{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:26:00Z","timestamp":1780385160217,"version":"3.54.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81202373"],"award-info":[{"award-number":["81202373"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shaanxi Provincial People's Hospital","award":["2016YX-06"],"award-info":[{"award-number":["2016YX-06"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.bbrc.2018.07.012","type":"journal-article","created":{"date-parts":[[2018,7,7]],"date-time":"2018-07-07T18:20:56Z","timestamp":1530987656000},"page":"2536-2542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Silencing of PMEL attenuates melanization via activating lysosomes and degradation of tyrosinase by lysosomes"],"prefix":"10.1016","volume":"503","author":[{"given":"Lijun","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huijin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingying","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.07.012_bib1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.det.2011.11.013","article-title":"Quality-of-life issues in vitiligo","volume":"30","author":"Bhandarkar","year":"2012","journal-title":"Dermatol. Clin."},{"key":"10.1016\/j.bbrc.2018.07.012_bib2","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/pcmr.12121","article-title":"Melanins and melanogenesis: methods, standards, protocols","volume":"26","author":"d'Ischia","year":"2013","journal-title":"Pigment. Cell. Melanoma. Res."},{"key":"10.1016\/j.bbrc.2018.07.012_bib3","first-page":"39","article-title":"Comparable down-regulation of TYR,TYRP1 and TYRP2 genes and inhibition of melanogenesis by tyrostat, tocotrienol-rich fraction and tocopherol in human skin melanocytes improves skin pigmentation","volume":"165","author":"Makpol","year":"2014","journal-title":"Clin. Ter."},{"key":"10.1016\/j.bbrc.2018.07.012_bib4","article-title":"Silencing of GPNMB by siRNA inhibits the formation of melanosomes in melanocytes in a MITF-independent fashion","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2018.07.012_bib5","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/pcmr.12084","article-title":"The PKD domain distinguishes the trafficking and amyloidogenic properties of the pigment cell protein PMEL and its homologue GPNMB","volume":"26","author":"Theos","year":"2013","journal-title":"Pigment. Cell. Melanoma. Res."},{"key":"10.1016\/j.bbrc.2018.07.012_bib6","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.3390\/ijms17091438","article-title":"PMEL amyloid fibril formation:the bright steps of pigmentation","volume":"17","author":"Bissig","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbrc.2018.07.012_bib7","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1074\/jbc.M708007200","article-title":"Premelanosome amyloid-like fibrils are composed of only Golgi-processed forms of Pmel17 that have been proteolytically processed in endosomes","volume":"283","author":"Harper","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.07.012_bib8","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1111\/pcmr.12067","article-title":"PMEL:a pigment cell-specific model for functional amyloid formation","volume":"26","author":"Watt","year":"2013","journal-title":"Pigment. Cell. Melanoma. Res."},{"key":"10.1016\/j.bbrc.2018.07.012_bib9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1034\/j.1600-0749.2003.00067.x","article-title":"The color loci of mice\u2013a genetic century","volume":"16","author":"Bennett","year":"2003","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.bbrc.2018.07.012_bib10","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1471-2156-7-46","article-title":"A\u00a0missense mutation in PMEL17 is associated with the Silver coat color in the horse","volume":"7","author":"Brunberg","year":"2006","journal-title":"BMC Genet."},{"key":"10.1016\/j.bbrc.2018.07.012_bib11","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1083\/jcb.152.4.809","article-title":"Distinct protein sorting and localization to premelanosomes, melanosomes, and lysosomes in pigmented melanocytic cells","volume":"152","author":"Raposo","year":"2001","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2018.07.012_bib12","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.04543","article-title":"An intracellular anion channel critical for pigmentation","volume":"3","author":"Bellono","year":"2014","journal-title":"eLife"},{"key":"10.1016\/j.bbrc.2018.07.012_bib13","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.ceb.2013.04.008","article-title":"Lysosome-related organelles: unusual compartments become mainstream","volume":"25","author":"Marks","year":"2013","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbrc.2018.07.012_bib14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1600-0749.1998.tb00736.x","article-title":"Enhanced melanogenesis induced by TYRosinase gene-transfer increases boron-uptake and killing effect of boron neutron capture therapy for amelanotic melanoma","volume":"11","author":"Tsuboi","year":"1998","journal-title":"Pigm. Cell Res."},{"key":"10.1016\/j.bbrc.2018.07.012_bib15","doi-asserted-by":"crossref","first-page":"9228","DOI":"10.1073\/pnas.88.20.9228","article-title":"A\u00a0melanocyte-specific gene, Pmel 17, maps near the silver coat color locus on mouse chromosome 10 and is in a syntenic region on human chromosome 12","volume":"88","author":"Kwon","year":"1991","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.bbrc.2018.07.012_bib16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1046\/j.1365-2249.2001.01516.x","article-title":"Molecular mapping of epitopes on melanocyte-specific protein Pmel17 which are recognized by autoantibodies in patients with vitiligo","volume":"124","author":"Kemp","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bbrc.2018.07.012_bib17","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1091\/mbc.12.11.3451","article-title":"Pmel17 initiates premelanosome morphogenesis within multivesicular bodies","volume":"12","author":"Berson","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2018.07.012_bib18","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1038\/jid.2012.320","article-title":"Association analyses identify three susceptibility loci for vitiligo in the Chinese Han Population","volume":"133","author":"Tang","year":"2013","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.bbrc.2018.07.012_bib19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ydbio.2005.06.001","article-title":"A\u00a0mutation in the silver gene leads to defects in melanosome biogenesis and alterations in the visual system in the zebrafish mutant fading vision","volume":"284","author":"Schonthaler","year":"2005","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbrc.2018.07.012_bib20","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1073\/pnas.0506940103","article-title":"Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dog","volume":"103","author":"Clark","year":"2006","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.bbrc.2018.07.012_bib21","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1242\/jcs.128561","article-title":"Expression of OA1 limits the fusion of a subset of MVBs with lysosomes\u2013a mechanism potentially involved in the initial biogenesis of melanosomes","volume":"126","author":"Burgoyne","year":"2013","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bbrc.2018.07.012_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002285","article-title":"Inactivation of Pmel alters melanosome shape but has only a subtle effect on visible pigmentation","volume":"7","author":"Hellstr\u00f6m","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbrc.2018.07.012_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143702","article-title":"Tyrosinase depletion prevents the maturation of melanosomes in the mouse hair follicle","volume":"10","author":"Paterson","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2018.07.012_bib24","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1038\/jid.2008.376","article-title":"Inulavosin, a melanogenesis inhibitor, leads to mistargeting of tyrosinase to lysosomes and accelerates its degradation","volume":"129","author":"Fujita","year":"2009","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.bbrc.2018.07.012_bib25","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1096\/fj.11-201376","article-title":"Cystinosin is a melanosomal protein that regulates melanin synthesis","volume":"26","author":"Chiaverini","year":"2012","journal-title":"FASEB J"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18315079?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18315079?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T15:00:28Z","timestamp":1537801228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18315079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0006291X18315079"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.07.012","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Silencing of PMEL attenuates melanization via activating lysosomes and degradation of tyrosinase by lysosomes","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.07.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}