{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:07:48Z","timestamp":1790680068220,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T00:00:00Z","timestamp":1545782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP15J09420"],"award-info":[{"award-number":["JP15J09420"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17H03570"],"award-info":[{"award-number":["JP17H03570"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP25460102"],"award-info":[{"award-number":["JP25460102"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["S2510"],"award-info":[{"award-number":["S2510"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004091","name":"Kumamoto University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004520","name":"Tokyo Institute of Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004520","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.bbrc.2018.12.152","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T18:55:27Z","timestamp":1546023327000},"page":"521-528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Integrative expression analysis identifies a novel interplay between CFTR and linc-SUMF1-2 that involves CF-associated gene dysregulation"],"prefix":"10.1016","volume":"509","author":[{"given":"Shunsuke","family":"Kamei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasumi","family":"Maruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Fujikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Nohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Ueno-Shuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6044-2770","authenticated-orcid":false,"given":"Yukihiro","family":"Tasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryunosuke","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisei","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Eto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"Suico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter C.","family":"Gruenert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Dong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Kai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Shuto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2018.12.152_bib1","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/j.jcf.2017.10.006","article-title":"Ion channels as targets to treat cystic fibrosis lung disease","volume":"17","author":"Martin","year":"2018","journal-title":"J.\u00a0Cyst. Fibros."},{"key":"10.1016\/j.bbrc.2018.12.152_bib2","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1016\/S0140-6736(16)00576-6","article-title":"Cystic fibrosis","volume":"388","author":"Elborn","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2018.12.152_bib3","doi-asserted-by":"crossref","first-page":"7674","DOI":"10.1074\/jbc.M210277200","article-title":"Transcriptional adaptation to cystic fibrosis transmembrane conductance regulator deficiency","volume":"278","author":"Xu","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.12.152_bib4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ygeno.2011.06.008","article-title":"Differential global gene expression in cystic fibrosis nasal and bronchial epithelium","volume":"98","author":"Ogilvie","year":"2011","journal-title":"Genomics"},{"key":"10.1016\/j.bbrc.2018.12.152_bib5","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.ygeno.2015.07.005","article-title":"Transcriptome meta-analysis reveals common differential and global gene expression profiles in cystic fibrosis and other respiratory disorders and identifies CFTR regulators","volume":"106","author":"Clarke","year":"2015","journal-title":"Genomics"},{"key":"10.1016\/j.bbrc.2018.12.152_bib6","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1096\/fj.05-4934fje","article-title":"Promoter hypomethylation of Toll-like receptor-2 gene is associated with increased proinflammatory response toward bacterial peptidoglycan in cystic fibrosis bronchial epithelial cells","volume":"20","author":"Shuto","year":"2006","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbrc.2018.12.152_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1471-2199-9-39","article-title":"DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription","volume":"9","author":"Furuta","year":"2008","journal-title":"BMC Mol. Biol."},{"key":"10.1016\/j.bbrc.2018.12.152_bib8","doi-asserted-by":"crossref","first-page":"39305","DOI":"10.1038\/srep39305","article-title":"Pharmacological and genetic reappraisals of protease and oxidative stress pathways in a mouse model of obstructive lung diseases","volume":"6","author":"Shuto","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2018.12.152_bib9","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.ebiom.2017.12.025","article-title":"Zinc deficiency via a splice switch in zinc importer ZIP2\/SLC39A2 causes cystic fibrosis-associated MUC5AC Hypersecretion in airway epithelial cells","volume":"27","author":"Kamei","year":"2017","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbrc.2018.12.152_bib10","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.cell.2013.02.012","article-title":"Long noncoding RNAs: cellular address codes in development and disease","volume":"152","author":"Batista","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2018.12.152_bib11","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.biocel.2014.02.022","article-title":"Long noncoding RNA are aberrantly expressed in\u00a0vivo in the cystic fibrosis bronchial epithelium","volume":"52","author":"McKiernan","year":"2014","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2018.12.152_bib12","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1073\/pnas.89.11.5171","article-title":"Characterization of immortal cystic fibrosis tracheobronchial gland epithelial cells","volume":"89","author":"Cozens","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.bbrc.2018.12.152_bib13","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1165\/ajrcmb.10.1.7507342","article-title":"CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells","volume":"10","author":"Cozens","year":"1994","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.bbrc.2018.12.152_bib14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1159\/000149783","article-title":"Cl transport in complemented CF bronchial epithelial cells correlates with CFTR mRNA expression levels","volume":"22","author":"Illek","year":"2008","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bbrc.2018.12.152_bib15","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1254\/jphs.11240FP","article-title":"Synergism between interleukin (IL)-17 and toll-like receptor 2 and 4 signals to induce IL-8 expression in cystic fibrosis airway epithelial cells","volume":"118","author":"Mizunoe","year":"2012","journal-title":"J.\u00a0Pharmacol. Sci."},{"key":"10.1016\/j.bbrc.2018.12.152_bib16","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1186\/s12864-015-1913-6","article-title":"Multi-platform assessment of transcriptional profiling technologies utilizing a precise probe mapping methodology","volume":"16","author":"Yu","year":"2015","journal-title":"BMC Genomics"},{"key":"10.1016\/j.bbrc.2018.12.152_bib17","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1186\/s12864-017-3819-y","article-title":"RNA sequencing and transcriptome arrays analyses show opposing results for alternative splicing in patient derived samples","volume":"18","author":"Nazarov","year":"2017","journal-title":"BMC Genomics"},{"key":"10.1016\/j.bbrc.2018.12.152_bib18","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cell.2018.01.011","article-title":"Leading edge review functional classification and experimental dissection of long noncoding RNAs","volume":"172","author":"Kopp","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2018.12.152_bib19","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.4161\/rna.21089","article-title":"Loss of the abundant nuclear non-coding RNA MALAT1 is compatible with life and development","volume":"9","author":"Ei\u00dfmann","year":"2012","journal-title":"RNA Biol."},{"key":"10.1016\/j.bbrc.2018.12.152_bib20","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1523\/JNEUROSCI.3389-16.2017","article-title":"Long noncoding RNA Malat1 regulates cerebrovascular pathologies in ischemic stroke","volume":"37","author":"Zhang","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2018.12.152_bib21","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1007\/s00109-013-1028-y","article-title":"MALAT1 - a paradigm for long noncoding RNA function in cancer","volume":"91","author":"Gutschner","year":"2013","journal-title":"J.\u00a0Mol. Med."},{"key":"10.1016\/j.bbrc.2018.12.152_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0072398","article-title":"IP-10 is a potential biomarker of cystic fibrosis acute pulmonary exacerbations","volume":"8","author":"Solomon","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2018.12.152_bib23","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.4049\/jimmunol.168.7.3195","article-title":"IFN-gamma-Inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking","volume":"168","author":"Dufour","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2018.12.152_bib24","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1080\/15476286.2016.1197484","article-title":"RPTOR, a novel target of miR-155, elicits a fibrotic phenotype of cystic fibrosis lung epithelium by upregulating CTGF","volume":"13","author":"Tsuchiya","year":"2016","journal-title":"RNA Biol."},{"key":"10.1016\/j.bbrc.2018.12.152_bib25","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1002\/jcb.26483","article-title":"Epiregulin (EREG) is upregulated through an IL-1\u03b2 autocrine loop in Caco-2 epithelial cells with reduced CFTR function","volume":"119","author":"Massip-Copiz","year":"2018","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.bbrc.2018.12.152_bib26","doi-asserted-by":"crossref","first-page":"L555","DOI":"10.1152\/ajplung.00458.2017","article-title":"Extracellular oxidation in Cystic Fibrosis airway epithelium causes enhanced EGFR\/ADAM17 activity","volume":"314","author":"Stolarczyk","year":"2017","journal-title":"Am. J. Physiol. Lung Cell Mol. Physiol."},{"key":"10.1016\/j.bbrc.2018.12.152_bib27","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/jcmm.12953","article-title":"MXRA5 is a TGF-\u03b21-regulated human protein with anti-inflammatory and anti-fibrotic properties","volume":"21","author":"Poveda","year":"2017","journal-title":"J.\u00a0Cell Mol. Med."},{"key":"10.1016\/j.bbrc.2018.12.152_bib28","doi-asserted-by":"crossref","first-page":"32436","DOI":"10.1074\/jbc.M110.120451","article-title":"Semaphorin 5A and plexin-B3 inhibit human glioma cell motility through RhoGDI alpha- mediated inactivation of Rac1 GTPase","volume":"285","author":"Li","year":"2010","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2018.12.152_bib29","doi-asserted-by":"crossref","first-page":"a014381","DOI":"10.1101\/cshperspect.a014381","article-title":"Roles for MYC in the establishment and maintenance of pluripotency","volume":"3","author":"Chappell","year":"2013","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.bbrc.2018.12.152_bib30","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3389\/fcimb.2017.00218","article-title":"Bronchial epithelial cells from cystic fibrosis patients express a specific long non-coding RNA signature upon Pseudomonas aeruginosa infection","volume":"7","author":"Balloy","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bbrc.2018.12.152_bib31","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1042\/BST20170469","article-title":"Non-coding RNA in cystic fibrosis","volume":"46","author":"Glasgow","year":"2018","journal-title":"Biochem. Soc. Trans."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18328213?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X18328213?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:34:59Z","timestamp":1762094099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X18328213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0006291X18328213"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.12.152","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Integrative expression analysis identifies a novel interplay between CFTR and linc-SUMF1-2 that involves CF-associated gene dysregulation","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2018.12.152","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}