{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:13:25Z","timestamp":1793146405452,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"name":"Jingzhou Science and Technology Development Plan","award":["2018081"],"award-info":[{"award-number":["2018081"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.bbrc.2019.03.118","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T19:06:35Z","timestamp":1553799995000},"page":"902-907","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Suppression of oncogenic protein translation via targeting eukaryotic translation initiation factor 4E overcomes chemo-resistance in nasopharyngeal carcinoma"],"prefix":"10.1016","volume":"512","author":[{"given":"Mingfang","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zezhang","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.03.118_bib1","first-page":"114","article-title":"The prevalence and prevention of nasopharyngeal carcinoma in China","volume":"30","author":"Cao","year":"2011","journal-title":"Chin. J. Canc."},{"key":"10.1016\/j.bbrc.2019.03.118_bib2","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1002\/cncr.11485","article-title":"Treatment outcome after radiotherapy alone for patients with Stage I-II nasopharyngeal carcinoma","volume":"98","author":"Chua","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.bbrc.2019.03.118_bib3","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.hoc.2015.07.004","article-title":"Chemotherapy for nasopharyngeal carcinoma - current recommendation and controversies","volume":"29","author":"Sze","year":"2015","journal-title":"Hematol. Oncol. Clin. N. Am."},{"key":"10.1016\/j.bbrc.2019.03.118_bib4","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/1440-1681.12581","article-title":"Molecular mechanisms for tumour resistance to chemotherapy","volume":"43","author":"Pan","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bbrc.2019.03.118_bib5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ejps.2016.03.025","article-title":"Cancer chemoresistance; biochemical and molecular aspects: a brief overview","volume":"89","author":"Kachalaki","year":"2016","journal-title":"Eur. J. Pharm. Sci.: official journal of the European Federation for Pharmaceutical Sciences"},{"key":"10.1016\/j.bbrc.2019.03.118_bib6","doi-asserted-by":"crossref","first-page":"14134","DOI":"10.1073\/pnas.1005320107","article-title":"eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression","volume":"107","author":"Furic","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2019.03.118_bib7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1158\/1078-0432.CCR-09-0986","article-title":"Overexpression of phospho-eIF4E is associated with survival through AKT pathway in non-small cell lung cancer","volume":"16","author":"Yoshizawa","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2019.03.118_bib8","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1038\/sj.onc.1202563","article-title":"Upregulation of protein synthesis initiation factor eIF-4E is an early event during colon carcinogenesis","volume":"18","author":"Rosenwald","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2019.03.118_bib9","doi-asserted-by":"crossref","first-page":"E2298","DOI":"10.1073\/pnas.1301838110","article-title":"Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function","volume":"110","author":"Lim","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2019.03.118_bib10","doi-asserted-by":"crossref","first-page":"6814","DOI":"10.1158\/0008-5472.CAN-07-0752","article-title":"Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors","volume":"67","author":"Larsson","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2019.03.118_bib11","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1146\/annurev.biochem.68.1.913","article-title":"eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation","volume":"68","author":"Gingras","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbrc.2019.03.118_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0959-440X(03)00009-5","article-title":"Eukaryotic translation initiation factors and regulators","volume":"13","author":"Sonenberg","year":"2003","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.bbrc.2019.03.118_bib13","doi-asserted-by":"crossref","first-page":"18105","DOI":"10.1073\/pnas.0406927102","article-title":"Ribavirin suppresses eIF4E-mediated oncogenic transformation by physical mimicry of the 7-methyl guanosine mRNA cap","volume":"101","author":"Kentsis","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2019.03.118_bib14","first-page":"1203","article-title":"Targeting the eIF4E\/beta-catenin axis sensitizes cervical carcinoma squamous cells to chemotherapy","volume":"9","author":"Xu","year":"2017","journal-title":"Am. J. Tourism Res."},{"issue":"9","key":"10.1016\/j.bbrc.2019.03.118_bib15","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.cellsig.2016.06.005","article-title":"Inhibition of MNK Pathways Enhances Cancer Cell Response to Chemotherapy with Temozolomide and Targeted Radionuclide Therapy","volume":"28","author":"Grzmil","year":"2016","journal-title":"Cell Signal"},{"issue":"4","key":"10.1016\/j.bbrc.2019.03.118_bib16","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1016\/j.bbrc.2018.06.150","article-title":"Inhibition of eukaryotic translation initiation factor 4E is effective against chemo-resistance in colon and cervical cancer","volume":"503","author":"Xi","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"Suppl 7","key":"10.1016\/j.bbrc.2019.03.118_bib17","doi-asserted-by":"crossref","first-page":"vii308","DOI":"10.1093\/annonc\/mdq277","article-title":"Nasopharyngeal carcinoma","volume":"21","author":"Chan","year":"2010","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.bbrc.2019.03.118_bib18","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.3109\/10428194.2010.496506","article-title":"Ribavirin as an anti-cancer therapy: acute myeloid leukemia and beyond?","volume":"51","author":"Borden","year":"2010","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.bbrc.2019.03.118_bib19","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1158\/1078-0432.CCR-10-2334","article-title":"Ribavirin treatment effects on breast cancers overexpressing eIF4E, a biomarker with prognostic specificity for luminal B-type breast cancer","volume":"17","author":"Pettersson","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2019.03.118_bib20","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/cncr.20768","article-title":"Recent perspectives in the role of chemotherapy in the management of advanced nasopharyngeal carcinoma","volume":"103","author":"Ma","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.bbrc.2019.03.118_bib21","article-title":"Phosphorylated Mnk1 and eIF4E are associated with lymph node metastasis and poor prognosis of nasopharyngeal carcinoma","volume":"9","author":"Zheng","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2019.03.118_bib22","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s12032-012-0400-z","article-title":"EIF4E over-expresses and enhances cell proliferation and cell cycle progression in nasopharyngeal carcinoma","volume":"30","author":"Wu","year":"2013","journal-title":"Med. Oncol."},{"key":"10.1016\/j.bbrc.2019.03.118_bib23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3892\/ol.2014.2631","article-title":"p53, MDM2, eIF4E and EGFR expression in nasopharyngeal carcinoma and their correlation with clinicopathological characteristics and prognosis: a retrospective study","volume":"9","author":"Zhang","year":"2015","journal-title":"Oncol Lett"},{"issue":"6","key":"10.1016\/j.bbrc.2019.03.118_bib24","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s12094-017-1786-z","article-title":"Inhibition of eIF4E cooperates with chemotherapy and immunotherapy in renal cell carcinoma","volume":"20","author":"Cao","year":"2018","journal-title":"Clin. Transl. Oncol."},{"key":"10.1016\/j.bbrc.2019.03.118_bib25","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/leu.2011.57","article-title":"Inhibition of eIF4E with ribavirin cooperates with common chemotherapies in primary acute myeloid leukemia specimens","volume":"25","author":"Kraljacic","year":"2011","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrc.2019.03.118_bib26","doi-asserted-by":"crossref","first-page":"8639","DOI":"10.1158\/0008-5472.CAN-04-2677","article-title":"Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities","volume":"64","author":"Topisirovic","year":"2004","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.bbrc.2019.03.118_bib27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.cgh.2016.10.034","article-title":"Identification of the best direct-acting antiviral regimen for patients with hepatitis C virus genotype 3 infection: a systematic review and network meta-analysis","volume":"15","author":"Berden","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol.: Official clinical practice journal of the American Gastroenterological Association"},{"key":"10.1016\/j.bbrc.2019.03.118_bib28","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1128\/JVI.02349-15","article-title":"Investigating the influence of ribavirin on human respiratory syncytial virus RNA synthesis by using a high-resolution transcriptome sequencing approach","volume":"90","author":"Aljabr","year":"2016","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.bbrc.2019.03.118_bib29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1182\/blood-2009-02-205153","article-title":"Molecular targeting of the oncogene eIF4E in acute myeloid leukemia (AML): a proof-of-principle clinical trial with ribavirin","volume":"114","author":"Assouline","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.03.118_bib30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1475-2867-14-63","article-title":"Anti-tumor effect of ribavirin in combination with interferon-alpha on renal cell carcinoma cell lines in\u00a0vitro","volume":"14","author":"Teng","year":"2014","journal-title":"Cancer Cell Int."},{"key":"10.1016\/j.bbrc.2019.03.118_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0123352","article-title":"Phosphorylation of eIF4E confers resistance to cellular stress and DNA-damaging agents through an interaction with 4E-T: a rationale for novel therapeutic approaches","volume":"10","author":"Martinez","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2019.03.118_bib32","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature13572","article-title":"eIF4F is a nexus of resistance to anti-BRAF and anti-MEK cancer therapies","volume":"513","author":"Boussemart","year":"2014","journal-title":"Nature"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19305091?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19305091?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:35:19Z","timestamp":1762094119000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19305091"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0006291X19305091"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.03.118","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Suppression of oncogenic protein translation via targeting eukaryotic translation initiation factor 4E overcomes chemo-resistance in nasopharyngeal carcinoma","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.03.118","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}