{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:48:26Z","timestamp":1764784106583,"version":"3.44.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Hubei Province Health and Family Planning Commission","award":["WJ2015M166"],"award-info":[{"award-number":["WJ2015M166"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.bbrc.2018.06.102","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T21:08:23Z","timestamp":1529615303000},"page":"956-962","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Amide-linked local anesthetics preferentially target leukemia stem cell through inhibition of Wnt\/\u03b2-catenin"],"prefix":"10.1016","volume":"503","author":[{"given":"Juan","family":"Ni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meifang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lishen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.06.102_bib1","first-page":"1","article-title":"The effects of anesthetics on tumor progression","volume":"5","author":"Mao","year":"2013","journal-title":"International journal of physiology, pathophysiology and pharmacology"},{"key":"10.1016\/j.bbrc.2018.06.102_bib2","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1213\/ANE.0b013e3181de0ab6","article-title":"Review article: the role of the perioperative period in recurrence after cancer surgery","volume":"110","author":"Gottschalk","year":"2010","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.bbrc.2018.06.102_bib3","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/anae.13342","article-title":"Anaesthesia for oncological surgery - can it really influence cancer recurrence?","volume":"71","author":"Ciechanowicz","year":"2016","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bbrc.2018.06.102_bib4","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/ijc.26448","article-title":"Cancer recurrence after surgery: direct and indirect effects of anesthetic agents","volume":"130","author":"Tavare","year":"2012","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.bbrc.2018.06.102_bib5","article-title":"Opioids and the immune system - friend or foe","volume":"18","author":"Plein","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2018.06.102_bib6","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/00000542-200610000-00008","article-title":"Can anesthetic technique for primary breast cancer surgery affect recurrence or metastasis?","volume":"105","author":"Exadaktylos","year":"2006","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bbrc.2018.06.102_bib7","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/ALN.0b013e31817f5b73","article-title":"Anesthetic technique for radical prostatectomy surgery affects cancer recurrence: a retrospective analysis","volume":"109","author":"Biki","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bbrc.2018.06.102_bib8","doi-asserted-by":"crossref","first-page":"e56540","DOI":"10.1371\/journal.pone.0056540","article-title":"The effect of anesthetic technique on survival in human cancers: a meta-analysis of retrospective and prospective studies","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2018.06.102_bib9","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1097\/ACO.0b013e3281c10a08","article-title":"Local anesthetics","volume":"20","author":"Heavner","year":"2007","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"10.1016\/j.bbrc.2018.06.102_bib10","doi-asserted-by":"crossref","first-page":"26277","DOI":"10.1038\/srep26277","article-title":"Local anesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in\u00a0vitro","volume":"6","author":"Xuan","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2018.06.102_bib11","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.phrs.2015.03.017","article-title":"Effects of ropivacaine, bupivacaine and sufentanil in colon and pancreatic cancer cells in\u00a0vitro","volume":"95\u201396","author":"Bundscherer","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2018.06.102_bib12","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.amjms.2017.11.011","article-title":"Local anesthetic drug inhibits growth and survival in chronic myeloid leukemia through suppressing PI3K\/Akt\/mTOR","volume":"355","author":"Zheng","year":"2018","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.bbrc.2018.06.102_bib13","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/ALN.0b013e3182661977","article-title":"Antimetastatic potential of amide-linked local anesthetics: inhibition of lung adenocarcinoma cell migration and inflammatory Src signaling independent of sodium channel blockade","volume":"117","author":"Piegeler","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bbrc.2018.06.102_bib14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.leukres.2016.05.010","article-title":"The sensitivity of chronic myeloid leukemia CD34 cells to Bcr-Abl tyrosine kinase inhibitors is modulated by ceramide levels,","volume":"47","author":"Wang","year":"2016","journal-title":"Leuk. Res."},{"key":"10.1016\/j.bbrc.2018.06.102_bib15","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbrc.2015.09.140","article-title":"Therapeutic effects of antibiotic drug tigecycline against cervical squamous cell carcinoma by inhibiting Wnt\/beta-catenin signaling","volume":"467","author":"Li","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2018.06.102_bib16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-61779-145-1_3","article-title":"Hematopoietic stem cell characterization and isolation","volume":"750","author":"Rossi","year":"2011","journal-title":"Meth. Mol. Biol."},{"key":"10.1016\/j.bbrc.2018.06.102_bib17","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/sj.gt.3303062","article-title":"Small molecules in stem cell self-renewal and differentiation","volume":"15","author":"Schugar","year":"2008","journal-title":"Gene Therapy"},{"key":"10.1016\/j.bbrc.2018.06.102_bib18","doi-asserted-by":"crossref","first-page":"36420","DOI":"10.1074\/jbc.M110.137471","article-title":"The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2)","volume":"285","author":"Kim","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.06.102_bib19","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1089\/zeb.2012.0739","article-title":"Activation of Wnt signaling using lithium chloride: inquiry-based undergraduate laboratory exercises","volume":"9","author":"Ross","year":"2012","journal-title":"Zebrafish"},{"key":"10.1016\/j.bbrc.2018.06.102_bib20","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/bja\/aeq164","article-title":"Effect of anaesthetic technique and other perioperative factors on cancer recurrence","volume":"105","author":"Snyder","year":"2010","journal-title":"BJA (Br. J. Anaesth.)"},{"key":"10.1016\/j.bbrc.2018.06.102_bib21","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1213\/ANE.0000000000002429","article-title":"Local anesthetics inhibit the growth of human hepatocellular carcinoma cells","volume":"125","author":"Le Gac","year":"2017","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.bbrc.2018.06.102_bib22","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.21037\/jtd.2016.09.66","article-title":"Amide-linked local anesthetics induce apoptosis in human non-small cell lung cancer","volume":"8","author":"Wang","year":"2016","journal-title":"J.\u00a0Thorac. Dis."},{"key":"10.1016\/j.bbrc.2018.06.102_bib23","article-title":"Local anesthetics induce apoptosis in human thyroid cancer cells through the mitogen-activated protein kinase pathway","volume":"9","author":"Chang","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2018.06.102_bib24","first-page":"132","article-title":"Cytotoxicity of local anesthetics on human mesenchymal stem cells","volume":"95","author":"Rahnama","year":"2013","journal-title":"The Journal of bone and joint surgery. American"},{"key":"10.1016\/j.bbrc.2018.06.102_bib25","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s00167-014-3312-y","article-title":"Local anesthetic cytotoxicity on human mesenchymal stem cells during chondrogenic differentiation, Knee surgery","volume":"23","author":"Breu","year":"2015","journal-title":"Sports Traumatology, Arthroscopy : Official Journal of the ESSKA"},{"key":"10.1016\/j.bbrc.2018.06.102_bib26","doi-asserted-by":"crossref","first-page":"365","DOI":"10.5966\/sctm.2013-0058","article-title":"Amide-type local anesthetics and human mesenchymal stem cells: clinical implications for stem cell therapy","volume":"3","author":"Dregalla","year":"2014","journal-title":"Stem cells translational medicine"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18314141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18314141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:30:37Z","timestamp":1757763037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18314141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0006291X18314141"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.06.102","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amide-linked local anesthetics preferentially target leukemia stem cell through inhibition of Wnt\/\u03b2-catenin","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.06.102","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}