{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T15:02:59Z","timestamp":1761490979070,"version":"3.44.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T00:00:00Z","timestamp":1585353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003995","name":"Natural Science Foundation of Anhui Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003995","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010816","name":"Anhui Science and Technology Department","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010816","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.bbrc.2020.03.154","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:54:09Z","timestamp":1585875249000},"page":"685-691","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["The Wnt3a\/\u03b2-catenin\/TCF7L2 signaling axis reduces the sensitivity of HER2-positive epithelial ovarian cancer to trastuzumab"],"prefix":"10.1016","volume":"526","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2521-8738","authenticated-orcid":false,"given":"Guodong","family":"Shen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fenfen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6559-4626","authenticated-orcid":false,"given":"Meng","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingjuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peipei","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dabing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiyan","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huirong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuanxuan","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinchun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shilian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.03.154_bib1","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"Ca - Cancer J. Clin."},{"key":"10.1016\/j.bbrc.2020.03.154_bib2","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrc2644","article-title":"The biology of ovarian cancer: new opportunities for translation","volume":"9","author":"Bast","year":"2009","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bbrc.2020.03.154_bib3","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/nrc4019","article-title":"Rethinking ovarian cancer II: reducing mortality from high-grade serous ovarian cancer","volume":"15","author":"Bowtell","year":"2015","journal-title":"Nat. Rev. Canc."},{"key":"10.1016\/j.bbrc.2020.03.154_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0191972","article-title":"The prognostic value of HER2 in ovarian cancer: a meta-analysis of observational studies","volume":"13","author":"Luo","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.bbrc.2020.03.154_bib5","first-page":"2420","article-title":"Overexpression of HER-2 in ovarian carcinomas","volume":"61","author":"Hellstrom","year":"2001","journal-title":"Canc. Res."},{"key":"10.1016\/j.bbrc.2020.03.154_bib6","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.2217\/fon.15.266","article-title":"A\u00a0review of HER2-targeted therapy in breast and ovarian cancer: lessons from antiquity - CLEOPATRA and PENELOPE","volume":"11","author":"Hodeib","year":"2015","journal-title":"Future Oncol."},{"key":"10.1016\/j.bbrc.2020.03.154_bib7","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.1200\/JCO.2008.18.1107","article-title":"New insights into the pathogenesis of serous ovarian cancer and its clinical impact","volume":"26","author":"Levanon","year":"2008","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.bbrc.2020.03.154_bib8","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/beta-Catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2020.03.154_bib9","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/nature03914","article-title":"Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development","volume":"437","author":"Nateri","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.03.154_bib10","doi-asserted-by":"crossref","first-page":"10703","DOI":"10.1074\/jbc.M111.323311","article-title":"MUC1-C oncoprotein induces TCF7L2 transcription factor activation and promotes cyclin D1 expression in human breast cancer cells","volume":"287","author":"Rajabi","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.03.154_bib11","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13048-019-0596-z","article-title":"Wnt\/beta-catenin signalling in ovarian cancer: insights into its hyperactivation and function in tumorigenesis","volume":"12","author":"Nguyen","year":"2019","journal-title":"J.\u00a0Ovarian Res."},{"key":"10.1016\/j.bbrc.2020.03.154_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijgo.2013.10.001","article-title":"Staging classification for cancer of the ovary, fallopian tube, and peritoneum","volume":"124","author":"Prat","year":"2014","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.bbrc.2020.03.154_bib13","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00262-010-0937-7","article-title":"In\u00a0vivo activity of novel anti-ErbB2 antibody chA21 alone and with Paclitaxel or Trastuzumab in breast and ovarian cancer xenograft models","volume":"60","author":"Shen","year":"2011","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.bbrc.2020.03.154_bib14","doi-asserted-by":"crossref","first-page":"5954","DOI":"10.1073\/pnas.1017496108","article-title":"An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt\/wingless signaling pathway","volume":"108","author":"Gonsalves","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2020.03.154_bib15","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41401-019-0271-3","article-title":"Garcinol inhibits esophageal cancer metastasis by suppressing the p300 and TGF-beta 1 signaling pathways","volume":"41","author":"Wang","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbrc.2020.03.154_bib16","first-page":"2831","article-title":"Clinical efficacy and safety of combination of abraxane and trastuzumab in treatment of recurrent ovarian cancer","volume":"31","author":"Yang","year":"2018","journal-title":"Pak. J. Pharm. Sci."},{"key":"10.1016\/j.bbrc.2020.03.154_bib17","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.canlet.2019.08.008","article-title":"Cullin 7 enhances resistance to trastuzumab therapy in Her2 positive breast cancer via degrading IRS-1 and downregulating IGFBP-3 to activate the PI3K\/AKT pathway","volume":"464","author":"Qiu","year":"2019","journal-title":"Canc. Lett."},{"key":"10.1016\/j.bbrc.2020.03.154_bib18","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1002\/jcb.26562","article-title":"NES1\/KLK10 promotes trastuzumab resistance via activation of PI3K\/AKT signaling pathway in gastric cancer","volume":"119","author":"Tang","year":"2018","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.bbrc.2020.03.154_bib19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/GCO.0000000000000600","article-title":"Mechanisms of PARP inhibitor resistance in ovarian cancer","volume":"32","author":"Kubalanza","year":"2020","journal-title":"Curr. Opin. Obstet. Gynecol."},{"key":"10.1016\/j.bbrc.2020.03.154_bib20","first-page":"8247","article-title":"Diverse mechanisms of beta-catenin deregulation in ovarian endometrioid adenocarcinomas","volume":"61","author":"Wu","year":"2001","journal-title":"Canc. Res."},{"key":"10.1016\/j.bbrc.2020.03.154_bib21","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1002\/mc.23064","article-title":"Activation of Wnt signaling promotes olaparib resistant ovarian cancer","volume":"58","author":"Yamamoto","year":"2019","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.bbrc.2020.03.154_bib22","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/modpathol.2014.114","article-title":"Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression","volume":"28","author":"Stewart","year":"2015","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.bbrc.2020.03.154_bib23","first-page":"3325","article-title":"Therapeutic intervention of proanthocyanidins on the migration capacity of melanoma cells is mediated through PGE2 receptors and beta-catenin signaling molecules","volume":"5","author":"Vaid","year":"2015","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.bbrc.2020.03.154_bib24","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1038\/onc.2014.141","article-title":"Receptor-type protein tyrosine phosphatase kappa directly dephosphorylates CD133 and regulates downstream AKT activation","volume":"34","author":"Shimozato","year":"2015","journal-title":"Oncogene"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20306513?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20306513?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:50:28Z","timestamp":1757764228000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20306513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0006291X20306513"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.03.154","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Wnt3a\/\u03b2-catenin\/TCF7L2 signaling axis reduces the sensitivity of HER2-positive epithelial ovarian cancer to trastuzumab","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.03.154","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}