{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:11:33Z","timestamp":1783476693413,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.bbrc.2019.07.107","type":"journal-article","created":{"date-parts":[[2019,7,31]],"date-time":"2019-07-31T17:25:48Z","timestamp":1564593948000},"page":"439-444","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prenylation-dependent Ras inhibition by pamidronate inhibits pediatric acute myeloid leukemia stem and differentiated cell growth and survival"],"prefix":"10.1016","volume":"517","author":[{"given":"Chengbin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.07.107_bib1","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra1406184","article-title":"Acute myeloid leukemia","volume":"373","author":"Dohner","year":"2015","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbrc.2019.07.107_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5045\/br.2018.53.1.1","article-title":"Current treatment for pediatric acute myeloid leukemia","volume":"53","author":"Im","year":"2018","journal-title":"Blood Res."},{"key":"10.1016\/j.bbrc.2019.07.107_bib3","first-page":"175","article-title":"Treatment of FLT3-ITD acute myeloid leukemia","volume":"1","author":"Fathi","year":"2011","journal-title":"American J. Blood Res."},{"key":"10.1016\/j.bbrc.2019.07.107_bib4","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1200\/JCO.2012.42.2907","article-title":"Acute Myeloid Leukemia (AML): different treatment strategies versus a common standard arm--combined prospective analysis by the German AML Intergroup","volume":"30","author":"Buchner","year":"2012","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.bbrc.2019.07.107_bib5","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/367645a0","article-title":"A\u00a0cell initiating human acute myeloid leukaemia after transplantation into SCID mice","volume":"367","author":"Lapidot","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2019.07.107_bib6","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1073\/pnas.0408107102","article-title":"A\u00a0small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells","volume":"102","author":"Winter-Vann","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2019.07.107_bib7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0898-6568(97)00120-4","article-title":"Membrane association and targeting of prenylated Ras-like GTPases","volume":"10","author":"Seabra","year":"1998","journal-title":"Cell. Signal."},{"key":"10.1016\/j.bbrc.2019.07.107_bib8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1146\/annurev.bi.65.070196.001325","article-title":"Protein prenylation: molecular mechanisms and functional consequences","volume":"65","author":"Zhang","year":"1996","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbrc.2019.07.107_bib9","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1359\/jbmr.1998.13.4.581","article-title":"Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras","volume":"13","author":"Luckman","year":"1998","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2019.07.107_bib10","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.2147\/DDDT.S141075","article-title":"Therapy with pamidronate in children with osteogenesis imperfecta","volume":"11","author":"Marginean","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.bbrc.2019.07.107_bib11","first-page":"CD004956","article-title":"Bisphosphonates for Paget's disease of bone in adults","volume":"12","author":"Corral-Gudino","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bbrc.2019.07.107_bib12","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/sj.bjc.6600476","article-title":"The bisphosphonate pamidronate induces apoptosis in human melanoma cells in\u00a0vitro","volume":"87","author":"Riebeling","year":"2002","journal-title":"Br. J. Canc."},{"key":"10.1016\/j.bbrc.2019.07.107_bib13","first-page":"1413","article-title":"Potentiated antitumor effects of the combination treatment with statins and pamidronate in\u00a0vitro and in\u00a0vivo","volume":"30","author":"Issat","year":"2007","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbrc.2019.07.107_bib14","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jhep.2005.09.022","article-title":"Pamidronate induced anti-proliferative, apoptotic, and anti-migratory effects in hepatocellular carcinoma","volume":"44","author":"Wada","year":"2006","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.bbrc.2019.07.107_bib15","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.3892\/or.2013.2316","article-title":"Sorting, identification and enrichment of side population cells in THP-1 acute monocytic leukemia cells","volume":"29","author":"Wang","year":"2013","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.bbrc.2019.07.107_bib16","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/sj.leu.2402740","article-title":"FLT3 mutations in acute myeloid leukemia cell lines","volume":"17","author":"Quentmeier","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.bbrc.2019.07.107_bib17","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1182\/asheducation-2013.1.220","article-title":"FLT3 mutations in acute myeloid leukemia: what is the best approach in 2013?","volume":"2013","author":"Levis","year":"2013","journal-title":"Hematol. Am. Soc. Hematol. Educ. Progr."},{"key":"10.1016\/j.bbrc.2019.07.107_bib18","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1182\/blood-2003-03-0970","article-title":"Inhibition of protein geranylgeranylation induces apoptosis in myeloma plasma cells by reducing Mcl-1 protein levels","volume":"102","author":"van de Donk","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.07.107_bib19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1073\/pnas.96.1.133","article-title":"Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in\u00a0vitro","volume":"96","author":"Fisher","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2019.07.107_bib20","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/343425a0","article-title":"Regulation of the mevalonate pathway","volume":"343","author":"Goldstein","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2019.07.107_bib21","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1038\/onc.2016.508","article-title":"Isoprenylcysteine carboxylmethyltransferase is critical for malignant transformation and tumor maintenance by all RAS isoforms","volume":"36","author":"Lau","year":"2017","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2019.07.107_bib22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.bbrc.2017.05.147","article-title":"Atorvastatin augments temozolomide's efficacy in glioblastoma via prenylation-dependent inhibition of Ras signaling","volume":"489","author":"Peng","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2019.07.107_bib23","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1182\/blood-2016-02-695312","article-title":"Evolution of acute myelogenous leukemia stem cell properties after treatment and progression","volume":"128","author":"Ho","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.07.107_bib24","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1007\/s00198-013-2530-3","article-title":"Osteoporosis foundation committee of scientific advisors working group on cancer-induced bone, cancer-associated bone disease","volume":"24","author":"Rizzoli","year":"2013","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bbrc.2019.07.107_bib25","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1002\/cncr.25744","article-title":"Addition of pamidronate to chemotherapy for the treatment of osteosarcoma","volume":"117","author":"Meyers","year":"2011","journal-title":"Cancer"},{"key":"10.1016\/j.bbrc.2019.07.107_bib26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.5045\/br.2013.48.2.99","article-title":"Efficacy of pamidronate in children with low bone mineral density during and after chemotherapy for acute lymphoblastic leukemia and non-Hodgkin lymphoma","volume":"48","author":"Lee","year":"2013","journal-title":"Blood Res."},{"key":"10.1016\/j.bbrc.2019.07.107_bib27","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.3892\/ijo.2015.2955","article-title":"Antitumor activity of pamidronate in breast cancer cells transformed by low doses of alpha-particles and estrogen in\u00a0vitro","volume":"46","author":"Ponce-Cusi","year":"2015","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.bbrc.2019.07.107_bib28","first-page":"263","article-title":"Pamidronate resistance and associated low ras levels in breast cancer cells: a role for combinatorial therapy","volume":"34","author":"Zhang","year":"2004","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.bbrc.2019.07.107_bib29","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1359\/JBMR.050522","article-title":"Skeletal retention of bisphosphonate (pamidronate) and its relation to the rate of bone resorption in patients with breast cancer and bone metastases","volume":"20","author":"Cremers","year":"2005","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2019.07.107_bib30","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1210\/js.2018-00268","article-title":"The bone phenotype and pain response to pamidronate in tyrosine kinase inhibitor-treated chronic myelogenous leukemia","volume":"3","author":"Lavoie","year":"2019","journal-title":"J.\u00a0Endocr. Soc."},{"key":"10.1016\/j.bbrc.2019.07.107_bib31","first-page":"246","article-title":"Nitrogen containing bisphosphonates induce apoptosis and inhibit the mevalonate pathway, impairing Ras membrane localization in prostate cancer cells","volume":"170","author":"Oades","year":"2003","journal-title":"J.\u00a0Urol."},{"key":"10.1016\/j.bbrc.2019.07.107_bib32","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1182\/blood-2012-05-378596","article-title":"Targeting oncogenic Ras signaling in hematologic malignancies","volume":"120","author":"Ward","year":"2012","journal-title":"Blood"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19314755?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19314755?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:39:09Z","timestamp":1757763549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19314755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":32,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0006291X19314755"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.07.107","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenylation-dependent Ras inhibition by pamidronate inhibits pediatric acute myeloid leukemia stem and differentiated cell growth and survival","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.07.107","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}