{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:48:07Z","timestamp":1792442887515,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["NHRI-EX106-10617SI"],"award-info":[{"award-number":["NHRI-EX106-10617SI"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["105-2628-B-182-009-MY4"],"award-info":[{"award-number":["105-2628-B-182-009-MY4"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3H0131"],"award-info":[{"award-number":["CMRPG3H0131"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3H0271"],"award-info":[{"award-number":["CMRPG3H0271"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3H0841"],"award-info":[{"award-number":["CMRPG3H0841"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3E1853"],"award-info":[{"award-number":["CMRPG3E1853"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG3E1893"],"award-info":[{"award-number":["CMRPG3E1893"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.bbrc.2018.07.005","type":"journal-article","created":{"date-parts":[[2018,7,6]],"date-time":"2018-07-06T10:23:53Z","timestamp":1530872633000},"page":"2493-2498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Excessive irisin increases oxidative stress and apoptosis in murine heart"],"prefix":"10.1016","volume":"503","author":[{"given":"Ming-Yun","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Shien","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jih-Kai","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I-Chang","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Chi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Jer","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Lung","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hung","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor Chien-Chia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Chun","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Chieh","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1546-7298","authenticated-orcid":false,"given":"Chao-Yung","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.07.005_bib1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A\u00a0PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"Bostrom","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2018.07.005_bib2","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.cmet.2015.08.001","article-title":"Detection and quantitation of circulating human irisin by tandem mass spectrometry","volume":"22","author":"Jedrychowski","year":"2015","journal-title":"Cell Metabol."},{"key":"10.1016\/j.bbrc.2018.07.005_bib3","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1210\/jc.2013-2373","article-title":"Circulating irisin in relation to insulin resistance and the metabolic syndrome","volume":"98","author":"Park","year":"2013","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2018.07.005_bib4","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/j.1753-0407.2012.00194.x","article-title":"Irisin: a new potential hormonal target for the treatment of obesity and type 2 diabetes","volume":"4","author":"Sanchis-Gomar","year":"2012","journal-title":"J.\u00a0Diabetes"},{"key":"10.1016\/j.bbrc.2018.07.005_bib5","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1530\/EJE-13-0276","article-title":"Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans","volume":"169","author":"Vamvini","year":"2013","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.bbrc.2018.07.005_bib6","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jdiacomp.2013.09.011","article-title":"Relationship between circulating irisin, renal function and body composition in type 2 diabetes","volume":"28","author":"Liu","year":"2014","journal-title":"J.\u00a0Diabet. Complicat."},{"key":"10.1016\/j.bbrc.2018.07.005_bib7","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.atherosclerosis.2015.08.002","article-title":"Irisin, a novel myokine is an independent predictor for sarcopenia and carotid atherosclerosis in dialysis patients","volume":"242","author":"Lee","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbrc.2018.07.005_bib8","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.cellsig.2015.04.010","article-title":"New role of irisin in hepatocytes: the protective effect of hepatic steatosis in\u00a0vitro","volume":"27","author":"Park","year":"2015","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2018.07.005_bib9","first-page":"6490","article-title":"Decreased irisin secretion contributes to muscle insulin resistance in high-fat diet mice","volume":"8","author":"Yang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.bbrc.2018.07.005_bib10","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1007\/s00198-014-2673-x","article-title":"Circulating irisin is associated with osteoporotic fractures in postmenopausal women with low bone mass but is not affected by either teriparatide or denosumab treatment for 3 months","volume":"25","author":"Anastasilakis","year":"2014","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bbrc.2018.07.005_bib11","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/cen.12672","article-title":"Irisin is associated with osteoporotic fractures independently of bone mineral density, body composition or daily physical activity","volume":"82","author":"Palermo","year":"2015","journal-title":"Clin. Endocrinol."},{"key":"10.1016\/j.bbrc.2018.07.005_bib12","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.bbrc.2015.01.032","article-title":"Adipocytokine, omentin inhibits doxorubicin-induced H9c2 cardiomyoblasts apoptosis through the inhibition of mitochondrial reactive oxygen species","volume":"457","author":"Kazama","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2018.07.005_bib13","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1002\/jcp.25857","article-title":"Irisin plays a pivotal role to protect the heart against ischemia and reperfusion injury","volume":"232","author":"Wang","year":"2017","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.bbrc.2018.07.005_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.peptides.2014.02.008","article-title":"Irisin: a potentially candidate marker for myocardial infarction","volume":"55","author":"Kuloglu","year":"2014","journal-title":"Peptides"},{"key":"10.1016\/j.bbrc.2018.07.005_bib15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ijcard.2017.11.072","article-title":"Serum irisin levels are associated with adverse cardiovascular outcomes in patients with acute myocardial infarction","volume":"261","author":"Hsieh","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.bbrc.2018.07.005_bib16","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aao6298","article-title":"Irisin protects mitochondria function during pulmonary ischemia\/reperfusion injury","volume":"9","author":"Chen","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbrc.2018.07.005_bib17","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.bbrc.2016.12.084","article-title":"Irisin suppresses the migration, proliferation, and invasion of lung cancer cells via inhibition of epithelial-to-mesenchymal transition","volume":"485","author":"Shao","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2018.07.005_bib18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/sj.cr.7290198","article-title":"Mechanical stretch induces mitochondria-dependent apoptosis in neonatal rat cardiomyocytes and G2\/M accumulation in cardiac fibroblasts","volume":"14","author":"Liao","year":"2004","journal-title":"Cell Res."},{"key":"10.1016\/j.bbrc.2018.07.005_bib19","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.jacc.2010.09.040","article-title":"Obesity induces signs of premature cardiac aging in younger patients: the role of mitochondria","volume":"57","author":"Niemann","year":"2011","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2018.07.005_bib20","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1161\/01.RES.0000263010.19273.48","article-title":"Transient exposure to hydrogen peroxide causes an increase in mitochondria-derived superoxide as a result of sustained alteration in L-type Ca2+ channel function in the absence of apoptosis in ventricular myocytes","volume":"100","author":"Viola","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2018.07.005_bib21","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1161\/CIRCRESAHA.111.246140","article-title":"Mitochondria and cardiovascular aging","volume":"110","author":"Dai","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2018.07.005_bib22","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/eurheartj\/ehu409","article-title":"Mitochondria at the heart of cardiovascular protection: p66shc-friend or foe?","volume":"36","author":"Heusch","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbrc.2018.07.005_bib23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1161\/CIRCRESAHA.110.223321","article-title":"Resurrecting hope for antioxidant treatment of cardiovascular disease: focus on mitochondria","volume":"107","author":"O'Connor","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2018.07.005_bib24","first-page":"143145","article-title":"Cardiovascular disease, mitochondria, and traditional Chinese medicine","volume":"2015","author":"Wang","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.bbrc.2018.07.005_bib25","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cmet.2013.09.008","article-title":"Exercise induces hippocampal BDNF through a PGC-1alpha\/FNDC5 pathway","volume":"18","author":"Wrann","year":"2013","journal-title":"Cell Metabol."},{"key":"10.1016\/j.bbrc.2018.07.005_bib26","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.yjmcc.2010.02.005","article-title":"Beneficial effects of exercise training after myocardial infarction require full eNOS expression","volume":"48","author":"de Waard","year":"2010","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2018.07.005_bib27","doi-asserted-by":"crossref","first-page":"e93304","DOI":"10.1371\/journal.pone.0093304","article-title":"Adenovirus-mediated eNOS expression augments liver injury after ischemia\/reperfusion in mice","volume":"9","author":"Palanisamy","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2018.07.005_bib28","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1073\/pnas.93.7.3056","article-title":"Successful expression of human factor IX following repeat administration of adenoviral vector in mice","volume":"93","author":"Walter","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2018.07.005_bib29","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1161\/CIRCRESAHA.114.300559","article-title":"Cardiac mitochondria and reactive oxygen species generation","volume":"114","author":"Chen","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2018.07.005_bib30","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1161\/01.HYP.0000258594.87211.6b","article-title":"Measurement of reactive oxygen species in cardiovascular studies","volume":"49","author":"Dikalov","year":"2007","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrc.2018.07.005_bib31","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1089\/ars.2009.2940","article-title":"PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload","volume":"13","author":"Lu","year":"2010","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.bbrc.2018.07.005_bib32","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(00)81410-5","article-title":"A\u00a0cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis","volume":"92","author":"Puigserver","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2018.07.005_bib33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/ncomms1003","article-title":"Mitochondrial respiration protects against oxygen-associated DNA damage","volume":"1","author":"Sung","year":"2010","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2018.07.005_bib34","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1006\/jmcc.1996.0193","article-title":"Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart","volume":"28","author":"Olivetti","year":"1996","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2018.07.005_bib35","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0968-0004(01)01844-8","article-title":"The mitochondrial apoptosome: a killer unleashed by the cytochrome seas","volume":"26","author":"Adrain","year":"2001","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbrc.2018.07.005_bib36","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1074\/jbc.273.5.2926","article-title":"An induced proximity model for caspase-8 activation","volume":"273","author":"Muzio","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.07.005_bib37","doi-asserted-by":"crossref","first-page":"E2154","DOI":"10.1210\/jc.2014-1437","article-title":"Exercise-induced irisin secretion is independent of age or fitness level and increased irisin may directly modulate muscle metabolism through AMPK activation","volume":"99","author":"Huh","year":"2014","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2018.07.005_bib38","first-page":"150","article-title":"A\u00a0transient elevated irisin blood concentration in response to prolonged, moderate aerobic exercise in young men and women","volume":"46","author":"Kraemer","year":"2014","journal-title":"Horm. Metab. Res."},{"key":"10.1016\/j.bbrc.2018.07.005_bib39","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1161\/01.CIR.100.17.1764","article-title":"Results of a multicenter randomized clinical trial of exercise and long-term survival in myocardial infarction patients: the National Exercise and Heart Disease Project (NEHDP)","volume":"100","author":"Dorn","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2018.07.005_bib40","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/0002-8703(83)90645-2","article-title":"The effect of early exercise on myocardial infarct scar formation","volume":"106","author":"Kloner","year":"1983","journal-title":"Am. Heart J."},{"key":"10.1016\/j.bbrc.2018.07.005_bib41","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ahj.2011.07.017","article-title":"Efficacy of exercise-based cardiac rehabilitation post-myocardial infarction: a systematic review and meta-analysis of randomized controlled trials","volume":"162","author":"Lawler","year":"2011","journal-title":"Am. Heart J."},{"key":"10.1016\/j.bbrc.2018.07.005_bib42","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1161\/01.CIR.80.2.234","article-title":"An overview of randomized trials of rehabilitation with exercise after myocardial infarction","volume":"80","author":"O'Connor","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2018.07.005_bib43","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1161\/CIRCULATIONAHA.108.821736","article-title":"Effects of different types of exercise training followed by detraining on endothelium-dependent dilation in patients with recent myocardial infarction","volume":"119","author":"Vona","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2018.07.005_bib44","doi-asserted-by":"crossref","first-page":"451","DOI":"10.7326\/0003-4819-149-7-200810070-00005","article-title":"Association of electrocardiographic morphology of exercise-induced ventricular arrhythmia with mortality","volume":"149","author":"Eckart","year":"2008","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bbrc.2018.07.005_bib45","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.cjca.2013.04.022","article-title":"Transient myocardial tissue and function changes during a marathon in less fit marathon runners","volume":"29","author":"Gaudreault","year":"2013","journal-title":"Can. J. Cardiol."},{"key":"10.1016\/j.bbrc.2018.07.005_bib46","article-title":"Irisin induces angiogenesis in human umbilical vein endothelial cells in\u00a0vitro and in zebrafish embryos in\u00a0vivo via activation of the ERK signaling pathway","volume":"10","author":"Wu","year":"2015","journal-title":"PLoS One"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18315006?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18315006?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T15:00:22Z","timestamp":1537801222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18315006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0006291X18315006"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.07.005","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Excessive irisin increases oxidative stress and apoptosis in murine heart","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.07.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}