{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:17:07Z","timestamp":1760300227446,"version":"3.40.5"},"reference-count":21,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.bbrc.2019.05.071","type":"journal-article","created":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T10:53:50Z","timestamp":1557658430000},"page":"946-952","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["On identifying low energy conformational excited states with differential ruggedness in human \u03b3S-crystallin promoting severe infantile cataracts"],"prefix":"10.1016","volume":"514","author":[{"given":"Khandekar Jishan","family":"Bari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shrikant","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1189-8867","authenticated-orcid":false,"given":"Kandala V.R.","family":"Chary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.05.071_bib1","doi-asserted-by":"crossref","first-page":"4282","DOI":"10.1073\/pnas.0407499102","article-title":"Local conformational fluctuations can modulate the coupling between proton binding and global structural transitions in proteins","volume":"102","author":"Whitten","year":"2005","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.bbrc.2019.05.071_bib2","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nsb1101-932","article-title":"Studying excited states of proteins by NMR spectroscopy","volume":"8","author":"Mulder","year":"2001","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.bbrc.2019.05.071_bib3","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.str.2005.08.006","article-title":"An experimental investigation of conformational fluctuations in proteins G and L.","volume":"13","author":"Tunnicliffe","year":"2005","journal-title":"Structure (Camb.)"},{"key":"10.1016\/j.bbrc.2019.05.071_bib4","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1002\/prot.10464","article-title":"Many residues in cytochrome c populate alternative states under equilibrium conditions","volume":"53","author":"Williamson","year":"2003","journal-title":"Proteins"},{"key":"10.1016\/j.bbrc.2019.05.071_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3109\/13816810.2013.865761","article-title":"A\u00a0G57W mutation of CRYGS associated with autosomal dominant pulverulent cataracts in a Chinese family","volume":"36","author":"Yang","year":"2015","journal-title":"Opthalmic Genet."},{"key":"10.1016\/j.bbrc.2019.05.071_bib6","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jsb.2019.02.003","article-title":"Structure of G57W mutant of human \u03b3S-crystallin and its involvement in cataract formation","volume":"205","author":"Bari","year":"2019","journal-title":"J.\u00a0Struct. Biol."},{"key":"10.1016\/j.bbrc.2019.05.071_bib7","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.bbrc.2019.02.124","article-title":"Conformational dynamics study on human \u03b3S-crystallin as an efficient route to childhood blindness","volume":"511","author":"Bari","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2019.05.071_bib8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s12104-018-9848-x","article-title":"Sequence specific 1H, 13C and 15N resonance assignments of the C-terminal domain of human \u03b3S-crystallin","volume":"13","author":"Bari","year":"2019","journal-title":"Biomol. NMR Assign."},{"key":"10.1016\/j.bbrc.2019.05.071_bib9","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.bbrc.2018.10.187","article-title":"Structural and functional characterization of a missense mutant of human \u03b3S-crystallin associated with dominant infantile cataracts","volume":"506","author":"Bari","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2019.05.071_bib10","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1006\/jmbi.1998.2265","article-title":"Characterization of low free-energy excited states of folded proteins","volume":"284","author":"Baxter","year":"1998","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.bbrc.2019.05.071_bib11","doi-asserted-by":"crossref","first-page":"8547","DOI":"10.1021\/ja963250h","article-title":"Extracting information from the temperature gradients of polypeptide HN chemical shifts. I. The importance of conformational averaging","volume":"119","author":"Anderson","year":"1997","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.bbrc.2019.05.071_bib12","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1023\/A:1018334207887","article-title":"Temperature dependence of 1H chemical shifts in proteins","volume":"9","author":"Baxter","year":"1997","journal-title":"J.\u00a0Biomol. NMR"},{"key":"10.1016\/j.bbrc.2019.05.071_bib13","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12104-017-9779-y","article-title":"Sequence specific 1H, 13C and 15N resonance assignments of a cataract-related variant G57W of human \u03b3S-crystallin","volume":"12","author":"Bari","year":"2018","journal-title":"Biomol. NMR Assign."},{"key":"10.1016\/j.bbrc.2019.05.071_bib14","doi-asserted-by":"crossref","first-page":"15248","DOI":"10.1021\/ja055251s","article-title":"Role of protein dynamics in reaction rate enhancement by enzymes","volume":"127","author":"Agarwal","year":"2005","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.bbrc.2019.05.071_bib15","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.sbi.2003.09.004","article-title":"Proteins in action: the physics of structural fluctuations and conformational changes","volume":"13","author":"Parak","year":"2003","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.bbrc.2019.05.071_bib16","doi-asserted-by":"crossref","first-page":"18908","DOI":"10.1073\/pnas.0507603102","article-title":"Structural changes involved in protein binding correlate with intrinsic motions of proteins in the unbound state","volume":"102","author":"Tobi","year":"2005","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.bbrc.2019.05.071_bib17","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/22357","article-title":"Millisecond-timescale motions contribute to the function of the bacterial response regulator protein Spo0F","volume":"400","author":"Feher","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2019.05.071_bib18","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.bpj.2010.12.3691","article-title":"Separating instability from aggregation propensity in \u03b3S-crystallin variants","volume":"100","author":"Brubaker","year":"2011","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbrc.2019.05.071_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2019.05.029","article-title":"Enhanced H\/D exchange unravels sequential structural excursions in G57W variant of human \u03b3S-crystallin with pro-cataractogenic conformations","author":"Bari","year":"2019","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2019.05.071_bib20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1023\/A:1012911329730","article-title":"Amide proton temperature coefficients as hydrogen bond indicators in proteins","volume":"21","author":"Cierpicki","year":"2001","journal-title":"J.\u00a0Biomol. NMR"},{"key":"10.1016\/j.bbrc.2019.05.071_bib21","doi-asserted-by":"crossref","first-page":"43891","DOI":"10.1074\/jbc.M111.247890","article-title":"Evolutionary remodeling of \u03b2\u03b3-crystallins for domain stability at cost of Ca2+-binding","volume":"51","author":"Suman","year":"2011","journal-title":"J.\u00a0Biol. Chem."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19309477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19309477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T05:49:57Z","timestamp":1720158597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19309477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S0006291X19309477"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.05.071","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"On identifying low energy conformational excited states with differential ruggedness in human \u03b3S-crystallin promoting severe infantile cataracts","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.05.071","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}