{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:37:02Z","timestamp":1778837822736,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.bbrc.2018.08.181","type":"journal-article","created":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T14:32:58Z","timestamp":1536330778000},"page":"525-531","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Platelet-derived growth factor receptor alpha (PDGFR\u03b1) is overexpressed in NK\/T-cell lymphoma and mediates cell survival"],"prefix":"10.1016","volume":"504","author":[{"given":"Lisha","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorui","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajuan","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiming","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiyuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingjun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengyuan","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingzhi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.08.181_bib1","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13045-017-0452-9","article-title":"The diagnosis and management of NK\/T-cell lymphomas","volume":"10","author":"Tse","year":"2017","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.bbrc.2018.08.181_bib2","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.1158\/1078-0432.CCR-16-0153","article-title":"DDGP versus smile in newly diagnosed advanced natural killer\/T-cell lymphoma: a randomized controlled, multicenter, open-label study in China","volume":"22","author":"Li","year":"2016","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.bbrc.2018.08.181_bib3","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1002\/path.2823","article-title":"Activated oncogenic pathways and therapeutic targets in extranodal nasal-type NK\/T cell lymphoma revealed by gene expression profiling","volume":"223","author":"Ng","year":"2011","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.bbrc.2018.08.181_bib4","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/leu.2009.3","article-title":"Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies","volume":"23","author":"Iqbal","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrc.2018.08.181_bib5","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1182\/blood-2009-05-221275","article-title":"Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK\/T-cell lymphoma, nasal type","volume":"115","author":"Huang","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2018.08.181_bib6","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/323226a0","article-title":"Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors","volume":"323","author":"Yarden","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2018.08.181_bib7","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1006\/bbrc.2001.4622","article-title":"Both platelet-derived growth factor receptor (PDGFR)-alpha and PDGFR-beta promote murine fibroblast cell migration","volume":"282","author":"Yu","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2018.08.181_bib8","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1158\/1541-7786.MCR-12-0071","article-title":"Differential tumorigenic potential and matriptase activation between PDGF B versus PDGF D in prostate cancer","volume":"10","author":"Najy","year":"2012","journal-title":"Mol. Canc. Res."},{"key":"10.1016\/j.bbrc.2018.08.181_bib9","first-page":"2178","article-title":"Plateletderived growth factor receptorbeta gene expression relates to recurrence in colorectal cancer","volume":"39","author":"Fujino","year":"2018","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbrc.2018.08.181_bib10","doi-asserted-by":"crossref","first-page":"39534","DOI":"10.18632\/oncotarget.17134","article-title":"Platelet-derived growth factor receptor alpha in hepatocellular carcinoma is a prognostic marker independent of underlying liver cirrhosis","volume":"8","author":"Yu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2018.08.181_bib11","doi-asserted-by":"crossref","first-page":"10307","DOI":"10.18632\/oncotarget.2537","article-title":"Overexpression of platelet-derived growth factor receptor alpha promotes tumor progression and indicates poor prognosis in hepatocellular carcinoma","volume":"5","author":"Wei","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2018.08.181_bib12","first-page":"83","article-title":"WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview","volume":"102","author":"Sabattini","year":"2010","journal-title":"Pathologica"},{"key":"10.1016\/j.bbrc.2018.08.181_bib13","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1038\/sj.onc.1209232","article-title":"Autocrine activation of PDGFRalpha promotes the progression of ovarian cancer","volume":"25","author":"Matei","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2018.08.181_bib14","first-page":"795","article-title":"PDGFRalpha\/HER2 and PDGFRalpha\/p53 Co-expression in oral squamous cell carcinoma","volume":"38","author":"Cierpikowski","year":"2018","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbrc.2018.08.181_bib15","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ygyno.2013.10.027","article-title":"Platelet-derived growth factor receptor alpha (PDGFRalpha) targeting and relevant biomarkers in ovarian carcinoma","volume":"132","author":"Matsuo","year":"2014","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.bbrc.2018.08.181_bib16","first-page":"749","article-title":"The characterization of PDGFR-alpha and PDGFR-beta expression in malignant non-Hodgkin lymphoma","volume":"53","author":"Duse","year":"2012","journal-title":"Rom. J. Morphol. Embryol."},{"key":"10.1016\/j.bbrc.2018.08.181_bib17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.prp.2008.07.007","article-title":"Histological expression of angiogenic factors: VEGF, PDGFRalpha, and HIF-1alpha in Hodgkin lymphoma","volume":"205","author":"Passam","year":"2009","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.bbrc.2018.08.181_bib18","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00277-008-0539-z","article-title":"The expression and prognostic significance of platelet-derived growth factor receptor alpha in mature T- and natural killer-cell lymphomas","volume":"87","author":"Chen","year":"2008","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.bbrc.2018.08.181_bib19","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s11060-005-9102-0","article-title":"Expression of survivin, platelet-derived growth factor A (PDGF-A) and PDGF receptor alpha in primary central nervous system lymphoma","volume":"79","author":"Karabatsou","year":"2006","journal-title":"J.\u00a0Neuro Oncol."},{"key":"10.1016\/j.bbrc.2018.08.181_bib20","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/S1470-2045(05)70213-8","article-title":"Expression of platelet-derived growth factor receptor alpha in peripheral T-cell lymphoma not otherwise specified","volume":"6","author":"Piccaluga","year":"2005","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.bbrc.2018.08.181_bib21","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.prp.2015.12.010","article-title":"Expression and significance of Ku80 and PDGFR-alpha in nasal NK\/T-cell lymphoma","volume":"212","author":"Li","year":"2016","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.bbrc.2018.08.181_bib22","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.phrs.2018.01.021","article-title":"The role of small molecule platelet-derived growth factor receptor (PDGFR) inhibitors in the treatment of neoplastic disorders","volume":"129","author":"Roskoski","year":"2018","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2018.08.181_bib23","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1158\/1078-0432.CCR-17-1258","article-title":"Olaratumab exerts antitumor activity in preclinical models of pediatric bone and soft tissue tumors through inhibition of platelet-derived growth factor receptor alpha","volume":"24","author":"Lowery","year":"2018","journal-title":"Clin. Canc. Res."},{"key":"10.1016\/j.bbrc.2018.08.181_bib24","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1038\/leu.2014.50","article-title":"Platelet-derived growth factor alpha mediates the proliferation of peripheral T-cell lymphoma cells via an autocrine regulatory pathway","volume":"28","author":"Piccaluga","year":"2014","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrc.2018.08.181_bib25","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1038\/nm.2966","article-title":"PDGFR blockade is a rational and effective therapy for NPM-ALK-driven lymphomas","volume":"18","author":"Laimer","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2018.08.181_bib26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1478-811X-11-97","article-title":"Targeting the PDGF signaling pathway in tumor treatment","volume":"11","author":"Heldin","year":"2013","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.bbrc.2018.08.181_bib27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbrc.2009.07.144","article-title":"PDGF stimulation of Muller cell proliferation: contributions of c-JNK and the PI3K\/Akt pathway","volume":"388","author":"Moon","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18318692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18318692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T05:35:31Z","timestamp":1604900131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18318692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0006291X18318692"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.08.181","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet-derived growth factor receptor alpha (PDGFR\u03b1) is overexpressed in NK\/T-cell lymphoma and mediates cell survival","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.08.181","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}