{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T02:02:49Z","timestamp":1767837769743,"version":"3.49.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Korea Healthcare Technology R&D Project"},{"DOI":"10.13039\/501100003710","name":"Korea Health Industry Development Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry for Health and Welfare, Republic of Korea","doi-asserted-by":"publisher","award":["HI13C0954"],"award-info":[{"award-number":["HI13C0954"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Creative Research Initiative Grant","award":["2014R1A3A2030423"],"award-info":[{"award-number":["2014R1A3A2030423"]}]},{"name":"Bio & Medical Technology Development Program","award":["2012M3A9C4048780"],"award-info":[{"award-number":["2012M3A9C4048780"]}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science & ICT, Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.bbrc.2019.05.003","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T01:35:22Z","timestamp":1557797722000},"page":"1081-1086","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["High mobility group box 1 secretion blockade results in the reduction of early pancreatic islet graft loss"],"prefix":"10.1016","volume":"514","author":[{"given":"Hyunwoo","family":"Chung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8248-4541","authenticated-orcid":false,"given":"Sung Ji","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9564-7119","authenticated-orcid":false,"given":"So Won","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ja Young","family":"Koo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingi","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Je","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1753-1433","authenticated-orcid":false,"given":"Seung Bum","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4083-8791","authenticated-orcid":false,"given":"Chung-Gyu","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.05.003_bib1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/nrendo.2016.178","article-title":"Clinical pancreatic islet transplantation","volume":"13","author":"Shapiro","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbrc.2019.05.003_bib2","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro","year":"2000","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2019.05.003_bib3","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.3727\/096368912X637514","article-title":"Low temperature condition prevents hypoxia-induced islet cell damage and HMGB1 release in a mouse model","volume":"21","author":"Itoh","year":"2012","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bbrc.2019.05.003_bib4","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s11892-013-0412-x","article-title":"Bioengineered sites for islet cell transplantation","volume":"13","author":"Veriter","year":"2013","journal-title":"Curr. Diabetes Rep."},{"key":"10.1016\/j.bbrc.2019.05.003_bib5","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.bbrc.2018.02.057","article-title":"Construction of EMSC-islet co-localizing composites for xenogeneic porcine islet transplantation","volume":"497","author":"Kim","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2019.05.003_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/srep14623","article-title":"DAMP production by human islets under low oxygen and nutrients in the presence or absence of an immunoisolating-capsule and necrostatin-1","volume":"5","author":"Paredes-Juarez","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2019.05.003_bib7","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.2119\/molmed.2015.00087","article-title":"High mobility group box protein 1 (HMGB1): the prototypical endogenous danger molecule","volume":"21","author":"Yang","year":"2015","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbrc.2019.05.003_bib8","doi-asserted-by":"crossref","first-page":"2914","DOI":"10.1002\/eji.201040601","article-title":"Islet-expressed TLR2 and TLR4 sense injury and mediate early graft failure after transplantation","volume":"40","author":"Kr\u00fcger","year":"2010","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.bbrc.2019.05.003_bib9","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1111\/ajt.12306","article-title":"Pretreatment of donor islets with the Na+\/Ca2+ exchanger inhibitor improves the efficiency of islet transplantation","volume":"13","author":"Mera","year":"2013","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.bbrc.2019.05.003_bib10","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1111\/j.1600-6143.2010.03151.x","article-title":"TLR4 mediates early graft failure after intraportal islet transplantation","volume":"10","author":"Gao","year":"2010","journal-title":"Am. J. Transplant."},{"key":"10.1016\/j.bbrc.2019.05.003_bib11","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/TP.0b013e31824d3508","article-title":"Prevention of high-mobility group box 1-mediated early loss of transplanted mouse islets in the liver by antithrombin III","volume":"93","author":"Kojima","year":"2012","journal-title":"Transplantation"},{"key":"10.1016\/j.bbrc.2019.05.003_bib12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/TP.0b013e31829b0744","article-title":"Efficacy of DHMEQ, a NF-\u03baB inhibitor, in islet transplantation: I. HMGB1 suppression by DHMEQ prevents early islet graft damage","volume":"96","author":"Kuraya","year":"2013","journal-title":"Transplantation"},{"key":"10.1016\/j.bbrc.2019.05.003_bib13","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/MPA.0000000000000188","article-title":"HMGB1-Mediated early loss of transplanted islets is prevented by anti\u2013IL-6r antibody in mice","volume":"44","author":"Itoh","year":"2015","journal-title":"Pancreas"},{"key":"10.1016\/j.bbrc.2019.05.003_bib14","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1038\/nchembio.1669","article-title":"A\u00a0small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation","volume":"10","author":"Lee","year":"2014","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbrc.2019.05.003_bib15","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1021\/acs.jmedchem.6b00954","article-title":"Treatment of sepsis pathogenesis with high mobility group box protein 1-regulating anti-inflammatory agents","volume":"60","author":"Cho","year":"2017","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.bbrc.2019.05.003_bib16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.trim.2004.04.001","article-title":"IL-6 protects pancreatic islet beta cells from pro-inflammatory cytokines-induced cell death and functional impairment in\u00a0vitro and in\u00a0vivo","volume":"13","author":"Choi","year":"2004","journal-title":"Transpl. Immunol."},{"key":"10.1016\/j.bbrc.2019.05.003_bib17","doi-asserted-by":"crossref","DOI":"10.1002\/0471143030.cb0403s69","article-title":"Immunofluorescence staining","volume":"69","author":"Donaldson","year":"2015","journal-title":"Curr. Protoc. Cell Biol."},{"key":"10.1016\/j.bbrc.2019.05.003_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2121-9-13","article-title":"Multiple immunofluorescence labelling of formalin-fixed paraffin-embedded (FFPE) tissue","volume":"9","author":"Robertson","year":"2008","journal-title":"BMC Cell Biol."},{"key":"10.1016\/j.bbrc.2019.05.003_bib19","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot4986","article-title":"Hematoxylin and eosin staining of tissue and cell sections","volume":"2008","author":"Fischer","year":"2008","journal-title":"Cold Spring Harb. Protoc."},{"key":"10.1016\/j.bbrc.2019.05.003_bib20","series-title":"Transplant. Proc","first-page":"3156","article-title":"High-mobility group box 1 expressions in hypoxia-induced damaged mouse islets","author":"Itoh","year":"2011"},{"key":"10.1016\/j.bbrc.2019.05.003_bib21","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.bbadis.2016.11.012","article-title":"Hypoxia\/reoxygenation-induced HMGB1 translocation and release promotes islet proinflammatory cytokine production and early islet graft failure through TLRs signaling","volume":"1863","author":"Cheng","year":"2017","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.bbrc.2019.05.003_bib22","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3858\/emm.2012.44.4.021","article-title":"Toll-like receptor 4 on islet \u03b2 cells senses expression changes in high-mobility group box 1 and contributes to the initiation of type 1 diabetes","volume":"44","author":"Li","year":"2012","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.bbrc.2019.05.003_bib23","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1172\/JCI41360","article-title":"High-mobility group box 1 is involved in the initial events of early loss of transplanted islets in mice","volume":"120","author":"Matsuoka","year":"2010","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.bbrc.2019.05.003_bib24","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.3727\/096368912X640592","article-title":"Correlation of released HMGB1 levels with the degree of islet damage in mice and humans and with the outcomes of islet transplantation in mice","volume":"21","author":"Itoh","year":"2012","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bbrc.2019.05.003_bib25","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3727\/096368912X658980","article-title":"Elevation of high-mobility group box 1 after clinical autologous islet transplantation and its inverse correlation with outcomes","volume":"23","author":"Itoh","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.bbrc.2019.05.003_bib26","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1097\/TP.0b013e318293b7e1","article-title":"Hmgb1-TLR4-IL-23-IL-17A axis promote ischemia-reperfusion injury in a cardiac transplantation model","volume":"95","author":"Zhu","year":"2013","journal-title":"Transplantation"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1930871X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X1930871X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,6]],"date-time":"2019-08-06T19:37:54Z","timestamp":1565120274000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X1930871X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,7]]}},"alternative-id":["S0006291X1930871X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.05.003","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High mobility group box 1 secretion blockade results in the reduction of early pancreatic islet graft loss","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}