{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T05:07:30Z","timestamp":1782536850213,"version":"3.54.5"},"reference-count":24,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H0297800"],"award-info":[{"award-number":["18H0297800"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K11388"],"award-info":[{"award-number":["15K11388"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.bbrc.2020.03.028","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T02:57:04Z","timestamp":1583981824000},"page":"889-894","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Optineurin regulates osteoblastogenesis through STAT1"],"prefix":"10.1016","volume":"525","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2142-1667","authenticated-orcid":false,"given":"Noriyoshi","family":"Mizuno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7345-7480","authenticated-orcid":false,"given":"Tomoyuki","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4909-5787","authenticated-orcid":false,"given":"Ryosuke","family":"Ohsawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhisa","family":"Ouhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4281-3216","authenticated-orcid":false,"given":"Shinji","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6652-0007","authenticated-orcid":false,"given":"Mikihito","family":"Kajiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kodai","family":"Kume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8620-0761","authenticated-orcid":false,"given":"Yui","family":"Tada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5190-3547","authenticated-orcid":false,"given":"Hiroyuki","family":"Morino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Yoshimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuyoshi","family":"Ueki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keichiro","family":"Mihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Sotomaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiro","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syuichi","family":"Munenaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Shiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1405-0901","authenticated-orcid":false,"given":"Hideshi","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Kurihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.03.028_bib1","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1126\/science.1066901","article-title":"Adult-onset primary open-angle glaucoma caused by mutations in optineurin","volume":"295","author":"Rezaie","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2020.03.028_bib2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nature08971","article-title":"Mutations of optineurin in amyotrophic lateral sclerosis","volume":"465","author":"Maruyama","year":"2010","journal-title":"Nature"},{"issue":"13","key":"10.1016\/j.bbrc.2020.03.028_bib3","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1093\/hmg\/ddq146","article-title":"Overexpression of optineurin E50K disrupts Rab8 interaction and leads to a progressive retinal degeneration in mice","volume":"19","author":"Chi","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2020.03.028_bib4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1083\/jcb.200501162","article-title":"Optineurin links myosin VI to the Golgi complex and is involved in Golgi organization and exocytosis","volume":"169","author":"Sahlender","year":"2005","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.bbrc.2020.03.028_bib5","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.cub.2007.07.041","article-title":"Optineurin negatively regulates TNFalpha- induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP","volume":"17","author":"Zhu","year":"2007","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2020.03.028_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/B978-0-12-394305-7.00005-7","article-title":"Cellular and molecular biology of optineurin","volume":"294","author":"Ying","year":"2012","journal-title":"Int Rev Cell Mol Biol"},{"key":"10.1016\/j.bbrc.2020.03.028_bib7","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/jnc.12326","article-title":"Optineurin suppression causes neuronal cell death via NF-\u03baB pathway","volume":"126","author":"Akizuki","year":"2013","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.bbrc.2020.03.028_bib8","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00439-010-0888-2","article-title":"The majority of the genetic risk for Paget\u2019s disease of bone is explained by genetic variants close to the CSF1, OPTN, TM7SF4, and TNFRSF11A genes","volume":"128","author":"Chung","year":"2010","journal-title":"Hum. Genet."},{"key":"10.1016\/j.bbrc.2020.03.028_bib9","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/ng.845","article-title":"Genome-wide association identifies three new susceptibility loci for Paget\u2019s disease of bone","volume":"43","author":"Albagha","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2020.03.028_bib10","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1086\/340731","article-title":"Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1\/p62) in Paget disease of bone","volume":"70","author":"Laurin","year":"2002","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2020.03.028_bib11","doi-asserted-by":"crossref","first-page":"85","DOI":"10.11005\/jbm.2014.21.2.85","article-title":"Pathobiology of Paget\u2019s disease of bone","volume":"21","author":"Galson","year":"2014","journal-title":"J.\u00a0Bone. Metab."},{"key":"10.1016\/j.bbrc.2020.03.028_bib12","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.celrep.2015.09.071","article-title":"Optineurin negatively regulates osteoclast differentiation by modulating NF-\u03baB and interferon signaling: implications for Paget\u2019s disease","volume":"13","author":"Obaid","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbrc.2020.03.028_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017477","article-title":"Optineurin is required for CYLD-dependent inhibition of TNF\u03b1-induced NF-\u03baB activation","volume":"6","author":"Nagabhushana","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.bbrc.2020.03.028_bib14","doi-asserted-by":"crossref","first-page":"35663","DOI":"10.1074\/jbc.M111.267567","article-title":"Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon \u03b2","volume":"286","author":"Gleason","year":"2011","journal-title":"J.\u00a0Biol Chem."},{"key":"10.1016\/j.bbrc.2020.03.028_bib15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.molmed.2004.12.004","article-title":"Osteoclast-derived activity in the coupling of bone formation to resorption","volume":"11","author":"Martin","year":"2005","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbrc.2020.03.028_bib16","doi-asserted-by":"crossref","first-page":"3244","DOI":"10.1172\/JCI45843","article-title":"3BP2-deficient mice are osteoporotic with impaired osteoblast and osteoclast functions","volume":"121","author":"Leavaot","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2020.03.028_bib17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/nature11000","article-title":"Osteoprotection by semaphorin 3A","volume":"485","author":"Hayashi","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.03.028_bib18","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1084\/jem.20091957","article-title":"The Blimp1-Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis","volume":"207","author":"Miyauchi","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2020.03.028_bib19","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bbrc.2015.01.012","article-title":"Bcl6 promotes osteoblastogenesis through Stat1 inhibition","volume":"457","author":"Fujie","year":"2013","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2020.03.028_bib20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40902-017-0104-6","article-title":"The effect of biomechanical stimulation on osteoblast differentiation of human jaw periosteum-derived stem cells","volume":"39","author":"Lee","year":"2017","journal-title":"Maxillofac. Plast. Reconstr. Surg."},{"key":"10.1016\/j.bbrc.2020.03.028_bib21","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00774-003-0426-6","article-title":"Changes in bone turnover markers during 14-day 6 head-down bed rest","volume":"21","author":"Kim","year":"2003","journal-title":"J.\u00a0Bone Miner. Metabol."},{"key":"10.1016\/j.bbrc.2020.03.028_bib22","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1210\/endo.141.5.7458","article-title":"Expression of vascular endothelial growth factors and their receptors during osteoblast differentiation","volume":"141","author":"Deckers","year":"2000","journal-title":"Endocrinology"},{"issue":"16","key":"10.1016\/j.bbrc.2020.03.028_bib23","doi-asserted-by":"crossref","DOI":"10.1101\/gad.1119303","article-title":"Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation","volume":"17","author":"Kim","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2020.03.028_bib24","doi-asserted-by":"crossref","first-page":"12547","DOI":"10.1038\/ncomms12547","article-title":"Linear ubiquitination is involved in the pathogenesis of optineurin-associated amyotrophic lateral sclerosis","volume":"7","author":"Nakazawa","year":"2016","journal-title":"Nat. Commun."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20305076?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20305076?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:26:11Z","timestamp":1777400771000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20305076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S0006291X20305076"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.03.028","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optineurin regulates osteoblastogenesis through STAT1","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.03.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}