{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:34:09Z","timestamp":1782513249657,"version":"3.54.5"},"reference-count":29,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.bbrc.2019.07.088","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T07:55:01Z","timestamp":1564473301000},"page":"507-512","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Envelope-deforming antiviral peptide derived from influenza virus M2 protein"],"prefix":"10.1016","volume":"517","author":[{"given":"Younghun","family":"Jung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoungjae","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seokoh","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok-Hyeon","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhyo","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2923-7039","authenticated-orcid":false,"given":"Choongjin","family":"Ban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woo-Jae","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Gun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae-Hyuk","family":"Kweon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.07.088_bib1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/01.qco.0000216628.51563.b1","article-title":"Respiratory viral threats","volume":"19","author":"Hayden","year":"2006","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.bbrc.2019.07.088_bib2","doi-asserted-by":"crossref","first-page":"5428","DOI":"10.3390\/v7102883","article-title":"Perspective of use of antiviral peptides against influenza virus","volume":"7","author":"Skalickova","year":"2015","journal-title":"Viruses-Basel"},{"key":"10.1016\/j.bbrc.2019.07.088_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0025333","article-title":"Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37","volume":"6","author":"Barlow","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2019.07.088_bib4","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1016\/j.febslet.2009.10.022","article-title":"Amphipathic helices and membrane curvature","volume":"584","author":"Drin","year":"2010","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2019.07.088_bib5","doi-asserted-by":"crossref","first-page":"44695","DOI":"10.1038\/srep44695","article-title":"Membrane remodeling by the M2 amphipathic helix drives influenza virus membrane scission","volume":"7","author":"Martyna","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2019.07.088_bib6","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.cell.2010.08.029","article-title":"Influenza virus M2 protein mediates ESCRT-independent membrane scission","volume":"142","author":"Rossman","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2019.07.088_bib7","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1172\/JCI114819","article-title":"Apolipoprotein A-I and its amphipathic helix peptide analogues inhibit human immunodeficiency virus-induced syncytium formation","volume":"86","author":"Owens","year":"1990","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.bbrc.2019.07.088_bib8","doi-asserted-by":"crossref","first-page":"3088","DOI":"10.1073\/pnas.0712380105","article-title":"A\u00a0virocidal amphipathic alpha-helical peptide that inhibits hepatitis C virus infection in\u00a0vitro","volume":"105","author":"Cheng","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2019.07.088_bib9","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/299371a0","article-title":"The helical hydrophobic moment: a measure of the amphiphilicity of a helix","volume":"299","author":"Eisenberg","year":"1982","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2019.07.088_bib10","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1016\/j.bbamem.2014.04.015","article-title":"Peptide entry inhibitors of enveloped viruses: the importance of interfacial hydrophobicity","volume":"1838","author":"Badani","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2019.07.088_bib11","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1006\/jmbi.1998.2346","article-title":"Folding of amphipathic alpha-helices on membranes: energetics of helix formation by melittin","volume":"285","author":"Ladokhin","year":"1999","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.bbrc.2019.07.088_bib12","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/prot.340080202","article-title":"Amphipathic helix motif: classes and properties","volume":"8","author":"Segrest","year":"1990","journal-title":"Proteins"},{"key":"10.1016\/j.bbrc.2019.07.088_bib13","doi-asserted-by":"crossref","first-page":"3824","DOI":"10.1073\/pnas.78.6.3824","article-title":"Prediction of protein antigenic determinants from amino acid sequences","volume":"78","author":"Hopp","year":"1981","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2019.07.088_bib14","doi-asserted-by":"crossref","first-page":"11960","DOI":"10.1128\/JVI.01678-06","article-title":"Inhibition of influenza virus infection by a novel antiviral peptide that targets viral attachment to cells","volume":"80","author":"Jones","year":"2006","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.bbrc.2019.07.088_bib15","doi-asserted-by":"crossref","first-page":"9770","DOI":"10.1073\/pnas.91.21.9770","article-title":"Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection","volume":"91","author":"Wild","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2019.07.088_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.virol.2012.05.010","article-title":"Antiviral activity of phage display selected peptides against Porcine reproductive and respiratory syndrome virus in\u00a0vitro","volume":"432","author":"Liu","year":"2012","journal-title":"Virology"},{"key":"10.1016\/j.bbrc.2019.07.088_bib17","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1021\/cb900149b","article-title":"Mechanism of an amphipathic alpha-helical peptide's antiviral activity involves size-dependent virus particle lysis","volume":"4","author":"Cho","year":"2009","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.bbrc.2019.07.088_bib18","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0014-5793(01)02648-5","article-title":"Optimization of the antimicrobial activity of magainin peptides by modification of charge","volume":"501","author":"Dathe","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2019.07.088_bib19","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrd2897","article-title":"Subcellular targeting strategies for drug design and delivery","volume":"9","author":"Rajendran","year":"2010","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrc.2019.07.088_bib20","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cell.2010.02.017","article-title":"Membrane curvature in synaptic vesicle fusion and beyond","volume":"140","author":"McMahon","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2019.07.088_bib21","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/nsmb.1455","article-title":"Mechanics of membrane fusion","volume":"15","author":"Chernomordik","year":"2008","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.bbrc.2019.07.088_bib22","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.3390\/v2051106","article-title":"A\u00a0potent, broad-spectrum antiviral agent that targets viral membranes","volume":"2","author":"Wojcechowskyj","year":"2010","journal-title":"Viruses-Basel"},{"key":"10.1016\/j.bbrc.2019.07.088_bib23","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1073\/pnas.0909587107","article-title":"A\u00a0broad-spectrum antiviral targeting entry of enveloped viruses","volume":"107","author":"Wolf","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2019.07.088_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2015.00517","article-title":"Broad-spectrum antiviral agents","volume":"6","author":"Zhu","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bbrc.2019.07.088_bib25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41467-018-08138-1","article-title":"Virucidal nano-perforator of viral membrane trapping viral RNAs in the endosome","volume":"10","author":"Kong","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2019.07.088_bib26","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1146\/annurev.physchem.012809.103450","article-title":"Thermodynamics and mechanics of membrane curvature generation and sensing by proteins and lipids","volume":"62","author":"Baumgart","year":"2011","journal-title":"Annu. Rev. Phys. Chem."},{"key":"10.1016\/j.bbrc.2019.07.088_bib27","doi-asserted-by":"crossref","first-page":"310a","DOI":"10.1016\/j.bpj.2016.11.1678","article-title":"Modulation of membrane rigidity by the ESCRT-III complex","volume":"112","author":"De Franceschi","year":"2017","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbrc.2019.07.088_bib28","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1039\/C6CS00636A","article-title":"Cellular uptake of nanoparticles: journey inside the cell","volume":"46","author":"Behzadi","year":"2017","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.bbrc.2019.07.088_bib29","series-title":"Influenza Drug Resistance, Seminars in Respiratory and Critical Care Medicine","first-page":"409","author":"Pizzorno","year":"2011"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19314421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19314421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:35:34Z","timestamp":1762094134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19314421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0006291X19314421"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.07.088","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Envelope-deforming antiviral peptide derived from influenza virus M2 protein","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.07.088","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}