"J.\u00a0Canc. Res. Clin. Oncol."},{"key":"10.1016\/j.bbrc.2018.05.026_bib16","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s10495-011-0580-6","article-title":"Interruption of the MEK\/ERK signaling cascade promotes dihydroartemisinin-induced apoptosis in\u00a0vitro and in\u00a0vivo","volume":"16","author":"Gao","year":"2011","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbrc.2018.05.026_bib17","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4103\/0973-1482.151855","article-title":"Dihydroartemisinin inhibits cell proliferation by induced G1 arrest and apoptosis in human nasopharyngealcarcinoma cells","volume":"12","author":"Huang","year":"2016","journal-title":"J.\u00a0Canc. Res. Therapeut."},{"key":"10.1016\/j.bbrc.2018.05.026_bib18","first-page":"15","article-title":"Single-cell analysis of dihydroartemisinin-induced apoptosis through reactive oxygen species-mediated caspase-8 activation and mitochondrial pathway in ASTC-a-1 cells using fluorescence imaging techniques","author":"Lu","year":"2010","journal-title":"J.\u00a0Biomed. Optic."},{"key":"10.1016\/j.bbrc.2018.05.026_bib19","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrc1074","article-title":"5-fluorouracil: mechanisms of action and clinical strategies","volume":"3","author":"Longley","year":"2003","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bbrc.2018.05.026_bib20","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1002\/cncr.20154","article-title":"New systemic frontline treatment for metastatic colorectal carcinoma","volume":"100","author":"Braun","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.bbrc.2018.05.026_bib21","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1056\/NEJM200009283431302","article-title":"Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group","volume":"343","author":"Saltz","year":"2000","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2018.05.026_bib22","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.ctrv.2006.07.001","article-title":"Irinotecan in the treatment of colorectal cancer","volume":"32","author":"Fuchs","year":"2006","journal-title":"Canc. Treat Rev."},{"key":"10.1016\/j.bbrc.2018.05.026_bib23","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000088957","article-title":"Intestinal permeability in the assessment of intestinal toxicity of cytotoxic agents","volume":"51","author":"Melichar","year":"2005","journal-title":"Chemotherapy"},{"key":"10.1016\/j.bbrc.2018.05.026_bib24","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","article-title":"Reactive oxygen species, cellular redox systems, and apoptosis","volume":"48","author":"Circu","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2018.05.026_bib25","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.tcb.2010.03.004","article-title":"The regulation of energy metabolism and the IGF-1\/mTOR pathways by the p53 protein","volume":"20","author":"Feng","year":"2010","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbrc.2018.05.026_bib26","first-page":"623","article-title":"Apoptotic death of tumor cells correlates with chemosensitivity, independent of p53 or bcl-2","volume":"2","author":"Wu","year":"1996","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.bbrc.2018.05.026_bib27","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/S0891-5849(96)00508-4","article-title":"Artemisinin enhances heme-catalysed oxidation of lipid membranes","volume":"22","author":"Berman","year":"1997","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2018.05.026_bib28","doi-asserted-by":"crossref","first-page":"2945","DOI":"10.1021\/jm030571c","article-title":"A\u00a0medicinal chemistry perspective on artemisinin and related endoperoxides","volume":"47","author":"O'Neill","year":"2004","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.bbrc.2018.05.026_bib29","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1007\/s13277-014-1691-9","article-title":"Dihydroartemisinin induces apoptosis in colorectal cancer cells through the mitochondria-dependent pathway","volume":"35","author":"Lu","year":"2014","journal-title":"Tumour Biol"},{"key":"10.1016\/j.bbrc.2018.05.026_bib30","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1177\/030089161109700615","article-title":"Dihydroartemisinin induces endoplasmic reticulum stress-mediated apoptosis in HepG2 human hepatoma cells","volume":"97","author":"Gao","year":"2011","journal-title":"Tumori"},{"key":"10.1016\/j.bbrc.2018.05.026_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/f7203563-87dc-4d11-a1b7-958f81cf743a","article-title":"Dihydroartemisinin enhances Apo2L\/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5","volume":"7","author":"Kong","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2018.05.026_bib32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm3722","article-title":"Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy","volume":"15","author":"Czabotar","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2018.05.026_bib33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrc.2015.17","article-title":"Thirty years of BCL-2: translating cell death discoveries into novel cancer therapies","volume":"16","author":"Delbridge","year":"2016","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bbrc.2018.05.026_bib34","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.18632\/oncotarget.6405","article-title":"Bcl-2 family proteins as regulators of cancer cell invasion and metastasis: a review focusing on mitochondrial respiration and reactive oxygen species","volume":"7","author":"Um","year":"2016","journal-title":"Oncotarget"},{"issue":"Pt A","key":"10.1016\/j.bbrc.2018.05.026_bib35","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.mito.2014.06.002","article-title":"Mitochondrial ROS and involvement of Bcl-2 as a mitochondrial ROS regulator","volume":"19","author":"Chong","year":"2014","journal-title":"Mitochondrion"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18310751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18310751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,21]],"date-time":"2018-08-21T16:22:43Z","timestamp":1534868563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18310751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0006291X18310751"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.05.026","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dihydroartemisinin potentiates antitumor activity of 5-fluorouracil against a resistant colorectal cancer cell line","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.05.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}