{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T07:30:46Z","timestamp":1780385446635,"version":"3.54.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014354","name":"Milstein Medical Asian American Partnership Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014354","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.bbrc.2019.10.027","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T17:05:00Z","timestamp":1570727100000},"page":"420-427","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Toll-like receptor 4 protects against irradiation-induced hematopoietic injury by promoting granulopoiesis and alleviating\u00a0marrow adipogenesis"],"prefix":"10.1016","volume":"520","author":[{"given":"Zhengxu","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunpeng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiwang","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Fei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.10.027_bib1","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrclinonc.2010.138","article-title":"Radiotherapy: intermediate-risk endometrial cancer--adjuvant treatment","volume":"7","author":"Eifel","year":"2010","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.bbrc.2019.10.027_bib2","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1182\/blood-2012-02-409805","article-title":"Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner","volume":"120","author":"Capitano","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.10.027_bib3","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ni1112","article-title":"Toll-like receptor control of the adaptive immune responses","volume":"5","author":"Iwasaki","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbrc.2019.10.027_bib4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.canlet.2015.02.007","article-title":"The many interactions between the innate immune system and the response to radiation","volume":"368","author":"Cand\u00e9ias","year":"2015","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2019.10.027_bib5","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1126\/science.1154986","article-title":"An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models","volume":"320","author":"Burdelya","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2019.10.027_bib6","doi-asserted-by":"crossref","first-page":"e29357","DOI":"10.1371\/journal.pone.0029357","article-title":"TLR9 agonist protects mice from radiation-induced gastrointestinal syndrome","volume":"7","author":"Saha","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2019.10.027_bib7","doi-asserted-by":"crossref","first-page":"e649","DOI":"10.1038\/cddis.2013.161","article-title":"A\u00a0critical role of toll-like receptor 4 (TLR4) and its\u2019 in\u00a0vivo ligands in basal radio-resistance","volume":"4","author":"Liu","year":"2013","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2019.10.027_bib8","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nri3660","article-title":"Emergency granulopoiesis","volume":"14","author":"Manz","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbrc.2019.10.027_bib9","doi-asserted-by":"crossref","first-page":"5824","DOI":"10.4049\/jimmunol.1103253","article-title":"Cutting edge: LPS-induced emergency myelopoiesis depends on TLR4-expressing nonhematopoietic cells","volume":"188","author":"Boettcher","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2019.10.027_bib10","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1128\/IAI.01280-12","article-title":"Toll-like receptor 4\/stem cell antigen 1 signaling promotes hematopoietic precursor cell commitment to granulocyte development during the granulopoietic response to Escherichia coli bacteremia","volume":"81","author":"Shi","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbrc.2019.10.027_bib11","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1182\/blood-2014-04-570762","article-title":"Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis","volume":"124","author":"Boettcher","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.10.027_bib12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/nature08099","article-title":"Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment","volume":"460","author":"Naveiras","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2019.10.027_bib13","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.stem.2014.06.008","article-title":"Leptin-receptor-Expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow","volume":"15","author":"Zhou","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.bbrc.2019.10.027_bib14","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1126\/science.284.5411.143","article-title":"Multilineage potential of adult human mesenchymal stem cells","volume":"284","author":"Pittenger","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2019.10.027_bib15","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nature09262","article-title":"Mesenchymal and haematopoietic stem cells form a unique bone marrow niche","volume":"466","author":"M Ndez-Ferrer","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2019.10.027_bib16","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1182\/blood-2006-06-028704","article-title":"Toll-like receptors and their ligands control mesenchymal stem cell functions","volume":"109","author":"Pevsner-Fischer","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.10.027_bib17","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.4049\/jimmunol.1602006","article-title":"Reactive oxygen species-producing myeloid cells act as a bone marrow niche for sterile inflammation-induced reactive granulopoiesis","volume":"198","author":"Zhu","year":"2017","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbrc.2019.10.027_bib18","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.bbcan.2014.04.009","article-title":"Radiation sensitivity of human and murine peripheral blood lymphocytes, stem and progenitor cells","volume":"1846","author":"Heylmann","year":"2014","journal-title":"Biochim. Biophys. Acta Rev. Canc."},{"key":"10.1016\/j.bbrc.2019.10.027_bib19","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1182\/blood-2012-05-429589","article-title":"Steady-state neutrophil homeostasis is dependent on TLR4\/TRIF signaling","volume":"121","author":"Bugl","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.10.027_bib20","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/s11684-015-0412-0","article-title":"Toll-like receptor signaling in hematopoietic homeostasis and the pathogenesis of hematologic diseases","volume":"9","author":"Cannova","year":"2015","journal-title":"Front. Med."},{"key":"10.1016\/j.bbrc.2019.10.027_bib21","first-page":"661","volume":"129","author":"Lanzkron","year":"2017","journal-title":"Gut microbiota sustains hematopoiesis, Blood"},{"key":"10.1016\/j.bbrc.2019.10.027_bib22","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1182\/blood-2003-02-0593","article-title":"Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway","volume":"102","author":"Richards","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2019.10.027_bib23","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/jrr\/rrv009","article-title":"Radioprotective effects of Sipunculus nudus L. polysaccharide combined with WR-2721, rhIL-11 and rhG-CSF on radiation-injured mice","volume":"56","author":"Jiang","year":"2015","journal-title":"J.\u00a0Radiat. Res."},{"key":"10.1016\/j.bbrc.2019.10.027_bib24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.freeradbiomed.2017.09.014","article-title":"Theaflavin ameliorates ionizing radiation-induced hematopoietic injury via the NRF2 pathway","volume":"113","author":"Han","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2019.10.027_bib25","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-017-0711-2","article-title":"Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice","volume":"8","author":"Sundaramoorthy","year":"2017","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.bbrc.2019.10.027_bib26","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.immuni.2014.12.017","article-title":"Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis","volume":"42","author":"Kwak","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.bbrc.2019.10.027_bib27","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1136\/neurintsurg-2016-012463","article-title":"NADPH oxidase inhibitor regulates microRNAs with improved outcome after mechanical reperfusion","volume":"9","author":"Liu","year":"2017","journal-title":"J.\u00a0Neurointerventional Surg."},{"key":"10.1016\/j.bbrc.2019.10.027_bib28","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.scr.2016.11.015","article-title":"Irradiation-induced secretion of BMP4 by marrow cells causes marrow adipogenesis post-myelosuppression","volume":"17","author":"Bajaj","year":"2016","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.bbrc.2019.10.027_bib29","first-page":"e323","article-title":"Simvastatin improves hematopoietic stem cell engraftment by preventing irradiation-induced marrow adipogenesis and radio-protecting the niche cells","volume":"100","author":"Bajaj","year":"2015","journal-title":"Haematologica"},{"key":"10.1016\/j.bbrc.2019.10.027_bib30","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/ncb3570","article-title":"Bone marrow adipocytes promote the regeneration of stem cells and haematopoiesis by secreting SCF","volume":"19","author":"Zhou","year":"2017","journal-title":"Nat. Cell Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19319163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19319163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:43:28Z","timestamp":1757763808000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19319163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S0006291X19319163"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.10.027","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toll-like receptor 4 protects against irradiation-induced hematopoietic injury by promoting granulopoiesis and alleviating\u00a0marrow adipogenesis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.10.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}