{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:41:47Z","timestamp":1768812107547,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31471091"],"award-info":[{"award-number":["31471091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["201601"],"award-info":[{"award-number":["201601"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People&apos;s Republic of China","doi-asserted-by":"publisher","award":["KeyME-2018-09"],"award-info":[{"award-number":["KeyME-2018-09"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["JC2019035"],"award-info":[{"award-number":["JC2019035"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.bbrc.2020.03.188","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:11:57Z","timestamp":1586909517000},"page":"960-966","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Distinct roles of calmodulin and Ca2+\/calmodulin-dependent protein kinase II in isopreterenol-induced cardiac hypertrophy"],"prefix":"10.1016","volume":"526","author":[{"given":"Siqi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuefei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiye","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiyuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaorong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0301-1827","authenticated-orcid":false,"given":"Liying","family":"Hao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.03.188_bib1","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.3389\/fphys.2018.01391","article-title":"Altered Ca(2+) and Na(+) homeostasis in human hypertrophic cardiomyopathy: implications for arrhythmogenesis","volume":"9","author":"Coppini","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbrc.2020.03.188_bib2","doi-asserted-by":"crossref","DOI":"10.1111\/febs.14969","article-title":"Diminished inhibition and facilitated activation of RyR2-mediated Ca(2+) release is a common defect of arrhythmogenic calmodulin mutations","author":"Sondergaard","year":"2019","journal-title":"FEBS J."},{"key":"10.1016\/j.bbrc.2020.03.188_bib3","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bbadis.2018.08.016","article-title":"Galectin-1 attenuates cardiomyocyte hypertrophy through splice-variant specific modulation of CaV1.2 calcium channel","volume":"1865","author":"Fan","year":"2019","journal-title":"Biochim. Biophys. Acta (BBA) - Mol. Basis Dis."},{"key":"10.1016\/j.bbrc.2020.03.188_bib4","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1161\/CIRCRESAHA.110.222562","article-title":"Alterations of L-type calcium current and cardiac function in CaMKII{delta} knockout mice","volume":"107","author":"Xu","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2020.03.188_bib5","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1089\/dna.2013.2231","article-title":"Dynamic alterations in the CaV1.2\/CaM\/CaMKII signaling pathway in the left ventricular myocardium of ischemic rat hearts","volume":"33","author":"Zhao","year":"2014","journal-title":"DNA Cell Biol."},{"key":"10.1016\/j.bbrc.2020.03.188_bib6","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2170\/physiolsci.RP000507","article-title":"Distinct roles of CaM and Ca(2+)\/CaM -dependent protein kinase II in Ca(2+) -dependent facilitation and inactivation of cardiac L-type Ca(2+) channels","volume":"57","author":"Nie","year":"2007","journal-title":"J.\u00a0Physiol. Sci."},{"key":"10.1016\/j.bbrc.2020.03.188_bib7","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1161\/HYPERTENSIONAHA.116.07420","article-title":"Type III transforming growth factor-beta receptor drives cardiac hypertrophy through beta-arrestin2-dependent activation of calmodulin-dependent protein kinase II","volume":"68","author":"Lou","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrc.2020.03.188_bib8","doi-asserted-by":"crossref","first-page":"H501","DOI":"10.1152\/ajpheart.00601.2016","article-title":"Caveolae-specific activation loop between CaMKII and L-type Ca(2+) channel aggravates cardiac hypertrophy in alpha1-adrenergic stimulation","volume":"312","author":"Tonegawa","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2020.03.188_bib9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.yjmcc.2016.06.007","article-title":"CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift","volume":"98","author":"Uchinoumi","year":"2016","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2020.03.188_bib10","doi-asserted-by":"crossref","first-page":"H532","DOI":"10.1152\/ajpheart.00765.2015","article-title":"CaMKII-dependent phosphorylation regulates basal cardiac pacemaker function via modulation of local Ca2+ releases","volume":"311","author":"Li","year":"2016","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2020.03.188_bib11","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.bbrc.2010.04.129","article-title":"Intracellular translocation of calmodulin and Ca2+\/calmodulin-dependent protein kinase II during the development of hypertrophy in neonatal cardiomyocytes","volume":"396","author":"Gangopadhyay","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2020.03.188_bib12","doi-asserted-by":"crossref","first-page":"35078","DOI":"10.1074\/jbc.M707083200","article-title":"CaMKIIdelta isoforms differentially affect calcium handling but similarly regulate HDAC\/MEF2 transcriptional responses","volume":"282","author":"Zhang","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.03.188_bib13","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.yjmcc.2006.08.010","article-title":"Class II HDACs mediate CaMK-dependent signaling to NRSF in ventricular myocytes","volume":"41","author":"Nakagawa","year":"2006","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2020.03.188_bib14","doi-asserted-by":"crossref","first-page":"H688","DOI":"10.1152\/ajpheart.01014.2009","article-title":"Calmodulin kinase II is required for angiotensin II-mediated vascular smooth muscle hypertrophy","volume":"298","author":"Li","year":"2010","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbrc.2020.03.188_bib15","doi-asserted-by":"crossref","first-page":"4545","DOI":"10.3892\/mmr.2017.7211","article-title":"Lercanidipine attenuates angiotensin II-induced cardiomyocyte hypertrophy by blocking calcineurin-NFAT3 and CaMKII-HDAC4 signaling","volume":"16","author":"Chen","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbrc.2020.03.188_bib16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0037176","article-title":"A\u00a0significant but rather mild contribution of T286 autophosphorylation to Ca2+\/CaM-stimulated CaMKII activity","volume":"7","author":"Coultrap","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.bbrc.2020.03.188_bib17","doi-asserted-by":"crossref","first-page":"12308","DOI":"10.1074\/jbc.M110.157057","article-title":"Lobe-specific functions of Ca2+.calmodulin in alphaCa2+.calmodulin-dependent protein kinase II activation","volume":"286","author":"Jama","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.03.188_bib18","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.pharmthera.2010.04.005","article-title":"Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies","volume":"128","author":"Bernardo","year":"2010","journal-title":"Pharmacol. Therapeut."},{"key":"10.1016\/j.bbrc.2020.03.188_bib19","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.yjmcc.2010.11.012","article-title":"Calcium influx through Cav1.2 is a proximal signal for pathological cardiomyocyte hypertrophy","volume":"50","author":"Chen","year":"2011","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2020.03.188_bib20","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1172\/JCI58227","article-title":"Decreased cardiac L-type Ca(2)(+) channel activity induces hypertrophy and heart failure in mice","volume":"122","author":"Goonasekera","year":"2012","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2020.03.188_bib21","first-page":"4","article-title":"Graded Ca(2)(+)\/calmodulin-dependent coupling of voltage-gated CaV1.2 channels","author":"Dixon","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.bbrc.2020.03.188_bib22","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1161\/CIRCRESAHA.118.313417","article-title":"Cardiomyocyte PKA ablation enhances basal contractility while eliminates cardiac beta-adrenergic response without adverse effects on the heart","volume":"124","author":"Zhang","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbrc.2020.03.188_bib23","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.yjmcc.2014.07.011","article-title":"NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII","volume":"75","author":"Wagner","year":"2014","journal-title":"J.\u00a0Mol. Cell. Cardiol."},{"key":"10.1016\/j.bbrc.2020.03.188_bib24","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1085\/jgp.201812115","article-title":"A\u00a0bilobal model of Ca(2+)-dependent inactivation to probe the physiology of L-type Ca(2+) channels","volume":"150","author":"Limpitikul","year":"2018","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.bbrc.2020.03.188_bib25","doi-asserted-by":"crossref","first-page":"E7976","DOI":"10.1073\/pnas.1617116113","article-title":"Loss of beta-adrenergic-stimulated phosphorylation of CaV1.2 channels on Ser1700 leads to heart failure","volume":"113","author":"Yang","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbrc.2020.03.188_bib26","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1172\/JCI29515","article-title":"Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel","volume":"117","author":"Yamaguchi","year":"2007","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.bbrc.2020.03.188_bib27","doi-asserted-by":"crossref","first-page":"12680","DOI":"10.1074\/jbc.M113.460949","article-title":"Competitive and non-competitive regulation of calcium-dependent inactivation in CaV1.2 L-type Ca2+ channels by calmodulin and Ca2+-binding protein 1","volume":"288","author":"Oz","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.03.188_bib28","doi-asserted-by":"crossref","first-page":"E10556","DOI":"10.1073\/pnas.1808733115","article-title":"Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel","volume":"115","author":"Wang","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20307026?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20307026?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:37:53Z","timestamp":1762094273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20307026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0006291X20307026"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.03.188","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Distinct roles of calmodulin and Ca2+\/calmodulin-dependent protein kinase II in isopreterenol-induced cardiac hypertrophy","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.03.188","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}