{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:30:49Z","timestamp":1779345049180,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.81873134"],"award-info":[{"award-number":["No.81873134"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["No.2017M611873"],"award-info":[{"award-number":["No.2017M611873"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010246","name":"Postdoctoral Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["No.1701120C"],"award-info":[{"award-number":["No.1701120C"]}],"id":[{"id":"10.13039\/501100010246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["No. BK20161320"],"award-info":[{"award-number":["No. BK20161320"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of the Jiangsu Higher Education Institutions of China","award":["No.16KJB360008"],"award-info":[{"award-number":["No.16KJB360008"]}]},{"name":"QingLan Project of Jiangsu Higher Education Institutions","award":["201239"],"award-info":[{"award-number":["201239"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.bbrc.2019.07.015","type":"journal-article","created":{"date-parts":[[2019,7,9]],"date-time":"2019-07-09T00:31:42Z","timestamp":1562632302000},"page":"1222-1228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Deoxyelephantopin suppresses hepatic stellate cells activation associated with inhibition of aerobic glycolysis via hedgehog pathway"],"prefix":"10.1016","volume":"516","author":[{"given":"Wei","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingya","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongyan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.07.015_bib1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrgastro.2010.97","article-title":"Evolving challenges in hepatic fibrosis","volume":"7","author":"Friedman","year":"2010","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.bbrc.2019.07.015_bib2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1146\/annurev-pathol-011110-130246","article-title":"Pathogenesis of liver fibrosis","volume":"6","author":"Hernandez-Gea","year":"2011","journal-title":"Annual review of pathology"},{"key":"10.1016\/j.bbrc.2019.07.015_bib3","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbrc.2019.07.015_bib4","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1053\/j.gastro.2012.07.115","article-title":"Hedgehog controls hepatic stellate cell fate by regulating metabolism","volume":"143","author":"Chen","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2019.07.015_bib5","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/hep.25559","article-title":"Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease","volume":"55","author":"Guy","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2019.07.015_bib6","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1002\/hep.26230","article-title":"Hedgehog pathway and pediatric nonalcoholic fatty liver disease","volume":"57","author":"Swiderska-Syn","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2019.07.015_bib7","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.biocel.2010.10.015","article-title":"The role of Hedgehog signaling in fibrogenic liver repair","volume":"43","author":"Choi","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbrc.2019.07.015_bib8","first-page":"1368","article-title":"Role for hedgehog signaling in hepatic stellate cell activation and viability, Laboratory investigation","volume":"85","author":"Sicklick","year":"2005","journal-title":"J\u00a0Tech. Method. Pathol."},{"key":"10.1016\/j.bbrc.2019.07.015_bib9","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jhep.2007.07.032","article-title":"Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells","volume":"48","author":"Yang","year":"2008","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2019.07.015_bib10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jss.2013.12.010","article-title":"The glypican 3 hepatocellular carcinoma marker regulates human hepatic stellate cells via Hedgehog signaling","volume":"187","author":"Magistri","year":"2014","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.bbrc.2019.07.015_bib11","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1517\/14728222.2014.927443","article-title":"Hedgehog signaling pathway as key player in liver fibrosis: new insights and perspectives","volume":"18","author":"Yang","year":"2014","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bbrc.2019.07.015_bib12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jhep.2013.08.012","article-title":"The intrahepatic signalling niche of hedgehog is defined by primary cilia positive cells during chronic liver injury","volume":"60","author":"Grzelak","year":"2014","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2019.07.015_bib13","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1002\/hep.26511","article-title":"Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice","volume":"58","author":"Xie","year":"2013","journal-title":"Hepatology"},{"key":"10.1016\/j.bbrc.2019.07.015_bib14","first-page":"790","article-title":"Curcumin regulates cell fate and metabolism by inhibiting hedgehog signaling in hepatic stellate cells, Laboratory investigation","volume":"95","author":"Lian","year":"2015","journal-title":"J.\u00a0Tech. Method. Pathol."},{"key":"10.1016\/j.bbrc.2019.07.015_bib15","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.imr.2017.03.004","article-title":"Molecular mechanisms of anticancer activity of deoxyelephantopin in cancer cells","volume":"6","author":"Kabeer","year":"2017","journal-title":"Integr. Med. Res."},{"key":"10.1016\/j.bbrc.2019.07.015_bib16","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.jnutbio.2012.01.013","article-title":"Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis","volume":"24","author":"Huang","year":"2013","journal-title":"J.\u00a0Nutr. Biochem."},{"key":"10.1016\/j.bbrc.2019.07.015_bib17","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.phymed.2013.09.011","article-title":"Bioassay-guided isolation of a sesquiterpene lactone of deoxyelephantopin from Elephantopus scaber Linn. active on Trypanosome brucei rhodesience","volume":"21","author":"Zahari","year":"2014","journal-title":"Phytomedicine: Int. J. Phytother. Phytopharmacol."},{"key":"10.1016\/j.bbrc.2019.07.015_bib18","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1111\/j.1476-5381.2009.00581.x","article-title":"Deoxyelephantopin, a novel multifunctional agent, suppresses mammary tumour growth and lung metastasis and doubles survival time in mice","volume":"159","author":"Huang","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.07.015_bib19","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s10565-014-9288-z","article-title":"Deoxyelephantopin impairs growth of cervical carcinoma SiHa cells and induces apoptosis by targeting multiple molecular signaling pathways","volume":"30","author":"Farha","year":"2014","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.bbrc.2019.07.015_bib20","doi-asserted-by":"crossref","DOI":"10.3390\/molecules22061013","article-title":"Deoxyelephantopin and isodeoxyelephantopin as potential anticancer agents with effects on multiple signaling pathways","volume":"22","author":"Mehmood","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.bbrc.2019.07.015_bib21","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/1440-1681.13017","article-title":"Resveratrol inhibits VEGF-induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation","volume":"45","author":"Wu","year":"2018","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bbrc.2019.07.015_bib22","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1126\/science.1058079","article-title":"Cooperation and competition in the evolution of ATP-producing pathways","volume":"292","author":"Pfeiffer","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2019.07.015_bib23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/biof.1324","article-title":"Deoxyelephantopin induces apoptosis in HepG2 cells via oxidative stress, NF-kappaB inhibition and mitochondrial dysfunction","volume":"43","author":"Mehmood","year":"2017","journal-title":"Biofactors"},{"key":"10.1016\/j.bbrc.2019.07.015_bib24","doi-asserted-by":"crossref","first-page":"e1336","DOI":"10.1038\/cddis.2014.285","article-title":"Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment","volume":"5","author":"Ciavardelli","year":"2014","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2019.07.015_bib25","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1002\/iub.1518","article-title":"Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate-activated protein kinase","volume":"68","author":"Lian","year":"2016","journal-title":"IUBMB Life"},{"key":"10.1016\/j.bbrc.2019.07.015_bib26","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.jhep.2010.10.003","article-title":"Hedgehog signaling in the liver","volume":"54","author":"Omenetti","year":"2011","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2019.07.015_bib27","doi-asserted-by":"crossref","first-page":"873","DOI":"10.2174\/156652409789105570","article-title":"Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation","volume":"9","author":"Katoh","year":"2009","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.bbrc.2019.07.015_bib28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bbrc.2012.07.051","article-title":"Hedgehog pathway regulators influence cervical cancer cell proliferation, survival and migration","volume":"425","author":"Samarzija","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2019.07.015_bib29","doi-asserted-by":"crossref","first-page":"5936","DOI":"10.1523\/JNEUROSCI.1040-07.2007","article-title":"Hedgehog signaling in the subventricular zone is required for both the maintenance of stem cells and the migration of newborn neurons","volume":"27","author":"Balordi","year":"2007","journal-title":"J.\u00a0Neurosci. : Off. J. Soc. Neurosci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19313452?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19313452?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T06:46:25Z","timestamp":1568961985000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19313452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0006291X19313452"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.07.015","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deoxyelephantopin suppresses hepatic stellate cells activation associated with inhibition of aerobic glycolysis via hedgehog pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.07.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}