{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:06:22Z","timestamp":1789992382345,"version":"4.0.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20150080"],"award-info":[{"award-number":["BK20150080"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Disciplines of Jiangsu Province","award":["ZDXKC2016006"],"award-info":[{"award-number":["ZDXKC2016006"]}]},{"name":"General Project of Nanjing Medical Science and Technology Development","award":["YKK15111"],"award-info":[{"award-number":["YKK15111"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.bbrc.2019.02.020","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T08:20:55Z","timestamp":1549959655000},"page":"274-279","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["NO in the dPAG modulates panic-like responses and ASIC1a expression in the prefrontal cortex and hippocampus in mice"],"prefix":"10.1016","volume":"511","author":[{"given":"Meng-Meng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huai-Sha","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.02.020_bib1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the national comorbidity survey replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.bbrc.2019.02.020_bib2","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1002\/da.22572","article-title":"Cross-national epidemiology of panic disorder and panic attacks in the world mental health surveys","volume":"33","author":"de Jonge","year":"2016","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.bbrc.2019.02.020_bib3","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/j.neubiorev.2005.04.018","article-title":"TMT-induced autonomic and behavioral changes and the neural basis of its processing","volume":"29","author":"Fendt","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbrc.2019.02.020_bib4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.physbeh.2004.02.010","article-title":"The rat exposure test: a model of mouse defensive behaviors","volume":"81","author":"Yang","year":"2004","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbrc.2019.02.020_bib5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.bbr.2012.11.023","article-title":"Ethopharmacological evaluation of the rat exposure test: a prey-predator interaction test","volume":"240","author":"Campos","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbrc.2019.02.020_bib6","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neubiorev.2014.03.010","article-title":"The Deakin\/Graeff hypothesis: focus on serotonergic inhibition of panic","volume":"46 Pt 3","author":"Paul","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbrc.2019.02.020_bib7","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.euroneuro.2007.02.015","article-title":"Serotonergic mechanisms in the basolateral amygdala differentially regulate the conditioned and unconditioned fear organized in the periaqueductal gray","volume":"17","author":"Martinez","year":"2007","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.bbrc.2019.02.020_bib8","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1177\/0269881113504012","article-title":"The dorsolateral periaqueductal grey N-methyl-D-aspartate\/nitric oxide\/cyclic guanosine monophosphate pathway modulates the expression of contextual fear conditioning in rats","volume":"28","author":"Aguiar","year":"2014","journal-title":"J.\u00a0Psychopharmacol."},{"key":"10.1016\/j.bbrc.2019.02.020_bib9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.neuropharm.2013.07.008","article-title":"Complex interaction between anandamide and the nitrergic system in the dorsolateral periaqueductal gray to modulate anxiety-like behavior in rats","volume":"75","author":"Lisboa","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbrc.2019.02.020_bib10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00213-009-1492-9","article-title":"Role of glutamate NMDA receptors and nitric oxide located within the periaqueductal gray on defensive behaviors in mice confronted by predator","volume":"204","author":"Carvalho-Netto","year":"2009","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbrc.2019.02.020_bib11","doi-asserted-by":"crossref","first-page":"16556","DOI":"10.1073\/pnas.0608018103","article-title":"Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines","volume":"103","author":"Zha","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.bbrc.2019.02.020_bib12","doi-asserted-by":"crossref","first-page":"e572","DOI":"10.1038\/tp.2015.67","article-title":"Acid-base dysregulation and chemosensory mechanisms in panic disorder: a translational update","volume":"5","author":"Vollmer","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbrc.2019.02.020_bib13","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2174\/1381612820666141027124506","article-title":"Acid-sensing ion channels: a novel therapeutic target for pain and anxiety","volume":"21","author":"Li","year":"2015","journal-title":"Curr. Pharmaceut. Des."},{"key":"10.1016\/j.bbrc.2019.02.020_bib14","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1073\/pnas.032678399","article-title":"Heteromultimers of DEG\/ENaC subunits form H+-gated channels in mouse sensory neurons","volume":"99","author":"Benson","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2019.02.020_bib15","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.cell.2009.11.008","article-title":"An acid-sensing channel sows fear and panic","volume":"139","author":"Maren","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2019.02.020_bib16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s12017-015-8380-8","article-title":"The RS685012 polymorphism of ACCN2, the human ortholog of murine acid-sensing ion channel (ASIC1) gene, is highly represented in patients with panic disorder","volume":"18","author":"Gugliandolo","year":"2016","journal-title":"NeuroMolecular Med."},{"key":"10.1016\/j.bbrc.2019.02.020_bib17","doi-asserted-by":"crossref","first-page":"13251","DOI":"10.1523\/JNEUROSCI.2135-07.2007","article-title":"Modulation of acid-sensing ion channel activity by nitric oxide","volume":"27","author":"Cadiou","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2019.02.020_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-017-0006-5","article-title":"The relationship between dlPFC activity during unpredictable threat and CO2-induced panic symptoms","volume":"7","author":"Balderston","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbrc.2019.02.020_bib19","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1017\/S1461145713000163","volume":"16","author":"Freitas","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbrc.2019.02.020_bib20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1034\/j.1600-0447.108.s417.3.x","article-title":"Neuroanatomical circuits modulating fear and anxiety behaviors","volume":"108","author":"Charney","year":"2003","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.bbrc.2019.02.020_bib21","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.neuropharm.2012.04.022","article-title":"Differential environmental regulation of neurogenesis along the septo-temporal axis of the hippocampus","volume":"63","author":"Tanti","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbrc.2019.02.020_bib22","first-page":"108","article-title":"Structural neuroimaging in patients with panic disorder: findings and limitations of recent studies","volume":"25","author":"Del Casale","year":"2013","journal-title":"Psychiatr. Danub."},{"key":"10.1016\/j.bbrc.2019.02.020_bib23","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1176\/appi.neuropsych.12090230","article-title":"Hippocampal and subcortical alterations of first-episode, medication-naive major depressive disorder with panic disorder patients","volume":"26","author":"Lai","year":"2014","journal-title":"J.\u00a0Neuropsychiatry Clin. Neurosci."},{"key":"10.1016\/j.bbrc.2019.02.020_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00406-010-0167-1","article-title":"A\u00a0new paradigm (Westphal-Paradigm) to study the neural correlates of panic disorder with agoraphobia","volume":"261","author":"Wittmann","year":"2011","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.bbrc.2019.02.020_bib25","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.neulet.2009.02.041","article-title":"Production of panic-like symptoms by lactate is associated with increased neural firing and oxidation of brain redox in the rat hippocampus","volume":"453","author":"Bergold","year":"2009","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2019.02.020_bib26","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2018.06.028","article-title":"Mechanism of nitric oxide and acid-sensing ion channel 1a modulation of panic-like behaviour in the dorsal periaqueductal grey of the mouse","volume":"353","author":"Zhou","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbrc.2019.02.020_bib27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0166-4328(01)00452-1","article-title":"Evaluation of the elevated plus-maze and open-field tests for the assessment of anxiety-related behaviour in inbred mice","volume":"134","author":"Carola","year":"2002","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbrc.2019.02.020_bib28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.bbr.2016.08.010","article-title":"The role of genes involved in stress, neural plasticity, and brain circuitry in depressive phenotypes: convergent findings in a mouse model of neglect","volume":"315","author":"Montalvo-Ortiz","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbrc.2019.02.020_bib29","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0166-4328(96)00047-2","article-title":"Effect of the GABA-transaminase inhibitor vigabatrin on exploratory behaviour in socially isolated rats","volume":"72","author":"Sherif","year":"1995","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbrc.2019.02.020_bib30","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/S0149-7634(01)00059-8","article-title":"Modulation of defensive behavior by periaqueductal gray NMDA\/glycine-B receptor","volume":"25","author":"Carobrez","year":"2001","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbrc.2019.02.020_bib31","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.biopsycho.2015.04.006","article-title":"Validation of candidate anxiety disorder genes using a carbon dioxide challenge task","volume":"109","author":"Savage","year":"2015","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.bbrc.2019.02.020_bib32","article-title":"Dynamic T1rho and bold functional imaging in panic disorder","volume":"73","author":"Magnotta","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbrc.2019.02.020_bib33","doi-asserted-by":"crossref","DOI":"10.1186\/1756-6606-6-1","article-title":"Acid-sensing ion channels: trafficking and synaptic function","volume":"6","author":"Zha","year":"2013","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bbrc.2019.02.020_bib34","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.conb.2013.01.013","article-title":"Towards new approaches to disorders of fear and anxiety","volume":"23","author":"Dias","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.bbrc.2019.02.020_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/jn.00153.2004","article-title":"New vistas on amygdala networks in conditioned fear","volume":"92","author":"Pare","year":"2004","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.bbrc.2019.02.020_bib36","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2015.0431","article-title":"Acid-sensing ion channels regulate spontaneous inhibitory activity in the hippocampus: possible implications for epilepsy","volume":"371","author":"Ievglevskyi","year":"2016","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.bbrc.2019.02.020_bib37","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.neuron.2012.09.028","article-title":"Gating of fear in prelimbic cortex by hippocampal and amygdala inputs","volume":"76","author":"Sotres-Bayon","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2019.02.020_bib38","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12047","article-title":"Conditioned respiratory threat in the subdivisions of the human periaqueductal gray","volume":"5","author":"Faull","year":"2016","journal-title":"Elife"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19302013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19302013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T21:12:20Z","timestamp":1576703540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19302013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S0006291X19302013"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.02.020","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NO in the dPAG modulates panic-like responses and ASIC1a expression in the prefrontal cortex and hippocampus in mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.02.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}