{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:39:33Z","timestamp":1790361573285,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008992","name":"International Society for Neurochemistry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008992","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000769","name":"University of Oxford","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000769","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004918","name":"University of Ibadan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004918","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.bbrc.2018.06.114","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T05:04:59Z","timestamp":1530075899000},"page":"1042-1048","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":115,"title":["Resveratrol prolongs lifespan and improves 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative damage and behavioural deficits in Drosophila melanogaster"],"prefix":"10.1016","volume":"503","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4203-452X","authenticated-orcid":false,"given":"Amos O.","family":"Abolaji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adeola O.","family":"Adedara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojisola A.","family":"Adie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Vicente-Crespo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebenezer O.","family":"Farombi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.06.114_bib1","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1007\/s007020100004","article-title":"Neurochemical findings in the MPTP model of Parkinson's disease","volume":"108","author":"Schmidt","year":"2001","journal-title":"J.\u00a0Neural. Transm."},{"key":"10.1016\/j.bbrc.2018.06.114_bib2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S0892-0362(02)00222-2","article-title":"MPTP: insights into Parkinsonian neurodegeneration","volume":"24","author":"Speciale","year":"2002","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.bbrc.2018.06.114_bib3","doi-asserted-by":"crossref","first-page":"7194","DOI":"10.4049\/jimmunol.181.10.7194","article-title":"Macrophage antigen complex-1 mediates reactive microgliosis and progressive dopaminergic neurodegeneration in the MPTP model of Parkinson's disease","volume":"181","author":"Hu","year":"2008","journal-title":"J.\u00a0Immunol."},{"issue":"4","key":"10.1016\/j.bbrc.2018.06.114_bib4","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/1750-3841.13656","article-title":"Rosemary extract-mediated lifespan extension and attenuated oxidative damage in Drosophila melanogaster fed on high-fat diet","volume":"82","author":"Wang","year":"2017","journal-title":"J.\u00a0Food Sci."},{"key":"10.1016\/j.bbrc.2018.06.114_bib5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrn3689","article-title":"Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases","volume":"15","author":"Hetz","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2018.06.114_bib6","article-title":"Influence of resveratrol on liver fibrosis induced by dimethylnitrosamine in male rats","author":"Abdu","year":"2017","journal-title":"Saudi J. Biol. Sci."},{"key":"10.1016\/j.bbrc.2018.06.114_bib7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.taap.2013.05.004","article-title":"Antioxidants; friends or foe in prevention or treatment of cancer; the debate of the century","volume":"271","author":"Saeidnia","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbrc.2018.06.114_bib8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cbi.2016.03.023","article-title":"Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson's disease","volume":"251","author":"Gaballah","year":"2016","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbrc.2018.06.114_bib9","article-title":"Evaluation of traditional medicines for neurodegenerative diseases using Drosophila models","volume":"2014","author":"Lee","year":"2014","journal-title":"Evid. Base Compl. Alternative Med."},{"key":"10.1016\/j.bbrc.2018.06.114_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/01616412.2018.1471118","article-title":"Resveratrol prevents high-calorie diet-induced learning and memory dysfunction in juvenile C57BL\/6J mice","volume":"24","author":"Xu","year":"2018","journal-title":"Neurol. Res."},{"key":"10.1016\/j.bbrc.2018.06.114_bib11","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1126\/science.287.5461.2216","article-title":"A\u00a0brief history of Drosophila's contributions to genome research","volume":"287","author":"Rubin","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2018.06.114_bib12","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/35006074","article-title":"A\u00a0Drosophilla model of Parkinson's disease","volume":"404","author":"Feany","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2018.06.114_bib13","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.redox.2015.06.001","article-title":"Ovotoxicants 4-vinylcyclohexene 1,2-monoepoxide and 4-vinylcyclohexene diepoxide disrupt redox status and modify different electrophile sensitive target enzymes and genes in Drosophila melanogaster","volume":"5","author":"Abolaji","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrc.2018.06.114_bib14","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.pestbp.2018.01.002","article-title":"Garcina kola seeds biflavonoid fraction (Kolaviron), increases longevity and attenuates rotenone induced toxicity in Drosophila melanogaster","volume":"145","author":"Farombi","year":"2018","journal-title":"Pestic. Biochem. Physiol."},{"key":"10.1016\/j.bbrc.2018.06.114_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.06.114_bib16","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"Ellman","year":"1959","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbrc.2018.06.114_bib17","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S0076-6879(81)77053-8","article-title":"Assays for differentiation of glutathione-S-transferases","volume":"77","author":"Habig","year":"1981","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbrc.2018.06.114_bib18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in\u00a0vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbrc.2018.06.114_bib19","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A\u00a0new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2018.06.114_bib20","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0076-6879(94)33021-2","article-title":"Ferrous ion oxidation in presence of ferric ion indicator xylenol orange for measurement of hydroperoxides","volume":"233","author":"Wolff","year":"1994","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbrc.2018.06.114_bib21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite and (15N) nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbrc.2018.06.114_bib22","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0168-0102(00)00188-7","article-title":"Measurement of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction activity and lactate dehydrogenase release using MTT","volume":"38","author":"Abe","year":"2000","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.bbrc.2018.06.114_bib23","series-title":"Theory and Practice of Histology Techniques","first-page":"83","author":"Bancroft","year":"2008"},{"key":"10.1016\/j.bbrc.2018.06.114_bib24","first-page":"1","article-title":"Mitochondrial biology and Parkinson's disease","volume":"4","author":"Perier","year":"2012","journal-title":"Cold Spring Harbor Perspect. Med."},{"key":"10.1016\/j.bbrc.2018.06.114_bib25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.neuro.2017.01.002","article-title":"Nicotine suppresses the neurotoxicity by MPP+\/MPTP through activating \u03b17nAChR\/PI3K\/Trx-1 and suppressing ER stress","volume":"59","author":"Cai","year":"2017","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bbrc.2018.06.114_bib26","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.neuro.2012.07.006","article-title":"Evidence of acrylamide induced oxidative stress and neurotoxicity in Drosophila melanogaster - its amelioration with spice active enrichment: relevance to neuropathy","volume":"33","author":"Prasad","year":"2012","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bbrc.2018.06.114_bib27","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/S0891-5849(01)00803-6","article-title":"The \u201cFrench paradox\u201d and beyond: neuroprotective effects of polyphenols","volume":"32","author":"Sun","year":"2002","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2018.06.114_bib28","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","article-title":"The hallmarks of aging cell","volume":"153","author":"L\u00f3pez-Ot\u00edn","year":"2013","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bbrc.2018.06.114_bib29","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1080\/19390211.2016.1275917","article-title":"Supplementation of Spirulina (Arthrospira platensis) improves lifespan and locomotor activity in paraquat-sensitive DJ-1\u03b2\u039493 Flies, a Parkinson's disease model in Drosophila melanogaster","volume":"14","author":"Kumar","year":"2017","journal-title":"J.\u00a0Diet. Suppl."},{"key":"10.1016\/j.bbrc.2018.06.114_bib30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1473-2165.2008.00354.x","article-title":"Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation","volume":"7","author":"Baxter","year":"2008","journal-title":"J.\u00a0Cosmet. Dermatol."},{"key":"10.1016\/j.bbrc.2018.06.114_bib31","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1016\/j.etp.2012.09.001","article-title":"Toxicity of MPTP on neurotransmission in three mouse models of Parkinson's disease","volume":"65","author":"Pain","year":"2013","journal-title":"Exp. Toxicol. Pathol."},{"key":"10.1016\/j.bbrc.2018.06.114_bib32","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.tips.2009.06.005","article-title":"Environmental toxins and Parkinson's disease: what have we learned from pesticide-induced animal models","volume":"30","author":"Cicchetti","year":"2009","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbrc.2018.06.114_bib33","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1023\/A:1027376303043","article-title":"Inactivation of acetylcholinesterase by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride","volume":"254","author":"Zang","year":"2003","journal-title":"Mol. Cell. Biochem."},{"key":"10.1016\/j.bbrc.2018.06.114_bib34","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.jep.2011.02.012","article-title":"Neuroprotective effect of SuHeXiang Wan in Drosophila models of Alzheimer's disease","volume":"134","author":"Hong","year":"2011","journal-title":"J.\u00a0Ethnopharmacol."},{"key":"10.1016\/j.bbrc.2018.06.114_bib35","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuint.2012.12.006","article-title":"Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury","volume":"62","author":"Farina","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bbrc.2018.06.114_bib36","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/0192623309356453","article-title":"Oxidative stress and oxidative damage in carcinogenesis","volume":"38","author":"Klaunig","year":"2010","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.bbrc.2018.06.114_bib37","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1432-1033.1974.tb03751.x","article-title":"Heterogeneity of erythrocyte catalase II. Isolation and characterization of normal and variant erythrocyte catalase and their subunits","volume":"48","author":"Aebi","year":"1974","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbrc.2018.06.114_bib38","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0014-5793(97)00469-9","article-title":"What nitrates tyrosine? Is nitrotyrosine specific as a biomarker of peroxynitrite formation in\u00a0vivo","volume":"411","author":"Halliwell","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2018.06.114_bib39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.freeradbiomed.2013.10.807","article-title":"Glutathione is essential to preserve nuclear function and cell survival under oxidative stress","volume":"67","author":"Hatem","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2018.06.114_bib40","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.freeradbiomed.2014.03.014","article-title":"Involvement of oxidative stress in 4-vinylcyclohexene-induced toxicity in Drosophila melanogaster","volume":"71","author":"Abolaji","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2018.06.114_bib41","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1089\/ars.2011.4501","article-title":"Thiol-redox signaling, dopaminergic cell death, and Parkinson's disease","volume":"17","author":"Garcia-Garcia","year":"2012","journal-title":"Antioxidants Redox Signal."},{"issue":"10","key":"10.1016\/j.bbrc.2018.06.114_bib42","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1128\/IAI.02318-14","article-title":"Nitric oxide levels regulate the immune response of Drosophila melanogaster reference laboratory strains to bacterial infections","volume":"82","author":"Eleftherianos","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbrc.2018.06.114_bib43","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1523\/JNEUROSCI.20-08-02817.2000","article-title":"The cytosolic antioxidant copper\/zinc-superoxide dismutase prevents the early release of mitochondrial cytochrome c in ischemic brain after transient focal cerebral ischemia in mice","volume":"20","author":"Fujimura","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2018.06.114_bib44","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/428010","article-title":"Mechanism of oxidative stress in neurodegeneration","volume":"2012","author":"Gandhi","year":"2012","journal-title":"Oxid. Med. Cell Longev."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18314268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18314268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:26:56Z","timestamp":1757762816000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18314268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0006291X18314268"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.06.114","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Resveratrol prolongs lifespan and improves 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced oxidative damage and behavioural deficits in Drosophila melanogaster","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.06.114","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}