{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T07:52:20Z","timestamp":1789804340762,"version":"4.0.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100013884","name":"Macula Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY025362-01"],"award-info":[{"award-number":["R01EY025362-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30EY003790"],"award-info":[{"award-number":["P30EY003790"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["R21EY023079-01 \/A1"],"award-info":[{"award-number":["R21EY023079-01 \/A1"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY014104"],"award-info":[{"award-number":["EY014104"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.bbrc.2019.10.138","type":"journal-article","created":{"date-parts":[[2019,10,28]],"date-time":"2019-10-28T19:41:32Z","timestamp":1572291692000},"page":"414-419","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"title":["Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells"],"prefix":"10.1016","volume":"521","author":[{"given":"Jong-Jer","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoji","family":"Notomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos E.","family":"Efstathiou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ueta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Maidana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Iesato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Caligiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8622-6478","authenticated-orcid":false,"given":"Demetrios G.","family":"Vavvas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.10.138_bib1","doi-asserted-by":"crossref","first-page":"12036","DOI":"10.1016\/S0021-9258(19)38504-7","article-title":"Characterization and cloning of lgp110, a lysosomal membrane glycoprotein from mouse and rat cells","volume":"265","author":"Granger","year":"1990","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2019.10.138_bib2","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1111\/j.1600-0854.2005.00337.x","article-title":"Unifying nomenclature for the isoforms of the lysosomal membrane protein LAMP-2","volume":"6","author":"Eskelinen","year":"2005","journal-title":"Traffic"},{"key":"10.1016\/j.bbrc.2019.10.138_bib3","doi-asserted-by":"crossref","first-page":"5747","DOI":"10.1128\/MCB.02070-07","article-title":"The chaperone-mediated autophagy receptor organizes in dynamic protein complexes at the lysosomal membrane","volume":"28","author":"Bandyopadhyay","year":"2008","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2019.10.138_bib4","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/35022595","article-title":"Accumulation of autophagic vacuoles and cardiomyopathy in LAMP-2-deficient mice","volume":"406","author":"Tanaka","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2019.10.138_bib5","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1242\/jcs.184770","article-title":"Danon disease \u2013 dysregulation of autophagy in a multisystem disorder with cardiomyopathy","volume":"129","author":"Rowland","year":"2016","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.bbrc.2019.10.138_bib6","doi-asserted-by":"crossref","first-page":"403","DOI":"10.4161\/auto.23002","article-title":"Discovery of a novel type of autophagy targeting RNA","volume":"9","author":"Fujiwara","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2019.10.138_bib7","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.4161\/auto.24880","article-title":"Direct uptake and degradation of DNA by lysosomes","volume":"9","author":"Fujiwara","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2019.10.138_bib8","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1212\/WNL.31.1.51","article-title":"Lysosomal glycogen storage disease with normal acid maltase","volume":"31","author":"Danon","year":"1981","journal-title":"Neurology"},{"key":"10.1016\/j.bbrc.2019.10.138_bib9","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/35022604","article-title":"Primary LAMP-2 deficiency causes X-linked vacoular cardiomyopathy and myopathy (Danon disease)","volume":"406","author":"Nishino","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2019.10.138_bib10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s00401-015-1385-4","article-title":"Danon disease: a phenotypic expression of LAMP-2 deficiency","volume":"129","author":"Endo","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbrc.2019.10.138_bib11","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00059-013-3900-5","article-title":"Danon disease: a novel mutation in the LAMP-2 gene and ophthalmic abnormality","volume":"39","author":"He","year":"2013","journal-title":"Herz"},{"key":"10.1016\/j.bbrc.2019.10.138_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.475","article-title":"Autophagy dysregulation in Danon disease","volume":"8","author":"Nascimbeni","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbrc.2019.10.138_bib13","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.ophtha.2006.02.030","article-title":"Ophthalmic manifestations of Danon disease","volume":"113","author":"Prall","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.bbrc.2019.10.138_bib14","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00417-011-1857-8","article-title":"Cone-rod dystrophy can be a manifestation of Danon disease","volume":"250","author":"Thiadens","year":"2012","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.bbrc.2019.10.138_bib15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/IAE.0000000000000736","article-title":"The physiology of the retinal pigment epithelium in Danon disease","volume":"36","author":"Thompson","year":"2016","journal-title":"Retina"},{"key":"10.1016\/j.bbrc.2019.10.138_bib16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.bbrc.2017.05.030","article-title":"LAMP-2 mediates oxidative stress-dependent cell death in Zn2+-treated lung epithelium cells","volume":"488","author":"Qin","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2019.10.138_bib17","article-title":"Small-vessel vasculopathy due to aberrant autophagy in LAMP-2 deficiency","volume":"8","author":"Nguyen","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2019.10.138_bib18","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4161\/auto.22971","article-title":"Upregulated autophagy protects cardiomyocytes from oxidative stress-induced toxicity","volume":"9","author":"Dutta","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2019.10.138_bib19","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.redox.2015.01.001","article-title":"Oxidative stress and autophagy: crucial modulators of kidney injury","volume":"4","author":"Sureshbabu","year":"2015","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrc.2019.10.138_bib20","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.4161\/auto.36184","article-title":"Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD","volume":"10","author":"Mitter","year":"2014","journal-title":"Autophagy"},{"key":"10.1016\/j.bbrc.2019.10.138_bib21","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.exer.2018.08.019","article-title":"Oxidative stress induces ferroptotic cell death in retinal pigment epithelial cells","volume":"181","author":"Totsuka","year":"2018","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbrc.2019.10.138_bib22","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1007\/s00726-014-1775-2","article-title":"Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis","volume":"47","author":"Carroll","year":"2015","journal-title":"Amino Acids"},{"key":"10.1016\/j.bbrc.2019.10.138_bib23","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1042\/BCJ20160822","article-title":"Amino acid homeostasis and signalling in mammalian cells and organisms","volume":"474","author":"Br\u00f6er","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2019.10.138_bib24","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1091\/mbc.e02-02-0114","article-title":"Role of LAMP-2 in lysosome biogenesis and autophagy","volume":"13","author":"Eskelinen","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.bbrc.2019.10.138_bib25","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1906643116","article-title":"Genetic LAMP2 deficiency accelerates the age-associated formation of basal laminar deposits in the retina","author":"Notomi","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"40","key":"10.1016\/j.bbrc.2019.10.138_bib26","doi-asserted-by":"crossref","first-page":"31505","DOI":"10.1074\/jbc.M002102200","article-title":"Age-related decline in chaperone-mediated autophagy","volume":"275","author":"Cuervo","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"issue":"9","key":"10.1016\/j.bbrc.2019.10.138_bib27","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nm.1851","article-title":"Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function","volume":"14","author":"Zhang","year":"2008","journal-title":"Nat. Med."}],"updated-by":[{"DOI":"10.1016\/j.bbrc.2024.149930","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000}}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19320467?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19320467?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:36:13Z","timestamp":1762094173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19320467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0006291X19320467"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.10.138","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.10.138","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}