{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T19:15:07Z","timestamp":1785784507433,"version":"3.56.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001368","name":"V Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001368","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011034","name":"Sidney Kimmel Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001784","name":"Pancreatic Cancer Action Network","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001784","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000043","name":"American Association for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000043","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.bbrc.2019.11.130","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T09:00:01Z","timestamp":1574931601000},"page":"633-638","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["A covalent small molecule inhibitor of glutamate-oxaloacetate transaminase 1 impairs pancreatic cancer growth"],"prefix":"10.1016","volume":"522","author":[{"given":"Tomohiro","family":"Yoshida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naofumi","family":"Taoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Tomimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiji","family":"Namatame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiko","family":"Yahata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadao","family":"Kuromitsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis C.","family":"Cantley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9309-6141","authenticated-orcid":false,"given":"Costas A.","family":"Lyssiotis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.11.130_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature12040","article-title":"Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway","volume":"496","author":"Son","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2019.11.130_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.canlet.2017.04.029","article-title":"GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells","volume":"400","author":"Abrego","year":"2017","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2019.11.130_bib3","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.18632\/oncotarget.2799","article-title":"GOT1\/AST1 expression status as a prognostic biomarker in pancreatic ductal adenocarcinoma","volume":"6","author":"Feld","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbrc.2019.11.130_bib4","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/s12885-018-4443-1","article-title":"Inhibition of glutamate oxaloacetate transaminase 1 in cancer cell lines results in altered metabolism with increased dependency of glucose","volume":"18","author":"Zhou","year":"2018","journal-title":"BMC Canc."},{"key":"10.1016\/j.bbrc.2019.11.130_bib5","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1053\/j.gastro.2016.07.011","article-title":"SLC25A22 promotes proliferation and survival of colorectal cancer cells with KRAS mutations and xenograft tumor progression in mice via intracellular synthesis of aspartate","volume":"151","author":"Wong","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2019.11.130_bib6","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1016\/j.bmcl.2018.04.061","article-title":"Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma","volume":"28","author":"Anglin","year":"2018","journal-title":"Bioorg. Med. Chem. Lett"},{"key":"10.1016\/j.bbrc.2019.11.130_bib7","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.1021\/acs.biochem.8b00914","article-title":"Biochemical characterization and structure-based mutational analysis provide insight into the binding and mechanism of action of novel aspartate aminotransferase inhibitors","volume":"57","author":"Holt","year":"2018","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2019.11.130_bib8","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12964-019-0425-4","article-title":"A\u00a0natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism","volume":"17","author":"Sun","year":"2019","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.bbrc.2019.11.130_bib9","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1517\/14656560903451690","article-title":"Vigabatrin: a comprehensive review of drug properties including clinical updates following recent FDA approval","volume":"18","author":"Tolman","year":"2009","journal-title":"Expert\u00a0Opin. Pharmacother."},{"key":"10.1016\/j.bbrc.2019.11.130_bib10","doi-asserted-by":"crossref","first-page":"6762","DOI":"10.1021\/ja00437a090","article-title":"The irreversible inhibition of mouse brain gammma-aminobutyric acid (GABA)-a-Ketoglutaric acid transaminase by gabaculine","volume":"98","author":"Rando","year":"1976","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.bbrc.2019.11.130_bib11","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0968-0004(83)90352-3","article-title":"Suicide substrates: mechanism-based enzyme inactivators with therapeutic potential","volume":"8","author":"Walsh","year":"1983","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbrc.2019.11.130_bib12","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1213\/01.ane.0000261519.04083.3e","article-title":"Increased gamma-aminobutyric acid levels in mouse brain induce loss of righting reflex, but not immobility, in response to noxious stimulation","volume":"104","author":"Katayama","year":"2007","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.bbrc.2019.11.130_bib13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1021\/ml200204m","article-title":"Discovery of brain-penetrant, irreversible kynurenine aminotransferase II inhibitors for schizophrenia","volume":"3","author":"Dounay","year":"2012","journal-title":"ACS Med. Chem. Lett."},{"key":"10.1016\/j.bbrc.2019.11.130_bib14","doi-asserted-by":"crossref","first-page":"5684","DOI":"10.1021\/jm100464k","article-title":"Crystal structure-based selective targeting of the pyridoxal 5\u2019-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement","volume":"53","author":"Rossi","year":"2010","journal-title":"J.\u00a0Med. Chem."},{"key":"10.1016\/j.bbrc.2019.11.130_bib15","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1471-4159.2009.05893.x","article-title":"On the relationship between the two branches of the kynurenine pathway in the rat brain in\u00a0vivo","volume":"109","author":"Amori","year":"2009","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.bbrc.2019.11.130_bib16","series-title":"Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists","isbn-type":"print","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/9781118540398","author":"Copeland","year":"2013","ISBN":"https:\/\/id.crossref.org\/isbn\/9781118488133"},{"key":"10.1016\/j.bbrc.2019.11.130_bib17","series-title":"Enzymes: Irreversible Inhibition","author":"McDonald","year":"2012"},{"key":"10.1016\/j.bbrc.2019.11.130_bib18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1039\/C2MD20166F","article-title":"Discovery of hydroxamate bioisosteres as KAT II inhibitors with improved oral bioavailability and pharmacokinetics","volume":"4","author":"Henderson","year":"2013","journal-title":"Med. Chem. Commun."},{"key":"10.1016\/j.bbrc.2019.11.130_bib19","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/S1096-7192(02)00037-9","article-title":"Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT)","volume":"76","author":"Goh","year":"2002","journal-title":"Mol. Genet. Metab."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19322582?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19322582?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:46:17Z","timestamp":1757763977000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19322582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S0006291X19322582"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.11.130","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A covalent small molecule inhibitor of glutamate-oxaloacetate transaminase 1 impairs pancreatic cancer growth","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.11.130","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}