{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T13:37:37Z","timestamp":1788788257615,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470574"],"award-info":[{"award-number":["81470574"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570426"],"award-info":[{"award-number":["81570426"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFC0903000"],"award-info":[{"award-number":["2016YFC0903000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.bbrc.2019.03.083","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T02:04:28Z","timestamp":1553133868000},"page":"498-504","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Rapamycin attenuates a murine model of thoracic aortic aneurysm by downregulating the miR-126\u20133p mediated activation of MAPK\/ERK signalling pathway"],"prefix":"10.1016","volume":"512","author":[{"given":"Mingyuan","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changshun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anqiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.03.083_bib1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/352337a0","article-title":"Marfan syndrome caused by a recurrent de novo missense mutation in the fibrillin gene","volume":"352","author":"Dietz","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2019.03.083_bib2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1172\/JCI200420641","article-title":"Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome","volume":"114","author":"Judge","year":"2004","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.bbrc.2019.03.083_bib3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1126\/science.1124287","article-title":"Losartan, an AT1 antagonist, prevents aortic aneurysm in a mouse model of Marfan syndrome","volume":"312","author":"Habashi","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2019.03.083_bib4","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1161\/CIRCGENETICS.114.000950","article-title":"Beneficial outcome of losartan therapy depends on type of FBN1 mutation in marfan syndrome","volume":"8","author":"Franken","year":"2015","journal-title":"Circ. Cardiovasc. Genet."},{"key":"10.1016\/j.bbrc.2019.03.083_bib5","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1056\/NEJMoa1404731","article-title":"I.\u00a0Pediatric Heart Network, Atenolol versus losartan in children and young adults with Marfan's syndrome","volume":"371","author":"Lacro","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2019.03.083_bib6","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1093\/eurheartj\/ehv151","article-title":"Marfan Sartan: a randomized, double-blind, placebo-controlled trial","volume":"36","author":"Milleron","year":"2015","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbrc.2019.03.083_bib7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12872-016-0263-x","article-title":"Ambulatory (24 h) blood pressure and arterial stiffness measurement in Marfan syndrome patients: a case control feasibility and pilot study","volume":"16","author":"Hillebrand","year":"2016","journal-title":"BMC Cardiovasc. Disord."},{"key":"10.1016\/j.bbrc.2019.03.083_bib8","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/jmri.25174","article-title":"Does altered aortic flow in marfan syndrome relate to aortic root dilatation?","volume":"44","author":"Wang","year":"2016","journal-title":"J.\u00a0Magn. Reson. Imaging"},{"key":"10.1016\/j.bbrc.2019.03.083_bib9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12968-017-0347-5","article-title":"Longitudinal evaluation of aortic hemodynamics in marfan syndrome: new insights from a 4D flow cardiovascular magnetic resonance multi-year follow-up study","volume":"19","author":"Geiger","year":"2017","journal-title":"J.\u00a0Cardiovasc. Magn. Reson."},{"key":"10.1016\/j.bbrc.2019.03.083_bib10","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbrc.2014.10.092","article-title":"Disruption of TGF-beta signaling in smooth muscle cell prevents flow-induced vascular remodeling","volume":"454","author":"Gao","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2019.03.083_bib11","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1161\/ATVBAHA.114.305150","article-title":"Dimorphic effects of transforming growth factor-beta signaling during aortic aneurysm progression in mice suggest a combinatorial therapy for Marfan syndrome","volume":"35","author":"Cook","year":"2015","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2019.03.083_bib12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/path.2516","article-title":"Syndromic and non-syndromic aneurysms of the human ascending aorta share activation of the Smad2 pathway","volume":"218","author":"Gomez","year":"2009","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.bbrc.2019.03.083_bib13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1161\/ATVBAHA.116.303229","article-title":"Altered smooth muscle cell force generation as a driver of thoracic aortic aneurysms and dissections","volume":"37","author":"Milewicz","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2019.03.083_bib14","doi-asserted-by":"crossref","first-page":"8271","DOI":"10.1073\/pnas.1700561114","article-title":"VAMP3 and SNAP23 mediate the disturbed flow-induced endothelial microRNA secretion and smooth muscle hyperplasia","volume":"114","author":"Zhu","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bbrc.2019.03.083_bib15","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.jvs.2018.05.246","article-title":"Rapamycin prevents thoracic aortic aneurysm and dissection in mice","volume":"69","author":"Zhou","year":"2019","journal-title":"J.\u00a0Vasc. Surg."},{"key":"10.1016\/j.bbrc.2019.03.083_bib16","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1161\/ATVBAHA.112.300407","article-title":"Rapamycin inhibits smooth muscle cell proliferation and obstructive arteriopathy attributable to elastin deficiency","volume":"33","author":"Li","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2019.03.083_bib17","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1172\/JCI69942","article-title":"Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis","volume":"124","author":"Li","year":"2014","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.bbrc.2019.03.083_bib18","first-page":"2","article-title":"Nonmyocyte ERK1\/2 signaling contributes to load-induced cardiomyopathy in Marfan mice","author":"Rouf","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbrc.2019.03.083_bib19","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12968-017-0345-7","article-title":"Altered aortic 3D hemodynamics and geometry in pediatric Marfan syndrome patients","volume":"19","author":"van der Palen","year":"2017","journal-title":"J.\u00a0Cardiovasc. Magn. Reson."},{"issue":"27","key":"10.1016\/j.bbrc.2019.03.083_bib20","doi-asserted-by":"crossref","DOI":"10.3791\/1291","article-title":"Measuring blood pressure in mice using volume pressure recording, a tail-cuff method","author":"Daugherty","year":"2009","journal-title":"J. Vis Exp."},{"key":"10.1016\/j.bbrc.2019.03.083_bib21","doi-asserted-by":"crossref","first-page":"[256]","DOI":"10.1038\/pr.2015.110","article-title":"Intrinsic cardiomyopathy in Marfan syndrome: results from in-vivo and ex-vivo studies of the Fbn1 C1039G\/+ model and longitudinal findings in humans","volume":"78","author":"Campens","year":"2015","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbrc.2019.03.083_bib22","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/FJC.0000000000000560","article-title":"The effect of a nonpeptide angiotensin II type 2 receptor agonist, compound 21, on aortic aneurysm growth in a mouse model of marfan syndrome","volume":"71","author":"Verbrugghe","year":"2018","journal-title":"J.\u00a0Cardiovasc. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.03.083_bib23","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1126\/science.1192152","article-title":"Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through ERK antagonism","volume":"332","author":"Habashi","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2019.03.083_bib24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.matbio.2017.07.004","article-title":"Marfan syndrome; A connective tissue disease at the crossroads of mechanotransduction, TGFbeta signaling and cell stemness","volume":"71\u201372","author":"Ramirez","year":"2018","journal-title":"Matrix Biol."},{"key":"10.1016\/j.bbrc.2019.03.083_bib25","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1126\/science.1253026","article-title":"Cell biology. Dysfunctional mechanosensing in aneurysms","volume":"344","author":"Humphrey","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2019.03.083_bib26","doi-asserted-by":"crossref","first-page":"H1110","DOI":"10.1152\/ajpheart.00677.2016","article-title":"Inhibition of the mTOR pathway in abdominal aortic aneurysm: implications of smooth muscle cell contractile phenotype, inflammation, and aneurysm expansion","volume":"312","author":"Li","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2019.03.083_bib27","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.2147\/DDDT.S166734","article-title":"Icariside II ameliorates endothelial dysfunction by regulating the MAPK pathway via miR-126\/SPRED1 in diabetic human cavernous endothelial cells","volume":"12","author":"Lei","year":"2018","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.bbrc.2019.03.083_bib28","doi-asserted-by":"crossref","first-page":"e92","DOI":"10.1161\/CIRCRESAHA.112.268268","article-title":"MMP-2 regulates Erk1\/2 phosphorylation and aortic dilatation in Marfan syndrome","volume":"110","author":"Xiong","year":"2012","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2019.03.083_bib29","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.bbrc.2017.04.096","article-title":"Loss of MURC\/Cavin-4 induces JNK and MMP-9 activity enhancement in vascular smooth muscle cells and exacerbates abdominal aortic aneurysm","volume":"487","author":"Miyagawa","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2019.03.083_bib30","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1016\/j.bbrc.2017.12.033","article-title":"Cortistatin attenuates angiotensin II-induced abdominal aortic aneurysm through inactivation of the ERK1\/2 signaling pathways","volume":"495","author":"Chai","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19304723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19304723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:34:44Z","timestamp":1757763284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19304723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0006291X19304723"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.03.083","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rapamycin attenuates a murine model of thoracic aortic aneurysm by downregulating the miR-126\u20133p mediated activation of MAPK\/ERK signalling pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.03.083","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}