{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T23:34:30Z","timestamp":1782862470025,"version":"3.54.5"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.bbrc.2019.11.040","type":"journal-article","created":{"date-parts":[[2019,11,12]],"date-time":"2019-11-12T20:35:02Z","timestamp":1573590902000},"page":"1042-1048","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["miR-145-5p attenuates hypertrophic scar via reducing Smad2\/Smad3 expression"],"prefix":"10.1016","volume":"521","author":[{"given":"Weichang","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingqiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.11.040_bib1","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.pmr.2011.02.002","article-title":"Hypertrophic scar","volume":"22","author":"Gabriel","year":"2011","journal-title":"Phys. Med. Rehabil. Clin. N. Am."},{"key":"10.1016\/j.bbrc.2019.11.040_bib2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00000372-200410000-00006","article-title":"Histopathological differential diagnosis of keloid and hypertrophic scar","volume":"26","author":"Lee","year":"2004","journal-title":"Am. J. Dermatopathol."},{"key":"10.1016\/j.bbrc.2019.11.040_bib3","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1067-1927.2005.130407.x","article-title":"Identification of fibrocytes in postburn hypertrophic scar","volume":"13","author":"Yang","year":"2005","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.bbrc.2019.11.040_bib4","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1046\/j.1524-475x.2000.00128.x","article-title":"Hypertrophic scar tissues and fibroblasts produce more transforming growth factor-beta1 mRNA and protein than normal skin and cells","volume":"8","author":"Wang","year":"2000","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.bbrc.2019.11.040_bib5","first-page":"105","article-title":"Morphological and immunochemical differences between keloid and hypertrophic scar","volume":"145","author":"Ehrlich","year":"1994","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2019.11.040_bib6","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/1523-1747.ep12371710","article-title":"Phenotypic differences in cytokine responsiveness of hypertrophic scar versus normal dermal fibroblasts","volume":"101","author":"Garner","year":"1993","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.bbrc.2019.11.040_bib7","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1111\/exd.12665","article-title":"Loureirin B inhibits fibroblast proliferation and extracellular matrix deposition in hypertrophic scar via TGF-beta\/Smad pathway","volume":"24","author":"Bai","year":"2015","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.bbrc.2019.11.040_bib8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1006\/cyto.1995.1025","article-title":"Immunolocalization of TGF-beta 1 in human hypertrophic scar and normal dermal tissues","volume":"7","author":"Ghahary","year":"1995","journal-title":"Cytokine"},{"key":"10.1016\/j.bbrc.2019.11.040_bib9","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1038\/jid.2014.169","article-title":"Mesenchymal stem cells prevent hypertrophic scar formation via inflammatory regulation when undergoing apoptosis","volume":"134","author":"Liu","year":"2014","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.bbrc.2019.11.040_bib10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00006534-196609000-00005","article-title":"The treatment of hypertrophic scar, keloid and scar contracture by triamcinolone acetonide","volume":"38","author":"Ketchum","year":"1966","journal-title":"Plast. Reconstr. Surg."},{"key":"10.1016\/j.bbrc.2019.11.040_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/(SICI)1096-9101(1997)21:1<7::AID-LSM2>3.0.CO;2-U","article-title":"Control of hypertrophic scar growth using selective photothermolysis","volume":"21","author":"Reiken","year":"1997","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.bbrc.2019.11.040_bib12","first-page":"27","article-title":"Recent advances in hypertrophic scar","volume":"33","author":"Zhang","year":"2018","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.bbrc.2019.11.040_bib13","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bbrc.2017.11.027","article-title":"LncRNA COL1A2-AS1 inhibits the scar fibroblasts proliferation via regulating miR-21\/Smad7 pathway","volume":"495","author":"Nong","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2019.11.040_bib14","first-page":"1931","article-title":"Extracorporeal shock wave therapy with low-energy flux density inhibits hypertrophic scar formation in an animal model","volume":"41","author":"Zhao","year":"2018","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbrc.2019.11.040_bib15","article-title":"MicroRNA-21 regulates hTERT via PTEN in hypertrophic scar fibroblasts","volume":"9","author":"Zhu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbrc.2019.11.040_bib16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.yexcr.2016.05.013","article-title":"Fibroproliferative effect of microRNA-21 in hypertrophic scar derived fibroblasts","volume":"345","author":"Li","year":"2016","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbrc.2019.11.040_bib17","doi-asserted-by":"crossref","first-page":"11831","DOI":"10.1038\/s41598-018-29840-6","article-title":"RNA-seq-based analysis of the hypertrophic scarring with and without pressure therapy in a Bama minipig model","volume":"8","author":"Liu","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2019.11.040_bib18","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/path.1539","article-title":"Gene expression profiles from hypertrophic scar fibroblasts before and after IL-6 stimulation","volume":"202","author":"Dasu","year":"2004","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.bbrc.2019.11.040_bib19","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2009.01.035","article-title":"Origins and Mechanisms of miRNAs and siRNAs","volume":"136","author":"Carthew","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2019.11.040_bib20","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1101\/gad.1399806","article-title":"Control of translation and mRNA degradation by miRNAs and siRNAs","volume":"20","author":"Valencia-Sanchez","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2019.11.040_bib21","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1093\/nar\/gki200","article-title":"Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis","volume":"33","author":"Cheng","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2019.11.040_bib22","doi-asserted-by":"crossref","first-page":"116779","DOI":"10.1016\/j.lfs.2019.116779","article-title":"MiR-152-3p regulates cell proliferation, invasion and extracellular matrix expression through by targeting FOXF1 in keloid fibroblasts","volume":"234","author":"Wang","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.bbrc.2019.11.040_bib23","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.18632\/aging.101965","article-title":"miR-495 inhibits the growth of fibroblasts in hypertrophic scars","volume":"11","author":"Guo","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bbrc.2019.11.040_bib24","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.omtn.2018.12.016","article-title":"Human novel MicroRNA seq-915_x4024 in keratinocytes contributes to skin regeneration by suppressing scar formation","volume":"14","author":"Zhao","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.bbrc.2019.11.040_bib25","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.bbrc.2018.05.049","article-title":"The lncRNA TUG1\/miR-145-5p\/FGF10 regulates proliferation and migration in VSMCs of hypertension","volume":"501","author":"Shi","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2019.11.040_bib26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.3109\/07357907.2015.1025407","article-title":"Overexpression of miR-145-5p inhibits proliferation of prostate cancer cells and reduces SOX2 expression","volume":"33","author":"Ozen","year":"2015","journal-title":"Canc. Invest."},{"key":"10.1016\/j.bbrc.2019.11.040_bib27","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1067-1927.2005.130407.x","article-title":"Identification of fibrocytes in postburn hypertrophic scar","volume":"13","author":"Yang","year":"2005","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.bbrc.2019.11.040_bib28","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/1523-1747.ep12343658","article-title":"Collagenase production is lower in post-burn hypertrophic scar fibroblasts than in normal fibroblasts and is reduced by insulin-like growth factor-1","volume":"106","author":"Ghahary","year":"1996","journal-title":"J.\u00a0Investig. Dermatol."},{"key":"10.1016\/j.bbrc.2019.11.040_bib29","first-page":"e114","article-title":"Computerized insulin infusion programs are safe and effective in the burn intensive care unit","volume":"33","author":"Lee","year":"2012","journal-title":"J.\u00a0Burn Care Res."},{"key":"10.1016\/j.bbrc.2019.11.040_bib30","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.burns.2010.04.013","article-title":"Use of procalcitonin for the detection of sepsis in the critically ill burn patient: a systematic review of the literature","volume":"37","author":"Mann","year":"2011","journal-title":"Burns"},{"key":"10.1016\/j.bbrc.2019.11.040_bib31","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nature07039","article-title":"Wound repair and regeneration","volume":"453","author":"Gurtner","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2019.11.040_bib32","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1172\/JCI93557","article-title":"Extracellular matrix as a driver of progressive fibrosis","volume":"128","author":"Herrera","year":"2018","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.bbrc.2019.11.040_bib33","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3009337","article-title":"Wound repair and regeneration: mechanisms, signaling, and translation","volume":"6","author":"Eming","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.bbrc.2019.11.040_bib34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.bbrc.2019.11.040_bib35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1172\/JCI93563","article-title":"Resolution of organ fibrosis","volume":"128","author":"Jun","year":"2018","journal-title":"J.\u00a0Clin. Investig."},{"key":"10.1016\/j.bbrc.2019.11.040_bib36","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/ncomms1734","article-title":"Activation of canonical Wnt signalling is required for TGF-beta-mediated fibrosis","volume":"3","author":"Akhmetshina","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2019.11.040_bib37","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0959-437X(98)80069-5","article-title":"SMADs: mediators and regulators of TGF-beta signaling","volume":"8","author":"Kretzschmar","year":"1998","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.bbrc.2019.11.040_bib38","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1002\/jcp.22448","article-title":"Role of Smad2\/3 and p38 MAP kinase in TGF-beta1-induced epithelial-mesenchymal transition of pulmonary epithelial cells","volume":"226","author":"Kolosova","year":"2011","journal-title":"J.\u00a0Cell. Physiol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19321606?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19321606?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:44:10Z","timestamp":1757763850000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19321606"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0006291X19321606"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.11.040","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"miR-145-5p attenuates hypertrophic scar via reducing Smad2\/Smad3 expression","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.11.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}