{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T02:53:22Z","timestamp":1773024802087,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"The University of North Carolina at Chapel Hill"},{"DOI":"10.13039\/501100006004","name":"Tohoku University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006004","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Japan Society for Promotion of Science (JSPS","award":["17K09682"],"award-info":[{"award-number":["17K09682"]}]},{"name":"Japan Society for Promotion of Science (JSPS","award":["16J03192"],"award-info":[{"award-number":["16J03192"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.bbrc.2019.01.110","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T02:09:12Z","timestamp":1549591752000},"page":"587-593","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL\/lpr mice treated with lipopolysaccharide"],"prefix":"10.1016","volume":"510","author":[{"given":"Kenta","family":"Imaruoka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Oe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomofumi","family":"Fushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emiko","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyo","family":"Sekimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Sugawara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadayoshi","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.01.110_bib1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJMra071297","article-title":"Systemic lupus erythematosus","volume":"358","author":"Rahman","year":"2008","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2019.01.110_bib2","first-page":"855","article-title":"Effect of pregnancy on disease flares in patients with systemic lupus erythematosus","volume":"77","author":"Eudy","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbrc.2019.01.110_bib3","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/rheumatology\/41.6.643","article-title":"Clinical predictors of fetal and maternal outcome in systemic lupus erythematosus: a prospective study of 103 pregnancies","volume":"41","author":"Cort\u00e9s-Hern\u00e1ndez","year":"2002","journal-title":"Rheumatology"},{"key":"10.1016\/j.bbrc.2019.01.110_bib4","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.2215\/CJN.00240110","article-title":"A\u00a0systematic review and meta-analysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis","volume":"5","author":"Smyth","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2019.01.110_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jaut.2017.02.009","article-title":"Impact of systemic lupus erythematosus on maternal and fetal outcomes following pregnancy: a meta-analysis of studies published between years 2001-2016","volume":"79","author":"Bundhun","year":"2017","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.bbrc.2019.01.110_bib6","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/annrheumdis-2016-209770","article-title":"EULAR recommendations for women's health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and\/or antiphospholipid syndrome","volume":"76","author":"Andreoli","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbrc.2019.01.110_bib7","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S1472-6483(10)60301-X","article-title":"Mechanisms behind flare of renal lupus during murine pregnancy","volume":"17","author":"Zenclussen","year":"2008","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.bbrc.2019.01.110_bib8","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1097\/01.ASN.0000121781.89599.16","article-title":"Signaling danger: toll-like receptors and their potential roles in kidney disease","volume":"15","author":"Anders","year":"2004","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2019.01.110_bib9","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.4049\/jimmunol.0803219","article-title":"Critical role of TLR2 and TLR4 in autoantibody production and glomerulonephritis in lpr mutation-induced mouse lupus","volume":"183","author":"Lartigue","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2019.01.110_bib10","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1172\/JCI88442","article-title":"CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus","volume":"127","author":"Faridi","year":"2017","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2019.01.110_bib11","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1002\/art.22571","article-title":"Protection against autoimmune nephritis in MyD88-deficient MRL\/lpr mice","volume":"56","author":"Sadanaga","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2019.01.110_bib12","doi-asserted-by":"crossref","first-page":"6763","DOI":"10.1007\/s11033-012-1501-7","article-title":"PDTC attenuate LPS-induced kidney injury in systemic lupus erythematosus-prone MRL\/lpr mice","volume":"39","author":"Zhai","year":"2012","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bbrc.2019.01.110_bib13","doi-asserted-by":"crossref","first-page":"535","DOI":"10.7754\/Clin.Lab.2015.150709","article-title":"Pro-inflammatory cytokines are elevated in pregnant women with systemic lupus erythematosus in association with the activation of TLR4","volume":"62","author":"Qu","year":"2016","journal-title":"Clin. Lab."},{"key":"10.1016\/j.bbrc.2019.01.110_bib14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1084\/jem.20130295","article-title":"Inflammation in rat pregnancy inhibits spiral artery remodeling leading to fetal growth restriction and features of preeclampsia","volume":"211","author":"Cotechini","year":"2014","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2019.01.110_bib15","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.ajog.2005.07.076","article-title":"Toll-like receptor 4: a potential link between \u201cdanger signals,\u201d the innate immune system, and preeclampsia?","volume":"193","author":"Kim","year":"2005","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.bbrc.2019.01.110_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082713","article-title":"Folic acid protects against lipopolysaccharide-induced preterm delivery and intrauterine growth restriction through its anti-inflammatory effect in mice","volume":"8","author":"Zhao","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2019.01.110_bib17","doi-asserted-by":"crossref","first-page":"13450","DOI":"10.1073\/pnas.1614947113","article-title":"Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia","volume":"113","author":"Li","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2019.01.110_bib18","doi-asserted-by":"crossref","first-page":"F366","DOI":"10.1152\/ajprenal.00501.2016","article-title":"Nicotinamide ameliorates a preeclampsia-like condition in mice with reduced uterine perfusion pressure","volume":"312","author":"Fushima","year":"2017","journal-title":"Am. J. Physiol. Renal. Physiol."},{"key":"10.1016\/j.bbrc.2019.01.110_bib19","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0065-2776(08)60342-9","article-title":"Murine models of systemic lupus erythematosus","volume":"37","author":"Theofilopoulos","year":"1985","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.bbrc.2019.01.110_bib20","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2019.01.110_bib21","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/sj.ki.5002033","article-title":"Tandem mass spectrometry measurements of creatinine in mouse plasma and urine for determining glomerular filtration rate","volume":"71","author":"Takahashi","year":"2007","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2019.01.110_bib22","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1161\/ATVBAHA.116.307883","article-title":"Coagulation factor Xa and protease-activated receptor 2 as novel therapeutic targets for diabetic nephropathy","volume":"36","author":"Oe","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2019.01.110_bib23","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1073\/pnas.1018766108","article-title":"A\u00a0modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy","volume":"108","author":"Wang","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2019.01.110_bib24","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"Maynard","year":"2003","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2019.01.110_bib25","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.phrs.2011.11.014","article-title":"Therapeutic benefits of the group B3 vitamin nicotinamide in mice with lethal endotoxemia and polymicrobial sepsis","volume":"65","author":"Yuan","year":"2012","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbrc.2019.01.110_bib26","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1177\/1753425915602545","article-title":"Nicotinamide: a vitamin able to shift macrophage differentiation toward macrophages with restricted inflammatory features","volume":"21","author":"Weiss","year":"2015","journal-title":"Innate Immun."},{"key":"10.1016\/j.bbrc.2019.01.110_bib27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.intimp.2014.07.006","article-title":"Niacin attenuates the production of pro-inflammatory cytokines in LPS-induced mouse alveolar macrophages by HCA2 dependent mechanisms","volume":"23","author":"Zhou","year":"2014","journal-title":"Int. Immunopharm."},{"key":"10.1016\/j.bbrc.2019.01.110_bib28","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1189\/jlb.1007691","article-title":"Novel PKC signaling is required for LPS-induced soluble Flt-1 expression in macrophages","volume":"84","author":"Lee","year":"2008","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.bbrc.2019.01.110_bib29","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1191\/0961203306lu2297oa","article-title":"Lack of flow-mediated dilation and enhanced angiotensin II-induced constriction in skeletal muscle arterioles of lupus-prone autoimmune mice","volume":"15","author":"Bagi","year":"2006","journal-title":"Lupus"},{"key":"10.1016\/j.bbrc.2019.01.110_bib30","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1042\/CS20080196","article-title":"Role of TNF-alpha in vascular dysfunction","volume":"116","author":"Zhang","year":"2009","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bbrc.2019.01.110_bib31","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0168-8278(97)80013-X","article-title":"Effect of bacterial lipopolysaccharide on endothelin-1 production in human vascular endothelial cells","volume":"26","author":"Ros","year":"1997","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2019.01.110_bib32","doi-asserted-by":"crossref","first-page":"14807","DOI":"10.1038\/s41598-017-14926-4","article-title":"Experimental preeclampsia in rats affects vascular gene expression patterns","volume":"7","author":"Lip","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2019.01.110_bib33","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.clim.2008.01.002","article-title":"Accelerated atherosclerosis in ApoE deficient lupus mouse models","volume":"127","author":"Ma","year":"2008","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.bbrc.2019.01.110_bib34","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12882-015-0145-y","article-title":"Methylprednisolone attenuates lipopolysaccharide-induced Fractalkine expression in kidney of Lupus-prone MRL\/lpr mice through the NF-kappaB pathway","volume":"16","author":"You","year":"2015","journal-title":"BMC Nephrol."},{"key":"10.1016\/j.bbrc.2019.01.110_bib35","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.4049\/jimmunol.1400977","article-title":"IL-2 protects lupus-prone mice from multiple end-organ damage by limiting CD4-CD8- IL-17-producing T cells","volume":"193","author":"Mizui","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2019.01.110_bib36","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1172\/JCI87037","article-title":"Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus","volume":"126","author":"Wang","year":"2016","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2019.01.110_bib37","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1136\/annrheumdis-2017-211641","article-title":"Influence of disease activity and medications on offspring birth weight, pre-eclampsia and preterm birth in systemic lupus erythematosus: a population-based study","volume":"77","author":"Skorpen","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbrc.2019.01.110_bib38","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jnutbio.2016.09.008","article-title":"Niacin and its metabolites as master regulators of macrophage activation","volume":"39","author":"Montserrat-de la Paz","year":"2017","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.bbrc.2019.01.110_bib39","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.jnutbio.2010.10.009","article-title":"The anti-inflammatory and antioxidative effects of nicotinamide, a vitamin B(3) derivative, are elicited by FoxO3 in human gestational tissues: implications for preterm birth","volume":"22","author":"Lappas","year":"2011","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.bbrc.2019.01.110_bib40","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1007\/s001250051536","article-title":"Safety of high-dose nicotinamide: a review","volume":"43","author":"Knip","year":"2000","journal-title":"Diabetologia"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19301391?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19301391?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T16:43:47Z","timestamp":1565196227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19301391"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S0006291X19301391"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.01.110","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL\/lpr mice treated with lipopolysaccharide","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.01.110","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}