{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:12:47Z","timestamp":1790111567840,"version":"4.0.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871795"],"award-info":[{"award-number":["81871795"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["13411950503"],"award-info":[{"award-number":["13411950503"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["134119a2802"],"award-info":[{"award-number":["134119a2802"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008410","name":"Shanghai Municipal Population and Family Planning Commission","doi-asserted-by":"publisher","award":["20164Y0270"],"award-info":[{"award-number":["20164Y0270"]}],"id":[{"id":"10.13039\/501100008410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.bbrc.2019.07.032","type":"journal-article","created":{"date-parts":[[2019,7,13]],"date-time":"2019-07-13T00:59:19Z","timestamp":1562979559000},"page":"132-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["CDK9 attenuation exerts protective effects on catabolism and hypertrophy in chondrocytes and ameliorates osteoarthritis development"],"prefix":"10.1016","volume":"517","author":[{"given":"Song","family":"Xue","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Libo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weilin","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3016-9726","authenticated-orcid":false,"given":"Jinzhong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.07.032_bib1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.20344\/amp.5477","article-title":"Osteoarthritis","volume":"28","author":"Pereira","year":"2015","journal-title":"Acta Med. Port."},{"key":"10.1016\/j.bbrc.2019.07.032_bib2","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.joca.2017.10.008","article-title":"Osteoarthritis year in review 2017: biology","volume":"26","author":"Appleton","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bbrc.2019.07.032_bib3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Osteoarthritis, Lancet (London, England)"},{"key":"10.1016\/j.bbrc.2019.07.032_bib4","first-page":"10","article-title":"Symptom onset, diagnosis and management of osteoarthritis","volume":"25","author":"MacDonald","year":"2014","journal-title":"Health Rep."},{"key":"10.1016\/j.bbrc.2019.07.032_bib5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2174\/1389450119666181026152221","article-title":"CDK9 as an appealing target for therapeutic interventions","volume":"20","author":"Eyvazi","year":"2019","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.bbrc.2019.07.032_bib6","article-title":"Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in ovarian cancer","author":"Wang","year":"2019","journal-title":"FASEB J. Off. Pub. Federation of Am. Soc. Experi. Biol."},{"key":"10.1016\/j.bbrc.2019.07.032_bib7","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ebiom.2018.12.022","article-title":"Cyclin-dependent kinase 9 (CDK9) is a novel prognostic marker and therapeutic target in osteosarcoma","volume":"39","author":"Ma","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbrc.2019.07.032_bib8","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/jor.24189","article-title":"Targeting regulation of cyclin dependent kinase 9 as a novel therapeutic strategy in synovial sarcoma","volume":"37","author":"Li","year":"2019","journal-title":"J.\u00a0Orthop. Res. : official publication of the Orthopaedic Research Society"},{"key":"10.1016\/j.bbrc.2019.07.032_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183425","article-title":"Targeting of CDK9 with indirubin 3'-monoxime safely and durably reduces HIV viremia in chronically infected humanized mice","volume":"12","author":"Medina-Moreno","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2019.07.032_bib10","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.18632\/oncotarget.6443","article-title":"Serum cyclin-dependent kinase 9 is a potential biomarker of atherosclerotic inflammation","volume":"7","author":"Han","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2019.07.032_bib11","doi-asserted-by":"crossref","first-page":"3559","DOI":"10.1038\/sj.emboj.7600351","article-title":"Activation of cardiac Cdk9 represses PGC-1 and confers a predisposition to heart failure","volume":"23","author":"Sano","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2019.07.032_bib12","doi-asserted-by":"crossref","first-page":"31441","DOI":"10.1038\/srep31441","article-title":"Inhibition of CDK9 as a therapeutic strategy for inflammatory arthritis","volume":"6","author":"Hellvard","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2019.07.032_bib13","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1161\/ATVBAHA.110.213934","article-title":"Flavopiridol protects against inflammation by attenuating leukocyte-endothelial interaction via inhibition of cyclin-dependent kinase 9","volume":"31","author":"Schmerwitz","year":"2011","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbrc.2019.07.032_bib14","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1002\/art.38378","article-title":"Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines","volume":"66","author":"Yik","year":"2014","journal-title":"Arthritis & rheumatology (Hoboken, N.J.)"},{"key":"10.1016\/j.bbrc.2019.07.032_bib15","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1080\/10717544.2018.1482971","article-title":"Controlled release of celecoxib inhibits inflammation, bone cysts and osteophyte formation in a preclinical model of osteoarthritis","volume":"25","author":"Tellegen","year":"2018","journal-title":"Drug Deliv."},{"key":"10.1016\/j.bbrc.2019.07.032_bib16","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1002\/art.34645","article-title":"Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice","volume":"64","author":"Weng","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2019.07.032_bib17","doi-asserted-by":"crossref","first-page":"3001","DOI":"10.1016\/j.bbadis.2017.08.009","article-title":"BRD4 has dual effects on the HMGB1 and NF-kappaB signalling pathways and is a potential therapeutic target for osteoarthritis, Biochimica et biophysica acta","volume":"1863","author":"Jiang","year":"2017","journal-title":"Molecular basis of disease"},{"key":"10.1016\/j.bbrc.2019.07.032_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/bph.12408","article-title":"Characterization of molecular and cellular functions of the cyclin-dependent kinase CDK9 using a novel specific inhibitor","volume":"171","author":"Albert","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.07.032_bib19","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/nrrheum.2016.148","article-title":"Changes in the osteochondral unit during osteoarthritis: structure, function and cartilage-bone crosstalk","volume":"12","author":"Goldring","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bbrc.2019.07.032_bib20","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1749-6632.2009.05240.x","article-title":"Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis","volume":"1192","author":"Goldring","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbrc.2019.07.032_bib21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s00223-014-9917-9","article-title":"Osteoarthritis pathogenesis: a review of molecular mechanisms","volume":"95","author":"Xia","year":"2014","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.bbrc.2019.07.032_bib22","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3389\/fphar.2018.00174","article-title":"Flavopiridol protects bone tissue by attenuating RANKL induced osteoclast formation","volume":"9","author":"Hu","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.07.032_bib23","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1136\/annrheumdis-2017-212037","article-title":"Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair","volume":"77","author":"Shkhyan","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbrc.2019.07.032_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197690","article-title":"Annexin A6 regulates catabolic events in articular chondrocytes via the modulation of NF-kappaB and Wnt\/ss-catenin signaling","volume":"13","author":"Minashima","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2019.07.032_bib25","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.intimp.2017.06.017","article-title":"Cryptotanshinone protects against IL-1 beta-induced inflammation in human osteoarthritis chondrocytes and ameliorates the progression of osteoarthritis in mice","volume":"50","author":"Feng","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2019.07.032_bib26","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.intimp.2018.01.016","article-title":"Inhibition of NF-kappaB pathway in fibroblast-like synoviocytes by alpha-mangostin implicated in protective effects on joints in rats suffering from adjuvant-induced arthritis","volume":"56","author":"Zuo","year":"2018","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbrc.2019.07.032_bib27","doi-asserted-by":"crossref","first-page":"200","DOI":"10.22203\/eCM.v030a14","article-title":"Inhibition of CDK9 prevents mechanical injury-induced inflammation, apoptosis and matrix degradation in cartilage explants","volume":"30","author":"Hu","year":"2016","journal-title":"Eur. Cells Mater."},{"key":"10.1016\/j.bbrc.2019.07.032_bib28","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.joca.2018.11.006","article-title":"Inhibition of early response genes prevents changes in global joint metabolomic profiles in mouse post-traumatic osteoarthritis","volume":"27","author":"Haudenschild","year":"2018","journal-title":"Osteoarthr. Cartil."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19313701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19313701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:38:13Z","timestamp":1757763493000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19313701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0006291X19313701"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.07.032","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CDK9 attenuation exerts protective effects on catabolism and hypertrophy in chondrocytes and ameliorates osteoarthritis development","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.07.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}