{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T07:07:27Z","timestamp":1777100847270,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["13-04-00276\u0410"],"award-info":[{"award-number":["13-04-00276\u0410"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.bbrc.2019.03.117","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T09:49:48Z","timestamp":1553766588000},"page":"908-913","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["\u03b12-Adrenoceptor signaling in cardiomyocytes of spontaneously hypertensive rats starts to impair already at early age"],"prefix":"10.1016","volume":"512","author":[{"given":"A.V.","family":"Maltsev","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.V.","family":"Evdokimovskii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.M.","family":"Kokoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.03.117_bib1","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.drudis.2013.05.017","article-title":"Agmatine: clinical applications after 100 years in translation","volume":"18","author":"Piletz","year":"2013","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.bbrc.2019.03.117_bib2","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1054-3589(08)60834-0","article-title":"Agmatine: a novel neurotransmitter?","volume":"42","author":"Reis","year":"1998","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.03.117_bib3","doi-asserted-by":"crossref","first-page":"885","DOI":"10.2165\/00023210-200721110-00002","article-title":"Agmatine: metabolic pathway and spectrum of activity in brain","volume":"21","author":"Halaris","year":"2007","journal-title":"CNS Drugs"},{"key":"10.1016\/j.bbrc.2019.03.117_bib4","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.jpsychires.2013.04.004","article-title":"Increased plasma agmatine levels in patients with schizophrenia","volume":"47","author":"Uzbay","year":"2013","journal-title":"J.\u00a0Psychiatr. Res."},{"key":"10.1016\/j.bbrc.2019.03.117_bib5","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/107424840100600105","article-title":"The effect of agmatine administration on ischemic-reperfused isolated rat heart","volume":"6","author":"Greenberg","year":"2001","journal-title":"J.\u00a0Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.bbrc.2019.03.117_bib6","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1134\/S1990747812040058","article-title":"Regulation of potential-dependent L-type Ca2+ currents by agmatine. Imidazoline receptors in isolated cardiomyocytes","volume":"6","author":"Maltsev","year":"2012","journal-title":"Biochem. (Moscow) Suppl.\u00a0Series A: Membr. Cell Biol."},{"key":"10.1016\/j.bbrc.2019.03.117_bib7","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/sj.bjp.0704153","article-title":"Biological significance of agmatine, an endogenous ligand at imidazoline binding sites","volume":"133","author":"Raasch","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.03.117_bib8","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.yjmcc.2013.12.030","article-title":"Alpha-2 adrenoceptors and imidazoline receptors in cardiomyocytes mediate counterbalancing effect of agmatine on NO synthesis and intracellular calcium handling","volume":"68","author":"Maltsev","year":"2014","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2019.03.117_bib9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.yjmcc.2016.09.006","article-title":"Sarcolemmal \u03b12-adrenoceptors control protective cardiomyocyte-delimited sympathoadrenal response","volume":"100","author":"Kokoz","year":"2016","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2019.03.117_bib10","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1134\/S1990747813020050","article-title":"Modulation of L-type Ca2+ currents and intracellular calcium by agmatine in rat cardiomyocytes","volume":"7","author":"Maltsev","year":"2013","journal-title":"Biochem. (Moscow) Suppl.\u00a0Series A: Membr. Cell Biol."},{"key":"10.1016\/j.bbrc.2019.03.117_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellsig.2018.07.004","article-title":"Agmatine modulates calcium handling in cardiomyocytes of hibernating ground squirrels through calcium-sensing receptor signaling","volume":"51","author":"Maltsev","year":"2018","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2019.03.117_bib12","first-page":"4043","article-title":"Phospholamban S-nitrosylation modulates Starling response in fish heart","volume":"276","author":"Garofalo","year":"2009","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.bbrc.2019.03.117_bib13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.coph.2009.11.008","article-title":"Targeting the redox regulation of SERCA in vascular physiology and disease","volume":"10","author":"Tong","year":"2010","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.03.117_bib14","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/00000441-199311000-00002","article-title":"Insulin-resistance and hypertension-glucose-intolerance, hyperinsulinemia, and elevated free fatty-acids in the lean spontaneously hypertensive rat","volume":"306","author":"Swislocki","year":"1993","journal-title":"Am. J. Med. Sci."},{"key":"10.1016\/j.bbrc.2019.03.117_bib15","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1161\/01.RES.84.4.424","article-title":"Cellular mechanisms of altered contractility in the hypertrophied heart: big hearts, big sparks","volume":"84","author":"Shorofsky","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2019.03.117_bib16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3109\/00498250903518228","article-title":"Impaired tissue clearance of verapamil in rat cardiac hypertrophy results in transcriptional repression of ion channels","volume":"40","author":"Zwadlo","year":"2010","journal-title":"Xenobiotica"},{"key":"10.1016\/j.bbrc.2019.03.117_bib17","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1152\/ajpheart.00955.2010","article-title":"The onset of left ventricular diastolic dysfunction in SHR rats is not related to hypertrophy or hypertension","volume":"302","author":"Dupont","year":"2012","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2019.03.117_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/CBB:42:1:001","article-title":"Inhibition of sarco(endo)plasmic reticulum Ca2+-ATPase differentially regulates contractile function in cardiac myocytes from normotensive and spontaneously hypertensive rats: role of Ca2+ regulatory proteins","volume":"42","author":"Li","year":"2005","journal-title":"Cell Biochem. Biophys."},{"key":"10.1016\/j.bbrc.2019.03.117_bib19","first-page":"172","article-title":"Physical exercise and regulation of intracellular calcium in cardiomyocytes of hypertensive rats","volume":"111","author":"Rodrigues","year":"2018","journal-title":"Arq. Bras. Cardiol."},{"key":"10.1016\/j.bbrc.2019.03.117_bib20","article-title":"T-tubule remodeling and increased heterogeneity of calcium release during the progression to heart failure in intact rat ventricle","volume":"5","author":"Singh","year":"2017","journal-title":"Phys. Rep."},{"key":"10.1016\/j.bbrc.2019.03.117_bib21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.bbrc.2019.02.054","article-title":"Synergism of myocardial \u03b2-adrenoceptor blockade and I1-imidazoline receptor-driven signaling: kinase-phosphatase switching","volume":"511","author":"Maltsev","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2019.03.117_bib22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4149\/gpb_2009_03_225","article-title":"Effect of 7-nitroindazole on the expression of intracellular calcium channels in the kidney of spontaneously hypertensive rats","volume":"28","author":"Sedlakova","year":"2009","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.bbrc.2019.03.117_bib23","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/S0008-6363(98)00059-5","article-title":"Selective dysregulation of nitric oxide synthase type 3 in cardiac myocytes but not coronary microvascular endothelial cells of spontaneously hypertensive rat","volume":"38","author":"Bayraktutan","year":"1998","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2019.03.117_bib24","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/S0008-6363(02)00676-4","article-title":"Differential regulation of nitric oxide synthases and their allosteric regulators in heart and vessels of hypertensive rats","volume":"57","author":"Piech","year":"2003","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.bbrc.2019.03.117_bib25","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1161\/01.RES.0000088351.58510.21","article-title":"Nitric oxide and cardiac function. Ten years after, and continuing","volume":"93","author":"Massion","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2019.03.117_bib26","doi-asserted-by":"crossref","first-page":"61","DOI":"10.18388\/abp.2003_3714","article-title":"Dynamics of nitric oxide release in the cardiovascular system","volume":"50","author":"Balbatun","year":"2003","journal-title":"Acta Biochim. Pol."},{"key":"10.1016\/j.bbrc.2019.03.117_bib27","doi-asserted-by":"crossref","first-page":"20612","DOI":"10.1073\/pnas.0706796104","article-title":"Deficient ryanodine receptor S-nitrosylation increases sarcoplasmic reticulum calcium leak and arrhythmogenesis in cardiomyocytes","volume":"104","author":"Gonzalez","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2019.03.117_bib28","doi-asserted-by":"crossref","first-page":"13985","DOI":"10.1021\/bi8012627","article-title":"Regulation of the cardiac muscle ryanodine receptor by O2 tension and S-nitrosoglutathione","volume":"47","author":"Sun","year":"2008","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2019.03.117_bib29","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/sj.bjp.0704275","article-title":"Guanosine 3':5'-cyclic monophosphate-dependent pathway alterations in ventricular cardiomyocytes of spontaneously hypertensive rats","volume":"134","author":"Mazzetti","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.03.117_bib30","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.cardiores.2004.04.002","article-title":"Interference of antihypertrophic molecules and signaling pathways with the Ca2+-calcineurin-NFAT cascade in cardiac myocytes","volume":"63","author":"Fiedler","year":"2004","journal-title":"Cardiovasc. Res."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1930508X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1930508X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T03:52:22Z","timestamp":1754970742000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X1930508X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0006291X1930508X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.03.117","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"\u03b12-Adrenoceptor signaling in cardiomyocytes of spontaneously hypertensive rats starts to impair already at early age","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.03.117","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}