{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:15:59Z","timestamp":1790201759141,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81661148051"],"award-info":[{"award-number":["81661148051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672010"],"award-info":[{"award-number":["81672010"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31370862"],"award-info":[{"award-number":["31370862"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.bbrc.2019.02.108","type":"journal-article","created":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T13:26:49Z","timestamp":1551446809000},"page":"787-793","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["The interaction between Vav1 and EBNA1 promotes survival of Burkitt's lymphoma cells by down-regulating the expression of Bim"],"prefix":"10.1016","volume":"511","author":[{"given":"Ruikun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianchao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0973-097X","authenticated-orcid":false,"given":"Yaohui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuizhu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5284-2558","authenticated-orcid":false,"given":"Hongkai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2077-1999","authenticated-orcid":false,"given":"Youjia","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.02.108_bib1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/path.4459","article-title":"The Epstein-Barr virus and the pathogenesis of lymphoma","volume":"235","author":"Vockerodt","year":"2015","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.bbrc.2019.02.108_bib2","doi-asserted-by":"crossref","first-page":"2041","DOI":"10.1016\/S0140-6736(05)66698-6","article-title":"Nasopharyngeal carcinoma","volume":"365","author":"Wei","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2019.02.108_bib3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/(SICI)1099-1654(200003\/04)10:2<83::AID-RMV262>3.0.CO;2-T","article-title":"EBNA-1: a protein pivotal to latent infection by Epstein-Barr virus","volume":"10","author":"Leight","year":"2015","journal-title":"Rev. Med. Virol."},{"key":"10.1016\/j.bbrc.2019.02.108_bib4","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1128\/jvi.71.3.1766-1775.1997","article-title":"Dominant-negative inhibitors of EBNA-1 of Epstein-Barr virus","volume":"71","author":"Kirchmaier","year":"1997","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.bbrc.2019.02.108_bib5","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.3390\/v4091537","article-title":"Contributions of Epstein\u2013Barr Nuclear Antigen 1 (EBNA1) to Cell Immortalization and Survival","volume":"4","author":"Frappier","year":"2012","journal-title":"Viruses"},{"key":"10.1016\/j.bbrc.2019.02.108_bib6","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3390\/v5010226","article-title":"Potential Cellular Functions of Epstein-Barr Nuclear Antigen 1 (EBNA1) of Epstein-Barr virus","volume":"5","author":"Smith","year":"2013","journal-title":"Viruses"},{"key":"10.1016\/j.bbrc.2019.02.108_bib7","doi-asserted-by":"crossref","first-page":"5991","DOI":"10.1128\/jvi.65.11.5991-6000.1991","article-title":"BHRF1, the Epstein-Barr virus gene with homology to Bc12, is dispensable for B-lymphocyte transformation and virus replication","volume":"65","author":"Marchini","year":"1991","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.bbrc.2019.02.108_bib8","doi-asserted-by":"crossref","first-page":"8479","DOI":"10.1073\/pnas.90.18.8479","article-title":"Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death","volume":"90","author":"Henderson","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2019.02.108_bib9","doi-asserted-by":"crossref","first-page":"6999","DOI":"10.1128\/JVI.00194-12","article-title":"Proteomic Profiling of EBNA1-Host Protein Interactions in Latent and Lytic Epstein-Barr Virus Infections","volume":"86","author":"Maliksoni","year":"2012","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.bbrc.2019.02.108_bib10","doi-asserted-by":"crossref","first-page":"e131","DOI":"10.1038\/emm.2014.84","article-title":"Epstein\u2013Barr virus latent genes","volume":"47","author":"Kieff","year":"2015","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbrc.2019.02.108_bib11","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.canlet.2007.04.015","article-title":"Flesh and blood: The story of Vav1, a gene that signals in hematopoietic cells but can be transforming in human malignancies","volume":"255","author":"Katzav","year":"2007","journal-title":"Canc. Lett."},{"key":"10.1016\/j.bbrc.2019.02.108_bib12","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/hon.935","article-title":"Vav-1 expression correlates with NF\u03baB activation and CD40-mediated cell death in diffuse large B-cell lymphoma cell lines","volume":"28","author":"Hollmann","year":"2010","journal-title":"Hematol. Oncol."},{"key":"10.1016\/j.bbrc.2019.02.108_bib13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1158\/0008-5472.CAN-05-2489","article-title":"Activation of Vav\/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion","volume":"66","author":"Bartolom\u00e9","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2019.02.108_bib14","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s11060-012-0936-y","article-title":"Expression of VAV1 in the tumour microenvironment of glioblastoma multiforme","volume":"110","author":"Garcia","year":"2012","journal-title":"J.\u00a0Neuro Oncol."},{"key":"10.1016\/j.bbrc.2019.02.108_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1002\/path.2579","article-title":"The haematopoietic specific signal transducer Vav1 is aberrantly expressed in lung cancer and plays a role in tumourigenesis","volume":"219","author":"Lazer","year":"2010","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.bbrc.2019.02.108_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1477-7800-5-23","article-title":"The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer","volume":"5","author":"Lane","year":"2008","journal-title":"Int. Semin. Surg. Oncol."},{"key":"10.1016\/j.bbrc.2019.02.108_bib17","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ccr.2004.11.024","article-title":"Ectopic expression of VAV1 reveals an unexpected role in pancreatic cancer tumorigenesis","volume":"7","author":"Fernandez-Zapico","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2019.02.108_bib18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/aps.2010.185","article-title":"The distinct role of guanine nucleotide exchange factor Vav1 in Bcl-2 transcription and apoptosis inhibition in Jurkat leukemia T cells","volume":"32","author":"Yin","year":"2011","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbrc.2019.02.108_bib19","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1016\/j.cellsig.2014.05.015","article-title":"Vav1 increases Bcl-2 expression by selective activation of Rac2\u2013Akt in leukemia T cells","volume":"26","author":"Wan","year":"2014","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2019.02.108_bib20","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.1074\/jbc.M112.426221","article-title":"The N-terminal 20-amino acid region of guanine nucleotide exchange factor Vav1 plays a distinguished role in T cell receptor-mediated calcium signaling","volume":"288","author":"Li","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2019.02.108_bib21","doi-asserted-by":"crossref","first-page":"23737","DOI":"10.1074\/jbc.M702975200","article-title":"The calponin homology domain of Vav1 associates with calmodulin and is prerequisite to T cell antigen receptor-induced calcium release in Jurkat T lymphocytes","volume":"282","author":"Zhou","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2019.02.108_bib22","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1128\/JVI.05648-11","article-title":"Changes in the nasopharyngeal carcinoma nuclear proteome induced by the EBNA1 protein of Epstein-Barr virus reveal potential roles for EBNA1 in metastasis and oxidative stress responses","volume":"86","author":"Cao","year":"2012","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.bbrc.2019.02.108_bib23","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1365-2141.2006.06094.x","article-title":"Overexpression of the VAV proto-oncogene product is associated with B-cell chronic lymphocytic leukaemia displaying loss on 13q","volume":"133","author":"Prietos\u00e1nchez","year":"2010","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.bbrc.2019.02.108_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0898-6568(03)00110-4","article-title":"Vav proteins, masters of the world of cytoskeleton organization","volume":"16","author":"Hornstein","year":"2004","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2019.02.108_bib25","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0092-8674(00)81688-8","article-title":"Signaling-2000 and Beyond","volume":"100","author":"Hunter","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2019.02.108_bib26","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.biocel.2008.11.006","article-title":"Vav1: A hematopoietic signal transduction molecule involved in human malignancies","volume":"41","author":"Katzav","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2019.02.108_bib27","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1099\/jgv.0.000681","article-title":"Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle","volume":"98","author":"Deschamps","year":"2017","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.bbrc.2019.02.108_bib28","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.4049\/jimmunol.175.5.2968","article-title":"EBV Infection of Human B Lymphocytes Leads to Down-Regulation of Bim Expression: Relationship to Resistance to Apoptosis","volume":"175","author":"Clybouw","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2019.02.108_bib29","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.cellsig.2011.11.017","article-title":"Vav1 in differentiation of tumoral promyelocytes","volume":"24","author":"Bertagnolo","year":"2012","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2019.02.108_bib30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1128\/MCB.16.1.37","article-title":"p95vav associates with the nuclear protein Ku-70","volume":"16","author":"Romero","year":"1996","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2019.02.108_bib31","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1016\/j.cellsig.2007.07.022","article-title":"The association of Sam68 with Vav1 contributes to tumorigenesis","volume":"19","author":"Lazer","year":"2007","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2019.02.108_bib32","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1084\/jem.20011701","article-title":"Vav1 Is a Component of Transcriptionally Active Complexes","volume":"195","author":"Houlard","year":"2002","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2019.02.108_bib33","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1038\/leu.2009.151","article-title":"The BH3 mimetic compound, ABT-737, synergizes with a range of cytotoxic chemotherapy agents in chronic lymphocytic leukemia","volume":"23","author":"Mason","year":"2009","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrc.2019.02.108_bib34","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.1182\/blood-2014-03-560284","article-title":"Acquired mutations in BCL2 family proteins conferring resistance to the BH3 mimetic ABT-199 in lymphoma","volume":"123","author":"Fresquet","year":"2014","journal-title":"Blood"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19303092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19303092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:34:55Z","timestamp":1762094095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19303092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S0006291X19303092"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.02.108","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The interaction between Vav1 and EBNA1 promotes survival of Burkitt's lymphoma cells by down-regulating the expression of Bim","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.02.108","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}