{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T08:52:38Z","timestamp":1784796758852,"version":"3.55.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670271"],"award-info":[{"award-number":["81670271"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.bbrc.2018.08.129","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T02:00:01Z","timestamp":1535076001000},"page":"3219-3224","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Platycodin D inhibits oxidative stress and apoptosis in H9c2 cardiomyocytes following hypoxia\/reoxygenation injury"],"prefix":"10.1016","volume":"503","author":[{"given":"Yi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gongning","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.08.129_bib1","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/0277-9536(91)90159-A","article-title":"Depression and acute myocardial infarction: a review and reinterpretation","volume":"32","author":"Fielding","year":"1991","journal-title":"Soc. Sci. Med."},{"key":"10.1016\/j.bbrc.2018.08.129_bib2","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12968-018-0474-7","article-title":"Relationship between CMR-derived parameters of ischemia\/reperfusion injury and the timing of CMR after reperfused ST-segment elevation myocardial infarction","volume":"20","author":"Masci","year":"2018","journal-title":"J.\u00a0Cardiovasc. Magn. Reson."},{"key":"10.1016\/j.bbrc.2018.08.129_bib3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/cphy.c160006","article-title":"Ischemia\/reperfusion","volume":"7","author":"Kalogeris","year":"2016","journal-title":"Comp. Physiol."},{"key":"10.1016\/j.bbrc.2018.08.129_bib4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell biology of ischemia\/reperfusion injury","volume":"298","author":"Kalogeris","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.bbrc.2018.08.129_bib5","doi-asserted-by":"crossref","DOI":"10.3390\/nu9090966","article-title":"Antioxidant therapeutic strategies for cardiovascular conditions associated with oxidative stress","volume":"9","author":"Farias","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.bbrc.2018.08.129_bib6","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s12272-017-0946-6","article-title":"Effect of processing method on platycodin D content in Platycodon grandiflorum roots","volume":"40","author":"Kwon","year":"2017","journal-title":"Arch Pharm. Res. (Seoul)"},{"key":"10.1016\/j.bbrc.2018.08.129_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.21934","article-title":"Platycodin D, a triterpenoid saponin from Platycodon grandiflorum, suppresses the growth and invasion of human oral squamous cell carcinoma cells via the NF-kappaB pathway","volume":"31","author":"Zhang","year":"2017","journal-title":"J.\u00a0Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bbrc.2018.08.129_bib8","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7918034","article-title":"Effects of platycodin D on reflux esophagitis due to modulation of antioxidant defense systems","volume":"2018","author":"Cho","year":"2018","journal-title":"Evid. Based Complement Alternat. Med."},{"key":"10.1016\/j.bbrc.2018.08.129_bib9","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.3389\/fimmu.2017.01929","article-title":"Platycodin D inhibits inflammatory response in LPS-stimulated primary rat microglia cells through activating LXRalpha-ABCA1 signaling pathway","volume":"8","author":"Fu","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2018.08.129_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.intimp.2017.03.009","article-title":"Platycodin D protects against cigarette smoke-induced lung inflammation in mice","volume":"47","author":"Gao","year":"2017","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2018.08.129_bib11","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1142\/S0192415X18500271","article-title":"Platycodin D reverses pathological cardiac hypertrophy and fibrosis in spontaneously hypertensive rats","volume":"46","author":"Lin","year":"2018","journal-title":"Am. J. Chin. Med."},{"key":"10.1016\/j.bbrc.2018.08.129_bib12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.brainres.2009.05.005","article-title":"Platycodin D and 2''-O-acetyl-polygalacin D2 isolated from Platycodon grandiflorum protect ischemia\/reperfusion injury in the gerbil hippocampus","volume":"1279","author":"Choi","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2018.08.129_bib13","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1038\/aps.2017.149","article-title":"Diterpene ginkgolides protect against cerebral ischemia\/reperfusion damage in rats by activating Nrf2 and CREB through PI3K\/Akt signaling","volume":"39","author":"Zhang","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbrc.2018.08.129_bib14","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.phymed.2018.01.004","article-title":"Protective effects of total flavonoids from Clinopodium chinense (Benth.) O. Ktze on myocardial injury in\u00a0vivo and in\u00a0vitro via regulation of Akt\/Nrf2\/HO-1 pathway","volume":"40","author":"Zhang","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2018.08.129_bib15","doi-asserted-by":"crossref","first-page":"11031","DOI":"10.2217\/bmm-2017-0110","article-title":"Oxidative stress in ischemia and reperfusion: current concepts, novel ideas and future perspectives","volume":"11","author":"Sinning","year":"2017","journal-title":"Biomarkers Med."},{"key":"10.1016\/j.bbrc.2018.08.129_bib16","doi-asserted-by":"crossref","DOI":"10.1161\/STROKEAHA.108.531632","article-title":"Apoptotic mechanisms after cerebral ischemia","volume":"40","author":"Broughton","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2018.08.129_bib17","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.foodchem.2011.10.086","article-title":"Evaluation of the total oxidant scavenging capacity of saponins isolated from Platycodon grandiflorum","volume":"132","author":"Ryu","year":"2012","journal-title":"Food Chem."},{"key":"10.1016\/j.bbrc.2018.08.129_bib18","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1039\/C5FO00094G","article-title":"Platycodin D isolated from the aerial parts of Platycodon grandiflorum protects alcohol-induced liver injury in mice","volume":"6","author":"Li","year":"2015","journal-title":"Food Funct"},{"key":"10.1016\/j.bbrc.2018.08.129_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12906-016-1126-9","article-title":"Allicin prevents oxidized low-density lipoprotein-induced endothelial cell injury by inhibiting apoptosis and oxidative stress pathway","volume":"16","author":"Chen","year":"2016","journal-title":"BMC Compl. Alternative Med."},{"key":"10.1016\/j.bbrc.2018.08.129_bib20","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.bbrc.2017.06.089","article-title":"CO-releasing molecules-2 attenuates ox-LDL-induced injury in HUVECs by ameliorating mitochondrial function and inhibiting Wnt\/beta-catenin pathway","volume":"490","author":"Sun","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2018.08.129_bib21","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1248\/bpb.b-y110129","article-title":"Anti-atherosclerotic activity of platycodin D derived from roots of Platycodon grandiflorum in human endothelial cells","volume":"35","author":"Wu","year":"2012","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.bbrc.2018.08.129_bib22","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbrc.2018.08.129_bib23","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1007\/s10495-017-1381-3","article-title":"Dihydromyricetin protects human umbilical vein endothelial cells from injury through ERK and Akt mediated Nrf2\/HO-1 signaling pathway","volume":"22","author":"Luo","year":"2017","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbrc.2018.08.129_bib24","first-page":"1","article-title":"Ferulic acid protects against heat stress-induced intestinal epithelial barrier dysfunction in IEC-6 cells via the PI3K\/Akt-mediated Nrf2\/HO-1 signaling pathway","author":"He","year":"2018","journal-title":"Int. J. Hyperther."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18318199?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18318199?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T19:48:03Z","timestamp":1583956083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18318199"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["S0006291X18318199"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.08.129","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platycodin D inhibits oxidative stress and apoptosis in H9c2 cardiomyocytes following hypoxia\/reoxygenation injury","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.08.129","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}