{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T13:30:38Z","timestamp":1783517438688,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"RFBR","doi-asserted-by":"publisher","award":["18-015-00165\u0410"],"award-info":[{"award-number":["18-015-00165\u0410"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.bbrc.2019.02.054","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T08:20:12Z","timestamp":1550564412000},"page":"363-368","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Synergism of myocardial \u03b2-adrenoceptor blockade and I1-imidazoline receptor-driven signaling: Kinase-phosphatase switching"],"prefix":"10.1016","volume":"511","author":[{"given":"A.V.","family":"Maltsev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.V.","family":"Evdokimovskii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.M.","family":"Kokoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.02.054_bib1","series-title":"Monitoring Health for the SDGs","author":"World Health Statistics 2016","year":"2016"},{"key":"10.1016\/j.bbrc.2019.02.054_bib2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.autneu.2018.01.002","article-title":"Neuroinflammation and sympathetic overactivity: mechanisms and implications in hypertension","volume":"210","author":"Haspula","year":"2018","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.bbrc.2019.02.054_bib3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s40119-016-0063-5","article-title":"A\u00a0review of the key clinical trials of 2015: results and implications","volume":"5","author":"McCune","year":"2016","journal-title":"Cardiol. Ther."},{"key":"10.1016\/j.bbrc.2019.02.054_bib4","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1056\/NEJMoa020803","article-title":"Synergistic polymorphisms of \u03b21- and \u03b12C-adrenergic receptors and the risk of congestive heart failure","volume":"347","author":"Small","year":"2002","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2019.02.054_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.yjmcc.2013.12.026","article-title":"Stimulation of ICa by basal PKA activity is facilitated by caveolin-3 in cardiac ventricular myocytes","volume":"68","author":"Bryant","year":"2014","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2019.02.054_bib6","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1152\/ajpcell.2001.281.6.C1743","article-title":"Regulation of cardiac and smooth muscle Ca2+ channels (Cav1.2a,b) by protein kinases","volume":"281","author":"Keef","year":"2001","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbrc.2019.02.054_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1146\/annurev.physiol.70.113006.100455","article-title":"Calcium cycling and signaling in cardiac myocytes","volume":"70","author":"Bers","year":"2008","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbrc.2019.02.054_bib8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/phar.2110","article-title":"Long-term beta-blocker therapy after myocardial infarction in the reperfusion era: a systematic review","volume":"38","author":"Hong","year":"2018","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.bbrc.2019.02.054_bib9","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1136\/thoraxjnl-2016-208412","article-title":"\u03b2-blockers, heart disease and COPD: current controversies and uncertainties","volume":"72","author":"Baker","year":"2017","journal-title":"Thorax"},{"key":"10.1016\/j.bbrc.2019.02.054_bib10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0014-2999(86)90138-X","article-title":"An endogenous, non-catecholamine clonidine antagonist, increases mean arterial blood pressure","volume":"124","author":"Bousquet","year":"1986","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.02.054_bib11","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/sj.bjp.0704153","article-title":"Biological significance of agmatine, an endogenous ligand at imidazoline binding sites","volume":"133","author":"Raasch","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.02.054_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.yjmcc.2013.12.030","article-title":"Alpha-2 adrenoceptors and imidazoline receptors in cardiomyocytes mediate counterbalancing effect of agmatine on NO synthesis and intracellular calcium handling","volume":"68","author":"Maltsev","year":"2014","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2019.02.054_bib13","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1134\/S1990747813020050","article-title":"Modulation of L-type Ca2+ currents and intracellular calcium by agmatine in rat cardiomyocytes","volume":"7","author":"Maltsev","year":"2013","journal-title":"Biochem. (Moscow) Suppl.\u00a0Series A: Membr. Cell Biol."},{"key":"10.1016\/j.bbrc.2019.02.054_bib14","first-page":"365","article-title":"Potential-dependent Ca2+ current in isolated heart cells of hibernators","volume":"33","author":"Alekseev","year":"1994","journal-title":"Biochem. Mol. Biol. Int."},{"key":"10.1016\/j.bbrc.2019.02.054_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.yjmcc.2016.09.006","article-title":"Sarcolemmal \u03b12-adrenoceptors control protective cardiomyocyte-delimited sympathoadrenal response","volume":"100","author":"Kokoz","year":"2016","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2019.02.054_bib16","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cbpb.2005.04.012","article-title":"Species- and tissue-dependent effects of NO and cyclic GMP on cardiac ion channels","volume":"142","author":"Fischmeister","year":"2005","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"10.1016\/j.bbrc.2019.02.054_bib17","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/FJC.0b013e3181b72c9f","article-title":"S-Nitrosylation of cardiac ion channels","volume":"54","author":"Gonzalez","year":"2009","journal-title":"J.\u00a0Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.02.054_bib18","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1046\/j.1471-4159.2001.00632.x","article-title":"The I1-imidazoline receptor in PC12 pheochromocytoma cells activates protein kinases C, extracellular signal-regulated kinase (ERK) and c-jun N-terminal kinase (JNK)","volume":"79","author":"Edwards","year":"2001","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.bbrc.2019.02.054_bib19","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1042\/CS20160036","article-title":"Protein kinase C mechanisms that contribute to cardiac remodeling","volume":"130","author":"Newton","year":"2016","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bbrc.2019.02.054_bib20","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nm1000","article-title":"PKC-alpha regulates cardiac contractility and propensity toward heart failure","volume":"10","author":"Braz","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2019.02.054_bib21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1113\/jphysiol.2003.059329","article-title":"Protein phosphatase 1 and an opposing protein kinase regulate steady-state L-type Ca2+ current in mouse cardiac myocytes","volume":"556","author":"duBell","year":"2004","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.bbrc.2019.02.054_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0003-9861(02)00242-4","article-title":"Differential susceptibilities of serine\/threonine phosphatases to oxidative and nitrosative stress","volume":"404","author":"Sommer","year":"2002","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbrc.2019.02.054_bib23","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.bbamcr.2007.11.003","article-title":"Differential splicing patterns of L-type calcium channel CaV 1.2. Subunit in hearts of spontaneously hypertensive rats and Wistar Kyoto rats","volume":"1783","author":"Tang","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2019.02.054_bib24","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1111\/bph.13035","article-title":"Chronic exercise normalizes changes in CaV 1.2 and KCa 1.1 channels in mesenteric arteries from spontaneously hypertensive rats","volume":"172","author":"Shi","year":"2015","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.02.054_bib25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/cvr\/cvv045","article-title":"Early subcellular Ca2+ remodelling and increased propensity for Ca2+ alternans in left atrial myocytes from hypertensive rats","volume":"106","author":"Pluteanu","year":"2015","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2019.02.054_bib26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.yjmcc.2017.07.119","article-title":"Beta-adrenergic regulation of the heart expressing the Ser1700A\/Thr1704A mutated CaV 1.2 channel","volume":"111","author":"Poomvanicha","year":"2017","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2019.02.054_bib27","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1161\/CIRCULATIONAHA.104.505784","article-title":"Improved myocardial beta-adrenergic responsiveness and signaling with exercise training in hypertension","volume":"111","author":"MacDonnell","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2019.02.054_bib28","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.yjmcc.2013.09.006","article-title":"Function and regulation of serine\/threonine phosphatases in the healthy and diseased heart","volume":"64","author":"Heijman","year":"2013","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2019.02.054_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jprot.2012.05.041","article-title":"Phosphoprotein abundance changes in hypertensive cardiac remodeling","volume":"77","author":"Kotlo","year":"2012","journal-title":"J.\u00a0Proteomics"},{"key":"10.1016\/j.bbrc.2019.02.054_bib30","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1074\/jbc.M116.753004","article-title":"Protein kinase C controls binding of Igo\/ENSA proteins to protein phosphatase 2A in budding yeast","volume":"292","author":"Thai","year":"2017","journal-title":"J.\u00a0Biol. Chem."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19302426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19302426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T21:12:48Z","timestamp":1576703568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19302426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S0006291X19302426"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.02.054","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Synergism of myocardial \u03b2-adrenoceptor blockade and I1-imidazoline receptor-driven signaling: Kinase-phosphatase switching","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.02.054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}