{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T12:33:12Z","timestamp":1784032392789,"version":"3.55.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.bbrc.2020.03.124","type":"journal-article","created":{"date-parts":[[2020,4,4]],"date-time":"2020-04-04T16:28:31Z","timestamp":1586017711000},"page":"733-737","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Salvianolic acid B improved insulin resistance through suppression of hepatic ER stress in ob\/ob mice"],"prefix":"10.1016","volume":"526","author":[{"given":"Yanan","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihong","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biao","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.03.124_bib1","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.124945","article-title":"Restoration of insulin receptor improves diabetic phenotype in T2DM mice","volume":"4","author":"Wang","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbrc.2020.03.124_bib2","doi-asserted-by":"crossref","first-page":"e442","DOI":"10.1371\/journal.pmed.0030442","article-title":"Projections of global mortality and burden of disease from 2002 to 2030","volume":"3","author":"Mathers","year":"2006","journal-title":"PLoS Med."},{"key":"10.1016\/j.bbrc.2020.03.124_bib3","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nrendo.2011.183","article-title":"The worldwide epidemiology of type 2 diabetes mellitus \u2014 present and future perspectives","volume":"8","author":"Chen","year":"2011","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbrc.2020.03.124_bib4","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1074\/jbc.M411860200","article-title":"Involvement of endoplasmic reticulum stress in insulin resistance and diabetes","volume":"280","author":"Nakatani","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.03.124_bib5","doi-asserted-by":"crossref","first-page":"S73","DOI":"10.2337\/diabetes.54.suppl_2.S73","article-title":"Role of endoplasmic reticulum stress and c-Jun NH2-terminal kinase pathways in inflammation and origin of obesity and diabetes","volume":"54","author":"Hotamisligil","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2020.03.124_bib6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1042\/CS20080680","article-title":"Endoplasmic reticulum stress in disease: mechanisms and therapeutic opportunities","volume":"118","author":"Hosoi","year":"2009","journal-title":"Clin. Sci. (Lond.)"},{"key":"10.1016\/j.bbrc.2020.03.124_bib7","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1159\/000440905","article-title":"Mechanism of ER stress and inflammation for hepatic insulin resistance in obesity","volume":"67","author":"Kim","year":"2015","journal-title":"Nutr. Metab."},{"key":"10.1016\/j.bbrc.2020.03.124_bib8","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1128\/MCB.16.8.4273","article-title":"Signals from the stressed endoplasmic reticulum induce C\/EBP-homologous protein (CHOP\/GADD153)","volume":"16","author":"Wang","year":"1996","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2020.03.124_bib9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1126\/science.1103160","article-title":"Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes","volume":"306","author":"Ozcan","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2020.03.124_bib10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cmet.2006.10.001","article-title":"GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress","volume":"4","author":"Yusta","year":"2006","journal-title":"Cell Metabol."},{"key":"10.1016\/j.bbrc.2020.03.124_bib11","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1126\/science.1128294","article-title":"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes","volume":"13","author":"Ozcan","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2020.03.124_bib12","first-page":"10","article-title":"Study on salvianolic acid, water-soluble compounds of Salvia miltiorrhiza","volume":"2","author":"Du","year":"2000","journal-title":"Basic. Med. Sci. Clin. (Chin)"},{"key":"10.1016\/j.bbrc.2020.03.124_bib13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.etap.2016.08.004","article-title":"Combination of chlorogenic acid and salvianolic acid B protects against polychlorinated biphenylsinduced oxidative stress through Nrf 2","volume":"46","author":"Chen","year":"2016","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.bbrc.2020.03.124_bib14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/s00240-019-01114-4","article-title":"Protective effect of salvianolic acid B against oxidative injury associated with cystine stone formation","volume":"47","author":"Zhang","year":"2019","journal-title":"Urolithiasis"},{"key":"10.1016\/j.bbrc.2020.03.124_bib15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.fct.2007.06.034","article-title":"Characterization of the radical scavenging and antioxidant activities of danshensu and salvianolic acid B","volume":"46","author":"Zhao","year":"2008","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbrc.2020.03.124_bib16","doi-asserted-by":"crossref","first-page":"679","DOI":"10.3748\/wjg.v8.i4.679","article-title":"Clinical observation of salvianolic acid B in treatment of liver fibrosis in chronic hepatitis B","volume":"8","author":"Liu","year":"2002","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.bbrc.2020.03.124_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep16013","article-title":"Inhibition of HMGB1 release via salvianolic acid B-mediated SIRT1 up-regulation protects rats against non-alcoholic fatty liver disease","volume":"5","author":"Zeng","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbrc.2020.03.124_bib18","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1159\/000453151","article-title":"Salvianolic acid B ameliorates hyperglycemia and dyslipidemia in db\/db mice through the AMPK pathway","volume":"40","author":"Huang","year":"2016","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.bbrc.2020.03.124_bib19","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1177\/0091270005282630","article-title":"Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use","volume":"45","author":"Zhou","year":"2005","journal-title":"J.\u00a0Clin. Pharmacol."},{"key":"10.1016\/j.bbrc.2020.03.124_bib20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/med.20077","article-title":"New developments in the chemistry and biology of the bioactive constituents of Tanshen","volume":"27","author":"Wang","year":"2007","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bbrc.2020.03.124_bib21","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1423-0127-18-30","article-title":"Salvianolic acids: small compounds with multiple mechanisms for cardiovascular protection","volume":"18","author":"Ho","year":"2011","journal-title":"J.\u00a0Biomed. Sci."},{"key":"10.1016\/j.bbrc.2020.03.124_bib22","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/BF00253736","article-title":"Hepatic and peripheral insulin resistance: a common feature of type 2 (non-insulin-dependent) and type 1 (insulin-dependent) diabetes mellitus","volume":"23","author":"DeFronzo","year":"1982","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2020.03.124_bib23","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bbrc.2010.11.120","article-title":"Caloric restriction decreases ER stress in liver and adipose tissue in ob\/ob mice","volume":"404","author":"Tsutsumi","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2020.03.124_bib24","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.molmed.2011.07.010","article-title":"Endoplasmic reticulum stress, obesity and diabetes","volume":"18","author":"Cnop","year":"2012","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbrc.2020.03.124_bib25","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1126\/science.1128294","article-title":"Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes","volume":"313","author":"Ozcan","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2020.03.124_bib26","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2030615X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X2030615X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:52:27Z","timestamp":1757764347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X2030615X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0006291X2030615X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.03.124","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Salvianolic acid B improved insulin resistance through suppression of hepatic ER stress in ob\/ob mice","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.03.124","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}