{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T06:38:22Z","timestamp":1782283102568,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006143","name":"Department of Science and Technology, Government of Kerala","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006143","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.bbrc.2019.10.058","type":"journal-article","created":{"date-parts":[[2019,10,12]],"date-time":"2019-10-12T07:15:47Z","timestamp":1570864547000},"page":"551-559","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Augmented therapeutic efficacy of 5-fluorouracil in conjunction with lantibiotic nisin against skin cancer"],"prefix":"10.1016","volume":"520","author":[{"given":"Komal","family":"Rana","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohit","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simran","family":"Preet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.10.058_bib1","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA A Cancer J. Clin."},{"key":"10.1016\/j.bbrc.2019.10.058_bib2","first-page":"70","article-title":"The side effects of chemotherapeutic agents","volume":"2","author":"Carr","year":"2008","journal-title":"Curr. Anaesth. Crit. Care"},{"key":"10.1016\/j.bbrc.2019.10.058_bib3","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.3390\/cancers6031769","article-title":"Drug resistance in cancer: an overview","volume":"6","author":"Housman","year":"2014","journal-title":"Cancers"},{"key":"10.1016\/j.bbrc.2019.10.058_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2013.00294","article-title":"From antimicrobial to anticancer peptides: a review","volume":"4","author":"Gaspar","year":"2013","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bbrc.2019.10.058_bib5","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3389\/fphar.2015.00272","article-title":"Bacteriocins as potential anti-cancer agents","volume":"6","author":"Kaur","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.10.058_bib6","doi-asserted-by":"crossref","first-page":"46635","DOI":"10.18632\/oncotarget.16743","article-title":"Antimicrobial peptides with selective antitumor mechanisms: prospect for anticancer applications","volume":"8","author":"Deslouches","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2019.10.058_bib7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/cam4.35","article-title":"Nisin, an apoptogenic bacteriocin and food preservative, attenuates HNSCC tumorigenesis via CHAC1","volume":"1","author":"Joo","year":"2012","journal-title":"Cancer Med"},{"key":"10.1016\/j.bbrc.2019.10.058_bib8","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/psc.1341","article-title":"Immunomodulatory efficacy of nisin \u2013a bacterial lantibiotic peptide","volume":"17","author":"Begde","year":"2011","journal-title":"J.\u00a0Pept. Sci."},{"key":"10.1016\/j.bbrc.2019.10.058_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131008","article-title":"A\u00a0bacteriocin and food preservative, inhibits head and neck cancer tumorigenesis and prolongs survival","volume":"10","author":"Kamarajan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2019.10.058_bib10","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.biochi.2017.10.009","article-title":"The antimicrobial peptide nisin Z induces selective toxicity and apoptotic cell death in cultured melanoma cells","volume":"144","author":"Lewies","year":"2018","journal-title":"Biochimie"},{"key":"10.1016\/j.bbrc.2019.10.058_bib11","doi-asserted-by":"crossref","first-page":"8301","DOI":"10.1007\/s13277-015-3571-3","article-title":"Effect of nisin and doxorubicin on DMBA-induced skin carcinogenesis -a possible adjunct therapy","volume":"36","author":"Preet","year":"2015","journal-title":"Tumor Biol."},{"key":"10.1016\/j.bbrc.2019.10.058_bib12","doi-asserted-by":"crossref","first-page":"101147","DOI":"10.1016\/j.jddst.2019.101147","article-title":"Gold nanoparticles assisted co-delivery of nisin and doxorubicin against murine skin cancer","volume":"53","author":"Preet","year":"2019","journal-title":"J.\u00a0Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.bbrc.2019.10.058_bib13","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4172\/2161-1025.1000161","article-title":"Nisin augments doxorubicin permeabilization and ameliorates signaling cascade during skin carcinogenesis","volume":"6","author":"Preet","year":"2016","journal-title":"Transl. Med."},{"key":"10.1016\/j.bbrc.2019.10.058_bib14","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.apsb.2013.12.013","article-title":"The effect of microneedles on the skin permeability and antitumor activity of topical 5- fluorouracil","volume":"4","author":"Naguib","year":"2014","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.bbrc.2019.10.058_bib15","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/ptr.3280","article-title":"Chemopreventive activity of Azadirachta indica on two-stage skin carcinogenesis in murine model","volume":"25","author":"Arora","year":"2011","journal-title":"Phytother Res."},{"key":"10.1016\/j.bbrc.2019.10.058_bib16","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3727\/096504011X12970940207724","article-title":"Azadirachta indica exerts chemopreventive action against murine skin cancer: studies on histopathological, ultrastructural changes and modulation of NF kappa B, AP1, and STAT1","volume":"19","author":"Arora","year":"2011","journal-title":"Oncol Res"},{"key":"10.1016\/j.bbrc.2019.10.058_bib17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1615\/JEnvironPatholToxicolOncol.2015012145","article-title":"Fourier transform infrared spectroscopic studies on modulation of n nitrosodiethylamine- induced hepatocarcinogenesis by Azadirachta indica","volume":"34","author":"Bharati","year":"2015","journal-title":"J.\u00a0Environ. Pathol. Toxicol. Oncol."},{"key":"10.1016\/j.bbrc.2019.10.058_bib18","doi-asserted-by":"crossref","first-page":"301","DOI":"10.2174\/1871520616666160526110913","article-title":"Cetumaxib immunoliposomes enhance delivery of 5-FU to skin squamous carcinoma cells","volume":"17","author":"Petrilli","year":"2017","journal-title":"Anti Cancer Agents Med. Chem."},{"key":"10.1016\/j.bbrc.2019.10.058_bib19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3126\/ijasbt.v5i2.17619","article-title":"Induction of cytotoxicity by selected nanoparticles in chinease hamster ovary- K1 cells","volume":"5","author":"Vidya","year":"2017","journal-title":"Int. J. Biotechnol. Appl."},{"key":"10.1016\/j.bbrc.2019.10.058_bib20","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/S0001-7310(07)70133-3","article-title":"Topical chemotherapy for actinic keratosis and nommelanoma skin cancer: current options and future perspectives","volume":"98","author":"Barrera","year":"2007","journal-title":"Actas Dermosifiligr"},{"key":"10.1016\/j.bbrc.2019.10.058_bib21","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1039\/C8CP06378H","article-title":"Attenuation of neuroblastoma cell growth by nisin is mediated by modulation of phase behaviour of serum glutamic oxaloacetic and pyruvic transaminases","volume":"21","author":"Prince","year":"2019","journal-title":"Phys. Chem. Chem. Phys."},{"key":"10.1016\/j.bbrc.2019.10.058_bib22","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1016\/j.bbamem.2018.06.004","article-title":"Bactericidal activity of amphiphatic catioinic antimicrobial peptides involves altering the membrane fluidity when interacting with the phospholipid bilayer","volume":"1860","author":"Omardien","year":"2018","journal-title":"BBA- Biomembranes"},{"key":"10.1016\/j.bbrc.2019.10.058_bib23","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1128\/AAC.00321-09","article-title":"Lipid segregation explains selective toxicity of a series of fragments derived from the human cathelicidin LL-37","volume":"53","author":"Epand","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.bbrc.2019.10.058_bib24","article-title":"Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms","volume":"27","author":"Allen","year":"2014","journal-title":"Elife"},{"key":"10.1016\/j.bbrc.2019.10.058_bib25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.micpath.2017.08.037","article-title":"The apoptotic impact of nisin as a potent bacteriocin on the colon cancer cells","volume":"111","author":"Ahmadi","year":"2017","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.bbrc.2019.10.058_bib26","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1177\/1535370215573396","article-title":"Resveratrol synergistically augments anti-tumor effect of 5-FU in\u00a0vitro and in\u00a0vivo by increasing S- phase arrest and tumor apoptosis","volume":"240","author":"Dun","year":"2015","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.bbrc.2019.10.058_bib27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12929-017-0328-x","article-title":"Evaluation of the use of therapeutic peptides for cancer treatment","volume":"24","author":"Marqus","year":"2017","journal-title":"J.\u00a0Biomed. Sci."},{"key":"10.1016\/j.bbrc.2019.10.058_bib28","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.3390\/md9101995","article-title":"Pardaxin, an antimicrobial peptide, triggers caspase dependent in ROS- mediated apoptosis in HT- 1080 cells","volume":"9","author":"Huang","year":"2011","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.bbrc.2019.10.058_bib29","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.2174\/138945010791591395","article-title":"Vascular endothelial growth factor as an anti-angiogenic target for cancer therapy","volume":"11","author":"Nui","year":"2010","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.bbrc.2019.10.058_bib30","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nrd2926","article-title":"Targeting the phosphatidylinositol 3-kinase (PI3K) pathway in cancer","volume":"8","author":"Liu","year":"2009","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbrc.2019.10.058_bib31","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1111\/j.1365-2133.2007.07821.x","article-title":"Combined targeting of MAPK and AKT signaling pathways is a promising strategy for melanoma treatment","volume":"156","author":"Meier","year":"2007","journal-title":"Br. J. Dermatol."},{"key":"10.1016\/j.bbrc.2019.10.058_bib32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.phymed.2018.04.007","article-title":"Bioactive compound 1,8-Cineole selectively induces G2\/M arrest in A431 cells through the upregulation of the p53 signaling pathway and molecular docking studies","volume":"46","author":"Sampath","year":"2018","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbrc.2019.10.058_bib33","first-page":"2811","article-title":"The combined effects of antibacterial peptide cecropin A and anti-cancer agents on leukemia cells","volume":"22","author":"Hui","year":"2002","journal-title":"Anticancer Res."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19319473?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19319473?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:36:21Z","timestamp":1762094181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19319473"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S0006291X19319473"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.10.058","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Augmented therapeutic efficacy of 5-fluorouracil in conjunction with lantibiotic nisin against skin cancer","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.10.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}