{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:29:37Z","timestamp":1787063377287,"version":"build-2736575974"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"JSPS KAKENHI","award":["JP17K08626"],"award-info":[{"award-number":["JP17K08626"]}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation (T.A.)","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.bbrc.2019.06.130","type":"journal-article","created":{"date-parts":[[2019,6,27]],"date-time":"2019-06-27T10:03:31Z","timestamp":1561629811000},"page":"293-299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["C\/EBP\u03b5 \u0394RS derived from a neutrophil-specific granule deficiency patient interacts with HDAC1 and its dysfunction is restored by trichostatin A"],"prefix":"10.1016","volume":"516","author":[{"given":"Masahiro","family":"Muraoka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1733-9452","authenticated-orcid":false,"given":"Tadayuki","family":"Akagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taizo","family":"Wada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Phillip","family":"Koeffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Yachie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.06.130_bib1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.cyto.2010.12.019","article-title":"The CCAAT\/enhancer (C\/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation","volume":"54","author":"Tsukada","year":"2011","journal-title":"Cytokine"},{"key":"10.1016\/j.bbrc.2019.06.130_bib2","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1634\/stemcells.19-2-125","article-title":"The role of C\/EBP(epsilon) in the terminal stages of granulocyte differentiation","volume":"19","author":"Lekstrom-Himes","year":"2001","journal-title":"Stem cells (Dayton, Ohio)"},{"key":"10.1016\/j.bbrc.2019.06.130_bib3","doi-asserted-by":"crossref","DOI":"10.1128\/MMBR.00057-17","article-title":"The ontogeny of a neutrophil: mechanisms of granulopoiesis and homeostasis","volume":"82","author":"Lawrence","year":"2018","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.bbrc.2019.06.130_bib4","doi-asserted-by":"crossref","first-page":"2999","DOI":"10.1182\/blood-2007-04-087213","article-title":"Impaired response to GM-CSF and G-CSF, and enhanced apoptosis in C\/EBPbeta-deficient hematopoietic cells","volume":"111","author":"Akagi","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.06.130_bib5","doi-asserted-by":"crossref","first-page":"e15419","DOI":"10.1371\/journal.pone.0015419","article-title":"In\u00a0vivo deficiency of both C\/EBPbeta and C\/EBPepsilon results in highly defective myeloid differentiation and lack of cytokine response","volume":"5","author":"Akagi","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2019.06.130_bib6","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1172\/JCI62070","article-title":"C\/EBPepsilon mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice","volume":"122","author":"Kyme","year":"2012","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.bbrc.2019.06.130_bib7","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1182\/blood-2013-12-543850","article-title":"Acetylation of C\/EBPepsilon is a prerequisite for terminal neutrophil differentiation","volume":"125","author":"Bartels","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.06.130_bib8","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1084\/jem.189.11.1847","article-title":"Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT\/enhancer binding protein epsilon","volume":"189","author":"Lekstrom-Himes","year":"1999","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2019.06.130_bib9","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1182\/blood.V97.9.2561","article-title":"Neutrophil-specific granule deficiency: homozygous recessive inheritance of a frameshift mutation in the gene encoding transcription factor CCAAT\/enhancer binding protein-epsilon","volume":"97","author":"Gombart","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.06.130_bib10","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1182\/blood-2005-05-022004","article-title":"Growth factor independence-1 (Gfi-1) plays a role in mediating specific granule deficiency (SGD) in a patient lacking a gene-inactivating mutation in the C\/EBPepsilon gene","volume":"109","author":"Khanna-Gupta","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.06.130_bib11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4049\/jimmunol.1402222","article-title":"A\u00a0novel in-frame deletion in the leucine zipper domain of C\/EBPepsilon leads to neutrophil-specific granule deficiency","volume":"195","author":"Wada","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2019.06.130_bib12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1615\/CritRevImmunol.2017019385","article-title":"Role of the leucine zipper domain of CCAAT\/enhancer binding protein-epsilon (C\/EBPepsilon) in neutrophil-specific granule deficiency","volume":"36","author":"Wada","year":"2016","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2019.06.130_bib13","doi-asserted-by":"crossref","first-page":"43481","DOI":"10.1074\/jbc.M204777200","article-title":"Novel combinatorial interactions of GATA-1, PU.1, and C\/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein","volume":"277","author":"Du","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2019.06.130_bib14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0378-1119(91)90434-D","article-title":"Efficient selection for high-expression transfectants with a novel eukaryotic vector","volume":"108","author":"Niwa","year":"1991","journal-title":"Gene"},{"key":"10.1016\/j.bbrc.2019.06.130_bib15","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.1128\/MCB.01863-08","article-title":"Dax1 binds to oct3\/4 and inhibits its transcriptional activity in embryonic Stem cells","volume":"29","author":"Sun","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2019.06.130_bib16","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1182\/blood-2003-01-0159","article-title":"C\/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis","volume":"103","author":"Gery","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.06.130_bib17","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1101\/gad.7.6.1047","article-title":"Dimerization specificity of the leucine zipper-containing bZIP motif on DNA binding: prediction and rational design","volume":"7","author":"Vinson","year":"1993","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2019.06.130_bib18","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.1182\/blood-2002-04-1039","article-title":"Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C\/EBP epsilon and PU.1","volume":"101","author":"Gombart","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.06.130_bib19","doi-asserted-by":"crossref","first-page":"17174","DOI":"10.1016\/S0021-9258(17)44885-X","article-title":"Potent and specific inhibition of mammalian histone deacetylase both in\u00a0vivo and in\u00a0vitro by trichostatin A","volume":"265","author":"Yoshida","year":"1990","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2019.06.130_bib20","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/sj.bjp.0705869","article-title":"Possible mechanism of action of the histone deacetylase inhibitors for the induction of differentiation of HL-60 clone 15 cells into eosinophils","volume":"142","author":"Ishihara","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.06.130_bib21","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/j.lfs.2006.12.016","article-title":"Differentiation of eosinophilic leukemia EoL-1 cells into eosinophils induced by histone deacetylase inhibitors","volume":"80","author":"Ishihara","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2019.06.130_bib22","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0092-8674(00)80214-7","article-title":"Histone deacetylase activity is required for full transcriptional repression by mSin3A","volume":"89","author":"Hassig","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2019.06.130_bib23","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S1097-2765(00)80111-2","article-title":"SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors","volume":"2","author":"Laherty","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2019.06.130_bib24","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S1097-2765(00)80299-3","article-title":"NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities","volume":"2","author":"Xue","year":"1998","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2019.06.130_bib25","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1073\/pnas.98.4.1454","article-title":"CoREST is an integral component of the CoREST-human histone deacetylase complex","volume":"98","author":"You","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2019.06.130_bib26","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1182\/blood.V99.4.1332","article-title":"Mutations in the gene encoding the transcription factor CCAAT\/enhancer binding protein alpha in myelodysplastic syndromes and acute myeloid leukemias","volume":"99","author":"Gombart","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.06.130_bib27","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/35895","article-title":"Role of the histone deacetylase complex in acute promyelocytic leukaemia","volume":"391","author":"Lin","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2019.06.130_bib28","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/ng.3812","article-title":"SMARCD2 subunit of SWI\/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBPe dependent mechanism","volume":"49","author":"Priam","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2019.06.130_bib29","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1038\/ng.3833","article-title":"Chromatin-remodeling factor SMARCD2 regulates transcriptional networks controlling differentiation of neutrophil granulocytes","volume":"49","author":"Witzel","year":"2017","journal-title":"Nat. Genet."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19312689?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19312689?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:50:03Z","timestamp":1610067003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19312689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["S0006291X19312689"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.06.130","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"C\/EBP\u03b5 \u0394RS derived from a neutrophil-specific granule deficiency patient interacts with HDAC1 and its dysfunction is restored by trichostatin A","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.06.130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}