{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:27:04Z","timestamp":1788852424624,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"Division of Intramural Research, National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.bbrc.2018.12.111","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T02:38:31Z","timestamp":1545273511000},"page":"235-240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Endoplasmic reticulum stress is induced in growth plate hypertrophic chondrocytes in G610C mouse model of osteogenesis imperfecta"],"prefix":"10.1016","volume":"509","author":[{"given":"Amanda L.","family":"Scheiber","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J.","family":"Guess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Kaito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Abzug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motomi","family":"Enomoto-Iwamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Leikin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9233-6614","authenticated-orcid":false,"given":"Satoru","family":"Otsuru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.12.111_bib1","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrendo.2011.81","article-title":"New perspectives on osteogenesis imperfecta","volume":"7","author":"Forlino","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbrc.2018.12.111_bib2","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/S0140-6736(15)00728-X","article-title":"Osteogenesis imperfecta","volume":"387","author":"Forlino","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2018.12.111_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1359\/jbmr.090720","article-title":"Variable bone fragility associated with an Amish COL1A2 variant and a knock-in mouse model","volume":"25","author":"Daley","year":"2010","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2018.12.111_bib4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1006\/jsbi.1998.3977","article-title":"Gly-X-Y tripeptide frequencies in collagen: a context for host-guest triple-helical peptides","volume":"122","author":"Ramshaw","year":"1998","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.bbrc.2018.12.111_bib5","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1002\/jbmr.2824","article-title":"Osteoblast malfunction caused by cell stress response to procollagen misfolding in \u03b12(I)-G610C mouse model of osteogenesis imperfecta","volume":"31","author":"Mirigian","year":"2016","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2018.12.111_bib6","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1371\/journal.pgen.0040007","article-title":"ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta","volume":"4","author":"Lisse","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbrc.2018.12.111_bib7","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.tcb.2010.11.007","article-title":"Chaperoning osteogenesis: new protein-folding disease paradigms","volume":"21","author":"Makareeva","year":"2011","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.bbrc.2018.12.111_bib8","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1002\/jemt.1070280606","article-title":"Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes","volume":"28","author":"Hunziker","year":"1994","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.bbrc.2018.12.111_bib9","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/jor.1100140613","article-title":"Differential growth by growth plates as a function of multiple parameters of chondrocytic kinetics","volume":"14","author":"Wilsman","year":"1996","journal-title":"J.\u00a0Orthop. Res."},{"key":"10.1016\/j.bbrc.2018.12.111_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004364","article-title":"SHP2 regulates chondrocyte terminal differentiation, growth plate Architecture and skeletal cell fates","volume":"10","author":"Bowen","year":"2014","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbrc.2018.12.111_bib11","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/9467","article-title":"VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation","volume":"5","author":"Gerber","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2018.12.111_bib12","doi-asserted-by":"crossref","first-page":"17192","DOI":"10.1073\/pnas.0407788101","article-title":"Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification","volume":"101","author":"Inada","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2018.12.111_bib13","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1038\/nm.2448","article-title":"Matrix-embedded cells control osteoclast formation","volume":"17","author":"Xiong","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2018.12.111_bib14","doi-asserted-by":"crossref","first-page":"12097","DOI":"10.1073\/pnas.1302703111","article-title":"Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation","volume":"111","author":"Yang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2018.12.111_bib15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.bone.2013.03.019","article-title":"Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation","volume":"55","author":"Golovchenko","year":"2013","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2018.12.111_bib16","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1302\/0301-620X.72B3.2187879","article-title":"Morphological changes in growth-plate cartilage in osteogenesis imperfecta","volume":"72","author":"Sanguinetti","year":"1990","journal-title":"J.\u00a0Bone Jt. Surg. Br."},{"key":"10.1016\/j.bbrc.2018.12.111_bib17","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.micron.2005.05.014","article-title":"Enzyme histochemical localisation of alkaline phosphatase activity in osteogenesis imperfecta bone and growth plate: a preliminary study","volume":"36","author":"Sarathchandra","year":"2005","journal-title":"Micron"},{"key":"10.1016\/j.bbrc.2018.12.111_bib18","first-page":"343","article-title":"Cartilaginous changes in osteogenesis imperfecta","volume":"200","author":"Stoss","year":"1985","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.bbrc.2018.12.111_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1359\/jbmr.2002.17.1.15","article-title":"Use of type I collagen green fluorescent protein transgenes to identify subpopulations of cells at different stages of the osteoblast lineage","volume":"17","author":"Kalajzic","year":"2002","journal-title":"J.\u00a0Bone Miner. Res.: Official J. Am. Soc. Bone Mineral Res."},{"key":"10.1016\/j.bbrc.2018.12.111_bib20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1432-1033.1983.tb07549.x","article-title":"A\u00a0monoclonal antibody specific for the amino terminal cleavage site of procollagen type I","volume":"134","author":"Foellmer","year":"1983","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbrc.2018.12.111_bib21","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1182\/blood-2011-12-400085","article-title":"Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms","volume":"120","author":"Otsuru","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2018.12.111_bib22","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jcyt.2014.10.013","article-title":"Genomic and functional comparison of mesenchymal stromal cells prepared using two isolation methods","volume":"17","author":"Otsuru","year":"2015","journal-title":"Cytotherapy"},{"key":"10.1016\/j.bbrc.2018.12.111_bib23","doi-asserted-by":"crossref","first-page":"9552","DOI":"10.1073\/pnas.85.24.9552","article-title":"Terminal differentiation and calcification in rabbit chondrocyte cultures grown in centrifuge tubes: regulation by transforming growth factor beta and serum factors","volume":"85","author":"Kato","year":"1988","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.bbrc.2018.12.111_bib24","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1083\/jcb.137.5.1149","article-title":"Regulated production of mineralization-competent matrix vesicles in hypertrophic chondrocytes","volume":"137","author":"Kirsch","year":"1997","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2018.12.111_bib25","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1002\/jbmr.2484","article-title":"ER stress during the pubertal growth spurt results in impaired long-bone growth in chondrocyte-specific ERp57 knockout mice","volume":"30","author":"Linz","year":"2015","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2018.12.111_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000691","article-title":"Targeted induction of endoplasmic reticulum stress induces cartilage pathology","volume":"5","author":"Rajpar","year":"2009","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbrc.2018.12.111_bib27","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/humu.20183","article-title":"Mutations of COL10A1 in Schmid metaphyseal chondrodysplasia","volume":"25","author":"Bateman","year":"2005","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.bbrc.2018.12.111_bib28","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/dvdy.24131","article-title":"Mechanisms and models of endoplasmic reticulum stress in chondrodysplasia: ER Stress Mechanisms in Chondrodysplasia","volume":"243","author":"Patterson","year":"2014","journal-title":"Dev. Dynam."},{"key":"10.1016\/j.bbrc.2018.12.111_bib29","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bone.2014.10.012","article-title":"Rapidly growing Brtl\/+ mouse model of osteogenesis imperfecta improves bone mass and strength with sclerostin antibody treatment","volume":"71","author":"Sinder","year":"2015","journal-title":"Bone"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18327608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18327608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:34:03Z","timestamp":1762094043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18327608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0006291X18327608"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.12.111","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endoplasmic reticulum stress is induced in growth plate hypertrophic chondrocytes in G610C mouse model of osteogenesis imperfecta","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.12.111","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}