{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:16:16Z","timestamp":1771456576048,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009334","name":"Pearl River S and T Nova Program of Guangzhou","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012245","name":"Science and Technology Planning Project of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.bbrc.2019.08.164","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T08:17:48Z","timestamp":1567585068000},"page":"234-239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["TAL1 mediates imatinib-induced CML cell apoptosis via the PTEN\/PI3K\/AKT pathway"],"prefix":"10.1016","volume":"519","author":[{"given":"Yifan","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xibao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yikai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaohua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0974-4036","authenticated-orcid":false,"given":"Yangqiu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1333-3918","authenticated-orcid":false,"given":"Chengwu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.08.164_bib1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1146\/annurev.immunol.22.012703.104753","article-title":"The BCR-ABL story: bench to bedside and back","volume":"22","author":"Wong","year":"2004","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2019.08.164_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s13045-018-0673-6","article-title":"Long non-coding RNAs in hematological malignancies: translating basic techniques into diagnostic and therapeutic strategies","volume":"11","author":"Wong","year":"2018","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.bbrc.2019.08.164_bib3","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13045-018-0624-2","article-title":"Past, present, and future of Bcr-Abl inhibitors: from chemical development to clinical efficacy","volume":"11","author":"Rossari","year":"2018","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.bbrc.2019.08.164_bib4","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1172\/JCI35721","article-title":"Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity","volume":"121","author":"Corbin","year":"2011","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.bbrc.2019.08.164_bib5","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12943-018-0884-z","article-title":"The c-Myc-regulated lncRNA NEAT1 and paraspeckles modulate imatinib-induced apoptosis in CML cells","volume":"17","author":"Zeng","year":"2018","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.bbrc.2019.08.164_bib6","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s13045-018-0685-2","article-title":"Management of adverse events associated with bosutinib treatment of chronic-phase chronic myeloid leukemia: expert panel review","volume":"11","author":"Cortes","year":"2018","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.bbrc.2019.08.164_bib7","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1182\/blood-2009-06-228130","article-title":"PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice","volume":"115","author":"Peng","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.08.164_bib8","doi-asserted-by":"crossref","first-page":"7442","DOI":"10.18632\/oncotarget.23448","article-title":"SALL1 expression in acute myeloid leukemia","volume":"9","author":"Salman","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2019.08.164_bib9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/978-1-4939-3661-8_13","article-title":"Chronic myeloid leukemia (CML) mouse model in translational Research","volume":"1438","author":"Peng","year":"2016","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbrc.2019.08.164_bib10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1158\/1078-0432.CCR-17-1533","article-title":"PTEN is fundamental for elimination of leukemia stem cells mediated by GSK126 targeting EZH2 in chronic myelogenous leukemia","volume":"24","author":"Zhou","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2019.08.164_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110682","article-title":"BCR-ABL promotes PTEN downregulation in chronic myeloid leukemia","volume":"9","author":"Panuzzo","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2019.08.164_bib12","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1182\/blood.V93.9.2760.409k44_2760_2770","article-title":"The SCL gene: from case report to critical hematopoietic regulator","volume":"93","author":"Begley","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.08.164_bib13","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.1242\/dev.128.23.4815","article-title":"Selective rescue of early haematopoietic progenitors in Scl(-\/-) mice by expressing Scl under the control of a stem cell enhancer","volume":"128","author":"Sanchez","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2019.08.164_bib14","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0092-8674(00)80076-8","article-title":"The T cell leukemia oncoprotein SCL\/tal-1 is essential for development of all hematopoietic lineages","volume":"86","author":"Porcher","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2019.08.164_bib15","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1182\/blood-2006-05-022988","article-title":"Low SCL\/TAL1 expression reveals its major role in adult hematopoietic myeloid progenitors and stem cells","volume":"108","author":"Brunet de la Grange","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.08.164_bib16","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1172\/JCI61269","article-title":"The molecular basis of T cell acute lymphoblastic leukemia","volume":"122","author":"Van Vlierberghe","year":"2012","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.bbrc.2019.08.164_bib17","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.ccr.2012.06.007","article-title":"Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia","volume":"22","author":"Sanda","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.bbrc.2019.08.164_bib18","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13045-017-0432-0","article-title":"T-ALL and thymocytes: a message of noncoding RNAs","volume":"10","author":"Wallaert","year":"2017","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.bbrc.2019.08.164_bib19","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1182\/blood-2013-10-536078","article-title":"Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia","volume":"123","author":"Herrmann","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.08.164_bib20","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1186\/1471-2407-14-693","article-title":"Inhibition of long non-coding RNA NEAT1 impairs myeloid differentiation in acute promyelocytic leukemia cells","volume":"14","author":"Zeng","year":"2014","journal-title":"BMC Canc."},{"key":"10.1016\/j.bbrc.2019.08.164_bib21","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s13045-017-0507-y","article-title":"Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia","volume":"10","author":"Zhou","year":"2017","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.bbrc.2019.08.164_bib22","first-page":"1","article-title":"The c-Myc-regulated miR-17-92 cluster mediates ATRA-induced APL cell differentiation","author":"Yu","year":"2019","journal-title":"Asia Pac. J. Clin. Oncol."},{"key":"10.1016\/j.bbrc.2019.08.164_bib23","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1111\/eci.12368","article-title":"DPPIV (CD26) as a novel stem cell marker in Ph+ chronic myeloid leukaemia","volume":"44","author":"Valent","year":"2014","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.bbrc.2019.08.164_bib24","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1101\/gad.276790.115","article-title":"UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia","volume":"30","author":"Benyoucef","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2019.08.164_bib25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0092-8674(00)81780-8","article-title":"Negative regulation of PKB\/Akt-dependent cell survival by the tumor suppressor PTEN","volume":"95","author":"Stambolic","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2019.08.164_bib26","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1007\/s11427-015-4967-4","article-title":"Pathways related to PMA-differentiated THP1 human monocytic leukemia cells revealed by RNA-Seq","volume":"58","author":"Zeng","year":"2015","journal-title":"Sci. China Life Sci."},{"key":"10.1016\/j.bbrc.2019.08.164_bib27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13045-017-0547-3","article-title":"The polycomb group protein EZH2 induces epithelial-mesenchymal transition and pluripotent phenotype of gastric cancer cells by binding to PTEN promoter","volume":"11","author":"Gan","year":"2018","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.bbrc.2019.08.164_bib28","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1182\/blood-2009-12-261602","article-title":"Evi1 represses PTEN expression and activates PI3K\/AKT\/mTOR via interactions with polycomb proteins","volume":"117","author":"Yoshimi","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.08.164_bib29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.stem.2013.05.025","article-title":"CD34(-) cells at the apex of the human hematopoietic stem cell hierarchy have distinctive cellular and molecular signatures","volume":"13","author":"Anjos-Afonso","year":"2013","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2019.08.164_bib30","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1002\/stem.2028","article-title":"The SCL\/TAL1 transcription factor represses the stress protein DDiT4\/REDD1 in human hematopoietic stem\/progenitor cells","volume":"33","author":"Benyoucef","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbrc.2019.08.164_bib31","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/emboj.2010.342","article-title":"Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages","volume":"30","author":"Palii","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2019.08.164_bib32","doi-asserted-by":"crossref","first-page":"5007","DOI":"10.1038\/onc.2012.8","article-title":"Dynamic interaction between TAL1 oncoprotein and LSD1 regulates TAL1 function in hematopoiesis and leukemogenesis","volume":"31","author":"Li","year":"2012","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2019.08.164_bib33","doi-asserted-by":"crossref","first-page":"5160","DOI":"10.1002\/j.1460-2075.1996.tb00900.x","article-title":"Tal-1 induces T cell acute lymphoblastic leukemia accelerated by casein kinase IIalpha","volume":"15","author":"Kelliher","year":"1996","journal-title":"EMBO J."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19317000?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19317000?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:39:51Z","timestamp":1757763591000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19317000"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S0006291X19317000"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.08.164","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TAL1 mediates imatinib-induced CML cell apoptosis via the PTEN\/PI3K\/AKT pathway","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.08.164","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}