{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T21:00:50Z","timestamp":1758402050700,"version":"3.44.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["2014R1A1A2056066"],"award-info":[{"award-number":["2014R1A1A2056066"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.bbrc.2020.02.046","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T16:36:32Z","timestamp":1583166992000},"page":"675-680","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["MLL2 regulates glucocorticoid receptor-mediated transcription of ENAC\u03b1 in human retinal pigment epithelial cells"],"prefix":"10.1016","volume":"525","author":[{"given":"Liu","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingli","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nahyun","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2258-8354","authenticated-orcid":false,"given":"Kwang Won","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.02.046_bib1","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.3283939","article-title":"The steroid and thyroid hormone receptor superfamily","volume":"240","author":"Evans","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2020.02.046_bib2","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1074\/jbc.274.3.1432","article-title":"Nucleocytoplasmic trafficking of steroid-free glucocorticoid receptor","volume":"274","author":"Hach\u00e9","year":"1999","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.02.046_bib3","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bbaexp.2004.09.004","article-title":"Mechanisms of glucocorticoid signalling","volume":"1680","author":"Schoneveld","year":"2004","journal-title":"Biochim. Biophys. Acta Gene Struct. Expr."},{"key":"10.1016\/j.bbrc.2020.02.046_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jsbmb.2010.03.058","article-title":"The role of the glucocorticoid receptor in inflammation and immunity","volume":"120","author":"Baschant","year":"2010","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bbrc.2020.02.046_bib5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jsbmb.2010.02.010","article-title":"Role of glucocorticoids and the glucocorticoid receptor in metabolism: insights from genetic manipulations","volume":"122","author":"Rose","year":"2010","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.bbrc.2020.02.046_bib6","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1002\/j.1460-2075.1992.tb05425.x","article-title":"Cell cycle regulation of glucocorticoid receptor function","volume":"11","author":"Hsu","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2020.02.046_bib7","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1210\/me.2002-0154","article-title":"Attenuation of glucocorticoid signaling through targeted degradation of p300 via the 26S proteasome pathway","volume":"16","author":"Li","year":"2002","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bbrc.2020.02.046_bib8","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood-2007-01-070755","article-title":"ATF2 impairs glucocorticoid receptor\u2013mediated transactivation in human CD8+ T cells","volume":"110","author":"Li","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2020.02.046_bib9","doi-asserted-by":"crossref","first-page":"19673","DOI":"10.1073\/pnas.1211803109","article-title":"G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes","volume":"109","author":"Bittencourt","year":"2012","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.bbrc.2020.02.046_bib10","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.15252\/embr.201744060","article-title":"A\u00a0post-translational modification switch controls coactivator function of histone methyltransferases G9a and GLP","volume":"18","author":"Poulard","year":"2017","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbrc.2020.02.046_bib11","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/S0960-9822(01)00600-5","article-title":"Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter","volume":"11","author":"Ma","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2020.02.046_bib12","doi-asserted-by":"crossref","first-page":"8931","DOI":"10.1074\/jbc.M113.540906","article-title":"The methyltransferase WBSCR22\/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer","volume":"289","author":"Jangani","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.02.046_bib13","doi-asserted-by":"crossref","first-page":"20185","DOI":"10.1073\/pnas.0810863105","article-title":"GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression","volume":"105","author":"Chinenov","year":"2008","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.bbrc.2020.02.046_bib14","doi-asserted-by":"crossref","first-page":"3483","DOI":"10.2741\/3466","article-title":"MLL histone methylases in gene expression, hormone signaling and cell cycle","volume":"14","author":"Ansari","year":"2009","journal-title":"Front. Biosci."},{"year":"2006","series-title":"MLL Core Components Give the Green Light to Histone Methylation","author":"Crawford","key":"10.1016\/j.bbrc.2020.02.046_bib15"},{"key":"10.1016\/j.bbrc.2020.02.046_bib16","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ceb.2008.03.019","article-title":"Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation","volume":"20","author":"Shilatifard","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbrc.2020.02.046_bib17","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1111\/j.1742-4658.2010.07606.x","article-title":"Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing","volume":"277","author":"Ansari","year":"2010","journal-title":"FEBS J."},{"key":"10.1016\/j.bbrc.2020.02.046_bib18","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1242\/dev.076687","article-title":"Histone recognition and nuclear receptor co-activator functions of Drosophila Cara Mitad, a homolog of the N-terminal portion of mammalian MLL2 and MLL3","volume":"139","author":"Chauhan","year":"2012","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2020.02.046_bib19","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/nrg2218","article-title":"Histone lysine demethylases: emerging roles in development, physiology and disease","volume":"8","author":"Shi","year":"2007","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbrc.2020.02.046_bib20","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.jmb.2011.05.050","article-title":"HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment","volume":"411","author":"Ansari","year":"2011","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.bbrc.2020.02.046_bib21","doi-asserted-by":"crossref","first-page":"15714","DOI":"10.1074\/jbc.M513245200","article-title":"Identification of the MLL2 complex as a coactivator for estrogen receptor \u03b1","volume":"281","author":"Mo","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.02.046_bib22","doi-asserted-by":"crossref","first-page":"17603","DOI":"10.1073\/pnas.1208807109","article-title":"Global identification of MLL2-targeted loci reveals MLL2\u2019s role in diverse signaling pathways","volume":"109","author":"Guo","year":"2012","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"key":"10.1016\/j.bbrc.2020.02.046_bib23","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1093\/nar\/gkt106","article-title":"The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover","volume":"41","author":"Coffey","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2020.02.046_bib24","doi-asserted-by":"crossref","first-page":"399","DOI":"10.4161\/cbt.24426","article-title":"Uncovering the genetic landscape driving castration-resistant prostate cancer","volume":"14","author":"Martin","year":"2013","journal-title":"Canc. Biol. Ther."},{"key":"10.1016\/j.bbrc.2020.02.046_bib25","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/ng.759","article-title":"Chromatin accessibility pre-determines glucocorticoid receptor binding patterns","volume":"43","author":"John","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2020.02.046_bib26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.molcel.2011.06.016","article-title":"Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding","volume":"43","author":"Biddie","year":"2011","journal-title":"Mol. Cell"},{"issue":"1","key":"10.1016\/j.bbrc.2020.02.046_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1507\/endocrj.EJ18-0343","article-title":"Flightless-I mediates the repression of estrogen receptor \u03b1 target gene expression by the glucocorticoid receptor in MCF-7 cells","volume":"66","author":"Yang","year":"2019","journal-title":"Endocr. J."},{"key":"10.1016\/j.bbrc.2020.02.046_bib28","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.bbrc.2014.03.011","article-title":"Flightless I (Drosophila) homolog facilitates chromatin accessibility of the estrogen receptor \u03b1 target genes in MCF-7 breast cancer cells","volume":"446","author":"Jeong","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2020.02.046_bib29","doi-asserted-by":"crossref","first-page":"2871","DOI":"10.1002\/ijc.31853","article-title":"Aberrant expression of SETD1A promotes survival and migration of estrogen receptor \u03b1-positive breast cancer cells","volume":"143","author":"Jin","year":"2018","journal-title":"Int. J. Canc."},{"key":"10.1016\/j.bbrc.2020.02.046_bib30","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s11033-017-4106-3","article-title":"Flightless-I homolog regulates glucocorticoid receptor-mediated transcription via direct interaction of the leucine-rich repeat domain","volume":"44","author":"Jin","year":"2017","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bbrc.2020.02.046_bib31","first-page":"2017","article-title":"Crosstalk between aryl hydrocarbon receptor and glucocorticoid receptor in human retinal pigment epithelial cells","author":"Jin","year":"2017","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.bbrc.2020.02.046_bib32","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1101\/gad.14.2.121","article-title":"The coregulator exchange in transcriptional functions of nuclear receptors","volume":"14","author":"Glass","year":"2000","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2020.02.046_bib33","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1101\/gr.097022.109","article-title":"Genomic determination of the glucocorticoid response reveals unexpected mechanisms of gene regulation","volume":"19","author":"Reddy","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.bbrc.2020.02.046_bib34","first-page":"209","article-title":"Chromatin remodeling in eukaryotes","volume":"1","author":"Phillips","year":"2008","journal-title":"Nat. Educ."},{"key":"10.1016\/j.bbrc.2020.02.046_bib35","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1046\/j.1432-1033.2002.02890.x","article-title":"Chromatin assembly","volume":"269","author":"Tyler","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.bbrc.2020.02.046_bib36","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1093\/nar\/gkt1236","article-title":"Establishment of active chromatin structure at enhancer elements by mixed-lineage leukemia 1 to initiate estrogen-dependent gene expression","volume":"42","author":"Jeong","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2020.02.046_bib37","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.tibs.2005.01.001","article-title":"Expanding functional diversity of the coactivators","volume":"30","author":"Lonard","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbrc.2020.02.046_bib38","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.molcel.2011.06.016","article-title":"Transcription factor AP1 potentiates chromatin accessibility and glucocorticoid receptor binding","volume":"43","author":"Biddie","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2020.02.046_bib39","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1089\/ars.2013.5240","article-title":"Role of unfolded protein response dysregulation in oxidative injury of retinal pigment epithelial cells","volume":"20","author":"Chen","year":"2014","journal-title":"Antioxidants Redox Signal."},{"key":"10.1016\/j.bbrc.2020.02.046_bib40","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1210\/me.2010-0392","article-title":"Research resource: nuclear receptor atlas of human retinal pigment epithelial cells: potential relevance to age-related macular degeneration","volume":"25","author":"Dwyer","year":"2011","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bbrc.2020.02.046_bib41","doi-asserted-by":"crossref","first-page":"257","DOI":"10.3109\/02713689408995786","article-title":"Dexamethasone induced proliferation of cultured retinal pigment epithelial cells","volume":"13","author":"He","year":"1994","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.bbrc.2020.02.046_bib42","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1089\/jop.2008.0090","article-title":"Fluocinolone inhibits VEGF expression via glucocorticoid receptor in human retinal pigment epithelial (ARPE-19) cells and TNF-\u03b1\u2013induced angiogenesis in chick chorioallantoic membrane (CAM)","volume":"25","author":"Ayalasomayajula","year":"2009","journal-title":"J.\u00a0Ocul. Pharmacol. Therapeut."},{"key":"10.1016\/j.bbrc.2020.02.046_bib43","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2174\/138945011794182746","article-title":"Clinical evidence of intravitreal triamcinolone acetonide in the management of age-related macular degeneration","volume":"12","author":"Becerra","year":"2011","journal-title":"Curr. Drug Targets"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20303144?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20303144?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:47:54Z","timestamp":1757764074000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20303144"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0006291X20303144"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.02.046","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MLL2 regulates glucocorticoid receptor-mediated transcription of ENAC\u03b1 in human retinal pigment epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.02.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}