{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T04:20:12Z","timestamp":1759033212612,"version":"3.44.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Natural Science Foundation of China","award":["81471305","81671260","81701258"],"award-info":[{"award-number":["81471305","81671260","81701258"]}]},{"name":"National Key R&D Program of China","award":["2016YFC1306000","2017YFC1310200"],"award-info":[{"award-number":["2016YFC1306000","2017YFC1310200"]}]},{"DOI":"10.13039\/501100008982","name":"National Science Foundation of Hubei Province","doi-asserted-by":"publisher","award":["2016CFB624"],"award-info":[{"award-number":["2016CFB624"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Youth Science and technology morning light program of Wuhan City","award":["2017050304010278"],"award-info":[{"award-number":["2017050304010278"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.bbrc.2019.03.159","type":"journal-article","created":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T11:29:45Z","timestamp":1554377385000},"page":"306-312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Reduced VMAT2 expression exacerbates the hyposmia in the MPTP model of Parkinson's disease"],"prefix":"10.1016","volume":"513","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2561-5955","authenticated-orcid":false,"given":"Kai","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoxin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingfang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sijia","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Kou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsha","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nian","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.03.159_bib1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrn.2017.25","article-title":"The two-century journey of Parkinson disease research","volume":"18","author":"Przedborski","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbrc.2019.03.159_bib2","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson's disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2019.03.159_bib3","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.tins.2018.01.010","article-title":"Long road to ruin: noradrenergic dysfunction in neurodegenerative disease","volume":"41","author":"Weinshenker","year":"2018","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbrc.2019.03.159_bib4","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00401-014-1261-7","article-title":"Olfactory bulb involvement in neurodegenerative diseases","volume":"127","author":"Attems","year":"2014","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbrc.2019.03.159_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00401-011-0830-2","article-title":"Increased dopaminergic cells and protein aggregates in the olfactory bulb of patients with neurodegenerative disorders","volume":"122","author":"Mundinano","year":"2011","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbrc.2019.03.159_bib6","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/mds.10713","article-title":"A\u00a0100% increase of dopaminergic cells in the olfactory bulb may explain hyposmia in Parkinson's disease","volume":"19","author":"Huisman","year":"2004","journal-title":"Mov. Disord."},{"key":"10.1016\/j.bbrc.2019.03.159_bib7","doi-asserted-by":"crossref","first-page":"a021287","DOI":"10.1101\/cshperspect.a021287","article-title":"Adult neurogenesis in neurodegenerative diseases","volume":"7","author":"Winner","year":"2015","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.bbrc.2019.03.159_bib8","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00018-012-1062-x","article-title":"Adult neurogenesis in Parkinson's disease","volume":"70","author":"Marxreiter","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbrc.2019.03.159_bib9","article-title":"Physiological and functional basis of dopamine receptors and their role in neurogenesis: possible implication for Parkinson's disease","volume":"12","author":"Mishra","year":"2018","journal-title":"J.\u00a0Exp. Neurosci."},{"key":"10.1016\/j.bbrc.2019.03.159_bib10","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1038\/nn1265","article-title":"Dopamine depletion impairs precursor cell proliferation in Parkinson disease","volume":"7","author":"Hoglinger","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbrc.2019.03.159_bib11","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1093\/brain\/awr256","article-title":"The proliferative capacity of the subventricular zone is maintained in the parkinsonian brain","volume":"134","author":"van den Berge","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.bbrc.2019.03.159_bib12","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.neuroscience.2007.11.036","article-title":"Increased progenitor cell proliferation and astrogenesis in the partial progressive 6-hydroxydopamine model of Parkinson's disease","volume":"151","author":"Aponso","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbrc.2019.03.159_bib13","first-page":"124165","article-title":"VMAT2-Deficient mice display nigral and extranigral pathology and motor and nonmotor symptoms of Parkinson's disease","volume":"2011","author":"Taylor","year":"2011","journal-title":"Parkinsons Dis"},{"key":"10.1016\/j.bbrc.2019.03.159_bib14","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1046\/j.1471-4159.1998.70051973.x","article-title":"Increased MPTP neurotoxicity in vesicular monoamine transporter 2 heterozygote knockout mice","volume":"70","author":"Gainetdinov","year":"1998","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.bbrc.2019.03.159_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/toxsci\/kfw106","article-title":"Vesicular monoamine transporter 2 (VMAT2) level regulates MPTP vulnerability and clearance of excess dopamine in mouse striatal terminals","volume":"153","author":"Lohr","year":"2016","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bbrc.2019.03.159_bib16","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/S0896-6273(00)80419-5","article-title":"Knockout of the vesicular monoamine transporter 2 gene results in neonatal death and supersensitivity to cocaine and amphetamine","volume":"19","author":"Wang","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2019.03.159_bib17","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1038\/sj.npp.1300724","article-title":"Novelty seeking and stereotypic activation of behavior in mice with disruption of the Dat1 gene","volume":"30","author":"Pogorelov","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbrc.2019.03.159_bib18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.jneumeth.2010.03.026","article-title":"A\u00a0rotarod test for evaluation of motor skill learning","volume":"189","author":"Shiotsuki","year":"2010","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.bbrc.2019.03.159_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(03)00219-5","article-title":"Olfactory function in apoE knockout mice","volume":"150","author":"Nathan","year":"2004","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbrc.2019.03.159_bib20","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fnins.2017.00112","article-title":"Antidyskinetic effects of MEK inhibitor are associated with multiple neurochemical alterations in the striatum of hemiparkinsonian rats","volume":"11","author":"Chen","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbrc.2019.03.159_bib21","first-page":"6500","article-title":"Glycogen synthase kinase-3beta regulates equilibrium between neurogenesis and gliogenesis in rat model of Parkinson's disease: a crosstalk with wnt and","volume":"55","author":"Singh","year":"2018","journal-title":"Notch Signaling"},{"key":"10.1016\/j.bbrc.2019.03.159_bib22","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.nbd.2014.10.016","article-title":"Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits","volume":"74","author":"Masoud","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbrc.2019.03.159_bib23","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.neuropharm.2015.08.016","article-title":"Small molecule TrkB agonist deoxygedunin protects nigrostriatal dopaminergic neurons from 6-OHDA and MPTP induced neurotoxicity in rodents","volume":"99","author":"Nie","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbrc.2019.03.159_bib24","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3389\/fnins.2017.00471","article-title":"Early postnatal but not late adult neurogenesis is impaired in the pitx3-mutant animal model of Parkinson's disease","volume":"11","author":"Brandt","year":"2017","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbrc.2019.03.159_bib25","doi-asserted-by":"crossref","first-page":"14430","DOI":"10.1523\/JNEUROSCI.5366-13.2014","article-title":"Adult neurogenesis restores dopaminergic neuronal loss in the olfactory bulb","volume":"34","author":"Lazarini","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2019.03.159_bib26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/jnr.23677","article-title":"Dopaminergic lesioning impairs adult hippocampal neurogenesis by distinct modification of alpha-synuclein","volume":"94","author":"Schlachetzki","year":"2016","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.bbrc.2019.03.159_bib27","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuro.2015.07.007","article-title":"Transiently impaired neurogenesis in MPTP mouse model of Parkinson's disease","volume":"50","author":"He","year":"2015","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bbrc.2019.03.159_bib28","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1634\/stemcells.2005-0487","article-title":"Enhanced de novo neurogenesis and dopaminergic neurogenesis in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease-like mice","volume":"24","author":"Shan","year":"2006","journal-title":"Stem Cell."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19305595?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19305595?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:34:04Z","timestamp":1757763244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19305595"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0006291X19305595"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.03.159","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced VMAT2 expression exacerbates the hyposmia in the MPTP model of Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.03.159","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}