{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T10:50:24Z","timestamp":1772707824077,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.bbrc.2020.04.006","type":"journal-article","created":{"date-parts":[[2020,4,18]],"date-time":"2020-04-18T16:56:31Z","timestamp":1587228991000},"page":"1092-1099","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["CARD6 protects against collagen-induced rheumatoid arthritis in mice through attenuating the inflammatory response and joint destruction via suppression of TNFR1\/TRAF2 signaling"],"prefix":"10.1016","volume":"526","author":[{"given":"Min","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongying","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianbao","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.bbrc.2020.04.006_bib1","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/ng.2462","article-title":"High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis","volume":"44","author":"Eyre","year":"2012","journal-title":"Nat. Genet."},{"issue":"11","key":"10.1016\/j.bbrc.2020.04.006_bib2","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/nrrheum.2012.153","article-title":"Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment","volume":"8","author":"Schett","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"issue":"2","key":"10.1016\/j.bbrc.2020.04.006_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.immuni.2017.02.006","article-title":"Immunopathogenesis of rheumatoid arthritis","volume":"46","author":"Firestein","year":"2017","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.bbrc.2020.04.006_bib4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nrrheum.2011.205","article-title":"Hypoxia-a key regulator of angiogenesis and inflammation in rheumatoid arthritis","volume":"8","author":"Konisti","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"issue":"4","key":"10.1016\/j.bbrc.2020.04.006_bib5","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1002\/art.38307","article-title":"Rheumatoid factor as a potentiator of anti-citrullinated protein antibody-mediated inflammation in rheumatoid arthritis","volume":"66","author":"Sokolove","year":"2014","journal-title":"Arthritis & rheumatology"},{"issue":"4","key":"10.1016\/j.bbrc.2020.04.006_bib6","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/art.33446","article-title":"Interleukin-22 promotes osteoclastogenesis in rheumatoid arthritis through induction of RANKL in human synovial fibroblasts","volume":"64","author":"Kim","year":"2012","journal-title":"Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.bbrc.2020.04.006_bib7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00011-012-0572-1","article-title":"Reduced apoptosis correlates with enhanced autophagy in synovial tissues of rheumatoid arthritis","volume":"62","author":"Xu","year":"2013","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.bbrc.2020.04.006_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jaut.2017.01.002","article-title":"MicroRNA-155 contributes to enhanced resistance to apoptosis in monocytes from patients with rheumatoid arthritis","volume":"79","author":"Rajasekhar","year":"2017","journal-title":"J.\u00a0Autoimmun."},{"issue":"5","key":"10.1016\/j.bbrc.2020.04.006_bib9","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s11926-012-0272-4","article-title":"Managing macrophages in rheumatoid arthritis by reform or removal","volume":"14","author":"Li","year":"2012","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.bbrc.2020.04.006_bib10","first-page":"2015","article-title":"Lipid peroxidation-mediated inflammation promotes cell apoptosis through activation of NF-\u03baB pathway in rheumatoid arthritis synovial cells","author":"Yin","year":"2015","journal-title":"Mediat. Inflamm."},{"issue":"34","key":"10.1016\/j.bbrc.2020.04.006_bib11","doi-asserted-by":"crossref","first-page":"31941","DOI":"10.1074\/jbc.M300009200","article-title":"CARD6 is a modulator of NF-\u03baB activation by Nod1-and Cardiak-mediated pathways","volume":"278","author":"Stehlik","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbrc.2020.04.006_bib12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3109\/00313020903434421","article-title":"Expression of CARD6, an NF-\u03baB activator, in gastric, colorectal and oesophageal cancers","volume":"42","author":"Kim","year":"2010","journal-title":"Pathology"},{"issue":"4","key":"10.1016\/j.bbrc.2020.04.006_bib13","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1073\/pnas.0510380103","article-title":"Caspase recruitment domain protein 6 is a microtubule-interacting protein that positively modulates NF-\u03baB activation","volume":"103","author":"Dufner","year":"2006","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"issue":"5","key":"10.1016\/j.bbrc.2020.04.006_bib14","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jhep.2018.06.014","article-title":"Caspase recruitment domain 6 protects against hepatic ischemia\/reperfusion injury by suppressing ASK1","volume":"69","author":"Qin","year":"2018","journal-title":"J.\u00a0Hepatol."},{"issue":"24","key":"10.1016\/j.bbrc.2020.04.006_bib15","article-title":"Targeting CARD6 attenuates spinal cord injury (SCI) in mice through inhibiting apoptosis, inflammation and oxidative stress associated ROS production","volume":"11","author":"Wang","year":"2019","journal-title":"Aging (Albany NY)"},{"issue":"2","key":"10.1016\/j.bbrc.2020.04.006_bib16","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.bbrc.2020.02.080","article-title":"Increased macrophage activation mediated by caspase recruitment domain 6 knockdown through negatively targeting AMPK","volume":"525","author":"Chen","year":"2020","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"10","key":"10.1016\/j.bbrc.2020.04.006_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2016.300","article-title":"1, 25-dihydroxy-vitamin D3 with tumor necrosis factor-alpha protects against rheumatoid arthritis by promoting p53 acetylation-mediated apoptosis via Sirt1 in synoviocytes","volume":"7","author":"Gu","year":"2016","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.bbrc.2020.04.006_bib18","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1038\/nprot.2007.173","article-title":"Collagen-induced arthritis","volume":"2","author":"Brand","year":"2007","journal-title":"Nat. Protoc."},{"issue":"11","key":"10.1016\/j.bbrc.2020.04.006_bib19","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1136\/ard.2008.097709","article-title":"Bortezomib attenuates murine collagen-induced arthritis","volume":"68","author":"Lee","year":"2009","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.bbrc.2020.04.006_bib20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1179\/135100005X83680","article-title":"ROS as signalling molecules in T cells-evidence for abnormal redox signalling in the autoimmune disease, rheumatoid arthritis","volume":"10","author":"Griffiths","year":"2005","journal-title":"Redox Rep."},{"issue":"5","key":"10.1016\/j.bbrc.2020.04.006_bib21","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/intimm\/dxs047","article-title":"Targeting TNF receptors in rheumatoid arthritis","volume":"24","author":"Bl\u00fcml","year":"2012","journal-title":"Int. Immunol."},{"issue":"3","key":"10.1016\/j.bbrc.2020.04.006_bib22","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/00002281-200305000-00015","article-title":"Apoptosis in rheumatoid arthritis","volume":"15","author":"Baier","year":"2003","journal-title":"Curr. Opin. Rheumatol."},{"issue":"1","key":"10.1016\/j.bbrc.2020.04.006_bib23","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3892\/mmr.2012.1168","article-title":"Effects of exercise therapy on knee joint function and synovial fluid cytokine levels in patients with knee osteoarthritis","volume":"7","author":"Zhang","year":"2013","journal-title":"Mol. Med. Rep."},{"issue":"5","key":"10.1016\/j.bbrc.2020.04.006_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095346","article-title":"Plasma levels of IL-37 and correlation with TNF-\u03b1, IL-17A, and disease activity during DMARD treatment of rheumatoid arthritis","volume":"9","author":"Zhao","year":"2014","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.bbrc.2020.04.006_bib25","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1517\/13543784.17.3.349","article-title":"The future of the IL-1 receptor antagonist anakinra: from rheumatoid arthritis to adult-onset Still\u2019s disease and systemic-onset juvenile idiopathic arthritis","volume":"17","author":"Kalliolias","year":"2008","journal-title":"Expet Opin. Invest. Drugs"},{"issue":"2","key":"10.1016\/j.bbrc.2020.04.006_bib26","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.bmc.2008.11.067","article-title":"Current perspective of TACE inhibitors: a review","volume":"17","author":"DasGupta","year":"2009","journal-title":"Bioorg. Med. Chem."},{"issue":"3","key":"10.1016\/j.bbrc.2020.04.006_bib27","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.neuron.2014.04.009","article-title":"TNF-\u03b1\/TNFR1 signaling is required for the development and function of primary nociceptors","volume":"82","author":"Wheeler","year":"2014","journal-title":"Neuron"},{"issue":"10","key":"10.1016\/j.bbrc.2020.04.006_bib28","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/sj.onc.1209945","article-title":"Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-\u03ba B activation and proliferation in human head and neck squamous cell carcinoma","volume":"26","author":"Jackson-Bernitsas","year":"2007","journal-title":"Oncogene"},{"issue":"6","key":"10.1016\/j.bbrc.2020.04.006_bib29","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1742-4658.2011.08015.x","article-title":"TNFR1-induced activation of the classical NF-\u03baB pathway","volume":"278","author":"Wajant","year":"2011","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.bbrc.2020.04.006_bib30","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2165\/00063030-200721010-00004","article-title":"Tumor necrosis factor receptor pre-ligand assembly domain is an important therapeutic target in inflammatory arthritis","volume":"21","author":"Deng","year":"2007","journal-title":"BioDrugs"},{"issue":"6","key":"10.1016\/j.bbrc.2020.04.006_bib31","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.4049\/jimmunol.1600360","article-title":"Microrna-17 suppresses TNF-\u03b1 signaling by interfering with TRAF2 and cIAP2 association in rheumatoid arthritis synovial fibroblasts","volume":"197","author":"Akhtar","year":"2016","journal-title":"J.\u00a0Immunol."},{"issue":"9","key":"10.1016\/j.bbrc.2020.04.006_bib32","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/ni.3253","article-title":"Phagocytosis of apoptotic cells in homeostasis","volume":"16","author":"Arandjelovic","year":"2015","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.bbrc.2020.04.006_bib33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1471-4892(03)00037-7","article-title":"The role of apoptosis in rheumatoid arthritis","volume":"3","author":"Liu","year":"2003","journal-title":"Curr. Opin. Pharmacol."},{"issue":"7","key":"10.1016\/j.bbrc.2020.04.006_bib34","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/nri846","article-title":"Apoptosis as a therapeutic tool in rheumatoid arthritis","volume":"2","author":"Pope","year":"2002","journal-title":"Nat. Rev. Immunol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20307038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20307038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:49:49Z","timestamp":1757764189000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20307038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["S0006291X20307038"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.04.006","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CARD6 protects against collagen-induced rheumatoid arthritis in mice through attenuating the inflammatory response and joint destruction via suppression of TNFR1\/TRAF2 signaling","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}