{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T17:50:26Z","timestamp":1783533026873,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"National Institute of HealthNational Institute of Health (NIH)","award":["AR-067667"],"award-info":[{"award-number":["AR-067667"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.bbrc.2019.01.066","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T22:30:26Z","timestamp":1548282626000},"page":"135-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Hyperhomocysteinemia induced endothelial progenitor cells dysfunction through hyper-methylation of CBS promoter"],"prefix":"10.1016","volume":"510","author":[{"given":"Jyotirmaya","family":"Behera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suresh C.","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1789-0754","authenticated-orcid":false,"given":"Neetu","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.01.066_bib1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/1479-5876-12-170","article-title":"Hypermethylation of DDAH2 promoter contributes to the dysfunction of endothelial progenitor cells in coronary artery disease patients","volume":"12","author":"Niu","year":"2014","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.bbrc.2019.01.066_bib2","doi-asserted-by":"crossref","first-page":"13061","DOI":"10.1038\/s41598-017-13436-7","article-title":"Ginsenoside Rb1 prevents homocysteine-induced EPC dysfunction via VEGF\/p38MAPK and SDF-1\/CXCR4 activation","volume":"7","author":"Lan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2019.01.066_bib3","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/1479-5876-10-143","article-title":"Correlation between the functional impairment of bone marrow-derived circulating progenitor cells and the extend of coronary artery disease","volume":"10","author":"Bozdag-Turan","year":"2012","journal-title":"J.\u00a0Transl. Med."},{"key":"10.1016\/j.bbrc.2019.01.066_bib4","doi-asserted-by":"crossref","first-page":"e74","DOI":"10.1161\/01.RES.0000246095.90247.d4","article-title":"Improvement of endothelial function by systemic transfusion of vascular progenitor cells","volume":"99","author":"Wassmann","year":"2006","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2019.01.066_bib5","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1002\/cyto.b.21095","article-title":"Personalized cytomic assessment of vascular health: evaluation of the vascular health profile in diabetes mellitus","volume":"84","author":"Kurtzman","year":"2013","journal-title":"Cytom. B Clin. Cytom."},{"key":"10.1016\/j.bbrc.2019.01.066_bib6","doi-asserted-by":"crossref","first-page":"3662","DOI":"10.2174\/0929867321666140706142335","article-title":"Endothelial dysfunction: the link between homocysteine and hydrogen sulfide","volume":"21","author":"Pushpakumar","year":"2014","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.bbrc.2019.01.066_bib7","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.yjmcc.2006.01.011","article-title":"Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells","volume":"40","author":"Zhu","year":"2006","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2019.01.066_bib8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/ars.2008.2073","article-title":"H2S protects against methionine\u2013induced oxidative stress in brain endothelial cells","volume":"11","author":"Tyagi","year":"2009","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.bbrc.2019.01.066_bib9","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/jor.21415","article-title":"Homocysteine mediated decrease in bone blood flow and remodeling: role of Folic Acid","volume":"29","author":"Tyagi","year":"2011","journal-title":"J.\u00a0Orthop. Res."},{"key":"10.1016\/j.bbrc.2019.01.066_bib10","doi-asserted-by":"crossref","first-page":"15226","DOI":"10.1038\/s41598-018-33149-9","article-title":"Hydrogen sulfide promotes bone homeostasis by balancing inflammatory cytokine signaling in CBS-deficient mice through an epigenetic mechanism","volume":"8","author":"Behera","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2019.01.066_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s13148-011-0022-x","article-title":"Differential effects of nutritional folic acid deficiency and moderate hyperhomocysteinemia on aortic plaque formation and genome-wide DNA methylation in vascular tissue from ApoE-\/- mice","volume":"2","author":"McNeil","year":"2011","journal-title":"Clin. Epigenet."},{"key":"10.1016\/j.bbrc.2019.01.066_bib12","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bone.2018.06.009","article-title":"Hydrogen sulfide epigenetically mitigates bone loss through OPG\/RANKL regulation during hyperhomocysteinemia in mice","volume":"114","author":"Behera","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.bbrc.2019.01.066_bib13","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s12035-013-8421-y","article-title":"Synergy of homocysteine, microRNA, and epigenetics: a novel therapeutic approach for stroke","volume":"48","author":"Kalani","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbrc.2019.01.066_bib14","doi-asserted-by":"crossref","first-page":"3836","DOI":"10.2741\/3492","article-title":"Anti-inflammatory strategies for homocysteine-related cardiovascular disease","volume":"14","author":"Lin","year":"2009","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bbrc.2019.01.066_bib15","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.21037\/jtd.2017.07.56","article-title":"The role of bone marrow-derived endothelial progenitor cells and angiogenic responses in chronic obstructive pulmonary disease","volume":"9","author":"Salter","year":"2017","journal-title":"J.\u00a0Thorac. Dis."},{"key":"10.1016\/j.bbrc.2019.01.066_bib16","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1089\/wound.2012.0398","article-title":"The role of endothelial progenitor cells in postnatal vasculogenesis: implications for therapeutic neovascularization and wound healing","volume":"2","author":"Balaji","year":"2013","journal-title":"Adv. Wound Care"},{"key":"10.1016\/j.bbrc.2019.01.066_bib17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/cyto.a.20669","article-title":"Endothelial progenitor cells: implications for cardiovascular disease","volume":"75","author":"M\u00f6bius-Winkler","year":"2009","journal-title":"Cytometry"},{"key":"10.1016\/j.bbrc.2019.01.066_bib18","doi-asserted-by":"crossref","DOI":"10.1007\/s11739-013-0915-0","article-title":"Endothelial progenitor cells, cardiovascular risk factors and lifestyle modifications","volume":"8","author":"Di Stefano","year":"2013","journal-title":"Intern. Emerg. Med."},{"key":"10.1016\/j.bbrc.2019.01.066_bib19","first-page":"103","article-title":"Hyperhomocysteinemia and atherosclerosis","volume":"57","author":"Yang","year":"2005","journal-title":"Acta Physiol. Sin."},{"key":"10.1016\/j.bbrc.2019.01.066_bib20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1042\/CS20030389","article-title":"Number and activity of endothelial progenitor cells from peripheral blood in patients with hypercholesterolaemia","volume":"107","author":"Chen","year":"2004","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bbrc.2019.01.066_bib21","first-page":"8043792","article-title":"Endothelial progenitor cells for diagnosis and prognosis in cardiovascular disease","volume":"2016","author":"Aragona","year":"2016","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.bbrc.2019.01.066_bib22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.jacc.2006.09.050","article-title":"Endothelial progenitor cells in cardiovascular disorders","volume":"49","author":"Shantsila","year":"2007","journal-title":"J.\u00a0Am. Coll. Cardiol."},{"key":"10.1016\/j.bbrc.2019.01.066_bib23","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s12192-013-0416-0","article-title":"Inhibition of cystathionine \u03b2-synthase is associated with glucocorticoids over-secretion in psychological stress-induced hyperhomocystinemia rat liver","volume":"18","author":"Zhao","year":"2013","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.bbrc.2019.01.066_bib24","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1002\/jcp.25693","article-title":"Homocysteine as a pathological biomarker for bone disease","volume":"232","author":"Behera","year":"2017","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.bbrc.2019.01.066_bib25","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/jcbfm.2014.74","article-title":"Role of microRNA29b in blood\u2013brain barrier dysfunction during hyperhomocysteinemia: an epigenetic mechanism","volume":"34","author":"Kalani","year":"2014","journal-title":"J.\u00a0Cerebr. Blood Flow Metabol."},{"key":"10.1016\/j.bbrc.2019.01.066_bib26","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1096\/fj.15-278648","article-title":"Cystathionine \u03b2-synthase regulates endothelial function via protein S-sulfhydration","volume":"30","author":"Saha","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2019.01.066_bib27","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1001\/archneurol.2010.275","article-title":"Emerging role of epigenetics in stroke: part 1: DNA methylation and chromatin modifications","volume":"67","author":"Qureshi","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbrc.2019.01.066_bib28","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s11011-014-9537-0","article-title":"Epigenetic impact of curcumin on stroke prevention","volume":"30","author":"Kalani","year":"2015","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbrc.2019.01.066_bib29","first-page":"111","article-title":"Epigenomics: genome-wide study of methylation phenomena","volume":"4","author":"Novik","year":"2002","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.bbrc.2019.01.066_bib30","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/aps.2010.22","article-title":"Atorvastatin inhibits homocysteine-induced dysfunction and apoptosis in endothelial progenitor cells","volume":"31","author":"Bao","year":"2010","journal-title":"Acta Pharmacol. Sin."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19300804?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19300804?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,30]],"date-time":"2019-01-30T00:47:01Z","timestamp":1548809221000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19300804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0006291X19300804"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.01.066","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperhomocysteinemia induced endothelial progenitor cells dysfunction through hyper-methylation of CBS promoter","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.01.066","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}