{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:09:28Z","timestamp":1784124568040,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2017A030312007"],"award-info":[{"award-number":["2017A030312007"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007786","name":"National Center for Child Health and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007786","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570279"],"award-info":[{"award-number":["81570279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81720102004"],"award-info":[{"award-number":["81720102004"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFA0108700"],"award-info":[{"award-number":["2018YFA0108700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFA0105602"],"award-info":[{"award-number":["2017YFA0105602"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.bbrc.2018.11.175","type":"journal-article","created":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T21:21:08Z","timestamp":1543699268000},"page":"583-589","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["5-aminolaevulinic acid (ALA), enhances heme oxygenase (HO)-1 expression and attenuates tubulointerstitial fibrosis and renal apoptosis in chronic cyclosporine nephropathy"],"prefix":"10.1016","volume":"508","author":[{"given":"Chi","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Fujino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Isaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidenori","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiwamu","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motowo","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0897-2141","authenticated-orcid":false,"given":"Xiao-Kang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.11.175_bib1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1681\/ASN.V12162","article-title":"Cellular and molecular mechanisms of cyclosporin nephrotoxicity","volume":"1","author":"Kopp","year":"1990","journal-title":"J.\u00a0Am. Soc. Nephrol. Jasn"},{"key":"10.1016\/j.bbrc.2018.11.175_bib2","first-page":"759","article-title":"Histopathology of cyclosporine nephrotoxicity","volume":"20","author":"Mihatsch","year":"1988","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.bbrc.2018.11.175_bib3","first-page":"536","article-title":"Cyclosporine nephropathy: pathophysiology and clinical impact","volume":"16","author":"Shihab","year":"1996","journal-title":"Semin. Nephrol."},{"key":"10.1016\/j.bbrc.2018.11.175_bib4","first-page":"565","article-title":"[Cyclosporin A causes oxidative stress and mitochondrial dysfunction in renal tubular cells]","volume":"27","author":"P\u00e9rez","year":"2007","journal-title":"Nefrolog\u00eda Publicaci\u00f3n Oficial De La Sociedad Espaola Nefrologia"},{"key":"10.1016\/j.bbrc.2018.11.175_bib5","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1046\/j.1523-1755.1998.00202.x","article-title":"Apoptosis and necrosis: mechanisms of cell death induced by cyclosporin A in a renal proximal tubular cell line","volume":"54","author":"Healy","year":"1998","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2018.11.175_bib6","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1097\/01.ASN.0000099383.57934.0E","article-title":"Intracellular mechanisms of cyclosporin A-induced tubular cell apoptosis","volume":"14","author":"Justo","year":"2003","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2018.11.175_bib7","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1248\/yakushi.131.437","article-title":"Reno-protective role of flunarizine (mitochondrial permeability transition pore inactivator) against gentamicin induced nephrotoxicity in rats","volume":"131","author":"Muthuraman","year":"2011","journal-title":"Yakugaku Zasshi J. Pharm. Soc. Jap."},{"key":"10.1016\/j.bbrc.2018.11.175_bib8","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1111\/j.1523-1755.2005.00726.x","article-title":"Cyclosporine A and NAC on the inducible nitric oxide synthase expression and nitric oxide synthesis in rat renal artery cultured cells","volume":"68","author":"Lessio","year":"2005","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2018.11.175_bib9","first-page":"170","article-title":"Protective effect of edaravone against cyclosporine-induced chronic nephropathy through antioxidant and nitric oxide modulating pathways in rats","volume":"42","author":"Sattarinezhad","year":"2017","journal-title":"Iran. J. Med. Sci."},{"key":"10.1016\/j.bbrc.2018.11.175_bib10","article-title":"Doxycycline potentiates antitumor effect of 5-aminolevulinic acid-mediated photodynamic therapy in malignant peripheral nerve sheath tumor cells","volume":"12","author":"Lee","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.bbrc.2018.11.175_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.intimp.2015.11.034","article-title":"5-Aminolevulinic acid regulates the inflammatory response and alloimmune reaction","volume":"37","author":"Fujino","year":"2016","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2018.11.175_bib12","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.bbrc.2016.01.136","article-title":"5-Aminolevulinic acid combined with ferrous iron ameliorate ischemia-reperfusion injury in the mouse fatty liver model","volume":"470","author":"Li","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2018.11.175_bib13","doi-asserted-by":"crossref","first-page":"F1149","DOI":"10.1152\/ajprenal.00275.2013","article-title":"5-Aminolevulinic acid combined with ferrous iron induces carbon monoxide generation in mouse kidneys and protects from renal ischemia-reperfusion injury","volume":"305","author":"Hou","year":"2013","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.bbrc.2018.11.175_bib14","first-page":"604981","article-title":"A\u00a0review on hemeoxygenase-2: focus on cellular protection and oxygen response","volume":"2014","author":"Mu","year":"2014","journal-title":"Oxid. Med. Cellular Longevity"},{"key":"10.1016\/j.bbrc.2018.11.175_bib15","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.3349\/ymj.2004.45.6.1004","article-title":"Chronic cyclosporine nephrotoxicity: new insights and preventive strategies","volume":"45","author":"Li","year":"2004","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.bbrc.2018.11.175_bib16","first-page":"103","article-title":"[New molecular mechanisms of nephrotoxicity]","volume":"24","author":"Ortiz","year":"2004","journal-title":"Nefrolog\u00eda Publicaci\u00f3n Oficial De La Sociedad Espaola Nefrologia"},{"key":"10.1016\/j.bbrc.2018.11.175_bib17","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1248\/bpb.30.1254","article-title":"Oxidative and nitrosative stress mediated renal cellular damage induced by cyclosporine A: role of sulphated polysaccharides","volume":"30","author":"Josephine","year":"2007","journal-title":"Biol. Pharmaceut. Bull."},{"key":"10.1016\/j.bbrc.2018.11.175_bib18","series-title":"Enhancement of Chronic Cyclosporine Nephrotoxicity by Sodium Depletion in an Experimental Mouse Model","first-page":"471","author":"Andoh","year":"1997"},{"key":"10.1016\/j.bbrc.2018.11.175_bib19","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/exd.13730","article-title":"Combination of 5-aminolevulinic acid and iron prevents skin fibrosis in murine sclerodermatous graft-versus-host disease","volume":"27","author":"Liu","year":"2018","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bbrc.2018.11.175_bib20","first-page":"168","article-title":"Protective effect of 5-Aminolevulinic acid combined with ferrous iron on ischemia-reperfusion injury (in Japanese)","volume":"45","author":"Fujino","year":"2015","journal-title":"Gendaikagaku Zoukan"},{"key":"10.1016\/j.bbrc.2018.11.175_bib21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1159\/000477947","article-title":"Activation of Nrf2\/HO-1 pathway by glycogen synthase kinase-3\u03b2 inhibition attenuates renal ischemia\/reperfusion injury in diabetic rats","volume":"42","author":"Shen","year":"2017","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.bbrc.2018.11.175_bib22","doi-asserted-by":"crossref","first-page":"C665","DOI":"10.1152\/ajpcell.00369.2014","article-title":"5-aminolevulinic acid combined with sodium ferrous citrate ameliorates H2O2-induced cardiomyocyte hypertrophy via activation of the MAPK\/Nrf2\/HO-1 pathway","volume":"308","author":"Zhao","year":"2015","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbrc.2018.11.175_bib23","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.intimp.2014.02.003","article-title":"5-Aminolevulinic acid combined with ferrous iron enhances the expression of heme oxygenase-1","volume":"19","author":"Nishio","year":"2014","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2018.11.175_bib24","doi-asserted-by":"crossref","first-page":"560","DOI":"10.5483\/BMBRep.2017.50.11.060","article-title":"Cytoprotective effect exerted by geraniin in HepG2 cells is through microRNA mediated regulation of BACH-1 and HO-1","volume":"50","author":"Aayadi","year":"2017","journal-title":"Bmb Reports"},{"key":"10.1016\/j.bbrc.2018.11.175_bib25","doi-asserted-by":"crossref","first-page":"14019","DOI":"10.1038\/s41598-018-32411-4","article-title":"Molecular hydrogen protects against ischemia-reperfusion injury in a mouse fatty liver model via regulating HO-1 and Sirt1 expression","volume":"8","author":"Li","year":"2018","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.bbrc.2018.11.175_bib26","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/exd.13730","article-title":"Combination of 5-aminolevulinic acid and iron prevents skin fibrosis in murine sclerodermatous grafts-vs-host disease","volume":"27","author":"Liu","year":"2018","journal-title":"Exp. Dermatol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1832610X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1832610X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T14:21:11Z","timestamp":1777386071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X1832610X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0006291X1832610X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.11.175","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"5-aminolaevulinic acid (ALA), enhances heme oxygenase (HO)-1 expression and attenuates tubulointerstitial fibrosis and renal apoptosis in chronic cyclosporine nephropathy","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.11.175","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}