{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T23:46:19Z","timestamp":1769816779683,"version":"3.49.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["16H04717"],"award-info":[{"award-number":["16H04717"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.bbrc.2018.09.032","type":"journal-article","created":{"date-parts":[[2018,9,11]],"date-time":"2018-09-11T23:47:02Z","timestamp":1536709622000},"page":"721-726","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562\u202fcells"],"prefix":"10.1016","volume":"504","author":[{"given":"Yu","family":"Kato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Kunimasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Tomida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.09.032_bib1","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S1097-2765(03)00105-9","article-title":"An integrated stress response regulates amino acid metabolism and resistance to oxidative stress","volume":"11","author":"Harding","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2018.09.032_bib2","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1038\/emboj.2010.81","article-title":"The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation","volume":"29","author":"Ye","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2018.09.032_bib3","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S1097-2765(00)80330-5","article-title":"Perk is essential for translational regulation and cell survival during the unfolded protein response","volume":"5","author":"Harding","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2018.09.032_bib4","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.cell.2010.01.001","article-title":"Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis","volume":"140","author":"Nakamura","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2018.09.032_bib5","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1182\/blood-2006-08-041830","article-title":"Regulation of protein synthesis by the heme-regulated eIF2alpha kinase: relevance to anemias","volume":"109","author":"Chen","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2018.09.032_bib6","doi-asserted-by":"crossref","first-page":"11269","DOI":"10.1073\/pnas.0400541101","article-title":"Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells","volume":"101","author":"Vattem","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2018.09.032_bib7","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1083\/jcb.200408003","article-title":"Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response","volume":"167","author":"Lu","year":"2004","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2018.09.032_bib8","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1101\/gad.189365.112","article-title":"Links between metabolism and cancer","volume":"26","author":"Dang","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2018.09.032_bib9","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nrc.2016.27","article-title":"New frontiers in translational control of the cancer genome","volume":"16","author":"Truitt","year":"2016","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bbrc.2018.09.032_bib10","doi-asserted-by":"crossref","first-page":"11971","DOI":"10.1038\/ncomms11971","article-title":"Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer","volume":"7","author":"Hao","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2018.09.032_bib11","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1172\/JCI62973","article-title":"ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth","volume":"122","author":"Hart","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2018.09.032_bib12","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0140-6736(07)61165-9","article-title":"Chronic myeloid leukemia","volume":"370","author":"Hehlmann","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2018.09.032_bib13","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0092-8674(84)90438-0","article-title":"An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity","volume":"37","author":"Konopka","year":"1984","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2018.09.032_bib14","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/leu.2017.267","article-title":"Phosphorylation of SOS1 on tyrosine 1196 promotes its RAC GEF activity and contributes to BCR-ABL leukemogenesis","volume":"32","author":"Gerboth","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrc.2018.09.032_bib15","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0092-8674(05)80094-7","article-title":"BCR-ABL-induced Oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein","volume":"75","author":"Pendergast","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2018.09.032_bib16","doi-asserted-by":"crossref","first-page":"6151","DOI":"10.1093\/emboj\/16.20.6151","article-title":"Transformation of hematopoietic cells by BCR\/ABL requires activation of a PI-3k\/Akt-dependent pathway","volume":"16","author":"Skorski","year":"1997","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2018.09.032_bib17","first-page":"3267","article-title":"Ovatodiolide targets chronic myeloid leukemia stem cells by epigenetically upregulating hsa-miR-155, suppressing the BCR-ABL fusion gene and dysregulating the PI3K\/AKT\/mTOR pathway","volume":"14","author":"Tu","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2018.09.032_bib18","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1038\/s41375-018-0117-x","article-title":"Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer","volume":"32","author":"Wingelhofer","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrc.2018.09.032_bib19","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1182\/blood.V95.6.2118","article-title":"STAT5 activation contributes to growth and viability in Bcr\/Abl-transformed cells","volume":"95","author":"Sillaber","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2018.09.032_bib20","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.1158\/0008-5472.CAN-08-2689","article-title":"Chemical genomics identifies the unfolded protein response as a target for selective cancer cell killing during glucose deprivation","volume":"69","author":"Saito","year":"2009","journal-title":"Canc. Res."},{"key":"10.1016\/j.bbrc.2018.09.032_bib21","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/S0021-9258(19)86009-X","article-title":"Effect of tunicamycin on the biosynthesis of the major human red cell sialoglycoprotein, glycophorin A, in the leukemia cell line K562","volume":"255","author":"Gahmberg","year":"1980","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.09.032_bib22","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nrc3800","article-title":"The impact of the endoplasmic reticulum protein-folding environment on cancer development","volume":"14","author":"Wang","year":"2014","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bbrc.2018.09.032_bib23","doi-asserted-by":"crossref","first-page":"6681","DOI":"10.1128\/MCB.22.19.6681-6688.2002","article-title":"The GCN2 eIF2\u03b1 kinase is required for adaptation to amino acid deprivation in mice","volume":"22","author":"Zhang","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2018.09.032_bib24","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1158\/1535-7163.MCT-11-0871","article-title":"Hyperactivation of 4E-binding protein 1 as a mediator of biguanide-induced cytotoxicity during glucose deprivation","volume":"11","author":"Matsuo","year":"2012","journal-title":"Mol. Canc. Therapeut."},{"key":"10.1016\/j.bbrc.2018.09.032_bib25","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.celrep.2017.04.042","article-title":"mTORC1 balances cellular amino acid supply with demand for protein synthesis through post-transcriptional control of ATF4","volume":"19","author":"Park","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2018.09.032_bib26","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1158\/0008-5472.CAN-12-3109","article-title":"Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity","volume":"73","author":"Atkins","year":"2013","journal-title":"Canc. Res."},{"key":"10.1016\/j.bbrc.2018.09.032_bib27","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.cell.2017.08.019","article-title":"TOR, the gateway to cellular metabolism, cell growth, and disease","volume":"171","author":"Blenis","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2018.09.032_bib28","first-page":"1","article-title":"The story of tyrosine kinase inhibitors discontinuation in clinical practice, Leuk","volume":"10","author":"Rousselot","year":"2018","journal-title":"Lymphoma"},{"key":"10.1016\/j.bbrc.2018.09.032_bib29","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1182\/blood-2016-09-696013","article-title":"The chronic myeloid leukemia stem cell: stemming the tide of persistence","volume":"129","author":"Holyoake","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2018.09.032_bib30","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1038\/bjc.2016.72","article-title":"Mipsagargin, a novel thapsigargin-based PSMA-activated prodrug: results of a first-in-man phase \u2160 clinical trial in patients with refractory, advanced or metastatic solid tumours","volume":"114","author":"Mahalingam","year":"2016","journal-title":"Br. J. Canc."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18319508?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18319508?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T03:24:23Z","timestamp":1662002663000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18319508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0006291X18319508"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.09.032","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BCR-ABL tyrosine kinase inhibition induces metabolic vulnerability by preventing the integrated stress response in K562\u202fcells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.09.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}