{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:54:20Z","timestamp":1790319260525,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["16-15-10192"],"award-info":[{"award-number":["16-15-10192"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.bbrc.2019.12.007","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T21:51:13Z","timestamp":1575669073000},"page":"1046-1051","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Ethanol inhibition of NMDA receptors in calcium-dependent and \u2013independent modes"],"prefix":"10.1016","volume":"522","author":[{"given":"Sergei I.","family":"Boikov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry A.","family":"Sibarov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0644-9330","authenticated-orcid":false,"given":"Sergei M.","family":"Antonov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2019.12.007_bib1","doi-asserted-by":"crossref","first-page":"44729","DOI":"10.1074\/jbc.M102800200","article-title":"Ethanol inhibition of N-methyl-D-aspartate receptors is reduced by site-directed mutagenesis of a transmembrane domain phenylalanine residue","volume":"276","author":"Ronald","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2019.12.007_bib2","doi-asserted-by":"crossref","first-page":"27302","DOI":"10.1074\/jbc.M111.338921","article-title":"Interactions among positions in the third and fourth membrane-associated domains at the intersubunit interface of the N-Methyl-D-aspartate receptor forming sites of alcohol action","volume":"287","author":"Ren","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2019.12.007_bib3","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1124\/mol.113.085993","article-title":"A\u00a0novel alcohol-sensitive position in the N-methyl-D-aspartate receptor GluN2A subunit M3 domain regulates agonist affinity and ion channel gating","volume":"84","author":"Ren","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.12.007_bib4","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neuropharm.2016.11.013","article-title":"Two adjacent phenylalanines in the NMDA receptor GluN2A subunit M3 domain interactively regulate alcohol sensitivity and ion channel gating","volume":"114","author":"Ren","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbrc.2019.12.007_bib5","doi-asserted-by":"crossref","first-page":"1950","DOI":"10.1111\/bph.13487","article-title":"Intersubunit interactions at putative sites of ethanol action in the M3 and M4 domains of the NMDA receptor GluN1 and GluN2B subunits","volume":"173","author":"Zhao","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbrc.2019.12.007_bib6","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0006-8993(96)00780-9","article-title":"Single-channel and whole-cell analysis of ethanol inhibition of NMDA-activated currents in cultured mouse cortical and hippocampal neurons","volume":"738","author":"Wright","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.bbrc.2019.12.007_bib7","doi-asserted-by":"crossref","first-page":"15019","DOI":"10.1074\/jbc.275.20.15019","article-title":"Reduced ethanol inhibition of N-methyl-D-aspartate receptors by deletion of the NR1 C0 domain or overexpression-of \u03b1-actinin-2 proteins","volume":"275","author":"Anders","year":"2000","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2019.12.007_bib8","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1046\/j.1471-4159.1998.71031095.x","article-title":"Intracellular calcium enhances the ethanol sensitivity of NMDA receptors through an interaction with the C0 domain of the NR1 subunit","volume":"71","author":"Mirshahi","year":"2002","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.bbrc.2019.12.007_bib9","doi-asserted-by":"crossref","first-page":"8831","DOI":"10.1523\/JNEUROSCI.0901-19.2019","article-title":"Spatial coupling tunes NMDA receptor responses via Ca2+ diffusion","volume":"39","author":"Iacobucci","year":"2019","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbrc.2019.12.007_bib10","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.ceca.2014.06.002","article-title":"Caveolin-rich lipid rafts of the plasma membrane of mature cerebellar granule neurons are microcompartments for calcium\/reactive oxygen and nitrogen species cross-talk signaling","volume":"56","author":"Marques-da-Silva","year":"2014","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbrc.2019.12.007_bib11","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1124\/jpet.115.227173","article-title":"Inhibition of plasma membrane Na\/Ca-exchanger by KB-R7943 or lithium reveals its role in Ca-dependent N-methyl-D-aspartate receptor inactivation","volume":"355","author":"Sibarov","year":"2015","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbrc.2019.12.007_bib12","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12868-018-0475-3","article-title":"Downregulation of calcium-dependent NMDA receptor desensitization by sodium-calcium exchangers: a role of membrane cholesterol","volume":"19","author":"Sibarov","year":"2018","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bbrc.2019.12.007_bib13","first-page":"1","article-title":"Ca2+-dependent inactivation of GluN2A and GluN2B NMDA receptors occurs by a common kinetic mechanism","author":"Iacobucci","year":"2019","journal-title":"Biophys. J."},{"key":"10.1016\/j.bbrc.2019.12.007_bib14","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1113\/jphysiol.2014.288209","article-title":"Cholesterol modulates open probability and desensitization of NMDA receptors","volume":"593","author":"Korinek","year":"2015","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.bbrc.2019.12.007_bib15","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0022-3565(25)10532-6","article-title":"Developmental decrease in ethanol inhibition of N-methyl-D-aspartate receptors in rat neocortical neurons: relation to the actions of ifenprodil","volume":"274","author":"Lovinger","year":"1995","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbrc.2019.12.007_bib16","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.bbrc.2018.10.140","article-title":"High sensitivity of cerebellar neurons to homocysteine is determined by expression of GluN2C and GluN2D subunits of NMDA receptors","volume":"506","author":"Sibarov","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2019.12.007_bib17","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/368144a0","article-title":"Changing subunit composition of heteromeric NMDA receptors during development of rat cortex","volume":"368","author":"Sheng","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2019.12.007_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneumeth.2007.02.010","article-title":"A\u00a0fluorescence vital assay for the recognition and quantification of excitotoxic cell death by necrosis and apoptosis using confocal microscopy on neurons in culture","volume":"163","author":"Mironova","year":"2007","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.bbrc.2019.12.007_bib19","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1007\/s002100000262","article-title":"Mechanism of inhibition by ethanol of NMDA and AMPA receptor channel functions in cultured rat cortical neurons","volume":"362","author":"Wirkner","year":"2000","journal-title":"Naunyn-Schmiedebergs Arch. Pharmakol."},{"key":"10.1016\/j.bbrc.2019.12.007_bib20","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1152\/jn.1994.72.2.754","article-title":"Regulation of glycine-insensitive desensitization of the NMDA receptor in outside-out patches","volume":"72","author":"Tong","year":"1994","journal-title":"J.\u00a0Neurophysiol."},{"key":"10.1016\/j.bbrc.2019.12.007_bib21","first-page":"1173","article-title":"Calcium dependent desensitization of NMDA receptors","volume":"83","author":"Sibarov","year":"2018","journal-title":"Biochem."},{"key":"10.1016\/j.bbrc.2019.12.007_bib22","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1016\/S0028-3908(00)00067-8","article-title":"Alcohols inhibit N-methyl-D-aspartate receptors via a site exposed to the extracellular environment","volume":"39","author":"Peoples","year":"2000","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbrc.2019.12.007_bib23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0741-8329(85)90029-1","article-title":"Differential effects of ethanol on two synaptic membrane Ca2+ transport systems","volume":"2","author":"Michaelis","year":"1985","journal-title":"Alcohol"},{"key":"10.1016\/j.bbrc.2019.12.007_bib24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0014-5793(98)00758-3","article-title":"Role of Na+\/Ca2+ exchange in regulation of neuronal Ca2+ homeostasis requires re-evaluation","volume":"431","author":"Storozhevykh","year":"1998","journal-title":"FEBS Lett."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19323277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X19323277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:44:53Z","timestamp":1757763893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X19323277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S0006291X19323277"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.12.007","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ethanol inhibition of NMDA receptors in calcium-dependent and \u2013independent modes","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2019.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}