{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T18:52:53Z","timestamp":1758048773796,"version":"3.44.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.bbrc.2020.05.025","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T07:46:45Z","timestamp":1589788005000},"page":"1021-1026","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Malaria: Paving the way to developing peptide-based vaccines against invasion in infectious diseases"],"prefix":"10.1016","volume":"527","author":[{"given":"C\u00e9sar","family":"Reyes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6865-3153","authenticated-orcid":false,"given":"Jessica","family":"Molina-Franky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Aza-Conde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8423-408X","authenticated-orcid":false,"given":"Carlos F.","family":"Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Pab\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Moreno-Vranich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel A.","family":"Patarroyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel E.","family":"Patarroyo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2020.05.025_bib1","article-title":"WHO Malaria report 2019","volume":"2019","author":"World Health Organization","year":"2019","journal-title":"Malar. Rep."},{"key":"10.1016\/j.bbrc.2020.05.025_bib2","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a025569","article-title":"Malaria pathogenesis","author":"Milner","year":"2018","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"10.1016\/j.bbrc.2020.05.025_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004670","article-title":"Revealing the sequence and resulting cellular morphology of receptor-ligand interactions during Plasmodium falciparum invasion of erythrocytes","author":"Weiss","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bbrc.2020.05.025_bib4","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.chom.2017.07.003","article-title":"The molecular basis of erythrocyte invasion by malaria parasites","volume":"22","author":"Cowman","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bbrc.2020.05.025_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.pt.2015.12.007","article-title":"Overlaying molecular and temporal aspects of malaria parasite invasion","author":"Weiss","year":"2016","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.bbrc.2020.05.025_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2010.12.003","article-title":"Super-resolution dissection of coordinated events during malaria parasite invasion of the human erythrocyte","author":"Riglar","year":"2011","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bbrc.2020.05.025_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpara.2012.11.002","article-title":"New approaches to studying Plasmodium falciparum merozoite invasion and insights into invasion biology","author":"Boyle","year":"2013","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.bbrc.2020.05.025_bib8","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.chom.2017.02.006","article-title":"Malaria parasite invasion: achieving superb resolution","volume":"21","author":"Baum","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bbrc.2020.05.025_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/S1471-4922(01)01948-1","article-title":"An expanding ebl family of Plasmodium falciparum","author":"Adams","year":"2001","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.bbrc.2020.05.025_bib10","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1008151107","article-title":"Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand","author":"Tham","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbrc.2020.05.025_bib11","doi-asserted-by":"crossref","DOI":"10.1038\/nature10606","article-title":"Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum","author":"Crosnier","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.05.025_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000104","article-title":"Antibodies targeting the PfRH1 binding domain inhibit invasion of Plasmodium falciparum merozoites","author":"Gao","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bbrc.2020.05.025_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2016.06.004","article-title":"Essential role of the PfRh5\/PfRipr\/CyRPA complex during Plasmodium falciparum invasion of erythrocytes","author":"Volz","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bbrc.2020.05.025_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017102","article-title":"Plasmodium falciparum reticulocyte binding-like homologue protein 2 (PfRH2) is a key adhesive molecule involved in erythrocyte invasion","author":"Sahar","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.bbrc.2020.05.025_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms3862","article-title":"Triggers of key calcium signals during erythrocyte invasion by Plasmodium falciparum","author":"Gao","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbrc.2020.05.025_bib16","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1021\/cr068407v","article-title":"Intimate molecular interactions of P. falciparum merozoite proteins involved in invasion of red blood cells and their implications for vaccine design","volume":"108","author":"Rodriguez","year":"2008","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bbrc.2020.05.025_bib17","doi-asserted-by":"crossref","first-page":"3459","DOI":"10.1021\/cr100223m","article-title":"Structural and immunological principles leading to chemically synthesized, multiantigenic, multistage, minimal subunit-based vaccine development","volume":"111","author":"Patarroyo","year":"2011","journal-title":"Chem. Rev."},{"key":"10.1016\/j.bbrc.2020.05.025_bib18","article-title":"Peptide-based immunotherapeutics and vaccines 2015","volume":"2015","author":"Reche","year":"2015","journal-title":"J.\u00a0Immunol. Res."},{"key":"10.1016\/j.bbrc.2020.05.025_bib19","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2217\/imt-2016-0091","article-title":"Functionally relevant proteins in Plasmodium falciparum host cell invasion","volume":"9","author":"Patarroyo","year":"2017","journal-title":"Immunotherapy"},{"key":"10.1016\/j.bbrc.2020.05.025_bib20","doi-asserted-by":"crossref","first-page":"7525","DOI":"10.1016\/j.vaccine.2015.09.109","article-title":"Immune protection-inducing protein structures (IMPIPS) against malaria: the weapons needed for beating Odysseus","volume":"33","author":"Patarroyo","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.bbrc.2020.05.025_bib21","first-page":"11","article-title":"The malaria parasite \u2019 s achilles \u2019 Heel\u00a0: functionally- relevant invasion structures","volume":"18","author":"Patarroyo","year":"2016","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.bbrc.2020.05.025_bib22","doi-asserted-by":"crossref","first-page":"278","DOI":"10.2174\/157340608784325160","article-title":"Shifting the polarity of some critical residues in malarial peptides\u2019 binding to host cells is a key factor in breaking conserved antigens\u2019 code of silence","volume":"4","author":"Cifuentes","year":"2008","journal-title":"Med. Chem."},{"key":"10.1016\/j.bbrc.2020.05.025_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0123249","article-title":"IMPIPS: the Immune Protection-Inducing Protein Structure concept in the search for steric-electron and topochemical principles for complete fully-protective chemically synthesised vaccine development","volume":"10","author":"Patarroyo","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.bbrc.2020.05.025_bib24","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.bbrc.2012.06.054","article-title":"Steric-electronic effects in malarial peptides inducing sterile immunity","volume":"423","author":"Moreno-Vranich","year":"2012","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2020.05.025_bib25","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1016\/j.vaccine.2014.02.003","article-title":"Gauche+ side-chain orientation as a key factor in the search for an immunogenic peptide mixture leading to a complete fully protective vaccine","volume":"32","author":"Berm\u00fadez","year":"2014","journal-title":"Vaccine"},{"key":"10.1016\/j.bbrc.2020.05.025_bib26","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.bbrc.2016.06.115","article-title":"TCR-contacting residues orientation and HLA-DR\u03b2\u2217 binding preference determine long-lasting protective immunity against malaria","volume":"477","author":"Alba","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2020.05.025_bib27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bbrc.2017.05.123","article-title":"Critical role of HLA-DR\u03b2\u2217 binding peptides\u2019 peripheral flanking residues in fully-protective malaria vaccine development","volume":"489","author":"Reyes","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2020.05.025_bib28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.bbrc.2017.01.077","article-title":"The role of pi-interactions and hydrogen bonds in fully protective synthetic malaria vaccine development","volume":"484","author":"Reyes","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"year":"2013","author":"Benson","journal-title":"Nucleic Acids Res.","key":"10.1016\/j.bbrc.2020.05.025_bib29"},{"key":"10.1016\/j.bbrc.2020.05.025_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbrc.2017.08.012","article-title":"Structural analysis of owl monkey MHC-DR shows that fully-protective malaria vaccine components can be readily used in humans","author":"Su\u00e1rez","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2020.05.025_bib31","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1007\/s00251-006-0127-0","article-title":"Owl monkey MHC-DRB exon 2 reveals high similarity with several HLA-DRB lineages","volume":"58","author":"Su\u00e1rez","year":"2006","journal-title":"Immunogenetics"},{"key":"10.1016\/j.bbrc.2020.05.025_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096973","article-title":"Characterising a microsatellite for DRB typing in Aotus vociferans and Aotus nancymaae (Platyrrhini)","volume":"9","author":"L\u00f3pez","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.bbrc.2020.05.025_bib33","doi-asserted-by":"crossref","DOI":"10.1111\/imm.12889","article-title":"Improved Methods for Predicting Peptide Binding Affinity to MHC Class II Molecules","author":"Jensen","year":"2018","journal-title":"Immunology"},{"key":"10.1016\/j.bbrc.2020.05.025_bib34","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gku1166","article-title":"Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations","author":"Gonz\u00e1lez-Galarza","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2020.05.025_bib35","article-title":"UniProt: a worldwide hub of protein knowledge","author":"Bateman","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2020.05.025_bib36","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gks469","article-title":"A\u00a0method for construction and visualization of amino acid binding motifs and sequence profiles including sequence weighting, pseudo counts and two-sided representation of amino acid enrichment and depletion","author":"Thomsen","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbrc.2020.05.025_bib37","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/368215a0","article-title":"Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide","volume":"368","author":"Stern","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.05.025_bib38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/378457a0","article-title":"The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3","volume":"378","author":"Ghosh","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2020.05.025_bib39","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20011194","article-title":"Structure of a complex of the human \u03b1\/\u03b2 T cell receptor (TCR) HA1.7, Influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA\u22170101 and DRBI\u22170401): insight into TCR cross-restriction and alloreactivity","author":"Hennecke","year":"2002","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2020.05.025_bib40","doi-asserted-by":"crossref","DOI":"10.1084\/jem.188.8.1511","article-title":"Crystal structure of HLA-DR2 (DRA\u22170101, DRB1\u22171501) Complexed with a peptide from human myelin basic protein","author":"Smith","year":"1998","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.bbrc.2020.05.025_bib41","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera - a visualization system for exploratory research and analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J.\u00a0Comput. Chem."},{"key":"10.1016\/j.bbrc.2020.05.025_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2005.05.033","article-title":"Structural basis for the EBA-175 erythrocyte invasion pathway of the malaria parasite Plasmodium falciparum","author":"Tolia","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2020.05.025_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2012.12.002","article-title":"The upstream sequence segment of the C-terminal cysteine-rich domain is required for microneme trafficking of Plasmodium falciparum erythrocyte binding antigen 175","author":"Sakura","year":"2013","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.bbrc.2020.05.025_bib44","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M113.450643","article-title":"Molecular basis for sialic acid-dependent receptor recognition by the Plasmodium falciparum invasion protein erythrocyte-binding antigen-140\/baebl","author":"Malpede","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.bbrc.2020.05.025_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.molbiopara.2012.01.002","article-title":"Identification of a specific region of Plasmodium falciparum EBL-1 that binds to host receptor glycophorin B and inhibits merozoite invasion in human red blood cells","author":"Li","year":"2012","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.bbrc.2020.05.025_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/S0166-6851(02)00067-1","article-title":"Plasmodium falciparum MAEBL is a unique member of the ebl family","author":"Blair","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.bbrc.2020.05.025_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12936-020-3141-z","article-title":"Plasmodium falciparum pre - erythrocytic stage vaccine development","volume":"19","author":"Molina-Franky","year":"2020","journal-title":"Malar. J."},{"key":"10.1016\/j.bbrc.2020.05.025_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.02712","article-title":"Plasmodium falciparum blood stage antimalarial vaccines: an analysis of ongoing clinical trials and new perspectives related to synthetic vaccines","author":"Salamanca","year":"2019","journal-title":"Front. Microbiol."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20309311?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X20309311?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T11:50:45Z","timestamp":1757764245000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X20309311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S0006291X20309311"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.05.025","relation":{},"ISSN":["0006-291X"],"issn-type":[{"type":"print","value":"0006-291X"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Malaria: Paving the way to developing peptide-based vaccines against invasion in infectious diseases","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2020.05.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}