{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T03:42:52Z","timestamp":1790221372416,"version":"4.1.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010014","name":"Six Talent Peaks Project in Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010014","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670996"],"award-info":[{"award-number":["81670996"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2016-WSW-168"],"award-info":[{"award-number":["2016-WSW-168"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010227","name":"Medical Science and Technology Development Foundation, Nanjing Municipality Health Bureau","doi-asserted-by":"publisher","award":["QRX17025"],"award-info":[{"award-number":["QRX17025"]}],"id":[{"id":"10.13039\/501100010227","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.bbrc.2019.11.074","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T19:26:52Z","timestamp":1574191612000},"page":"184-190","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Porphyromonas gingivalis triggers inflammatory responses in periodontal ligament cells by succinate-succinate dehydrogenase\u2013HIF\u20131\u03b1 axis"],"prefix":"10.1016","volume":"522","author":[{"given":"Wenqi","family":"Su","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhe","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuhua","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houxuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.11.074_bib1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1177\/1753425912440598","article-title":"Regulatory role of periodontal ligament fibroblasts for innate immune cell function and differentiation","volume":"18","author":"Konermann","year":"2012","journal-title":"Innate Immun."},{"key":"10.1016\/j.bbrc.2019.11.074_bib2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.coi.2019.05.009","article-title":"Metabolic reprogramming: an innate cellular defence mechanism against intracellular bacteria","volume":"60","author":"Escoll","year":"2019","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.bbrc.2019.11.074_bib3","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/imm.12777","article-title":"Metabolic reprogramming in the tumour microenvironment: a hallmark shared by cancer cells and T lymphocytes","volume":"152","author":"Allison","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.bbrc.2019.11.074_bib4","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2018.07.030","article-title":"Krebs cycle reimagined: the emerging roles of succinate and itaconate as signal transducers","volume":"174","author":"Murphy","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2019.11.074_bib5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.cell.2016.08.064","article-title":"Succinate dehydrogenase supports metabolic repurposing of mitochondria to drive inflammatory macrophages","volume":"167","author":"Mills","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2019.11.074_bib6","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1161\/CIRCULATIONAHA.117.028069","article-title":"Metabolic and proliferative state of vascular adventitial fibroblasts in pulmonary hypertension is regulated through a MicroRNA-124\/PTBP1 (polypyrimidine tract binding protein 1)\/pyruvate kinase muscle Axis","volume":"136","author":"Zhang","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.bbrc.2019.11.074_bib7","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41385-018-0087-3","article-title":"Succinate receptor mediates intestinal inflammation and fibrosis","volume":"12","author":"Macias-Ceja","year":"2019","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.bbrc.2019.11.074_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2018.07.009","article-title":"Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF-1\u03b1\/VEGF axis","volume":"126","author":"Li","year":"2018","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2019.11.074_bib9","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.3389\/fimmu.2018.01552","article-title":"Nrf2 is a central regulator of metabolic reprogramming of myeloid-derived suppressor cells in steady state and sepsis","volume":"9","author":"Ohl","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbrc.2019.11.074_bib10","first-page":"972313","article-title":"Periodontal ligament stem cells: current status, concerns, and future prospects","volume":"2015","author":"Zhu","year":"2015","journal-title":"Stem Cell. Int."},{"key":"10.1016\/j.bbrc.2019.11.074_bib11","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1902\/jop.2012.120177","article-title":"Toll-like receptor 2 knockdown modulates interleukin (IL)-6 and IL-8 but not stromal derived factor-1 (SDF-1\/CXCL12) in human periodontal ligament and gingival fibroblasts","volume":"84","author":"Morandini","year":"2013","journal-title":"J.\u00a0Periodontol."},{"key":"10.1016\/j.bbrc.2019.11.074_bib12","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.archoralbio.2017.08.007","article-title":"Relatively low invasive capacity of Porphyromonas gingivalis strains into human gingival fibroblasts in\u00a0vitro","volume":"83","author":"Jang","year":"2017","journal-title":"Arch. Oral Biol."},{"key":"10.1016\/j.bbrc.2019.11.074_bib13","doi-asserted-by":"crossref","first-page":"16246","DOI":"10.1038\/nmicrobiol.2016.246","article-title":"Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes","volume":"2","author":"Lachmandas","year":"2016","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.bbrc.2019.11.074_bib14","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is a danger signal that induces IL-1\u03b2 via HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2019.11.074_bib15","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.cmet.2015.01.017","article-title":"Pyruvate kinase M2 regulates Hif-1\u03b1 activity and IL-1\u03b2 induction and is a critical determinant of the Warburg effect in LPS-activated macrophages","volume":"21","author":"Palsson-McDermott","year":"2015","journal-title":"Cell Metabol."},{"key":"10.1016\/j.bbrc.2019.11.074_bib16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.neuroscience.2018.09.041","article-title":"Inhibiting succinate dehydrogenase by dimethyl malonate alleviates brain damage in a rat model of cardiac arrest","volume":"393","author":"Xu","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbrc.2019.11.074_bib17","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cmet.2016.06.004","article-title":"Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation","volume":"24","author":"Lampropoulou","year":"2016","journal-title":"Cell Metabol."},{"key":"10.1016\/j.bbrc.2019.11.074_bib18","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1089\/scd.2015.0193","article-title":"Energy metabolism in mesenchymal stem cells during osteogenic differentiation","volume":"25","author":"Shum","year":"2016","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.bbrc.2019.11.074_bib19","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.redox.2018.10.007","article-title":"TMEM126B deficiency reduces mitochondrial SDH oxidation by LPS, attenuating HIF-1\u03b1 stabilization and IL-1\u03b2 expression","volume":"20","author":"Fuhrmann","year":"2019","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbrc.2019.11.074_bib20","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1021\/bi901627u","article-title":"Regulation of succinate dehydrogenase activity by SIRT3 in mammalian mitochondria","volume":"49","author":"Cimen","year":"2010","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2019.11.074_bib21","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s00244-011-9656-0","article-title":"Combined effect of N-acetyl cysteine, zinc, and selenium against chronic dimethylmercury-induced oxidative stress: a biochemical and histopathological approach","volume":"61","author":"Joshi","year":"2011","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.bbrc.2019.11.074_bib22","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.tibs.2017.01.003","article-title":"Mitochondrial complex II: at the crossroads","volume":"42","author":"Bezawork-Geleta","year":"2017","journal-title":"Trends Biochem. Sci."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19321941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19321941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T03:30:10Z","timestamp":1778643010000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19321941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0006291X19321941"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.11.074","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Porphyromonas gingivalis triggers inflammatory responses in periodontal ligament cells by succinate-succinate dehydrogenase\u2013HIF\u20131\u03b1 axis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.11.074","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}