{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T18:53:28Z","timestamp":1758048808984,"version":"3.44.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003481","name":"Hebei Normal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003481","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.bbrc.2020.01.155","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T07:52:29Z","timestamp":1580889149000},"page":"736-743","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Deferasirox protects against hydrogen peroxide-induced cell apoptosis by inhibiting ubiquitination and degradation of p21WAF1\/CIP1"],"prefix":"10.1016","volume":"524","author":[{"given":"Junhua","family":"Miao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhuan","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianyuan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengxiu","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianglin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanzhong","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4097-1007","authenticated-orcid":false,"given":"Habelhah","family":"Hasem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0781-6681","authenticated-orcid":false,"given":"Ke","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.01.155_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molcel.2007.03.016","article-title":"Hydrogen peroxide sensing and signaling","volume":"26","author":"Veal","year":"2007","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2020.01.155_bib2","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1016\/j.bcp.2008.11.009","article-title":"Reactive oxygen species: destroyers or messengers?","volume":"77","author":"Bartosz","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbrc.2020.01.155_bib3","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.chemosphere.2017.05.039","article-title":"Hydroxyl radical yields in the Fenton process under various pH, ligand concentrations and hydrogen peroxide\/Fe(II) ratios","volume":"182","author":"Fischbacher","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.bbrc.2020.01.155_bib4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/j.taap.2013.09.031","article-title":"Toxicological and pharmacological concerns on oxidative stress and related diseases","volume":"273","author":"Saeidnia","year":"2013","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbrc.2020.01.155_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/2008-2231-20-61","article-title":"Is it right to look for anti-cancer drugs amongst compounds having antioxidant effect?","volume":"20","author":"Abdollahi","year":"2012","journal-title":"Daru"},{"key":"10.1016\/j.bbrc.2020.01.155_bib6","first-page":"179","article-title":"Human ovarian tissue vitrification\/warming has minor effect on the expression of apoptosis-related genes","volume":"17","author":"Abdollahi","year":"2013","journal-title":"Iran. Biomed. J."},{"key":"10.1016\/j.bbrc.2020.01.155_bib7","doi-asserted-by":"crossref","first-page":"3749157","DOI":"10.1155\/2017\/3749157","article-title":"Lysosomes as oxidative targets for cancer therapy","volume":"2017","author":"Dielschneider","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.bbrc.2020.01.155_bib8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1136\/bjo.2006.107037","article-title":"Inhibition of nuclear factor-kappa B activation attenuates hydrogen peroxide-induced cytotoxicity in human lens epithelial cells","volume":"91","author":"Jin","year":"2007","journal-title":"Br. J. Ophthalmol."},{"key":"10.1016\/j.bbrc.2020.01.155_bib9","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.freeradbiomed.2011.05.004","article-title":"Reactive oxygen species in cardiovascular disease","volume":"51","author":"Sugamura","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2020.01.155_bib10","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1177\/0192623309356453","article-title":"Oxidative stress and oxidative damage in carcinogenesis","volume":"38","author":"Klaunig","year":"2010","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.bbrc.2020.01.155_bib11","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1172\/JCI200318182","article-title":"Oxidative stress, cell cycle, and neurodegeneration","volume":"111","author":"Klein","year":"2003","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2020.01.155_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.freeradbiomed.2013.12.006","article-title":"Role of intracellular labile iron, ferritin, and antioxidant defence in resistance of chronically adapted Jurkat T cells to hydrogen peroxide","volume":"68","author":"Al-Qenaei","year":"2014","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2020.01.155_bib13","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S0891-5849(01)00608-6","article-title":"Intracellular iron, but not copper, plays a critical role in hydrogen peroxide-induced DNA damage","volume":"31","author":"Barbouti","year":"2001","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2020.01.155_bib14","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1007\/s00277-015-2476-y","article-title":"The long-term efficacy and tolerability of oral deferasirox for patients with transfusion-dependent beta-thalassemia in Taiwan","volume":"94","author":"Chang","year":"2015","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.bbrc.2020.01.155_bib15","doi-asserted-by":"crossref","first-page":"381","DOI":"10.12998\/wjcc.v5.i10.381","article-title":"Juvenile hemochromatosis: HAMP mutation and severe iron overload treated with phlebotomies and deferasirox","volume":"5","author":"Lescano","year":"2017","journal-title":"World J. Clin. Cases"},{"key":"10.1016\/j.bbrc.2020.01.155_bib16","first-page":"CD007476","article-title":"Deferasirox for managing iron overload in people with thalassaemia","volume":"8","author":"Bollig","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bbrc.2020.01.155_bib17","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1186\/s12885-016-2744-9","article-title":"Deferasirox, a novel oral iron chelator, shows antiproliferative activity against pancreatic cancer in\u00a0vitro and in\u00a0vivo","volume":"16","author":"Harima","year":"2016","journal-title":"BMC Canc."},{"key":"10.1016\/j.bbrc.2020.01.155_bib18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12957-016-0829-1","article-title":"The potential of deferasirox as a novel therapeutic modality in gastric cancer","volume":"14","author":"Choi","year":"2016","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.bbrc.2020.01.155_bib19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.molmed.2017.02.001","article-title":"p21: a two-faced genome guardian","volume":"23","author":"Georgakilas","year":"2017","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbrc.2020.01.155_bib20","doi-asserted-by":"crossref","first-page":"11254","DOI":"10.1158\/0008-5472.CAN-06-1569","article-title":"p21 blocks irradiation-induced apoptosis downstream of mitochondria by inhibition of cyclin-dependent kinase-mediated caspase-9 activation","volume":"66","author":"Sohn","year":"2006","journal-title":"Canc. Res."},{"key":"10.1016\/j.bbrc.2020.01.155_bib21","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/emboj\/18.5.1223","article-title":"Apoptosis inhibitory activity of cytoplasmic p21(Cip1\/WAF1) in monocytic differentiation","volume":"18","author":"Asada","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2020.01.155_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fct.2015.12.004","article-title":"P21(Waf1\/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation","volume":"88","author":"Deng","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrc.2020.01.155_bib23","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbrc.2007.04.120","article-title":"Cytoplasmic localization and ubiquitination of p21(Cip1) by reactive oxygen species","volume":"358","author":"Hwang","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2020.01.155_bib24","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00204-017-2070-2","article-title":"P21(Waf1\/Cip1) depletion promotes dexamethasone-induced apoptosis in osteoblastic MC3T3-E1 cells by inhibiting the Nrf2\/HO-1 pathway","volume":"92","author":"Han","year":"2018","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bbrc.2020.01.155_bib25","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1016\/j.bbamcr.2014.06.015","article-title":"The effect of anti-inflammatory properties of ferritin light chain on lipopolysaccharide-induced inflammatory response in murine macrophages","volume":"1843","author":"Fan","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2020.01.155_bib26","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1021\/tx100125t","article-title":"Comparison of clinically used and experimental iron chelators for protection against oxidative stress-induced cellular injury","volume":"23","author":"Bendova","year":"2010","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bbrc.2020.01.155_bib27","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/j.freeradbiomed.2012.06.006","article-title":"Improvement of iron-mediated oxidative DNA damage in patients with transfusion-dependent myelodysplastic syndrome by treatment with deferasirox","volume":"53","author":"Kikuchi","year":"2012","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2020.01.155_bib28","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.freeradbiomed.2015.05.025","article-title":"Role of extracellular Hydrogen peroxide in regulation of iron homeostasis genes in neuronal cells: implication in iron accumulation","volume":"86","author":"Dev","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2020.01.155_bib29","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1007\/s10495-013-0835-5","article-title":"Reactive oxygen species-mediated activation of the Akt\/ASK1\/p38 signaling cascade and p21(Cip1) downregulation are required for shikonin-induced apoptosis","volume":"18","author":"Ahn","year":"2013","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbrc.2020.01.155_bib30","doi-asserted-by":"crossref","first-page":"3530","DOI":"10.1128\/MCB.00086-06","article-title":"Negative regulation of ASK1 by p21Cip1 involves a small domain that includes Serine 98 that is phosphorylated by ASK1 in\u00a0vivo","volume":"27","author":"Zhan","year":"2007","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2020.01.155_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fct.2015.12.004","article-title":"P21(Waf1\/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation","volume":"88","author":"Deng","year":"2016","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrc.2020.01.155_bib32","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1038\/sj.onc.1202409","article-title":"Caspase 3 inactivation to suppress Fas-mediated apoptosis: identification of binding domain with p21 and ILP and inactivation machinery by p21","volume":"18","author":"Suzuki","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2020.01.155_bib33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.metabol.2018.01.005","article-title":"Iron-induced oxidative stress stimulates osteoclast differentiation via NF-kappaB signaling pathway in mouse model","volume":"83","author":"Xiao","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.bbrc.2020.01.155_bib34","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1039\/C7MT00116A","article-title":"The elemental role of iron in DNA synthesis and repair","volume":"9","author":"Puig","year":"2017","journal-title":"Metallomics"},{"key":"10.1016\/j.bbrc.2020.01.155_bib35","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.freeradbiomed.2016.07.002","article-title":"Intracellular labile iron determines H2O2-induced apoptotic signaling via sustained activation of ASK1\/JNK-p38 axis","volume":"97","author":"Mantzaris","year":"2016","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2020.01.155_bib36","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.redox.2016.10.006","article-title":"Hydroxytyrosol inhibits hydrogen peroxide-induced apoptotic signaling via labile iron chelation","volume":"10","author":"Kitsati","year":"2016","journal-title":"Redox Biol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20302400?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20302400?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:47:20Z","timestamp":1757764040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20302400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S0006291X20302400"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.01.155","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Deferasirox protects against hydrogen peroxide-induced cell apoptosis by inhibiting ubiquitination and degradation of p21WAF1\/CIP1","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.01.155","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}